• 1999
  • The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), suggesting that they have evolved from a common peptidase (Bzdega et al 1997). (ifcc.org)
  • vascular
  • The fibrinogen-derived peptide Bβ15-42 bound to HSVECs ( K d 0.18 μmol/L). Preincubation of HSVECs with Bβ15-42, a neutralizing antibody to urokinase plasminogen activator (uPA), or the F(ab) 1 fragment of a monoclonal antibody to vascular endothelial cadherin significantly attenuated the increase in ICAM-1 stimulated by fibrinogen. (ahajournals.org)
  • The demonstration that fibrinogen acts as a bridging ligand for adhesion of THP-1 cells (a monocytic cell line) to cultured HUVECs 12 could signify a potential mechanism for the promotion of monocyte infiltration into the vascular wall. (ahajournals.org)
  • humans
  • In humans, FLG-1 is encoded by the FGL1 gene. (wikipedia.org)
  • The present invention relates to cellular senescence, markers of cellular senescence, and methods and reagents for identifying senescent cells and agents that alter senescent gene expression expression of cells, as well as for detecting, diagnosing, preventing, and treating senescence-related diseases and conditions in humans and other mammals. (google.es)
  • 1994
  • As cells undergo replicative senescence in vitro and in vivo, cells not only lose the ability to divide in response to growth stimuli, but also exhibit significant deleterious changes in the pattern of gene expression (West, 1994, Arch. (google.es)
  • domain
  • sFGL2 is capable of inhibiting the proliferation of T cells stimulated by alloantigens and this inhibition is alleviated by the addition of a monoclonal antibody against sFGL2's fibrinogen-like domain (FRED). (wikipedia.org)
  • contributes
  • The altered pattern of gene expression exhibited by senescent cells contributes significantly to age-related pathologies. (google.es)
  • expression
  • To investigate whether these two circuits are activated during unconditioned fear to a predator odor, the expression of immediate early genes EGR-1 and C-fos in brain was analyzed in rats after exposure to a synthetic predator odor originally derived from fox feces, 2,4,5-trimethylthiazoline (TMT). (udel.edu)
  • functional
  • However, in the absence of specific MT1-MMP inhibitors or gene-deleted animals, the functional importance of this metalloproteinase in a physiologically relevant cell population has remained the subject of conjecture. (rupress.org)
  • products
  • such agents as well as GC6 gene and gene products and products corresponding thereto can be used to prevent and treat diseases and conditions relating to cell senescence. (google.es)
  • shown
  • Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator. (wikipedia.org)
  • In keeping with this hypothesis, fibrinogen has been shown to mediate endothelium-dependent vasoactive effects on the saphenous vein that can be partially inhibited by a neutralizing antibody against ICAM-1. (ahajournals.org)
  • Research
  • The goal of this research was to clone genes from the common garden snail Helix aspersa in the hopes of finding a gene responsible for neurotransmitter production using PCR. (udel.edu)
  • release
  • Capillary electrophoretic analysis indicated that anti-uPA prevented the release of any fibrinopeptide B (Bβ1-14) in cultures of HSVECs incubated with 4 μmol/L fibrinogen for 6 hours. (ahajournals.org)