Gene recombinant growth. Medical search. Frequent questions

The following is a list of notable proteins that are produced from recombinant DNA, using biomolecular engineering. (wikipedia.org)
In many cases, recombinant human proteins have replaced the original animal-derived version used in medicine. (wikipedia.org)
A much larger number of recombinant proteins is used in the research laboratory. (wikipedia.org)
As a result, recombinant lysosomal proteins are usually produced in mammalian cells. (wikipedia.org)
Recent studies have shown that it may be possible to produce recombinant lysosomal proteins with microorganisms such as Escherichia coli and Saccharomyces cerevisiae. (wikipedia.org)
Recombinant lysosomal proteins are used for both research and medical applications, such as enzyme replacement therapy. (wikipedia.org)
When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. (prosci-inc.com)
Wnt-3a belongs to Wnt family of proteins that consist of structurally related genes encoding highly conserved cysteine rich secreted glycoproteins. (biolegend.com)
Why choose BioLegend recombinant proteins? (biolegend.com)
Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. (origene.com)
In this study, we showed that the human RFC (hRFC) gene can serve as a novel selectable marker for the overproduction of recombinant proteins. (aspetjournals.org)
These results establish a novel RFC-based metabolic selection system for the efficient overexpression of recombinant proteins. (aspetjournals.org)
Shenandoah Biotechnology is a privately held company located in Warminster, Pennsylvania, that manufactures recombinant proteins including cytokines and growth factors. (fujifilm.com)
Shenandoah Biotechnology's portfolio of recombinant proteins complement our advanced cell culture solutions and expertise in bioprocessing, providing our collective customers a single point of access for their life science research, discovery, and cell and gene therapy needs. (fujifilm.com)
Yamaguchi added, "The team at Shenandoah Biotechnology has years of proven experience in supplying the life science industry with high quality recombinant proteins at scale. (fujifilm.com)
At Shenandoah Biotechnology, our vision is to provide a superior and affordable source of recombinant proteins to the drug discovery, life science research, and cell and gene therapy markets. (fujifilm.com)
Recombinant proteins are used in a variety of life science applications. (fujifilm.com)
Specific types of recombinant proteins such as growth factors and cytokines are essential for cell therapy, gene therapy and regenerative medicine in the areas of research, development and manufacturing. (fujifilm.com)
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. (prospecbio.com)
This process assists research professionals in studying the somatic cells, recombinant therapeutic proteins, and gene therapy. (powershow.com)
Whether you are producing antibodies, recombinant proteins, vaccines or viral vectors for gene therapies, our cell line platforms can accelerate your upstream progress. (sigmaaldrich.com)
Our recombinant cell culture supplements include albumin, transferrin, insulin, trypsin, NAO growth factors and transport proteins for production of mAbs and recombinant proteins, as well as cell and gene therapies. (sigmaaldrich.com)
In recent years, an increasing variety of biologic drugs have been developed including vaccines, recombinant proteins, gene and cell therapies. (westpharma.com)
The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
Therefore, the various concentration of the insulin proteins regulates the cell activity in different context, for instance in excess of glucose or lack of Growth Hormone. (proteopedia.org)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
This has equivalent bioactivity to Recombinant Human IL-4 Proteins ( BT-004 ) and Catalog # BT-004-AFL.These combine R&D Systems quality with scalability that allows for a solid supply chain. (rndsystems.com)
All Recombinant Human IL-4 proteins are measured in a cell proliferation assay using TF-1 human erythroleukemic cell line. (rndsystems.com)
135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)

The following product was used in this experiment: Inhibin, alpha (INHA) Recombinant Rabbit Monoclonal Antibody (INHA, 6598R) from Thermo Fisher Scientific, catalog # 3623-RBM8-P1. (thermofisher.com)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human testicular carcinoma using Inhibin, alpha (INHA) Recombinant Monoclonal Antibody (Product # 3623-RBM8-P1) at 2 µg/mL in PBS for 30 min RT. (thermofisher.com)
The following product was used in this experiment: Neuropilin 1 Recombinant Rabbit Monoclonal Antibody (042) from Thermo Fisher Scientific, catalog # MA5-43129, RRID AB_2912266. (thermofisher.com)

