• They believe that, normally, the KCNQ1-KCNE2 potassium channel helps another protein (the sodium/iodide symporter) to transport iodide into the thyroid. (sciencedaily.com)
  • The vertebrate sodium-iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. (zfin.org)
  • Cedars' researchers successfully tested a new reporter gene method known as "human sodium iodide symporter, or hNIS)" during the first year of this project. (ca.gov)
  • The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
  • MV-NIS attacks cells expressing the human CD46 antigen and it also acts as an activator of human thyroidal sodium iodide symporter. (pharmaceutical-technology.com)
  • Our investigators have pioneered first-in-human testing of different viral platforms that they developed as oncolytic agents, including measles virus strains encoding the sodium iodide symporter gene, vesicular stomatitis virus strains encoding the human interferon beta and NIS genes, and measles virus strains encoding the TLR-2 agonist neutrophil activating protein. (mayo.edu)
  • They reduce sodium/iodide symporter gene expression. (purovitalis.com)
  • We investigated whether reporter gene PET can be used to detect the effects of atorvastatin and VEGF on survival of EPCs after transplantation in the rat heart.Methods: Healthy nude rats received an intramyocardial injection of 4 million human EPCs retrovirally transduced with the sodium/iodide symporter gene for reporter gene imaging. (elsevierpure.com)
  • The control group received EPCs transduced only with the reporter gene, whereas treatment groups received oral atorvastatin (10 mg/kg/d) and EPCs cotransduced with adenoviral vectors encoding VEGF in addition to sodium/iodide symporter. (elsevierpure.com)
  • The functional effect of iodide occurs at multiple steps, which include inhibition of sodium/iodide symporter (NIS) expression, transient block of organification, and inhibition of hormonal release. (johnshopkins.edu)
  • In this report, we show that excess iodide coordinately suppresses the expression of the NIS and VEGF genes in FRTL-5 thyroid cells. (johnshopkins.edu)
  • We also demonstrate that the mechanism of iodide suppression of NIS gene expression is transcriptional, which is synergized by the addition of thyroglobulin. (johnshopkins.edu)
  • Based on the findings of reporter gene assays and electrophoretic gel mobility shift analysis, we also report two novel DNA binding proteins that responded specifically to iodide and modulated NIS promoter activity. (johnshopkins.edu)
  • Human sodium/iodide symporter (hNIS) is considered as one of the most prevalent nuclear imaging reporter transgenes that provides precise information regarding the kinetics of gene expression, viral biodistribution, toxicity, and therapeutic outcomes using the accumulation of radiotracers at the site of transgene expression. (biomedcentral.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
  • Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
  • The authors' findings, published online this week by the peer-reviewed journal Nature Medicine , suggest that mutations of either of two gene products -- proteins called KCNE2 and KCNQ1 -- already known to be involved in human cardiac arrhythmias, could also cause thyroid dysfunction. (sciencedaily.com)
  • While we have identified KCNQ1 and KCNE2 in both mouse and human thyroid, much additional work is required before we can fully understand how inherited mutations in the genes coding these proteins affect human thyroid function, how this in turn influences the health of human heart and other tissues, and how useful our discoveries will be in developing therapies to treat thyroid and thyroid-related human disease," explains Dr. Abbott. (sciencedaily.com)
  • Mutations in this gene cause cystinosis, a lysosomal storage disorder. (nih.gov)
  • Cystinosis and two rare mutations in CTNS gene: two case reports. (nih.gov)
  • Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)
  • A neurotransmitter sodium symporter (NSS) (TC# 2.A.22) is type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters, amino acids, osmolytes and related nitrogenous substances by a solute:Na+ symport mechanism. (wikipedia.org)
  • Neurotransmitter sodium symporters (NSS) are targets for anti-depressants, psychostimulants and other drugs. (wikipedia.org)
  • To test the hypothesis that SLC5A5 paralogs are expressed in tissues necessary for the development of reproductive organs, and therefore are plausible candidates to mediate the effects of perchlorate on sexual development, we first investigated the evolutionary history of Slc5a paralogs to better understand potential functional trajectories of the gene family. (zfin.org)
  • Using a heat-inducible promoter to drive transgene expression enables us to control the activation of the therapeutic NIS gene locally as well as temporally. (lmu-klinikum.de)
  • GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
  • We also characterized expression patterns of slc5a genes during development. (zfin.org)
  • These findings show novel expression domains of slc5 genes in stickleback and zebrafish, which suggest similar functions across vertebrates including humans, and provide candidates to mediate the effects of perchlorate on sexual development. (zfin.org)
  • However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
  • In addition, the expression of ERG2, ERG24 and ERG11 genes and the ergosterol content had no differences between wild type and the mutant. (ncl.edu.tw)
  • Cedars' research group successfully demonstrated the expression of the reporter hNIS in MSCs that had differentiated into bone-forming cells - demonstrating the ability to image stem cell differentiation long after the transfection of the reporter gene into the original MSC population. (ca.gov)
  • She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
  • 2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. (uth.edu)
  • Reporter gene expression was imaged at days 1 and 3 after injection on a small-animal PET scanner with 124I, and the presence of EPCs was confirmed by immunohistochemistry with human CD31 antibodies. (elsevierpure.com)
  • Additionally, SPX domain proteins were shown to be involved in nitrate-phosphate signaling crosstalk in rice where nitrate-dependent interaction with NRT1.1B caused ubiquitination and degradation of OsSPX4 and consequently translocation of OsPHR2 and OsNLP3 into nucleus to induce PSI genes and nitrate inducible genes, respectively [ 11 ]. (biomedcentral.com)
