• cell cycle
  • The cell cycle includes 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). Tight regulation of the transition between these phases halts cell cycle progression if a phase is not properly completed. (qiagen.com)
  • For example, the G2-M DNA damage checkpoint ensures the fidelity of DNA replication, and arrests the cell cycle to allow time for replication error correction and DNA damage repair. (qiagen.com)
  • Cell cycle progression is regulated by the cyclic rise and fall of kinase expression, and their interaction with, and action on, their cyclin targets. (qiagen.com)
  • Key genes that regulate cell cycle progression and checkpoints encode cullins, cyclins, and cyclin-dependent kinases and their inhibitors. (qiagen.com)
  • QIAGEN provides a broad range of assay technologies for cell cycle research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • The Human Cell Cycle RT² Profiler PCR Array profiles the expression of 84 genes key to cell cycle regulation. (qiagen.com)
  • The Human Cell Cycle EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes key to cell cycle regulation. (qiagen.com)
  • The Human Cell Cycle EpiTect Chip qPCR Array profiles the histone modification status or "histone code" of 84 genes key to cell cycle regulation. (qiagen.com)