The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. (prosci-inc.com)

This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP1-85561. (novusbio.com)

A putative acylphosphatase gene (PhAcP) was cloned from the genomic DNA of Pyrococcus horikoshii and was expressed in Escherichia coli. (rcsb.org)
For efficient production of P4HB recombinant Escherichia coli has been employed. (biomedcentral.com)
Phytol feeding and enzyme assays with Arabidopsis and recombinant Escherichia coli cells demonstrated that VTE6 has phytyl-P kinase activity. (nih.gov)

Recombinant mouse IL-11 was expressed in E. coli and is supplied in a lyophilized form. (cellsignal.com)
In the study, glycerol uptake facilitator or aquaglyceroporin gene (glpF) and glycerol kinase (glpK) gene were PCR-cloned from E. coli, inserted into a shuttle vector pBS29P2gfp, and expressed in P. chlororaphis by a Pseudomonas promoter P2. (usda.gov)
E. coli JM109 was found to be the best strain regarding the specific growth rate and the P4HB content. (biomedcentral.com)
The effect of growth conditions such as temperature and physiological stage of Na-4HB addition on P4HB synthesis was also studied in E. coli JM109 recombinant in batch culture. (biomedcentral.com)

Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. (mdpi.com)
A plethora of biological agents are currently available in the market, including insulins, vaccines, human growth hormone, erythropoietin, interleukins, interferon, clotting factors and monoclonal antibodies 3 4 . (lww.com)
A third production technology for flu vaccines was approved for use in the U.S. market in 2013 and involves using recombinant technology . (cdc.gov)

The bioactivity of recombinant mIL-11 was determined in a B9 cell proliferation assay. (cellsignal.com)

Scientists first started making synthetic genes by cutting and pasting parts of different genes together. (thetech.org)
In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)

However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. (thermofisher.com)

