• The expression of ASPP1 and ASPP2 also enhances the apoptotic function of p63 and p73 by selectively inducing the expression of endogenous p53 target genes, such as PIG3 and PUMA, but not mdm2 or p21(WAF-1/CIP1). (ox.ac.uk)
  • The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
  • A TF can interact with DNA at specific binding sites to regulate one of its target genes. (ucf.edu)
  • This GRN identified several key transcription factors, including RUNX1, that regulate target genes using feed-forward loop and cascade motifs. (ox.ac.uk)
  • MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to ʻseed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences' may compromise or enhance miRNA/mRNA interaction leading to either ʻloss‑of‑function' or ʻgain‑of‑function' effects. (spandidos-publications.com)
  • We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. (ox.ac.uk)
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
  • SIRPγ (CD172g) may play a regulatory role in T cell-T cell interactions and may induce apoptosis through CD47. (bdbiosciences.com)
  • Ionizing radiation is well known to induce oxidative DNA damage, such as DNA double-strand breaks (DSBs), and consequently trigger the DNA damage response (DDR), including cell cycle arrest and apoptosis. (researchsquare.com)
  • During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
  • Instead of accumulating in mouse cells and halting cell division in the genetically engineered mice, the altered p53 protein performed flawlessly: it was unstable when no DNA damage was present and was stable and fully functional when needed to halt the cycle cell to repair DNA damage or to induce apoptosis. (news-medical.net)
  • We tested gene-centric single nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD. (ox.ac.uk)
  • TGF-β signaling is initiated when the ligand binds to type II serine/threonine kinase receptor (TGFBR2), which then phosphorylates and activates type I serine/threonine kinase receptor (TGFBR1) [ 13 ]. (degruyter.com)
  • Proteins tyrosine kinases are attractive medication focuses on because many human being diseases are from the deregulation of kinase activity. (cancer-ecosystem.com)
  • of proteins tyrosine kinases and establishes a potential conduit where level of resistance Rabbit Polyclonal to SFRS11 mutations to ATP-competitive kinase inhibitors make a difference their activity. (cancer-ecosystem.com)
  • As the primary of an extremely modular enzyme, the structurally conserved catalytic (kinase) domain name of the PTK integrates indicators from regulatory domains (for instance, SH3, SH2 and PH domains6), activators (for instance, the activator kinase within an energetic epidermal growth aspect receptor kinase dimer7) and post-translational adjustments (for instance, myristoylation and phosphorylation8) inside the kinase area. (cancer-ecosystem.com)
  • To modify the catalytic activity, such indicators have to propagate through the proteins regulatory sites towards the ATP- and substrate-binding sites inside the kinase domain. (cancer-ecosystem.com)
  • Helping the findings from the simulations, our biochemical tests show harmful cooperativity between ATP and substrate binding in Src kinase. (cancer-ecosystem.com)
  • Lately, important progress continues to be Desmopressin Acetate supplier manufactured in using MD simulations to characterize the dynamics Desmopressin Acetate supplier as well as the intermediate conformations mixed up in transitions of the proteins kinase area between its energetic and inactive expresses11,12,13. (cancer-ecosystem.com)
  • Our simulations hence claim that the allosteric network could be switched with the phosphoryl transfer in the kinase catalytic routine, which ATP and ADP binding may favour different C-lobe conformational says connected with different substrate-binding features. (cancer-ecosystem.com)
  • Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
  • Finally, Western blotting assay predicted constant expression of phosphatidylinositol 3-kinase and protein kinase B and reduced expression of phosphorylated phosphatidylinositol 3-kinase. (ijpsonline.com)
  • Hence, evidenced the blocking of phosphatidylinositol 3-kinase/protein kinase B signaling pathway. (ijpsonline.com)
  • It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
  • RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
  • Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
  • In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
  • should the term ['GO:0006919] activation of caspase activity' be a child of positive regulation of apoptosis or induction of apoptosis rather than directly to apoptosis? (geneontology.org)
  • when looking at experimental data - often counting number of cells they've died and committed to apoptosis so how can we work out induction or positive regulation? (geneontology.org)
