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  • proteins
  • Previously, we showed that several genes essential for seed development, including those encoding storage proteins, fatty acid biosynthesis enzymes, and transcriptional regulators (e.g. (pnas.org)
  • In a nested case-control study of 839 prevalent breast cancer cases and 1040 controls (frequency matched to cases on year of birth in 5-year strata), we evaluated 19 SNPs in eight genes coding for base excision repair (BER), BRCA1 interacting proteins and growth regulatory pathways for associations with breast cancer risk. (aacrjournals.org)
  • For BRCA1 interacting proteins and BER genes, the p-values for trend were 0.008 and 0.09, respectively. (aacrjournals.org)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins. (wikipedia.org)
  • Notably, alternative splicing allows the human genome to direct the synthesis of many more proteins than would be expected from its 20,000 protein-coding genes. (wikipedia.org)
  • citation needed] Pole plasm is organized by and contains the proteins and mRNA of the posterior group genes (such as oskar, nanos gene, Tudor, vasa, and Valois). (wikipedia.org)
  • mutations
  • These studies are very important because the assisted reproduction techniques (mainly intracytoplasmic sperm injection) bypass the natural selection process and some classical chromosomal abnormalities, microdeletions of AZF genes or some deleterious genic mutations could pass through generations. (scielo.br)
  • Mutations in this gene have been associated with multifocal stenosing ulceration of the small intestine. (wikipedia.org)
  • 2002
  • Chugh A, Khurana P (2002) Gene expression during somatic embryogenesis-recent advances. (springer.com)
  • Genes referred to as early or primary auxin response genes can undergo transcriptional alterations within minutes of exposure to auxin, and fall into three major classes- Aux/IAA s, SAURs , and GH3 s ( Hagen and Guilfoyle, 2002 ). (frontiersin.org)
  • platelet-derive
  • Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNa), Interferon gamma (IFNg), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF) or Interleukin 6 (IL-6) Type I interferons (IFN-a, IFN-b) bind to receptors, cause signaling via kinases, phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. (wikipedia.org)
  • receptor
  • Díez JJ, Hernanz A, Medina S, Bayón C, Iglesias P. Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function. (springer.com)
  • The current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor (VEGF) gene (rs2010963) and its receptor, kinase insert domain-containing receptor (KDR) gene polymorphism (rs2071559), and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). (hindawi.com)
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (wikipedia.org)
  • All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. (wikipedia.org)
  • After binding to its receptor, type I IFNs activate multiple cellular factors that transduce the signal from the cell surface into the nucleus. (wikipedia.org)
  • The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene. (wikipedia.org)
  • Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR. (wikipedia.org)
  • EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. (wikipedia.org)
  • Epidermal growth factor has been shown to interact with epidermal growth factor receptor. (wikipedia.org)
  • In this study, bFGF was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. (wikipedia.org)
  • mRNA
  • Upstream of the coding sequence is the promoter region that contains sequences that regulate the transcription of the IFNA2 gene into a messenger RNA (mRNA). (wikipedia.org)
  • In this process, particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene. (wikipedia.org)
  • These genes play a role in germ line development to localize nanos mRNA to the posterior and localize germ cell determinants. (wikipedia.org)
  • polymorphisms
  • Impact of TNF-α and LTα gene polymorphisms on genetic susceptibility in Indian SLE patients. (springer.com)
  • Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. (springer.com)
  • 1 studied polymorphisms in the tumour necrosis factor (TNF) and lymphotoxin A genes with respect to their effect on lung function of smokers, and failed to find any association with chronic obstructive pulmonary disease (COPD) phenotypes. (ersjournals.com)
  • As part of a European Union collaborative project, we have studied polymorphisms within the TNF gene in a large collection of well-characterised Caucasian COPD patients (n = 1,018) and control subjects (n = 911). (ersjournals.com)
  • The fact that we see no association with any of the tumour necrosis factor single nucleotide polymorphisms or haplotypes makes it highly unlikely that polymorphisms in this gene play a major role in the susceptibility to chronic obstructive pulmonary disease. (ersjournals.com)
  • Several environmental and genetic factors (i.e., hypoxia, hyperglycemia, oxidative stress, ischemia, and gene polymorphisms of VEGF) influence plasma VEGF levels [ 12 - 16 ]. (hindawi.com)
  • Among several polymorphisms of the VEGF gene, the rs2010963 (−634C/G polymorphism of the VEGF gene) and few others were reported to affect serum VEGF levels [ 13 - 15 ]. (hindawi.com)
  • Single nucleotide polymorphisms (SNPs) in genes coding for highly conserved cellular pathways may cause subtle functional deficiencies (or proficiencies) in those pathways that could increase (or decrease) susceptibility to breast cancer. (aacrjournals.org)
  • encodes
  • It encodes a protein known as CGRP (calcitonin gene related peptide). (wikipedia.org)
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. (wikipedia.org)
  • This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. (wikipedia.org)
  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. (wikipedia.org)
  • glycoprotein
  • Vascular permeability factor (VPF), also known as vascular endothelial growth factor, is a homodimeric glycoprotein that acts on vascular endothelium as a potent permeability-inducing agent and mitogen. (aacrjournals.org)
