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  • phospholipase
  • Systemic RNA interference (RNAi) screening of the six C. elegans phospholipase C (PLC)-encoding genes demonstrated that pBoc and Ca 2+ oscillations require the combined function of PLC-γ and PLC-β homologues. (rupress.org)
  • Phospholipase C Gamma 1 is a Physiological Guanine Nucleotide Exchange Factor for the Nuclear GTPase PIKE Nature. (jove.com)
  • however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. (jove.com)
  • Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. (wikipedia.org)
  • Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. (wikipedia.org)
  • NFAT
  • CaN activation therefore triggers short-term effects directly at the synapse as well as long-term modifications of synaptic plasticity by modulating gene expression through NFAT. (jneurosci.org)
  • putative
  • 2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.» . (wikipedia.org)
  • Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene. (wikipedia.org)
  • The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. (wikipedia.org)
  • This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). (wikipedia.org)
  • mammalian
  • Publications] Zhao,H.: 'Functional expression of a mammalian odorant receptor. (nii.ac.jp)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (nih.gov)
  • Insp3
  • This gene belongs to the Insp3 receptor family. (bio-rad.com)
  • We can also express that CaBP1 may regulate Ca2+ dependent activity of InSP3Rs by promoting structural contacts between suppressor and core domains but has no effect on INsP3 binding to the receptor. (wikipedia.org)
  • novel
  • Some of the applications of SCG include the discovery of new gene networks and novel cell subpopulations, fine mapping of transcription kinetics, and the relationships between cell clonality. (paperity.org)
  • kinase
  • Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). (jove.com)
  • Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast Biochemistry. (jove.com)
  • Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (wikipedia.org)
  • A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. (wikipedia.org)
  • Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene. (wikipedia.org)
  • Mutations
  • Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. (nih.gov)
  • Mutations in this gene are associated with autosomal dominant sensory ataxia. (jax.org)
  • Loss-of-function mutations in the inositol-1,4,5-trisphosphate (IP 3 ) receptor ITR-1 reduce pBoc and Ca 2+ oscillation frequency and intercellular Ca 2+ wave velocity. (rupress.org)
  • In contrast, gain-of-function mutations in the IP 3 binding and regulatory domains of ITR-1 have no effect on pBoc or Ca 2+ oscillation frequency but dramatically increase the speed of the intercellular Ca 2+ wave. (rupress.org)
  • 26770814 }. Note=The disease is caused by mutations affecting the gene represented in this entry. (expasy.org)
  • Niemann-Pick type C disease (NP-C) is a progressive lysosomal lipid storage disease caused by mutations in the NPC1 and NPC2 genes. (paperity.org)
  • Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. (wikipedia.org)
  • Alzheimer's
  • In vivo , when VIVIT or its nuclear counterpart were overexpressed in a transgenic model of Alzheimer's disease via a gene therapy approach, the spine loss and neuritic abnormalities observed in the vicinity of amyloid plaques were blocked. (jneurosci.org)
  • expression
  • Real-time PCR primer assay designed for SYBR ® Green gene expression analysis. (bio-rad.com)
  • Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. (bio-rad.com)
  • Gene expression in nematodes is relatively easy and economical to manipulate using RNA interference (RNAi), knockout, and transgenesis. (rupress.org)
  • Signaling pathways regulate cells through activating or inactivating gene expression, transport of metabolites, and controlling enzymatic activity in order to manage growth and functions of metabolism. (wikipedia.org)
  • In the absence of ligand, receptor molecules bind corepressors in order to repress gene expression, compacting chromatin through histone deacetylatase. (wikipedia.org)
  • These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression. (wikipedia.org)
  • activates
  • The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. (wikipedia.org)
  • Human
  • Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets. (wikipedia.org)
