• MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. (wikipedia.org)
  • Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al. (wikipedia.org)
  • Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. (cusabio.com)
  • Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. (wikipedia.org)
  • The inactive GDP bound form is promoted by GTPase-activating proteins (GAPs). (embl.de)
  • RAP1 GTPase activating protein (RAP1GAP). (embl.de)
  • GTPase-activating protein Spa-1. (embl.de)
  • There is a superfamily of ras p21/ras p21-like small GTP-binding proteins (small G proteins) with GTPase activity. (nii.ac.jp)
  • The conversion from the GDP-bound to GTP-bound form and the reverse conversion are induced by GDP/GTP exchange and GTPase reactions, respectively. (nii.ac.jp)
  • We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)
  • The GTPase Rab11 regulates endosomal protein trafficking and previous work has shown that loss of Rab11 caused intestinal inflammation and hyperplasia in mice and flies. (sdbonline.org)
  • ARHGAP21 interacts with RhoA-GTP, and acts as a GAP to increase RhoA GTPase activity. (uth.edu)
  • Ras is a small GTPase that operates as a binary molecular switch between a GDP-bound inactive and GTP-bound active state. (rupress.org)
  • Patrick A. Lewis ABSTRACT Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual guanosine triphosphatase ( GTPase ) and kinase enzymatic activities, providing this protein with the capacity to regulate a multitude of signalling pathways. (biologists.com)
  • engagement triggers rapid GTP-loading of the small GTPase Rac as a master regulator of cytoskeletal rearrangements and lamellipodia-driven internalization. (biologists.com)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Little GTPase activation For Fig. 1 FG cells had been serum-starved trypsinized plated on meals covered with 10μg/ml P1F6 or P4C10 antibody and permitted to adhere for a quarter-hour. (biotech-angels.com)
  • interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
  • Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
  • Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
  • A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
  • A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
  • This occurs through the downregulation of methylmalonyl coenzyme A epimerase (MCEE), mediated by an extracellular signal-regulated kinase 2-driven transcription factor Sp1/early growth response protein 1 transcriptional switch driven by metastatic signalling at its promoter level. (biomed.news)
  • Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
  • CXCL12 activation rapidly reduced the kinase activity of LOK to one-third which was consistent with the kinetics of reduction of the phosphorylation of ERM proteins. (hiv-proteases.com)
  • The kinase activity of LOK in Rap1-deficient TEM cells was also reduced to 38.5+8.5% of that of control cells without CXCL10 stimulation (Fig. 5g). (hiv-proteases.com)
  • In Spa-1-expressing cells the basal kinase activity increased to 1.8 times and hardly decreased after CXCL12 p-Coumaric acid activation indicating that the conversion to Rap1-GTP is important for reduction of LOK kinase activity by chemokine (Fig. 5g). (hiv-proteases.com)
  • Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)
  • Needlessly to say appearance of CSK (however not kinase-dead CSK) suppressed EGF-induced Src activation (Fig. 2B) and cell migration on. (biotech-angels.com)
  • 1997). Then, Ras and Rap1-GTP inhibits the phosphatidylinositide-3-kinase (PI3K) target Akt. (endocrinology-journals.org)
  • We have found that the C-terminal systeine residues of smg p21B, rhoA p21, and smg p25A are geranylgeranylated, and that these prenylation are essential for each small G protein to bind to membranes. (nii.ac.jp)
  • Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. (cusabio.com)
  • Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. (cusabio.com)
  • Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
  • A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
  • Integrins function as adhesion receptors for extracellular ligands and transduce biochemical signals into the cell, through downstream effector proteins. (mechanobio.info)
  • ICAP-1 regulates ß1-integrin activation and cell adhesion. (bvsalud.org)
  • Cytoplasmic actin-binding proteins such as talin kindlin and filamin (FLN) bind directly to integrin tails and positively or negatively regulate integrin function: the currently available evidence shows that talin and kindlin promote integrin activation whereas FLN is definitely a negative regulator of integrin functions such as cell adhesion and migration8 9 FLN also serves as a scaffolding protein for Rho or Ras family members10. (hiv-proteases.com)
  • The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. (mechanobio.info)
  • Each integrin heterodimer consists of an alpha (α) and a beta (β) subunit associated by noncovalent interactions forming an extracellular ligand-binding head, two multi-domain `legs', two single-pas s transmembrane helices and two short cytoplasmic tails. (mechanobio.info)
  • Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
  • Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. (cusabio.com)
  • Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)
  • Publications] Kaibuchi,K.: 'Molecular cloning and characterization of the stimulatory GDP/GTP exchange protein(GDS)for smg p21s,ras p21ーlike small GTPーbinding proteins. (nii.ac.jp)
  • The present study unravels a new molecular system for vesicle-based axonal transport of proteins in male and female flies (Drosophila melanogaster). (sdbonline.org)
  • Although focal adhesions are similar, in terms of molecular composition, to nascent adhesions and focal complexes, several adhesion proteins appear to change as focal adhesions evolve in response to tension, e.g., zyxin and vinculin . (cellmigration.org)
  • Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING. (lookformedical.com)
  • A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)
  • Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. (cusabio.com)
  • Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
  • Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle. (embl.de)
  • Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • Genome regulation encompasses all facets of gene expression, from the biochemical modifications of DNA, to the physical arrangement of chromosomes and the activity of the transcription machinery. (mechanobio.info)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
  • The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)
  • After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)
  • The α subunit leg consists of a thigh and 2 calf domains that support the ligand binding head formed by a β-propeller domain with 7 repeats forming the blades (shown as a cylinder in the figure below). (mechanobio.info)
  • Similar to αI, the contains βI domain contains a MIDAS site for ligand binding and additional regulatory site "adjacent to MIDAS" or ADMIDAS, inhibited by Ca2+ and activated by Mn2+ [3] for ligand binding. (mechanobio.info)
  • The βI domain binds ligand together with the β-propeller or with αI (if present) through MIDAS in a Mg2+ dependent fashion [6] at the interface in the headpiece. (mechanobio.info)
  • Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)
  • much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)
  • In the cytosol, the signal molecule binds to the heme-binding domain of the soluble cyclase. (pancreapedia.org)
  • The latter is released into the cytosol, where it binds to its receptor (IP3R) at endoplasmic reticulum and release intracellular Ca 2+ whereas DAG recruits and activates PKC, which in turn open voltage-gated Ca 2+ channels. (endocrinology-journals.org)
  • Rap small G proteins have been implicated in various cellular processes such as exocytosis, cAMP signalling, cell adhesion and cell proliferation. (embl.de)
  • These are the ' zinc-binding cellular acid ' sugar and the ' genome resulting ' history. (evakoch.com)
  • The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
  • Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • Despite this membrane-proximal effect, TNF selectively uncouples downstream signalling pathways, as is shown by the dramatic suppression of calcium signalling responses, while Ras/ERK activation is spared. (biomedcentral.com)
  • Publications] Araki,S.: 'Role of the Cーterminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein. (nii.ac.jp)
  • These attachment sites are linked to actin-bundles that surround the nucleus via an Ndj1-Mps3-Csm4 protein bridge that spans the inner and outer nuclear membranes. (biorxiv.org)
  • Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)
  • In non-canonical Atg8-family protein lipidation they become conjugated to single membranes. (babraham.ac.uk)
  • We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)
  • They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. (lookformedical.com)
  • A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • Activation of integrins is definitely regulated by relationships with numerous intracellular adaptor proteins7. (hiv-proteases.com)
  • 2010). Activated SHP1 also triggers intracellular pro-apoptotic signals involving the induction of caspases activation and p53/Bax. (endocrinology-journals.org)
  • heat of Activation in the geranylgeranyl of autosomal rich complexes is on the result( interaction) and is circular recruiting of the 5' such mechanism( 5'-UTR) for an descending grove replication step. (evakoch.com)
  • GAP proteins specific for Rap contain a conserved region of around 200 amino-acid residues, the RapGAP domain. (embl.de)
  • Two aspartic acid residues in the active site of the cyclase (AC or GC) promotes the binding of ATP. (pancreapedia.org)
  • Fig. 1 (A) EGF induces avβ5-mediated Rap1 activation and cell metastasis Fig. 5 The first 9 YXXP tyrosine residues in the CAS substrate domain name are required for αvβ5-mediated migration and metastasis Statistics Unless stated otherwise bar graphs represent mean±SD of triplicate samples. (biotech-angels.com)
  • Mammalian tuberin protein, the product of a familial tuberous sclerosis gene which, when deleted, causes begnin tumours. (embl.de)
  • Mammalian tuberin-like protein TULIP. (embl.de)
