• Autosomal dominant disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor ( FGFR) 2 and FGFR3 . (aacrjournals.org)
  • FGFR 3 encodes a transmembrane tyrosine kinase receptor involved in signaling via interaction with the family of fibroblast growth factors. (aacrjournals.org)
  • The effects of 13-cis retinoic acid (RA) and dexamethasone on the levels of epidermal growth factor (EGF) receptor and fibroblast derived proteoglycan core protein (PG40) mRNAs were studied in human skin fibroblasts. (medicaljournals.se)
  • Simultaneous treatment of the fibroblasts with 13-cis-RA and dexamethasone resulted in similar decreases in EGF receptor and PG40 mRNAs as with 13-cis-RA alone. (medicaljournals.se)
  • Surprisingly, the proliferation rate of the fibroblasts was increased in the presence of dexamethasone under conditions similar to those which caused slight decrease in the EGF receptor mRNA levels. (medicaljournals.se)
  • Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. (wikipedia.org)
  • FGF8 attaches (binds) to another protein called fibroblast growth factor receptor 1 (FGFR1) on the cell surface, which triggers a cascade of chemical reactions inside the cell. (medlineplus.gov)
  • Fusions of fibroblast growth factor receptor genes with other partner genes were recently discovered in cholangiocarcinoma. (mayo.edu)
  • The Hepatobiliary Cancer Lab is identifying and characterizing fibroblast growth factor receptor family gene aberrations and determining the effectiveness of targeting the aberrations in the treatment of cholangiocarcinoma. (mayo.edu)
  • Drug resistance to fibroblast growth factor receptor inhibitors (FGFR) has emerged as a major challenge to their clinical use. (mayo.edu)
  • Achondroplasia is caused by mutations in the fibroblast growth factor receptor-3 ( FGFR3 ) gene. (medscape.com)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
  • The FGFR2 gene produces a protein called fibroblast growth factor receptor 2. (medicalnewstoday.com)
  • It can be prescribed to adults with a specific abnormal change in the fibroblast growth factor receptor 1 gene. (medicalnewstoday.com)
  • Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfate proteoglycans as co‑factors. (rndsystems.com)
  • CHICAGO, June 5, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an interim analysis of Cohort 1 of the Phase 3 THOR study, evaluating treatment with BALVERSA ® (erdafitinib) versus chemotherapy in patients with metastatic or unresectable urothelial carcinoma (UC) and selected fibroblast growth factor receptor (FGFR) gene alterations who had received prior treatment with an anti-programmed death ligand 1 (PD-[L]1) agent. (janssen.com)
  • FGFR3 is a receptor that inhibits growth as part of a feedback loop that controls growth. (kaiserpermanente.org)
  • The mutations causing achondroplasia "turn on" this receptor causing growth to be inhibited more than it would normally be. (kaiserpermanente.org)
  • Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
  • Shiang R, Thompson LM, Zhu YZ: Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. (medigraphic.com)
  • Results: In BEAS-2B and hAELVi, hypoxia significantly dowregulated genes related to fibrosis, mitochondrial stress, oxidative stress, apoptosis and inflammation whereas VEGF receptor 2 increased. (lu.se)
  • Las mutaciones en el gen para el receptor 3 de factores de crecimiento de fibroblastos se han asociado con la ACONDROPLASIA, la DISPLASIA TANATOFÓRICA y la TRANSFORMACIÓN DE LAS CÉLULAS NEOPLÁSICAS. (bvsalud.org)
  • A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. (bvsalud.org)
  • Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene. (cdc.gov)
  • Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)
  • Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. (nih.gov)
  • This indicates that glucocorticoids also affect the cellular growth by mechanisms which do not involve EGF receptors. (medicaljournals.se)
  • Five distinct genes encode closely related FGF receptors, FGF R1 through 5. (rndsystems.com)
  • Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. (prospecbio.com)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
  • The researchers found that levels of molecules called fibroblast growth factors (FGFs), and two of the receptors that bind to them, were significantly lower among people who had been diagnosed with severe clinical depression and had died in a depressed state. (biopsychiatry.com)
  • Presents autosomal dominant inheritance assigned to mutations in the fibroblast growth factor receptors gene. (bvsalud.org)
  • In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
  • Background: bFGF, a member of the fibroblast growth factor family, potently induces vascular smooth muscle cell proliferation and decreased synthesis of the collagens. (dsmc.or.kr)
  • These mutations cause decreased endochondral ossification, decreased cellular hypertrophy, decreased cartilage matrix production, and inhibited proliferation of chondrocytes in growth plate cartilage. (medscape.com)
  • Profibrotic growth factors and cytokines contribute directly to fibroblast proliferation and collagen production. (cdc.gov)
  • Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. (thermofisher.com)
  • Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. (thermofisher.com)
  • Apert syndrome is a birth abnormality caused by a mutation of the FGFR2 gene. (medicalnewstoday.com)
  • When this gene mutation occurs, FGFR2 continues to signal for longer than usual, leading to early fusion of the skull, facial, feet, and hand bones. (medicalnewstoday.com)
  • Using a transgenic mouse model in which an ALS-like mutation was introduced in the mouse Fus gene, we could show that ALS pathology starts at the neuromuscular juction (the transition between motor nerves and skeletal muscle cells), long before motor neuron cell bodies in the spinal cord degenerate. (europa.eu)
  • XLH is considered to be a systemic disorder, from mutation of the phosphate-regulating gene homologous to endopeptidases on the X chromosome (PHEX). (medscape.com)
  • Mutations in the FGFR2 gene cause Apert syndrome. (childrens.com)
  • A gene-based high-resolution comparative radiation hybrid map as a framework for genome sequence assembly of a bovine chromosome 6 region associated with QTL for growth, body composition, and milk performance traits. (fbn-dummerstorf.de)
  • Assignment of the fibroblast growth factor 10 (FGF10) gene to bovine chromosome 20q16→q17 by fluorescence in situ hybridization and somatic cell panel analysis. (fbn-dummerstorf.de)
  • High-resolution comparative mapping between human chromosomes 4 and 8 and bovine chromosome 27 provides genes and segments serving as positional candidates for udder health in cattle. (fbn-dummerstorf.de)
  • Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. (prospecbio.com)
  • FGFs are a family of molecules that stimulate cell growth in many areas of the body, and are involved in the growth of multiple tissues and in growth that takes place at various stages of life. (biopsychiatry.com)
  • Gene sequencing revealed that this group was in fact the same FGF2 protein and that it was a member of a family of FGF proteins. (wikidoc.org)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • mRNA expression of genes and proteins related to disease pathology were. (lu.se)
  • Interleukin secretion, proteoglycan and procollagen alpha(1)(I) gene expression in Crouzon fibroblasts treated with basic fibroblast growth factor « Dott. (carinci.org)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • Database searches and analysis of available genomic DNA sequence from the region revealed the presence of the fibroblast growth factor homologous factor gene, FHF2, within the duplication breakpoint interval. (edu.au)
  • The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. (nih.gov)
  • Results: The steady state levels of type I and VII collagen gene mRNA were decreased with age dependent pattern up to 0.13 and 0.44 folds respectively. (dsmc.or.kr)
  • Messenger RNA levels are a measure of how active different genes are, and the researchers took care only to study brains that had no complicating factors that would have changed their mRNA levels at death. (biopsychiatry.com)
  • 2,3 An additional exciting milestone was even more recently achieved when two independent research teams discovered GAA repeat expansions in an intron of the FGF14 gene, encoding Fibroblast Growth Factor 14, as a cause of another LOCA subtype (SCA27B) with a seemingly broader phenotypic spectrum. (movementdisorders.org)
  • Currently, the intronic repeat expansions in RFC1 and FGF14 are not detectable with standard gene panels or exome sequencing, thus requiring specific testing. (movementdisorders.org)
  • One important injury-activated pathway involves the release of pericellular fibroblast growth factor 2 (FGF-2) from the articular cartilage. (ox.ac.uk)
  • Cucchiarini, M., Madry, H. Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair. (uniklinikum-saarland.de)
  • Method: We examined that recombinant human bFGF affects the expression of genes involved in ECM synthesis and remodeling in human dermal fibroblasts cultures as judged by Northern blot analysis. (dsmc.or.kr)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
  • Somatropin (recombinant human growth hormone [HGH]) therapy should be administered to foster linear growth. (medscape.com)
  • We cultivated human lung epithelial A549 cells (ATCC CCL-185), human hepatoma Huh7 cells ( 13 ), human cervix carcinoma HeLa cells (ATCC CCL-2), African green monkey kidney Vero cells (ATCC CCL-81), and transformed human dermal fibroblast cultures ( 14 ) in Dulbecco modified eagle medium supplemented with 10% fetal calf serum at 37°C and 5% CO 2 . (cdc.gov)
  • Many of these genes, including those for activin A (Inhba), tumor necrosis factor-stimulated gene 6 (Tnfaip6), matrix metalloproteinase 19 (Mmp19), tissue inhibitor of metalloproteinases 1 (Timp1), and podoplanin (Pdpn), were significantly FGF-2 dependent following injury to cartilage in vitro and to joint tissues in vivo. (ox.ac.uk)
  • PHEX stimulates fibroblast growth factor-23 (FGF-23), expressed in bone. (medscape.com)
  • Reverse transcription-polymerase chain reaction was performed to examine a number of inflammatory response genes that had previously been identified in a microarray analysis. (ox.ac.uk)
  • Increased reactive oxygen species activate various cytokine/growth factor signaling cascades resulting in increased expression of inflammatory and fibrotic genes. (cdc.gov)