The present project aims to introduce microarray technology as a new analytical tool into the field of doping control analysis to gain insight in specific effects of recombinant human growth hormone (hgh) on blood cells (leukocytes). (wada-ama.org)
Microarray technology will be used to search for changes in leukocyte gene expression which are directly related to the application of human growth hormone (hgh). (wada-ama.org)
The aim was to establish a selective human Growth Hormone (hgh) microarray which can be used in hgh doping control by detecting the specific effects of hgh administration rather than the presence of the hormone itself as its very short half-life complicates direct detection. (wada-ama.org)
The prefix "rh" for "recombinant human" appears less and less in the literature. (wikipedia.org)
Human growth hormone (rHGH): Humatrope from Lilly and Serostim from Serono replaced cadaver harvested human growth hormone human insulin (BHI): Humulin from Lilly and Novolin from Novo Nordisk among others largely replaced bovine and porcine insulin for human therapy. (wikipedia.org)
Recombinant fragment corresponding to Human Growth Hormone. (abcam.com)
Publications] Noriaki Sugawa, Yoshio Nakagawa, Satoshi Ueda: 'Point mutations of Epidermal Growth Factor Receptor Transcripts in Primary Human Malignant Gliomas' Brain Tumor Research and Therapy. (nii.ac.jp)
Recombinant Human Neuropilin-1/NRP1/CD304 protein. (thermofisher.com)
A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human TPP1. (novusbio.com)
The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. (prosci-inc.com)
Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein. (prosci-inc.com)
Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative disease. (biolegend.com)
This gene is localized to human chromosome 3q. (sigmaaldrich.com)
Using a preterm rabbit pup model, we investigated the uptake of systemic recombinant human (rh) IGF-1 in complex with its main binding protein IGF-binding protein 3 (BP-3) to the brain parenchyma via the choroid plexus. (lu.se)
Genotropin is a recombinant human growth hormone (also called somatropin). (pfizer.co.uk)
Somatropin has the same structure as natural human growth hormone which is needed for bones and muscles to grow. (pfizer.co.uk)
It is recombinant meaning it is not made from human or animal tissue. (pfizer.co.uk)
At this time, FDA recommends that patients continue their recombinant human growth hormone treatment as prescribed by their healthcare provider. (fda.gov)
Recombinant human growth hormone is a protein that is manufactured to be nearly identical to the main form of the naturally occurring human growth hormone. (fda.gov)
In the United States, recombinant human growth hormone is used in the pediatric population to treat short stature due to growth hormone deficiency (including idiopathic [of unknown cause] growth hormone deficiency), Turner syndrome, Noonan syndrome, Prader-Willi syndrome, short stature homeobox-containing gene (SHOX) deficiency, chronic renal insufficiency, idiopathic short stature and children small for gestational age. (fda.gov)
1-3 It was designed to assess the long-term mortality of patients treated with recombinant human growth hormone during childhood. (fda.gov)
The study population was based on a mandatory registry of patients in France who received recombinant human growth hormone treatment during childhood between 1985 and 1996 and whose vital status and cause of death was determined through September 2009. (fda.gov)
Do not stop taking recombinant human growth hormone without talking to your healthcare professional. (fda.gov)
Discuss any questions or concerns about recombinant human growth hormone with your healthcare professional. (fda.gov)
If you prescribe recombinant human growth hormone, follow the recommended indications and doses in the product labels. (fda.gov)
FDA is aware of the results of a long-term epidemiological study called SAGhE (Santé Adulte GH Enfant), which was designed to assess the long-term mortality of patients treated with recombinant human growth hormone during childhood. (fda.gov)
The investigators report a 30% increased risk of death with recombinant human growth hormone therapy compared to the general population, with 93 observed deaths in the treated group versus 70 expected deaths in the general population in France. (fda.gov)
BMP-7 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 30-38kDa due to glycosylation. (prospecbio.com)
Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
Thus, even a small insulin-like effect of IGF-I could be more important than that of insulin itself, were it not for the IGFBPs that control the availability and activity of IGF-I. In fact, intravenous infusion of recombinant human IGF-I (rhIGF-I) can induce hypoglycemia, especially in the IGFBP3 deficient state. (medscape.com)
The specific activity of Animal-Free™ Recombinant Human IL-4 is >1.0x10 7 IU/mg, which is calibrated against the human IL-4 WHO International Standard (NIBSC code: 88/656). (rndsystems.com)
As an alternative, please consider our next generation Recombinant Human IL-4 Protein, ( BT-004-GMP ). (rndsystems.com)
Recombinant Human IL‑4 stimulates cell proliferation of TF‑1 human erythroleukemic cells. (rndsystems.com)
2 μg/lane of Animal-Free™ Recombinant Human IL‑4 Protein (Catalog # BT-004-AFL) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 13 kDa underreducing conditions. (rndsystems.com)
As a result of the rapid advances in genetics technology and the Human Genome Project, most of the estimated 100,000 genes in humans will be identified by the year 2005 (1). (cdc.gov)
Antigenic drift involves small mutations in the genes of influenza viruses that lead to changes in HA and NA that accumulate over time, resulting in the emergence of novel strains that the human immune system may not recognize. (cdc.gov)

Some of the other factors contributing to the market growth include the rising prevalence of viral diseases and extensive research and development (RD) activities conducted by key players to introduce improved product variants in the market. (powershow.com)

This gene encodes a member of the collapsin response mediator protein family. (origene.com)
Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)

These components are the Haemophilus influenzae type b capsular polysaccharide [polyribosylribitol phosphate (PRP)] that is covalently bound to an outer membrane protein complex (OMPC) of Neisseria meningitidis and hepatitis B surface antigen (HBsAg) from recombinant yeast cultures. (theodora.com)
The antigen is harvested and purified from fermentation cultures of a recombinant strain of the yeast Saccharomyces cerevisiae containing the gene for the adw subtype of HBsAg. (theodora.com)

Acquired forms of GH insensitivity include the rare GH1 mutation (in which GH inhibiting antibodies develop after a few months of replacement therapy with recombinant GH) and, far more commonly, malnutrition, hepatic disease, renal disease, and diabetes. (medscape.com)

