• 2017
  • Graph generated 11 March 2017 using data from PubMed using criteria . (cancerindex.org)
  • A number of studies reported IL-11 as a possible cancer progression marker suggesting that therapeutic targeting of IL-11 or IL11RA in humans may be beneficial, however as of 2017 clinically relevant IL-11 signalling antagonists were still under development. (wikipedia.org)
  • STAT3
  • Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. (uniprot.org)
  • When bound to IL-21, the IL-21 receptor acts through the Jak/STAT pathway, utilizing Jak1 and Jak3 and a STAT3 homodimer to activate its target genes. (wikipedia.org)
  • When IL-31 binds to the receptor complex, JAK kinases are activated which phosphorylate and activate STAT1, STAT3, and STAT5. (wikipedia.org)
  • IL10RA
  • The bovine candidate genes, interleukin-10 (IL10), IL10 receptor alpha/beta (IL10RA/B), transforming growth factor beta 1 (TGFB1) , TGFB receptor class I/II (TGFBR1/2) , and natural resistance-associated macrophage protein 1 (SLC11A1) were sequenced for SNP discovery using pooled DNA samples, and the identified SNPs were genotyped in a case-control association study comprised of 242 MAP negative and 204 MAP positive Holstein dairy cattle. (pubmedcentralcanada.ca)
  • target genes
  • Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. (kegg.jp)
  • A number of presumptive target genes for the Ets-family transcription factor PU.1 have been identified in the B cell lineage. (readbyqxmd.com)
  • The pathways allow for target genes to be transcribed. (wikipedia.org)
  • kinases
  • The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. (wikipedia.org)
  • 1997
  • 1997). "The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y". Hum. (wikipedia.org)
  • candidate genes
  • Since this pathogen has been implicated in the pathogenesis of human IBDs, the goal of this study was to assess whether single nucleotide polymorphism (SNPs) in several well-known candidate genes for human IBD are associated with susceptibility to MAP infection in dairy cattle. (pubmedcentralcanada.ca)
  • antigen
  • However, a number of common susceptibility variants have also been also described in genes involved in the activation of B lymphocytes and antigen presenting cells. (springer.com)
  • IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation IL-11 causes bone-resorption. (wikipedia.org)