  • Publications] Sasaki,T.: 'A mammalian inhibitory GDP/GTP exchange protein(GDI)for smg p25A is active on the yeast SEC4 protein. (nii.ac.jp)
  • Our understanding of mitochondrial transcription in mammalian cells has largely progressed, but the mechanisms regulating mtDNA gene expression are still poorly understood despite their profound importance for human disease. (biomed.news)
  • Here, we review mechanisms of mitochondrial gene expression with a focus on the recent findings in the field of mammalian mtDNA transcription and disease phenotypes caused by defects in proteins involved in this process. (biomed.news)
  • Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)
  • This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
  • When rolling lymphocytes are exposed to chemokines present within the HEV chemokine signalling coupled with Gi proteins activates leukocyte function-associated-1 (LFA-1) a major receptor that mediates homing to peripheral lymph nodes. (hiv-proteases.com)
  • NO activates soluble guanylate cyclase (GC), which converts GTP to cGMP. (endocrinology-journals.org)
  • However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
  • in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)
  • Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
  • After inhibition of adenylate cyclase by Gαi subunit activation, SSTR5 affects phospholipase C (PLC) which in turn cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). (endocrinology-journals.org)
  • This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). (uth.edu)
  • 600 genes differentially expressed during Leber congenital amaurosis_Retina_GSE3249 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. (maayanlab.cloud)
  • Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. (mechanobio.info)
  • In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
  • Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)
  • The manifestation levels of the activation reporter epitopes identified by the antibodies KIM127 and MEM148 were significantly upregulated from the knockdown of FLN (Fig. 7i and Supplementary Fig. 6a) indicating that FLN restrains the active conformation of LFA-1. (hiv-proteases.com)
  • Since the deletion of cytoplasmic region of β2 induced spontaneous arrest4 the dissociation of a using mice harbouring T-cell-specific knockouts of and and knockdown (and conditional double-knockout mice (Rap1 CKO) mice transporting floxed and alleles (CKO mice develop p-Coumaric acid spontaneous colitis with adenoma. (hiv-proteases.com)
  • Knockdown of Rap1b expression in FG cells selectively blocked EGF-induced migration on vitronectin (Fig. 1B) supporting a role for Rap1 in the β5/EGF-mediated cell migratory response. (biotech-angels.com)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)
  • Loss of Pcs impairs Rab11 localization on the trans-side of Golgi units and induces the cytoplasmic accumulation of post-Golgi vesicles bearing rhabdomere proteins, as observed in Rab11-deficiency. (sdbonline.org)
  • This study identifies the gene CG14579 as the transcription unit corresponding to the regulatory mutations known as central complex broad , ccb . (sdbonline.org)
  • They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
  • I conclude by speculating about how our understanding of T-cell activation in chronic inflammation may influence future therapy, and discuss this in the context of the prevailing view that in a susceptible host, chronic inflammatory disease occurs through a failure of regulatory T cells to downregulate the inflammatory process. (biomedcentral.com)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Association of RUNX3 with the events: clear biogenesis has activation of the astrocytes: mitochondrial to the CTGF surface, very co-translationally inhibiting activation of the CTGF damage which is the bovine machinery source pH( Yagi et al. (evakoch.com)
  • The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • The second signaling mechanism involves the binding of a small signaling molecule to a soluble cyclase. (pancreapedia.org)
  • Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)
  • D: In the download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa phase of the module, the pattern-recognition: GTP plays the form, widely containing the region out of the A chaperone to spiral Loss and binds the Convention lipid: GDP. (evakoch.com)
  • In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. (cusabio.com)
  • Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
  • Here we identified Nup2 in a pool of enriched proteins that co-purify with tagged Ndj1 from meiotic cell extracts. (biorxiv.org)
  • losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration. (cusabio.com)
  • This Rap1-dependent rules of T-cell blood circulation prevents the onset of colitis. (hiv-proteases.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • In contrast, loss of the specific subunits of TRAPPII, another known Rab11-GEF, does not cause any defects on the eye development nor the transport of rhabdomere proteins, however, simultaneous loss of TRAPPII and Pcs shows severe defects on eye development. (sdbonline.org)
  • For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)