  • Human CA8 genome location and CA8 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • LAT-1 (1014 amino acids, 113 KDa coded by the B0457.1 gene) and LAT-2 (1338 amino acids, 147 KDa coded by the B0286.2 gene) are located presynaptically at the neuromuscular junction in Caenorhabditis elegans and share 21% amino acid identity with each other (the amino acid sequence homology LAT-1 shares with rat, bovine and human latrophilins has been shown to be 22, 23 and 21% respectively). (wikipedia.org)
  • MRVI1 human gene location in the UCSC Genome Browser. (wikipedia.org)
  • Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • Genetic
  • How are genetic conditions and genes named? (nih.gov)
  • Genetic model organisms provide a number of powerful experimental advantages for defining the genes and genetic pathways involved in biological processes such as Ca 2+ signaling. (rupress.org)
  • tyrosine
  • PLCG1 can be activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. (wikipedia.org)
  • Non-receptor tyrosine kinases interact with PLCG1 in large complexes at the plasma membrane. (wikipedia.org)
  • For example, in T cells, Lck and Fyn (Src family kinases) phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the T-cell antigen receptor (TCR). (wikipedia.org)
  • Signaling
  • Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. (semanticscholar.org)
  • Publications] Kume,S: 'Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos. (nii.ac.jp)
  • The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)
  • Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behavior of the target cells. (wikipedia.org)
  • The presence of hormone or multiple hormones enables a response in the receptor which begins a cascade of signaling. (wikipedia.org)
  • If a signaling pathway ends with the increase in production of a nutrient, that nutrient is then a signal back to the receptor that acts as a competitive inhibitor to prevent further production. (wikipedia.org)
  • Hormone receptors can behave as transcription factors by interacting directly with DNA or by cross-talking with signaling pathways. (wikipedia.org)
  • The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. (wikipedia.org)
  • isoforms
  • Several transcript variants encoding two different isoforms have been found for this gene. (thermofisher.com)
  • Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. (wikipedia.org)
  • Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. (wikipedia.org)
  • ankyrin
  • The protein encoded by this gene, Ankyrin 1, is the prototype of the ankyrin family, was first discovered in erythrocytes, but since has also been found in brain and muscles. (wikipedia.org)
  • Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. (wikipedia.org)
  • interactions
  • 2009). «Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.» . (wikipedia.org)
  • Because of the relatively large size of enzymes and receptors, the large amount of surface area provides the basis for these weak interactions to occur. (wikipedia.org)
  • Because of these highly specific and high affinity interactions between hormones and their receptors, very low concentrations of hormone are needed to produce significant cellular response. (wikipedia.org)
  • Therefore, hormone binding to its receptor is a complex process which can be mediated by cooperative binding, reversible and irreversible interactions, and multiple binding sites. (wikipedia.org)
  • promoter
  • Transcription factor binding sites identified by Qiagen in the CABP1 gene promoter include Nkx2-5, RSRFC4, TAL1, and HSF1. (wikipedia.org)
  • release
  • Ca 2+ release is also isomer specific, with other structurally related inositol phosphates shown to be far less efficacious in releasing Ca 2+ ( 54 ). (pancreapedia.org)
  • If the N-terminal domain(NT) is deleted it abolishes the effect of CaBP1 prolonging Cav1.2 Ca2+ currents, but spared Ca2+-dependent is inactivated due to CaM overexpressed L-CaBP1 suppresses the rise in [Ca2+] in response to physiological agonists acting on purinergic receptors and thus this inhibition occurs in large part to blockade of release from intracellular Ca2+ stores. (wikipedia.org)
  • Finally, a molecule of inorganic phosphate attacks the thioester and forms a tetrahedral intermediate, which then collapses to release 1,3-bisphosphoglycerate, and the thiol group of the enzyme's cysteine residue. (wikipedia.org)
  • variants
  • Multiple transcript variants have been identified for this gene. (nih.gov)
  • Alternatively spliced transcript variants have been found for this gene. (jax.org)
  • Interestingly, GAPDH is encoded by a single gene that produces a single mRNA transcript with no known splice variants, though an isoform does exist as a separate gene that is expressed only in spermatozoa. (wikipedia.org)
  • Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. (wikipedia.org)