• novel
  • Therefore, identification of gene expression alterations in the striatum will greatly assist the development of novel therapy strategies. (springer.com)
  • Most of these are shared between the two species, but some appear to be expanding or contracting, and there seem to be as many as several hundred novel C. briggsae gene families. (plos.org)
  • isoforms
  • Several transcript variants encoding two different isoforms have been found for this gene. (thermofisher.com)
  • Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. (wikipedia.org)
  • Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. (wikipedia.org)
  • Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. (wikipedia.org)
  • kinase
  • Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). (jove.com)
  • Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast Biochemistry. (jove.com)
  • A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. (wikipedia.org)
  • This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. (wikipedia.org)
  • Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (wikipedia.org)
  • Mutations
  • Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. (nih.gov)
  • Mutations in this gene are associated with autosomal dominant sensory ataxia. (jax.org)
  • Loss-of-function mutations in the inositol-1,4,5-trisphosphate (IP 3 ) receptor ITR-1 reduce pBoc and Ca 2+ oscillation frequency and intercellular Ca 2+ wave velocity. (rupress.org)
  • In contrast, gain-of-function mutations in the IP 3 binding and regulatory domains of ITR-1 have no effect on pBoc or Ca 2+ oscillation frequency but dramatically increase the speed of the intercellular Ca 2+ wave. (rupress.org)
  • 26770814 }. Note=The disease is caused by mutations affecting the gene represented in this entry. (expasy.org)
  • Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. (wikipedia.org)
  • cDNA
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (nih.gov)
  • differentially
  • We performed a comprehensive gene expression analysis in 15 PD patients and 15 normal controls to identify differentially expressed genes (DEGs) using the expression profile GSE20291 from Gene Expression Omnibus (GEO). (springer.com)
  • This gene is differentially expressed in the liver tissues from Meishan and Large White pigs. (antikoerper-online.de)
  • regulation
  • In contrast, IP 3 generated by PLC-β appears to play little or no direct role in ITR-1 regulation. (rupress.org)
  • Our findings provide new insights into intestinal cell Ca 2+ signaling mechanisms and establish C. elegans as a powerful model system for defining the gene networks and molecular mechanisms that underlie the generation and regulation of Ca 2+ oscillations and intercellular Ca 2+ waves in nonexcitable cells. (rupress.org)
  • activates
  • The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. (wikipedia.org)
  • elegans
  • Operons, a distinctive feature of C. elegans , are highly conserved in C. briggsae , with the arrangement of genes being preserved in 96% of cases. (plos.org)
  • Based on similarity to C. briggsae , we found strong evidence for 1,300 new C. elegans genes. (plos.org)
  • LAT-1 (1014 amino acids, 113 KDa coded by the B0457.1 gene) and LAT-2 (1338 amino acids, 147 KDa coded by the B0286.2 gene) are located presynaptically at the neuromuscular junction in Caenorhabditis elegans and share 21% amino acid identity with each other (the amino acid sequence homology LAT-1 shares with rat, bovine and human latrophilins has been shown to be 22, 23 and 21% respectively). (wikipedia.org)
  • Mutational studies involving LAT-1 knockout and LAT-2 gene deletion mutants have revealed that the role of latrophilin receptors in the different tissues that they are expressed differs between subtypes, with LAT-1 being expressed in the pharynx of C.elegans (thereby modulating pharyngeal pumping) and LAT-2 having a role in locomotion. (wikipedia.org)
  • genetic
  • How are genetic conditions and genes named? (nih.gov)
  • Genetic model organisms provide a number of powerful experimental advantages for defining the genes and genetic pathways involved in biological processes such as Ca 2+ signaling. (rupress.org)
  • neurons
  • GO functional enrichment analysis indicated that the genes related with neurons function and cell morphogenesis might be changed upon PD. (springer.com)
  • Signaling
  • Publications] Kume,S: 'Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos. (nii.ac.jp)
  • KEGG pathway enrichment analysis showed that most of the genes were enriched in the nodes of Gap junction, calcium signaling pathway, phosphatidylinositol signaling system, long-term potentiation, Alzheimer's disease and GnRH signaling pathway. (springer.com)
  • The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)
  • Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behavior of the target cells. (wikipedia.org)
  • The presence of hormone or multiple hormones enables a response in the receptor which begins a cascade of signaling. (wikipedia.org)
  • If a signaling pathway ends with the increase in production of a nutrient, that nutrient is then a signal back to the receptor that acts as a competitive inhibitor to prevent further production. (wikipedia.org)
  • Signaling pathways regulate cells through activating or inactivating gene expression, transport of metabolites, and controlling enzymatic activity in order to manage growth and functions of metabolism. (wikipedia.org)
  • Hormone receptors can behave as transcription factors by interacting directly with DNA or by cross-talking with signaling pathways. (wikipedia.org)
  • ankyrin
  • The protein encoded by this gene, Ankyrin 1, is the prototype of the ankyrin family, was first discovered in erythrocytes, but since has also been found in brain and muscles. (wikipedia.org)
  • Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. (wikipedia.org)
  • interactions
  • Because of the relatively large size of enzymes and receptors, the large amount of surface area provides the basis for these weak interactions to occur. (wikipedia.org)
  • Because of these highly specific and high affinity interactions between hormones and their receptors, very low concentrations of hormone are needed to produce significant cellular response. (wikipedia.org)
  • Therefore, hormone binding to its receptor is a complex process which can be mediated by cooperative binding, reversible and irreversible interactions, and multiple binding sites. (wikipedia.org)
  • transduction
  • The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. (wikipedia.org)
  • expression
  • Gene expression in nematodes is relatively easy and economical to manipulate using RNA interference (RNAi), knockout, and transgenesis. (rupress.org)
  • In the absence of ligand, receptor molecules bind corepressors in order to repress gene expression, compacting chromatin through histone deacetylatase. (wikipedia.org)
  • These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression. (wikipedia.org)
  • promoter
  • Transcription factor binding sites identified by Qiagen in the CABP1 gene promoter include Nkx2-5, RSRFC4, TAL1, and HSF1. (wikipedia.org)
  • variants
  • Multiple transcript variants have been identified for this gene. (nih.gov)
  • Alternatively spliced transcript variants have been found for this gene. (jax.org)
  • Interestingly, GAPDH is encoded by a single gene that produces a single mRNA transcript with no known splice variants, though an isoform does exist as a separate gene that is expressed only in spermatozoa. (wikipedia.org)
  • Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. (wikipedia.org)