Utilizing the upstream regulator (i.e. transcription factors, cytokines, growth factors) analysis, the lung had 285, blood cells 30, aorta 39, and heart 32 significantly altered mediators 4 h post-exposure. (cdc.gov)
Growth regulated oncogene-gamma belongs to the family of chemotyctic cytokines called chemokines. (topsan.org)
Shenandoah Biotechnology recently launched their CTG Grade™ line of cytokines and growth factors that are manufactured according to cGMP guidelines in the Company's new state-of-the-art, ISO 9001:2015 certified facility. (fujifilm.com)
Growth factors and cytokines are important drivers of many cellular processes such as cell proliferation, growth, differentiation and cell signaling. (fujifilm.com)

The purity of Mouse IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant mIL-11 and staining with Coomassie Blue. (cellsignal.com)

The 334 amino acid recombinant protein has a predicted molecular mass of approximately 37.4 kD. (biolegend.com)

This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. (thermofisher.com)

After confirming SSH-genes to be differentially expressed in a series of microarray experiments, oligonucleotide probes will be designed for both SSH-genes and the candidate genes identified along gene expression profiling using whole genome/leukocyte relevant arrays. (wada-ama.org)
One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)

A portion of the hepatitis B virus gene, coding for HBsAg, is cloned into yeast, and the vaccine for hepatitis B is produced from cultures of this recombinant yeast strain according to methods developed in the Merck Research Laboratories. (theodora.com)
The gene ontology (GO) terms associated with monooxygenase, iron binding, and passive transmembrane transporter activities were significantly enriched in four out of six resistant vs. susceptible comparisons while serine protease activity was elevated in all insecticide-resistant groups relative to the susceptible strain. (cdc.gov)

Publications] Noriaki Sugawa, Satoshi Ueda: 'Gene therapy using antisense DNA' Clinical Neuroscience. (nii.ac.jp)
More recently they've also been used to create genes used in gene therapy and genetically modified foods . (thetech.org)
We are pleased to join FUJIFILM Irvine Scientific given their experience with manufacturing ancillary materials for cell and gene therapy and commitment to providing high quality products and service to customers," said Pamela De Lacy, president, Shenandoah Biotechnology. (fujifilm.com)
Our off-the-shelf and customizable bioprocessing cell culture media (CCM) products enhance productivity in upstream mAb, vaccine, gene/cell therapy processes. (sigmaaldrich.com)
Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. (biomedcentral.com)
Survival analysis results of multiple cancer models confirmed that BF-rTK + GCV system has a wide field of application in solid tumor gene therapy. (biomedcentral.com)
Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 - 11 ]. (biomedcentral.com)

Moreover, using choroid plexus in vitro cell cultures, gene expression and protein synthesis were further investigated upon rhIGF-1/rhIGFBP-3 stimulation as compared to rhIGF-1 alone, and found not to be differently altered. (lu.se)

In the first phase of the project cell lines of specific leukocyte subsets (THP-1/monocyte, IM-9/T lymphocyte, H9/B lymphocyte), PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively will be treated in vitro with hgh to identify candidate genes influenced by hghapplication. (wada-ama.org)
To this purpose cell lines of specific leukocyte subsets (THP-1/ monocyte, IM-9/ B- lymphocyte, H9/ T-lymphocyte) and PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively were treated in vitro with hgh to identify candidate hgh-sensitive genes. (wada-ama.org)
Genes clustering in the categories fatty acid beta oxidation, cell adhesion, DNA replication and polyamine biosynthesis were up-regulated indicating increased lipolysis, cell attachment, proliferation and growth. (wada-ama.org)
Genes for non-apoptotic cell death and regulation of osmotic pressure were down-regulated. (wada-ama.org)
The B lymphocyte cell line RA-1 showed gene upregulation in the categories opioid receptor, oxidoreductase and GMP-reductase activity. (wada-ama.org)
Genes of groups similar to those detected as repressed in H9 cells were also down-regulated in the RA-1 cell line along with genes responsible for muscle development. (wada-ama.org)
Protein production Gene expression Protein purification Host cell protein Young CL, Britton ZT, Robinson AS (May 2012). (wikipedia.org)
We studied the growth inhibition of the malignant glioma cell lines using an antisense EGFR oligonucleotide (normal phosphodister oligonucleotide) enveloped with Lipofectin^R (BRL) and we could have a good result. (nii.ac.jp)
This time, we succeeded to develop the recombinant retro-virus vector expressiog EGFR antisense oligonucleotide, and we could inhibit the growth of the malignant glioma cell line using this retro-virus vector. (nii.ac.jp)
The antitumor efficacy of the recombinant virus on hepatoma was examined both in cell cultures and in mice. (usda.gov)
The P. chlororaphis recombinants were then tested for cell growth and glycerol metabolism in chemically defined medium containing 0.5 and 1.0 % glycerol. (usda.gov)
The simultaneous expression of glpF and glpK resulted in an increased rate of glycerol metabolism for cell growth of P. chlororaphis. (usda.gov)
The colo320 cell was analyzed by the gene silencing method. (biomedcentral.com)
It was previously found that the P4HB synthesis is co-related with the cell growth. (biomedcentral.com)
Interestingly, three phases were identified during P4HB production: the "growth phase", in which the cells grew exponentially, the "accumulation phase", in which the exponential cell growth stopped while P4HB was accumulated exponentially, and the "stagnation phase", in which the P4HB accumulation stopped and the total biomass remained constant. (biomedcentral.com)
P4HB synthesis was found to be separated from the cell growth, i.e. (biomedcentral.com)
P4HB synthesis mainly took place after the end of the exponential cell growth. (biomedcentral.com)
[1] . It is the main actor in primary growth cell control. (proteopedia.org)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