  • The research goal of our lab is to create novel machine learning and statistical algorithms to understand gene/protein function and regulation, to understand complex biological processes and how organisms will respond at the genetic level to changes in their external environment. (ucf.edu)
  • Gene transcriptional regulation refers to any process by which a cell regulates genes' expression. (ucf.edu)
  • The discovery of various types of non-coding RNAs have been shown important to gene regulation. (ucf.edu)
  • For decades, we have realized that besides the DNA/genome, there is a second genome named epigenome that can also contribute to the gene regulation. (ucf.edu)
  • We develop computational methods to integrate advanced high-throughput sequencing data to understand genome-epigenome interaction and epigenetic gene regulation. (ucf.edu)
  • Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
  • The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
  • Also, a KCNN4 and S100A14-centered protein interaction subnetwork was built from the STRING database, and the shortest regulation path between them, called the KCNN4-UBA52-KLF4-S100A14 axis, was identified. (oncotarget.com)
  • Regulation of metformin response by breast cancer associated gene 2. (karmanos.org)
  • Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
  • The current study demonstrated that the rs78378222 polymorphism minor allele introduces a novel potential miR‑125b binding site in the TP53 3'‑UTR with a consecutive 8‑bp perfect match, creating a ʻgain‑of‑function' variant and affecting the regulation of TP53 expression. (spandidos-publications.com)
  • Sjöberg A., Trouw L., McGrath F., Hack E. C. and Blom A. M. (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (lu.se)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
  • Li-Fraumeni syndrome (LFS) is a rare autosomal dominant syndrome in which patients are predisposed to cancer due to mutations in the TP53 gene. (medscape.com)
  • Li-Fraumeni syndrome has been linked to pathogenic germline mutations of the tumor suppressor gene TP53 . (medscape.com)
  • Somatic (nongermline) TP53 tumor suppressor gene mutations are common in sporadic human cancers, suggesting that TP53 alterations play an important role in the development of cancer. (medscape.com)
  • Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
  • As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
  • You can find over 440 noted mutations within the calpain 3 gene up to now, included in this 212 (50%) are missense mutations, a lot of which alter its catalytic activity (22). (exposed-skin-care.net)
  • Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
  • Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome. (thermofisher.com)
  • ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
  • Consequently our understanding of Ca2+ signalling is now advancing rapidly through experimental approaches that involve the controlled expression, inhibition of expression and use of naturally occurring or engineered mutations of channels, pumps, effectors and other proteins related to Ca2+ signalling pathways. (hstalks.com)
  • SCID results from mutations in any of more than 15 known genes. (medscape.com)
  • Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
  • [ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)
  • MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability. (nih.gov)
  • This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. (cancerindex.org)
  • More recently we have demonstrated that C/EBPβ regulates the expression of several genes involved in inflammatory processes and brain injury [ 14 ] and mice lacking C/EBPβ showed a reduced inflammatory response after kainic acid injection and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus [ 15 ]. (biomedcentral.com)
  • But whether and how metformin regulates necroptosis and apoptosis through the ZBP1 in the context of AP remains unknown. (bvsalud.org)
  • 2. We recently identified a novel PDX1 stress inducible complex (es) positioned over CARE sites and involving ATF4 and ATF5 that regulates expression of stress and apoptosis genes to govern β cell survival. (upenn.edu)
  • Our current efforts on this project are directed at (1) determining the mechanisms whereby Pdx1 and Oc1 cooperate to establish a chromatin landscape permissive for endocrine differentiation and proliferation, (2) Defining the roles of the Pdx1 and Oc1 IDPRs in protein-protein interaction and endocrine differentiation, and (3) Defining the molecular mechanisms by which the Pdx1 C-terminal domain regulates protein stability and function during pancreas organogenesis and endocrine differentiation. (upenn.edu)
  • AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE). (biomedcentral.com)
