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  • 1999
  • The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), suggesting that they have evolved from a common peptidase (Bzdega et al 1997). (ifcc.org)
  • Antibody
  • sFGL2 is capable of inhibiting the proliferation of T cells stimulated by alloantigens and this inhibition is alleviated by the addition of a monoclonal antibody against sFGL2's fibrinogen-like domain (FRED). (wikipedia.org)
  • In keeping with this hypothesis, fibrinogen has been shown to mediate endothelium-dependent vasoactive effects on the saphenous vein that can be partially inhibited by a neutralizing antibody against ICAM-1. (ahajournals.org)
  • human
  • Abstract -It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells and to Mac-1 on THP-1 cells (a monocytic cell line) to increase adhesion. (ahajournals.org)
  • In this study, we investigated whether fibrinogen altered the expression of ICAM-1 and, thus, increased the adhesion of THP-1 cells to cultured human saphenous vein endothelial cells (HSVECs). (ahajournals.org)
  • functional
  • However, in the absence of specific MT1-MMP inhibitors or gene-deleted animals, the functional importance of this metalloproteinase in a physiologically relevant cell population has remained the subject of conjecture. (rupress.org)
  • expression
  • To investigate whether these two circuits are activated during unconditioned fear to a predator odor, the expression of immediate early genes EGR-1 and C-fos in brain was analyzed in rats after exposure to a synthetic predator odor originally derived from fox feces, 2,4,5-trimethylthiazoline (TMT). (udel.edu)
  • analysis
  • Capillary electrophoretic analysis indicated that anti-uPA prevented the release of any fibrinopeptide B (Bβ1-14) in cultures of HSVECs incubated with 4 μmol/L fibrinogen for 6 hours. (ahajournals.org)
  • Research
  • The goal of this research was to clone genes from the common garden snail Helix aspersa in the hopes of finding a gene responsible for neurotransmitter production using PCR. (udel.edu)
  • proteins
  • The invention provides oligonucleotide probes and primers, polynucleotide plasmids or vectors, peptides, proteins, and antibodies relating to genes and gene products associated with the senescence in mammalian cells. (google.es)
  • sequence
  • and (3) a methylase conjugation element linked to the gene fusion sequence, the methylase conjugation element including a methylase binding site having at least one copy of a nucleotide sequence including a cytidine suicide analog capable of irreversibly binding the DNA methylase. (google.com)
  • 1994
  • As cells undergo replicative senescence in vitro and in vivo, cells not only lose the ability to divide in response to growth stimuli, but also exhibit significant deleterious changes in the pattern of gene expression (West, 1994, Arch. (google.es)
  • addition
  • sFGL2 is capable of inhibiting the proliferation of T cells stimulated by alloantigens and this inhibition is alleviated by the addition of a monoclonal antibody against sFGL2's fibrinogen-like domain (FRED). (wikipedia.org)
  • specific
  • However, in the absence of specific MT1-MMP inhibitors or gene-deleted animals, the functional importance of this metalloproteinase in a physiologically relevant cell population has remained the subject of conjecture. (rupress.org)
  • products
  • such agents as well as GC6 gene and gene products and products corresponding thereto can be used to prevent and treat diseases and conditions relating to cell senescence. (google.es)
  • Analysis
  • Their unadjusted analysis shows a positive association of γ′ fibrinogen with incident coronary heart disease, ischemic stroke, peripheral artery disease, heart failure, and CVD deaths. (ahajournals.org)
  • studies
  • Together with data from in vitro studies demonstrating clots formed from purified γA/γ′ fibrinogen are composed of abnormally structured fibers and are highly resistant to fibrinolysis, 12 - 15 these observations have led to the notion that γA/γ′ fibrinogen is a causal risk factor for CVD. (ahajournals.org)
  • In contrast to previous studies, Appiah et al 16 conclude that γ′ fibrinogen levels reflect an inflammatory process that accompanies, and may promote, CVD, but that γ′ fibrinogen does not independently contribute to CVD. (ahajournals.org)
  • expression
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • individual
  • S-methadone is normally a more powerful inhibitor from the individual ether-a-go-go-related gene (hERG) K+ gated stations that are essential for QTc prolongation [35, (colinsbraincancer.com)