• Individuals
  • This guideline has been prepared by the authors for and on behalf of the Medical and Scientific Advisory Council (MASAC) of the South African Haemophilia Foundation to facilitate the appropriate management of individuals with haemophilia in South Africa. (scielo.org.za)
  • Individuals with haemophilia and their physicians should be advised by a Comprehensive Haemophilia Treatment Centre. (scielo.org.za)
  • Color blindness affects many individuals in the population. (wikipedia.org)
  • The biggest concern for individuals with afibrinogenemia is CNS hemorrhage, bleeding in the brain, which can be fatal. (wikipedia.org)
  • Hemophilia C is developed on occasion in individuals with systemic lupus erythematosus, because of inhibitors to the FXI protein. (wikipedia.org)
  • tendency
  • A tendency to bleed from the nose, mouth, and gums with minor trauma, teeth brushing, and/or dental work is often an indication of hemophilia. (medcentral.org)
  • Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency. (wikipedia.org)
  • clotting factor
  • Buttock bleeds are typical in the initial stages of learning to walk and should be recorded and reported immediately, as they frequently need to be treated with clotting factor. (express-scripts.com)
  • HealthDay News) -- Gene therapy has helped 10 men with a form of the bleeding disorder hemophilia produce a critical blood clotting factor. (wlox.com)
  • Standard treatment involves weekly infusions of a manufactured clotting factor to prevent bleeding problems. (wlox.com)
  • The dose contained a 'bioengineered payload' of the gene that codes for a naturally occurring clotting factor that's eight to 10 times stronger than the normal factor and known as factor IX-Padua. (wlox.com)
  • What's transformative about this [study] is they converted people who were at risk of having these bleeds to now having levels of clotting factor where they can pretty much do anything they want,' said Dr. Matthew Porteus. (wlox.com)
  • protein
  • The diseases and conditions treated by plasma protein therapies are considered rare diseases because they affect a relatively small percent of the population. (pptaglobal.org)
  • defective
  • Hemophilia normally passes on at birth from an affected father to daughter, who then becomes a carrier of the hemophilia gene having every possibility of passing the defective gene on to her children. (rxpgnews.com)
  • A woman who has the defective gene is considered a carrier and any male offspring have a 50% chance of having hemophilia A and female offspring a 50% chance of being a carrier. (pptaglobal.org)
  • When any of the 9 genes involved in sperm production are missing or defective the result is usually very low sperm counts and infertility. (wikipedia.org)
  • A person needs to inherit a defective gene from both parents. (wikipedia.org)
  • People who have only one defective gene are asymptomatic, but may have lower FXII levels and can pass the gene on to half their offspring. (wikipedia.org)
  • patients
  • Scientists have shed light on a common bleeding disorder by growing and analysing stem cells from patients' blood to discover the cause of the disease in individual patients. (bio-medicine.org)
  • Professor Mike Laffan, a collaborator in the study and in charge of patients with VWD at Hammersmith Hospital in West London, is looking to apply these findings to reduce severe bleeding in these patients. (bio-medicine.org)
  • Some patients with vWD suffer severe bleeding from the gut because defects in vWF cause their blood vessels to develop abnormally. (bio-medicine.org)
  • Pharmacists and nurses in the Bleeding Disorders TRC help patients understand the complexity of their disease and manage the treatment plan. (express-scripts.com)
  • The experienced specialist pharmacists and nurses in the Express Scripts Bleeding Disorders Therapeutic Resource Center (TRC) are dedicated to counseling patients and their families. (express-scripts.com)
  • The pharmacists and nurses in the Bleeding Disorders TRC can help patients understand the complexities of the disease and manage medication changes to ensure healthy outcomes. (express-scripts.com)
  • The disorder has two major forms: hemophilia A, which affects about 80 percent of all patients, and hemophilia B. (wlox.com)