  • We have been interested in how the human HMGB1 gene is regulated as well as how HMGB1 regulates other genes in the cell. (edu.hk)
  • It regulates life and death processes that include fertilization, cell proliferation, apoptosis and cell necrosis. (hstalks.com)
  • This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. (nih.gov)
  • Excessive apoptosis causes atrophy, such as in ischemic damage, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (geneontology.org)
  • TP53, which is located on band 17p13.1, codes for a 53-kd nuclear protein transcription factor that has important regulatory control over cell proliferation and homeostasis, specifically the cell cycle, DNA repair processes, and apoptosis. (medscape.com)
  • Properly regulated spatial and temporal expression of genes is crucial to precise execution of biological processes such as development, proliferation, apoptosis, aging, and differentiation. (ucf.edu)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
  • Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
  • also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • 3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)
  • Composed of multiple constituent enhancers, super enhancers (SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. (nature.com)
  • HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low level expression, HDAC inhibitor treatment is frequently associated with autophagy. (ox.ac.uk)
  • In animals, morphological distinctions have since been used to distinguish different types of cell deaths, including apoptosis, necrosis and autophagy. (essaywriter.org)
  • Primarily, the aim of anti-cell death in animals is to describe the processes of autophagy and apoptosis, while necrosis is the mechanism for defining the uncontrollable or chaotic mode of death. (essaywriter.org)
  • Majority of the literature and experiments in the field of programmed cell death in plants draw heavily on comparative analysis retrieved from paradigms of animal systems such as apoptosis, necrosis and autophagy. (essaywriter.org)
  • In contrast to necrosis (murdered cells), in apoptosis (commit suicide) and autophagy process, cytoplasmic membranes are maintained and cell body is completely removed without any inflammation. (biomedcentral.com)
  • By binding with these binding sites, TFs cooperatively interact with their cofactors, RNA polymerase and the chromatin to regulate gene expression. (ucf.edu)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • The dominant discovery in these experiments indicates that there is a heterologous expression of certain genes in plants that can regulate cell death. (essaywriter.org)
  • Based on the possible role of HMGB1 in the p53 network, investigattion on whether HMGB1 could regulate some potential downstream genes at the transcriptional level was carried out. (edu.hk)
  • miRNAs bind to complementary sequences present in the 3′-untranslated regions (3′-UTR) of target gene mRNAs and, thus, regulate translational interference or degradation of mRNAs ( 8 ). (spandidos-publications.com)
  • Inside the cell, elevated Ca2+ will activate regulatory proteins (many of its actions are mediated through Ca2+-binding proteins such as calmodulin) or enter intracellular organelles where it can regulate their internal processes. (hstalks.com)
  • Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. (nih.gov)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • CCAAT/enhancer-binding protein β (C/EBPβ), is a member of a family of transcription factors consisting of six structurally related basic leucine-zipper DNA-binding proteins. (biomedcentral.com)
  • One type of gene regulatory proteins is transcription factors (TFs). (ucf.edu)
  • The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. (thermofisher.com)
  • p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. (thermofisher.com)
  • These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
  • After the binding of the RPAP2-Pol II complex to BRD4 on SEs, RPAP2 dephosphorylates Ser5 at the Pol II CTD to terminate the transcriptional pause, and BRD4 phosphorylates Ser2 at the Pol II CTD to initiate transcriptional elongation, which synergistically drives efficient transcription of ZBTB16, ensuring proper osteogenesis. (nature.com)
  • It has long been known as an architectural transcription factor involved in gene activation as well as in other nuclear processes. (edu.hk)
  • Furthermore, these genes were classified into 11 functional groups including transcription factors, cell cycle related factors, apoptosis regulators, kinases and metabolism-related proteins, etc. (edu.hk)
  • Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
  • Knockout of Zbp1 by CRISPR/Cas9 technology significantly reduced LPS-induced necroptosis and apoptosis in vitro. (bvsalud.org)