Mouse IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. (cellsignal.com)

HER2 overexpression or HER2 gene amplification as determined by an accurate and validated assay (see sections 4.4 and 5.1). (who.int)

IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)
The situation is more complex when it comes to patents that in some way claim genes isolated, extracted or derived from viruses and related genetic information, or that claim potentially new uses or applications of genes or genetic information. (who.int)
In some countries laws specifically provide that isolated genetic material, such as gene sequences, may be considered patentable inventions (as long as they meet the other criteria for the granting of a patent) even if corresponding genes occur in nature. (who.int)
This situation typically arises when it is considered that the isolated gene or genetic material may serve a distinct useful purpose. (who.int)
Antigenic shifts are probably due to genetic recombination (an exchange of a gene segment) between influenza A viruses that affect humans and/or animals. (cdc.gov)

Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. (novusbio.com)
Frequency of mutations in PIK3CA gene is higher in tumors without lymph node metastasis, than those with in gastric cancer. (sigmaaldrich.com)
Thus, it might be essential to evaluate the mutations in this gene to determine cetuximab treatment in gastric cancer patients. (sigmaaldrich.com)

The fermentation process involves growth of Saccharomyces cerevisiae on a complex fermentation medium which consists of an extract of yeast, soy peptone, dextrose, amino acids and mineral salts. (theodora.com)

Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)

PPARGC1A, a transcription factor regulating mitochondrial biogenesis and function and induced by oxidative stress, was increased and linked to many of the altered cardiac upstream regulators and genes associated with mitochondrial dysfunction. (cdc.gov)
Toward this end, a hemagglutinin (HA) epitope tagged hRFC (hRFC-HA) was introduced into a bicistronic vector (pIRES2-EGFP), upstream of an enhanced green fluorescent protein (EGFP) reporter gene. (aspetjournals.org)

HB-EGF is an EGF-related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. (prosci-inc.com)

Abstract Under salt stress conditions, plant growth is reduced due to osmotic, nutritional and oxidative imbalance. (bvsalud.org)

Whole genome cDNA microarrays as well as oligonucleotide microarrays including leukocyte-relevant genes will be used to characterize potential hgh-specific genes by comparing gene expression profiles of treated and untreated cells. (wada-ama.org)
The "hgh-chip" will then be thoroughly evaluated by performing numerous gene expression experiments on hgh-treated and untreated leukocyte subsets, cultured PBMCs as well as PBMCs obtained from hgh-patients. (wada-ama.org)
During the proposed project new, nucleic acid-based analytical techniques will be used to gain insight into specific effects of hgh on gene expression of leukocytes. (wada-ama.org)
Results obtained from gene expression profiling utilising whole genome arrays were in accordance with published data. (wada-ama.org)
IGF-1 expression is regulated by growth hormone. (joplink.net)
Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. (biolegend.com)
We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
In addition, choroid plexus gene expression was observed to increase with postnatal age. (lu.se)
Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. (prospecbio.com)
Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. (microbiologyresearch.org)
Here, we applied Illumina RNA-Seq to study the gene expression patterns associated with resistance to three widely used insecticides (malathion, alphacypermethrin, and lambda-cyhalothrin) in Ae. (cdc.gov)
These results could inform development of novel molecular tools for detection of resistance-associated gene expression in this important arbovirus vector and guide the design and implementation of resistance management strategies. (cdc.gov)
Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)

