• 2017
  • Graph generated 11 March 2017 using data from PubMed using criteria . (cancerindex.org)
  • A number of studies reported IL-11 as a possible cancer progression marker suggesting that therapeutic targeting of IL-11 or IL11RA in humans may be beneficial, however as of 2017 clinically relevant IL-11 signalling antagonists were still under development. (wikipedia.org)
  • STAT3
  • Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. (uniprot.org)
  • When bound to IL-21, the IL-21 receptor acts through the Jak/STAT pathway, utilizing Jak1 and Jak3 and a STAT3 homodimer to activate its target genes. (wikipedia.org)
  • When IL-31 binds to the receptor complex, JAK kinases are activated which phosphorylate and activate STAT1, STAT3, and STAT5. (wikipedia.org)
  • membrane
  • Ligands for rhodopsin like GPCR's release an alpha unit (Gaq11) which activates phospholipase C, which cleaves PIP2, releasing IP3 which opens calcium channels, and DAG, which attracts PKC to the cell membrane. (brainscape.com)
  • Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the bα-chain. (wikipedia.org)
  • Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene. (wikipedia.org)
  • kinases
  • The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. (wikipedia.org)
  • 1997
  • 1997). "The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y". Hum. (wikipedia.org)