  • CitM, H+/citrate symporter [Ensembl]. (ntu.edu.sg)
  • GLUTs are encoded by the SLC2 genes, and the SGLTs are encoded by the SLC5 genes. (medscape.com)
  • This is a dramatic improvement in the ability to visualize stem cells the hNIS gene stays with the descendents of the originally transfected cells and they will temporarily "shine" or become visible when 99mTc is injected into the body as a contrast tracer. (ca.gov)
  • The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. (uth.edu)
  • Introduction of heterologous glucose- or fructose-proton symporters in an hxt 0 yeast background strain (derived from CEN.PK2-1C) restored growth on the corresponding sugar under aerobic conditions. (biomedcentral.com)
  • To apply this strategy to increase the ethanol yield on sucrose, we constructed a platform strain in which all genes encoding hexose transporters, disaccharide transporters and disaccharide hydrolases were deleted, after which a combination of a glucose-proton symporter, fructose-proton symporter and extracellular invertase ( SUC2 ) were introduced. (biomedcentral.com)
  • The SGLT2 gene is localized to p11.2 on chromosome 16. (medscape.com)
  • Here, we report two crystal structures of an APC member from Methanococcus maripaludis , the alanine or glycine:cation symporter (AgcS), with l- or d-alanine bound. (rcsb.org)
  • To improve the effectiveness and tumor selectivity of MSC-mediated gene therapy, we are investigating the combination of regional hyperthermia with NIS gene therapy. (lmu-klinikum.de)
  • These studies provide initial insights into substrate selectivity in AgcS symporters. (rcsb.org)
  • This "reporter gene" imaging technique works not only with the originally engineered cells but also with the progeny cells that result from splitting and differentiation of the stem cells. (ca.gov)
  • The reporter gene engineering effort is led by Professor Dan Gazit of Cedars-Sinai Medical Center. (ca.gov)
  • The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
  • The favorable biodistribution and high image contrast observed warrant further studies of this new reporter gene. (snmjournals.org)
  • Reporter gene PET, by successfully quantifying the effect, is an attractive tool for monitoring stem cell survival in vivo. (elsevierpure.com)
  • The vascular effect likely involves suppression of the vascular endothelial growth factor (VEGF) gene. (johnshopkins.edu)
  • Genes previously known to be essential to the coordinated, rhythmic electrical activity of cardiac muscle -- a healthy heartbeat -- have now also been found to play a key role in thyroid hormone (TH) biosynthesis, according to researchers. (sciencedaily.com)
  • We then wanted to test what the mechanism was in the mice that caused deletion of the KCNE2 gene to have negative consequences for the thyroid," says Dr. Abbott. (sciencedaily.com)
  • They found that absorption of the radioisotope in the thyroid was greatly impaired in mice lacking the KCNE2 gene. (sciencedaily.com)
  • Stickleback embryos and early larvae expressed NIS clade genes in connective tissue, cartilage, teeth, and thyroid. (zfin.org)
  • Quercetin's side effects on the thyroid can affect other thyroid-restricted genes. (purovitalis.com)
  • They successfully detected the inward and outward confirmations of the symporter Sugar Transport Protein 10 (STP10) - a protein responsible for monosaccharide transport across cell membranes - at high resolutions (1.8 and 2.6 Å respectively) in Arabidopsis thaliana. (lu.se)
  • We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. (uth.edu)
  • While studying mice that had the KCNE2 gene removed from their genome, the researchers observed that the animals developed symptoms of hypothyroidism, especially during pregnancy, and gave birth to pups with dwarfism, alopecia (baldness) and cardiomegaly (enlarged heart). (sciencedaily.com)
  • The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). (uth.edu)
  • We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. (uth.edu)
  • We analyzed SPX gene family evolution in legumes and in a number of key species from algae to angiosperms. (biomedcentral.com)
  • In addition, we found that the WGD/segmentally or dispersed duplication types were the most frequent contributors to the SPX expansion, and that there is a positive correlation between the amount of WGD contribution to the SPX expansion in individual species and its number of EXS genes. (biomedcentral.com)
  • To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. (uth.edu)
  • A symporter is an integral membrane protein that is involved in the transport of two different molecules across the cell membrane in the same direction. (lu.se)
  • The symporter works in the plasma membrane which exists in plants. (lu.se)
  • This gene has no orthologs in other dataset(s). (uth.edu)
  • The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
  • cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)
  • Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure. (jax.org)
  • Harnessing genes and viruses to infect and kill tumor cells offers a promising step forward in cancer treatment. (mayo.edu)
  • The sub- or neo-functionalization of the duplicated genes in the legumes makes it difficult to find the functional orthologous genes. (biomedcentral.com)
  • There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior. (uth.edu)
  • In low P supply, low availability of PP-InsPs-SPX results in the release of PHR1 to translocate to nucleus and to activate Pi starvation induced (PSI) genes [ 8 ]. (biomedcentral.com)
  • Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. (uth.edu)
  • The Gene and Virus Therapy Program focuses on developing new gene-delivery systems and gene-based and virus-based therapies for cancer treatment. (mayo.edu)
  • The Gene and Virus Therapy Program is advancing numerous discoveries about cancer that can ultimately benefit patient care and outcomes. (mayo.edu)
  • The Gene and Virus Therapy Program is directed by Mitesh J. Borad, M.D., and Richard G. Vile, Ph.D. (mayo.edu)
  • Hematopoietic Stem Cell Gene Therapy for Cystinosis: From Bench-to-Bedside. (nih.gov)
  • This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. (nih.gov)