To find additional hgh-candidate genes, suppression subtractive hybridization (SSH) technology will be applied on hgh-treated PBMCs and on those cultured leukocyte subsets which showed a response to hgh before during in vitro studies. (wada-ama.org)

The basidiomycete Schizophyllum commune , which completes its life cycle in ∼ 10 d, is a notable exception insofar as it can be cultured on defined media and there are a wealth of molecular tools to study its growth and development. (nature.com)

It is made by an organism that has received a gene (DNA), which makes it able to produce growth hormone. (pfizer.co.uk)
If the patient is not growing properly and does not have enough of their own growth hormone. (pfizer.co.uk)
Growth hormone will help the child grow taller if they are still growing, and will also improve their body composition. (pfizer.co.uk)
Growth hormone can help the child grow taller if they have not been able to catch up or maintain normal growth by four years of age or later. (pfizer.co.uk)
In adults, Genotropin is used to treat persons with pronounced growth hormone deficiency. (pfizer.co.uk)
If an individual has been treated with Genotropin for growth hormone deficiency during childhood, their growth hormone status will be retested after completion of growth. (pfizer.co.uk)
If severe growth hormone deficiency is confirmed, the doctor will propose that the patient continues with the Genotropin treatment. (pfizer.co.uk)
At this time, FDA believes the benefits of recombinant growth hormone continue to outweigh its potential risks. (fda.gov)
1-3 This study was based on a mandatory registry of patients in France treated with recombinant growth hormone during childhood between 1985 and 1996. (fda.gov)
The risk of death was reported to be increased when doses of recombinant growth hormone that are higher than what is normally prescribed for pediatric growth hormone deficiency were used. (fda.gov)
The approved doses in the United States for pediatric growth hormone deficiency are below 50 mcg/kg/day, except during puberty, when a higher dose regimen is approved for a limited duration of time.For short stature indications other than growth hormone deficiency, doses up to 69 mcg/kg/day (0.48 mg/kg/week) are currently approved. (fda.gov)
Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). (medscape.com)
In the pituitary gland inside the brain, Growth Hormone ( GH ) is secreted and its release enable transcription of IGF1 in liver and depending on the nutritional state, a paracrine or autocrine activation IGF-1 occurs. (proteopedia.org)
Inside the liver, this mechanism is responsible for positive feedback, more precisely it allows growth hormone to continuously act upon the liver to produce more IGF-1. (proteopedia.org)

IGF-1 then acts as a ligand and can interact with Insulin Receptor protein and Insulin-like Growth Factor Binding Protein . (proteopedia.org)

When a scientist changes a gene it is called recombinant technology. (thetech.org)

Given the lack of effective treatments, we constructed a bifidobacterial recombinant thymidine kinase (BF-rTK) -ganciclovir (GCV) targeting system (BKV) to meet this requirement and to explore antitumor mechanisms. (biomedcentral.com)

PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four catalytic subunits of PI3K protein, which plays an essential role in extracellular growth signaling. (sigmaaldrich.com)
The severe growth retardation of vte6 mutants was partially rescued by introducing the phytol kinase mutation vte5. (nih.gov)

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. (joplink.net)
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. (joplink.net)

THP-1 cells, a model system for monocytes, were least sensitive to the application of hgh due to the lack of insulin-like growth factor 1 (IGF-1) production. (wada-ama.org)
Serial dilutions of Mouse IL-11 Recombinant Protein were added to B9 cells. (cellsignal.com)
There was no obvious difference of the growth capability between the recombinant NDV and the parental virus in the cancer cells. (usda.gov)
Chinese hamster ovary cells deficient in RFC activity were isolated and transfected with this construct, followed by gradual deprivation of leucovorin, the sole folate source in the growth medium. (aspetjournals.org)
In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. (microbiologyresearch.org)
HBsAg is produced in recombinant yeast cells. (theodora.com)
PHA accumulation appears when bacterial cells grow under conditions where nutrients other than carbon source, such as nitrogen or phosphorus, are limiting growth. (biomedcentral.com)
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting pbmc. (lu.se)