  • For the study, George and her colleagues delivered one dose of the gene therapy each into 10 hemophilia B patients' livers. (wlox.com)
  • All of the patients benefited from the gene therapy, the researchers said. (wlox.com)
  • Patients will really be able to live essentially normal lives, even playing sports like soccer, which we now discourage patients with hemophilia from playing,' added Porteus, who wrote an editorial accompanying the study. (wlox.com)
  • Another hurdle is that about one-third of hemophilia B patients have a pre-existing immunity to the virus that delivers this type of gene therapy, making them ineligible to receive it, George and Porteus noted. (wlox.com)
  • A study in the March issue of the American Journal of Roentgenology says that even among patients who have taken aspirin in proximity to an image-guided percutaneous biopsy, risk of major bleeding associated with the procedure is low. (medindia.net)
  • The incidence of bleeding in patients taking aspirin within 10 days before biopsy was 0.6 percent (18/3,195)," he said. (medindia.net)
  • The ultimate responsibility for the care and choice of treatment of patients with haemophilia lies with the attending doctor and the patient being treated. (scielo.org.za)
  • Two Dutch studies have followed hemophilia patients for a number of years. (wikipedia.org)
  • Although the new factor was created, it wasn't available for haemophilia B patients till 1997. (wikipedia.org)
  • treatment
  • World Hemophilia Day is observed every April 17 to promote a global effort to secure appropriate care and treatment for a disease that is the oldest known inherited bleeding disorder caused by a defect in the genes. (rxpgnews.com)
  • UroGen Corp. is a biotechnology company currently developing products for the treatment of hemophilia and prostate cancer. (siliconinvestor.com)
  • These results support the further development of MiniAdFVIII for clinical trials toward the treatment of hemophilia A. (siliconinvestor.com)
  • The treatment corrected bleeding abnormalities in mice with Hemophilia A,' said Wei-Wei Zhang, MD, PhD UroGen's senior vice president and chief scientific officer. (siliconinvestor.com)
  • While saying the one-time gene therapy was an ideal treatment goal because of its effects, the researchers stopped short of calling it a cure for hemophilia B since it's unclear if the benefits will be permanent. (wlox.com)
  • These bleeds may cause death or musculoskeletal deformities, and advice on their treatment should be sought from a haemophilia treatment centre physician. (scielo.org.za)
  • and, where published empirical evidence is unavailable, the consensus expert opinion of the Medical and Scientific Advisory Council members and the international haemophilia fraternity, taking into account the availability of expertise and treatment products in South Africa. (scielo.org.za)
  • World Federation of Haemophilia data show that treatment of persons with haemophilia outside haemophilia treatment centres results in higher mortality and cost compared with treatment in the haemophilia treatment centres. (scielo.org.za)
  • Microwave helmets have been designed to detect internal bleeding in the brain to aid in faster treatment and care for the patient. (medindia.net)
  • These are usually performed by specialists at a special bleeding disorder treatment centre. (haemophilia.org.uk)
  • Bleeding into soft tissues such as muscles and subcutaneous tissues is less severe but can lead to damage and requires treatment. (wikipedia.org)
  • Lusher and her colleague Indira Warrier were among the first to use intravenous immunoglobulin (IVIG) for the treatment of ITP in children, and reported its therapeutic effect in 1984. (wikipedia.org)
  • The available treatment for hemophilia at the time included transfusion of large volumes of fresh frozen plasma to replenish the missing clotting factors. (wikipedia.org)
  • Lusher was able to demonstrate their efficacy in the treatment of joint bleeding in hemophilia in two multi-center studies in the early 1980s. (wikipedia.org)
  • carries
  • The vector is devoid of all viral genes and carries the full-length hFVIII cDNA under the control of the human 12.5-kb albumin promoter. (siliconinvestor.com)
  • 1997
  • Polly, a transgenic cloned Poll Dorset sheep carrying the gene for factor IX, was produced by Dr Ian Wilmut at the Roslin Institute in 1997. (wikipedia.org)