  • Furthermore, RR inhibited inflammation, oxidative stress, cell apoptosis, and PI3K-AKT activation in lipopolysaccharide-stimulated HUVECs and ALI mice, which was consistent with the network pharmacology results. (bvsalud.org)
  • GLT) and that depletion of JUND in β cells reduces oxidative stress and apoptosis caused by GLT. (upenn.edu)
  • The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. (researchsquare.com)
  • The DNA guardian protein p53 plays the most important role in DDR: it promotes DNA repair and the elimination of cells that are unable to repair the damage caused by oxidative stresses, including radiation. (researchsquare.com)
  • High-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by S.T . The mRNA levels of inflammatory cytokines in the ileum of mice showed that the regulatory effects of EPSs on inflammatory cytokines were better than those of penicillin. (biomedcentral.com)
  • This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. (wikipedia.org)
  • BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
  • Shouldn't we have an apoptosis signalling pathway terms? (geneontology.org)
  • The intrinsic apoptotic pathway has been chosen for a Reference Genome project as the curation work will complement and inform a planned apoptosis content meeting scheduled for June the 1st, assisted by domain experts from the Apo-Sys Consortium. (geneontology.org)
  • Anti-apoptotic strategies include inhibition of caspase, poly [ADP-ribose] polymerase (PARP), and Bcl-2 proteins as well as induction of the PKB/Akt pathway and inhibitors of apoptosis (IAP) family of proteins. (biomedcentral.com)
  • EPSs could inhibit the expression and activation of key proteins of the TLR4/NF-κB/MAPK pathway and thereby suppress the level of S.T -induced ileal inflammation. (biomedcentral.com)
  • EPSs attenuate S.T -induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway. (biomedcentral.com)
  • The classical pathway is triggered by interaction of the Fc portion of an antibody (immunoglobulin [Ig] M, IgG1, IgG2, IgG3) or C-reactive protein with C1q. (medscape.com)
  • for example, the proteins factor H and factor I inhibit the formation of the enzyme C3 convertase of the alternative pathway. (medscape.com)
  • Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)
  • We used CRISPR screening in the presence of the BCL-2 inhibitor venetoclax to identify functional impacts on apoptosis. (ox.ac.uk)
  • Our results define a regulatory mechanism that involves the interplay between HR23B and HDAC6 that influences the biological outcome of HDAC inhibitor treatment. (ox.ac.uk)
  • Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097. (karmanos.org)
  • Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
  • This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • 1. The Stoffers laboratory recently identified the polyC binding protein (PCBP) family of RBPs as important players in the post-transcriptional regulatory landscape of pancreatic beta cells. (upenn.edu)
  • MicroRNAs (miRNAs), a class of endogenous small non-coding RNAs of 20-25 nucleotides, modulate the expression of genes at the post-transcriptional level ( 7 ). (spandidos-publications.com)
  • Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. (karmanos.org)
  • Here we identify ASPP2, a haploinsufficient tumour suppressor, p53 activator and PAR3 binding partner, as a molecular switch of MET and EMT. (ox.ac.uk)
  • Understanding of underlying molecular mechanisms of a cell requires understanding the interplay between different genes, proteins and small molecules. (ucf.edu)
  • We first construct a p21 regulatory network based on data from the literature and further expand it using algorithms that predict molecular interactions. (hindawi.com)
  • a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
  • Although such conversation continues to be explored previously9,10, the root mechanismsand if they result in an allosteric relationship between your two binding siteshave not really been totally elucidated, despite their importance for an improved knowledge of PTK legislation at a molecular level. (cancer-ecosystem.com)
  • Heat shock family of proteins (HSPs) is proposed to play pivotal role in breast tumor development owing to their intrinsic molecular chaperone properties [ 5 ]. (biomedcentral.com)
  • Thus, understanding the mechanism of apoptosis gives detailed insights of anti-apoptotic molecular targets. (biomedcentral.com)
  • The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. (news-medical.net)
  • Overall, we suggest that miR-31 functions like a tumor suppressor by selectively regulating cell cycle and EMT regulatory proteins in human being hepatocarcinogenesis providing a novel target FANCG for the molecular treatment of liver malignancies. (nos-nop.org)
  • These antigens include organic dusts containing bacteria, fungi,4 animal or plant proteins, or low-molecular-weight chemicals. (cdc.gov)
  • Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
  • Mechanistically, ASPP2 induces MET through its PAR3-binding amino-terminus, independently of p53 binding. (ox.ac.uk)
  • PMID:14996496, table 1 provides links to papers that describe subcellular location of many pro- and anti-apoptotic proteins. (geneontology.org)
  • In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)
  • Metformin also promoted mitochondrial apoptosis, which is critical for the elimination of intracellular bacterial infection. (bvsalud.org)
  • Bioinformatics analysis demonstrated that the EIF5B transcript and protein levels as well as the EIF5Bcopy number were significantly higher in the HCC tissues compared with the non-cancerous liver tissues. (techscience.com)
  • The expression levels of the p53 and MDM2 genes were found to be significantly lower in the HMGB1 down-regulated MCF-7 cells. (edu.hk)
  • The mRNA/protein expression levels of BAX and p21 were significantly increased in p63-siRNA-treated HMECs (sip63) after X-ray irradiation (4 Gy, 0.7 Gy/min) but not in scramble-siRNA treated HMECs (scr). (researchsquare.com)
  • On the other hand, both the ectopic and entopic expression of ΔNp63α in apoptosis-sensitive hiPSCs reduced the expression levels of BAX after irradiation and significantly decreased the number of apoptotic cells induced by radiation. (researchsquare.com)
  • Additionally, transfection with 50 nM miR‑125b mimics markedly reduced the mRNA and protein expression levels of TP53 in the cultured lens epithelial cells, and miR‑125b significantly induced apoptosis in the epithelial cells compared with negative control cells. (spandidos-publications.com)
  • HCC tissues derived from chemical-induced rat liver cancer models validated that miR-31 manifestation is significantly down-regulated, and that those cell cycle- and EMT-regulatory proteins are deregulated in rat liver cancer. (nos-nop.org)
  • Consistently, and genes were significantly over-expressed in these two different HCC cohorts (Fig. (nos-nop.org)
  • However, the specific regulatory mechanisms of ZBP1 in AP are not fully elucidated. (bvsalud.org)
  • Currently, an increasing number of studies are being carried out to deepen our understanding of miRNA regulatory mechanisms and functions. (hindawi.com)
  • This illustrates how our GRN can be used to better understand potential mechanisms of drug resistance acquisition.Graphical abstract captionA network model of the MLL-AF4 regulatory landscape identifies feed-forward loop and cascade motifs. (ox.ac.uk)
  • Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)
  • FINDINGS: After allowance for multiple testing none of the 120 comparisons yielded significant evidence of a gene-environment interaction. (ox.ac.uk)
  • The mechanism responsible involves the interaction of HDAC6 with HR23B, which downregulates HR23B and thereby reduces the level of ubiquitinated substrates targeted to the proteasome, ultimately desensitising cells to apoptosis. (ox.ac.uk)
  • Then, to determine whether HDAC2 and CDK2 are selectively governed by miR-31 via immediate interaction using the 3-UTR of the genes, we cloned the 3-UTR of and right into a reporter vector linking the luciferase open up reading body downstream to create psi-CHECK2-HDAC2_3-UTR and psiCHECK-CDK2_3-UTR plasmid, respectively (Fig. (nos-nop.org)
  • This is not surprising given the strong evidence for interaction between myelin and axon gene expression in development and after experimental nerve lesions. (medscape.com)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • Blom, A. M. , Rytkönen, A., Vasquez, P., Dahlbäck, B. and Johnsson, A-B. (2001) A novel interaction between type IV pili of Neisseria gonorrhoeae and complement regulatory protein - C4b-binding protein. (lu.se)
  • A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. (bmj.com)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • Two alternatively spliced transcript variants encoding distinct proteins have been described. (wikipedia.org)
  • There is no longer a need for signals to activate these genes. (cancerquest.org)
  • When higher than normal levels of p53 tumor suppressor exist, there is enough p53 to bind to many regulatory sites in the cell's genome to activate the production of other proteins that will halt cell division if the DNA damage can be repaired. (news-medical.net)
  • This gene encodes a protein phosphatase 1 binding protein. (nih.gov)
  • When this conversion occurs in the coding region of mRNA, it results in an altered nucleotide codon and, therefore, can change the amino acid sequence of the coded protein in what is referred to as a re-coding editing event. (biomedcentral.com)
  • Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study. (ox.ac.uk)
  • To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study. (ox.ac.uk)