BMP-7 (Bone Morphogenetic Protein-7), also known as Osteogenic Protein 1 or BMP-7, is a potent growth factor that plays a crucial role in various biological processes, particularly in osteogenesis and tissue regeneration. (prospecbio.com)
BMP-7, also known as Osteogenic Protein 1 or BMP-7, is a growth factor with multifaceted roles in osteogenesis, tissue regeneration, and disease. (prospecbio.com)

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. (biovision.com)
The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. (fishersci.com)

Epidermal growth factor receptor (EGFR) plays an important role in the progression of malignancy in gliomas. (nii.ac.jp)
Insulin-like Growth Factor 1 Receptor ( IGF-1R ) is a transmembrane protein receptor. (proteopedia.org)

Our data suggest that, while PhAcP is less efficient than other mammalian homologues at 25 degrees C, the thermophilic enzyme is fully active at the optimal growth temperature (98 degrees C) of P. horikoshii. (rcsb.org)
So if you know the DNA letters of your gene, then you can use the right enzyme to cut it in the right place. (thetech.org)

Once IGF1 is bound to Insulin-like Growth Binding Protein (IGFBP), IGF-1 cannot be linked to IGF1R any longer. (proteopedia.org)

In conclusion, the recombinant P. chlororaphis that grows more efficiently in glycerol is expected to improve the techno-economics of PHA and RL production using surplus bioglycerol byproduct stream from biodiesel production. (usda.gov)

Insulin-like growth factor 1 (IGF-1) Rasburicase, a Urate Oxidase analog sold as Elitek from Sanofi Bovine somatotropin (bST) Porcine somatotropin (pST) Bovine Chymosin Xylanases Proteases, which have found applications in both the industrial (such as the food industry) and domestic settings. (wikipedia.org)
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and stabilization. (lu.se)
Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. (prospecbio.com)
Heparin-binding epidermal growth factor (HB-EGF)-like growth factor (EGF) is found in cerebral neurons. (watson-int.cn)
Insulin-like Growth Factor ( IGF-1 ) is a member of the insulin protein family. (proteopedia.org)

The modified virus contained an enhanced green fluorescent protein (EGFP) gene as a marker, which was named as NDV/Anh-EGFP. (usda.gov)

It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)

In this study, we aimed to investigate the physiology of P4HB synthesis, and to reduce the total production cost by using cheap and widely available xylose as the growth substrate and sodium 4-hydroxybutyrate (Na-4HB) as the precursor for P4HB synthesis. (biomedcentral.com)
However, salicylic acid acts in the mitigation of this abiotic stress by promoting an increase in growth, photosynthesis, nitrogen metabolism, synthesis of osmoregulators and antioxidant enzymes. (bvsalud.org)

Enzymatic parameters of the recombinant PhAcP were measured using benzoyl phosphate as the substrate. (rcsb.org)

Anatomy3

Organisms12

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes16

Information Science3

Health Care1

Proteins29

Monoclonal antibody3

Exposing the recombinant protein1

Antibody1

Escherichia3

Coli4

Vaccines3

Bioactivity1

Different genes2

Differentiated tumor1

Human36

Viral1

Encodes2

Antigen2

Antibodies1

Cytokines4

Purity1

Amino acid1

Regulator1

Differentially expressed2

Strain2

Therapy8

Protein synthesis1

Cell19

Sterile1

Overexpression1

Genetic5

Mutations3

Saccharomyces1

Transcriptional1

Upstream2

Stimulates1

Abstract1

Expression14

Vitro1

Molecular1

Hormone14

Insulin-like gr1

Technology1

Antitumor1

Kinase2

Structurally2

Cells8

Tissue2

Cytokine2

Receptor2

Enzyme2

IGF11

Glycerol1

Factor5

EGFP1

Homologous1

Synthesis2

Parameters1