  • Apert syndrome is a genetic disorder that causes abnormal head and face growth, as well as fused fingers and toes. (childrens.com)
  • This means the parents are of average height and do not have the abnormal gene. (childrenshospital.org)
  • A keloid is an abnormal growth of scar tissue that forms at the site of an injury or incision. (proprofs.com)
  • Apert syndrome can be inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is all that is needed to cause the disorder. (childrens.com)
  • However, new mutations in the gene usually cause most cases of Apert syndrome, and happen in babies with no family history of the disorder. (childrens.com)
  • We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)
  • Fibroblast growth factor 10: A potential candidate gene for bovine developmental defect Tetradysmelia? (fbn-dummerstorf.de)
  • The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. (wikipedia.org)
  • the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikidoc.org)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • The main research aim is to examine a variety of antagonists to identify those with possible therapeutic inhibitory effects on mesothelioma growth and determine the mechanisms underlying the contribution to tumour growth. (edu.au)
  • This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. (nih.gov)
  • The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
  • Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo. (ox.ac.uk)
  • Using a novel model of murine cartilage injury and surgically destabilized joints in mice, we examined the extent to which FGF-2 contributes to the cellular gene response to injury. (ox.ac.uk)
  • Almost all genes identified in murine joints following surgical destabilization were also regulated in cartilage explants upon injury. (ox.ac.uk)
  • CONCLUSION: FGF-2-dependent gene expression occurs in vitro and in vivo in response to cartilage/joint injury in mice. (ox.ac.uk)
  • Genes (Basel), 2023 Jan 18. (nih.gov)
  • Researchers from the Tissue Repair Group, within the Institute for Respiratory Health, are investigating whether the Hedgehog (Hh) pathway is important in the growth of mesothelioma. (edu.au)
  • Hexanucleotide repeat expansions in a gene called C9orf72 are the most prevalent cause of familial ALS. (europa.eu)
  • 1 However, in 2019, a new milestone in the field was reached when biallelic repeat expansions (mainly involving AAGGG repeats) were found in an intron of the RFC1 gene, encoding Replication Factor C subunit. (movementdisorders.org)
  • Prior to the identification of these two genes with previously unrecognized intronic repeat expansions, many were skeptical that there remained prevalent genetic causes of LOCA to be discovered. (movementdisorders.org)
  • The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis. (fbn-dummerstorf.de)
  • The FHF2 gene localisation and tissue-specific expression pattern suggest it to be a candidate gene for familial cases of the BFLS syndrome and other syndromal and non-specific forms of X-linked mental retardation mapping to the region. (edu.au)
  • The study relied on microarray analysis of 32 post-mortem brain samples - the microarray method can simultaneously measure the level of activity of tens of thousands of genes that are functional in a given tissue. (biopsychiatry.com)
  • Here, we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological functions and the current research progress of DsbA-L in metabolic diseases, and found that DsbA-L may be a promising target for metabolic diseases. (bvsalud.org)
  • FGF18 is a member of the fibroblast growth factor (FGF) family. (thermofisher.com)
  • It is unclear how mutations in the FGF8 gene lead to these other signs and symptoms. (medlineplus.gov)
  • These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (nih.gov)
  • FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC. (cdc.gov)
  • A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. (wikipedia.org)
  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
  • Patients with the FIP1L1/PDGFRA -associated fusion gene are more often males and may be responsive to low-dose imatinib (a tyrosine kinase inhibitor). (msdmanuals.com)
  • The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
  • A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)
  • Understanding gene polymorphisms will help us move toward personalized medicine and determine which patients will actually benefit from therapies for HNSCCs. (researchsquare.com)
  • However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
  • A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae. (fbn-dummerstorf.de)
  • Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
  • We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis. (cdc.gov)
  • Together with Emeritus Professor Geoff Laurent (UWA), Professor Darryl Knight (The University of Newcastle) and Professor Robin McAnulty (University College London), they successfully obtained National Health and Medical Research Council (NHMRC) funding to investigate cross talk between epithelial cells and fibroblasts and the role this plays in the progression and development of fibrosis. (edu.au)