  • We develop methods to computationally predict TF binding interactions through binding site identification at the whole genome scale. (ucf.edu)
  • In addition, to find out the possible interactions among these differentially expressed genes, Pathwayassist Software was used for analysis. (edu.hk)
  • The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. (nih.gov)
  • In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
  • MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
  • For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
  • The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
  • Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. (wikipedia.org)
  • CYP1A1, a typical XRE-regulated gene, mRNA was induced without the application of ligand to the culture medium. (biomedcentral.com)
  • sfRON lacks almost all of the extracellular domain and is incapable of ligand binding. (spandidos-publications.com)
  • Metformin suppressed ZBP1-mediated necroptosis and promoted apoptosis, thereby contributing to the soothing of inflammation and bone healing in AP. (bvsalud.org)
  • Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
  • Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
  • miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)
  • These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
  • Intracellular iron levels are elaborately balanced by iron efflux, uptake, and storage proteins that are regulated by iron regulatory proteins (IRPs, including IRP1 and IRP2) [ 16 ]. (nature.com)
  • 2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)
  • Alterations of p53 function are the result of either loss of function of wild type p53, increased or aberrant protein function, or dominant negative effects of the mutated protein. (medscape.com)
  • MLL-AF4 is thought to drive leukemogenesis by directly binding to genes and inducing aberrant overexpression of key gene targets, including anti-apoptotic factors such as BCL-2. (ox.ac.uk)
  • Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). (springer.com)
  • With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
  • Our recent research showed the crucial role of Z-DNA binding protein 1 (ZBP1)-mediated necroptosis and apoptosis in the pathogenesis of AP. (bvsalud.org)
  • He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)
  • IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. (geneticsmr.com)
  • Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases. (geneontology.org)
  • Depletion of HSP70-2 in MDA-MB-231 and MCF7 cells resulted in a significant reduction in cellular growth, motility, onset of apoptosis, senescence, cell cycle arrest as well as reduction of tumor growth in the xenograft model. (biomedcentral.com)
  • Since the p53 protein is able to trigger such drastic action as cellular suicide, the cells of the body must ensure that the p53 protein is only activated when damage is sensed and that the protein is quickly degraded when it is not needed. (news-medical.net)
  • Cataracts are the leading cause of blindness worldwide and are characterized by progressive aggregation and precipitation of lens proteins, and the development of age‑related cataracts is associated with dysregulated cellular activities of lens epithelial cells. (spandidos-publications.com)
  • Gene knockdown showed caspase-8 to be the apical caspase in the AIM2- and NLRP3-dependent apoptotic pathways, with little or no requirement for caspase-9. (nih.gov)
  • Cytochrome c then forms a multi-protein complex known as the 'apoptosome' and initiates activation of the caspase cascade through caspase 9. (geneontology.org)
  • Although the presence of active caspases and DNA fragmentation is helpful in identifying possible apoptosis, they should not be employed as an exclusive means to demonstrate this process as apototic cell death can occur without DNA fragmentation or caspase activity. (geneontology.org)
  • Different adhesion molecules are required for apoptosis, particularly caspase family as well as noncaspase proteases. (biomedcentral.com)
  • A germline mutation of the TP53 tumor suppressor gene results in Li-Fraumeni syndrome. (medscape.com)
  • A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (ox.ac.uk)
  • p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. (thermofisher.com)
  • Further, we studied the effect of HSP70-2 protein ablation on signaling cascades involved in apoptosis, cell cycle and Epithelial-Mesenchymal-Transition both in culture as well as in-vivo human breast xenograft mouse model. (biomedcentral.com)
  • In addition, we have examined the putative role of HSP70-2 in apoptosis, cell cycle arrest and epithelial-mesenchymal transition (EMT) in-vitro and in-vivo xenograft mouse model using gene silencing approach. (biomedcentral.com)
  • Transcriptomic analysis showed decreased RNA expression of cell cycle-related genes and increased expression of programmed cell death-related genes in sip63 cells compared to scr cells. (researchsquare.com)
  • 100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
  • Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
  • Genes that encode the proteins of complement components or their isotypes are distributed throughout different chromosomes, with 19 genes comprising 3 significant complement gene clusters in the human genome. (medscape.com)
  • To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)
  • In the present study, we have investigated the possible association of HSP70-2 mRNA and protein expression with various stages, grades and histotypes of breast cancer patients. (biomedcentral.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
  • The main aim of this paper is to review the pathways that lead to cell death in plants with a purpose of identifying the anti-cell death genes. (essaywriter.org)
  • Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
  • The potential regulatory roles of HMGB1 on some of these groups were then discussed. (edu.hk)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Procaspase-8 localised to ASC inflammasome 'specks' in cells, and bound directly to the pyrin domain of ASC. (nih.gov)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • First identified in embryonic stem cells, SEs mediate pluripotent state maintenance by promoting the expression of pluripotent identity genes, including Oct4 , Sox2 , Nanog and Klf4 . (nature.com)
  • Acridine orange/ethidium bromine staining assay revealed that piperine induced apoptosis in MCF-7 cells which was further investigated by Western blotting. (ijpsonline.com)
  • Among these genes, 96 were down regulated and 76 were up regulated in the HMGB1 suppressed MCF-7 cells. (edu.hk)
  • Apoptosis was first described by Kerr and colleagues in 1972 [ 17 ] as a physiological situation characterized by distinguishable morphological features such as nuclear changes (nuclear chromatin condensation and nuclear fragmentation), cell contraction, and losing attachment with adjacent cells. (biomedcentral.com)
  • After irradiation, the expression of DDR-related genes and proteins in ΔNp63α-expressing and control cells was analysed by RT-qPCR, Western blotting, and flow cytometry. (researchsquare.com)
  • Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
  • Cells will adapt by activating the expression of genes involved in metabolic adaptation, such as those involved in glycolysis. (bmj.com)
  • 7 Severe hypoxia in the presence of energy stimulates cells to undergo apoptosis, whereas oxygen levels above 0.5% prevent cell death. (bmj.com)
  • Until now, scientists had assumed, based on studies in cultured cells, that p53 had to be modified by attaching chemical groups to specific sites on the protein to function normally in the body. (news-medical.net)
  • metastatic potential of HCC cells by selectively regulating epithelial-mesenchymal transition (EMT) regulatory proteins such as N-cadherin, E-cadherin, vimentin and fibronectin. (nos-nop.org)
  • As demonstrated in Fig. ?Fig.2B,2B, knockdown augmented HDAC2 and CDK2 protein expressions in SNU-449 and SKHep-1 cells, whereas co-transfection of miR-31 mimics attenuated knockdown effect on the same cells. (nos-nop.org)
  • Next, to verify that miR-31 particularly binds to 3UTRs of also to interfere translation of these transcripts, mutant vectors harboring random mutation sequences of miR-31 biding sites from the 3UTR of and genes had been generated, and each vector was co-transfected with miR-31 into SNU-449 and SKHep-1 cells. (nos-nop.org)
  • It had been discovered that miR-31 could suppress reporter gene activity in these cells, whereas mutants plasmids showed zero noticeable adjustments. (nos-nop.org)
  • they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)
  • Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
  • Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)
  • Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
  • Previous studies from our laboratory indicated that C/EBPβ is implicated in inflammatory process and brain injury, since mice lacking this gene were less susceptible to kainic acid-induced injury. (biomedcentral.com)
  • Among the genes displaying significant changes in expression was complement component 3 ( C3 ), which showed a dramatic decrease in mRNA content in the hippocampus of C/EBPβ −/− mice. (biomedcentral.com)
  • To explore the effects of these modifications in vivo, Salk scientists genetically engineered mice to produce a p53 protein with an altered C-terminus instead of the normal version. (news-medical.net)
  • Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. (thermofisher.com)
  • A diagram showing the major cancer genes for some cancers. (cancerquest.org)