  • The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. (wikipedia.org)
  • protein
  • Here we explore a novel approach to neurotrophic factor-based therapy by engineering zinc finger protein transcription factors (ZFP TFs) that activate the expression of the endogenous glial cell line-derived neurotrophic factor (GDNF) gene. (jneurosci.org)
  • Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the STAT protein family. (wikipedia.org)
  • In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. (wikipedia.org)
  • Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. (wikipedia.org)
  • Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. (wikipedia.org)
  • Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. (wikipedia.org)
  • Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. (wikipedia.org)
  • The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation. (wikipedia.org)
  • Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene. (wikipedia.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1, RPL6 and ribosomal protein S19. (wikipedia.org)
  • Continuing his research at the institute, Deo and his colleagues, discovered an Enhancing Factor (EF), a 14 kDa protein, isolated from the small intestine of mice. (wikipedia.org)
  • Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. (wikipedia.org)
  • Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene. (wikipedia.org)
  • variants
  • Two transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
  • Abnormal splicing variants are also thought to contribute to the development of cancer, and splicing factor genes are frequently mutated in different types of cancer. (wikipedia.org)
  • The "record-holder" for alternative splicing is a D. melanogaster gene called Dscam, which could potentially have 38,016 splice variants. (wikipedia.org)
  • tumor
  • The stimulatory effect of oncogenic Ras on the induction of PlGF expression in hypoxic cells suggests that PlGF could be an important proangiogenic factor in the tumor microenvironment. (aacrjournals.org)
  • Fragoso JM, Vargas-Alarcón G, Jiménez-Morales S, Reyes-Hernández OD, Ramírez-Bello J. Tumor necrosis factor alpha (TNF-α) in autoimmune diseases (AIDs): molecular biology and genetics. (springer.com)
  • Tumor necrosis factor. (springer.com)
  • It is a tumor suppressor gene. (wikipedia.org)
  • subunit
  • In fact, the RUNX family is often referred to as α-subunits, together with binding of a common β-subunit CBFβ, RUNX can behave as heterodimeric transcription factors collectively called the core binding factors (CBFs). (wikipedia.org)
  • isoforms
  • There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
  • vascular
  • Placenta growth factor (PlGF) is a mitogen for endothelial cells that can potentiate the growth and permeabilizing effects on endothelium of vascular endothelial growth factor. (aacrjournals.org)
  • Marino and coworkers have recently reported that both circulating and intraplaque polymorphonuclear neutrophil leukocytes from subjects with carotid atherosclerosis are active producers of different inflammatory mediators including the vascular endothelial growth factor (VEGF) [ 11 ]. (hindawi.com)
  • Genetic
  • Hirankarn N, Avihingsanon Y, Wongpiyabovorn J. Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism -863, but not -308 and -238, in Thai population. (springer.com)
  • These analyses suggest a genetic complexity that may be under estimated when SNPs in single genes are analyzed or when pathway coverage is incomplete. (aacrjournals.org)
  • Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. (wikipedia.org)
  • Genetic factors and smoking also play a role. (wikipedia.org)
  • interaction
  • While previous studies have identified members of this family, a recent spurt in gene expression data coupled with genome update and reannotation calls for a reassessment of the prevalence of ARF genes and their interaction networks in M. truncatula . (frontiersin.org)
  • functional
  • Comparison of transcription factor genes of C. elegans and Caenorhabditis briggsae was therefore carried out and revealed very few examples of functional gene duplication since the divergence of these species for most, but not all, transcription factor gene families. (harvard.edu)
  • In summary, this study not just shines new light on an important gene family, but also provides a guideline for identification of new members of gene families and their functional characterization through network analyses. (frontiersin.org)
  • Oskar is sufficient to recruit the other genes to form functional germ plasm. (wikipedia.org)
  • GDNF
  • We assessed the effectiveness of glial cell line-derived neurotrophic factor (GDNF) gene therapy to restore TIDA neuron function in senile female rats and reverse their chronic hyperprolactinemia. (biomedsearch.com)
  • GDNF is a potent neurotrophic factor, and small changes in its expression levels can have profound effects on neuronal survival. (jneurosci.org)
  • transcripts
  • Examples of alternative splicing in immunoglobin gene transcripts in mammals were also observed in the early 1980s. (wikipedia.org)
  • histone
  • Seed DMVs are enriched in transcription factor (TF) genes and are decorated with histone marks that fluctuate developmentally, resembling their animal counterparts in significant ways. (pnas.org)
  • Mice knockout for the histone acetyltransferase p300/CBP-associated factor (PCAF) develop a resistan. (biomedsearch.com)
  • somatic
  • Braybrook SA, Stone SL, Park S, Bui AQ, Le BH, Fischer RL, Goldberg RB, Harada JJ (2006) Genes directly regulated by LEAFY COTYLEDON2 provide insight into the control of embryo maturation and somatic embryogenesis. (springer.com)
  • The objective of the present study was to determine the frequency of somatic chromosomal anomalies and Y chromosomal microdeletions (azoospermia factor genes, AZF) in infertile males who seek assisted reproduction. (scielo.br)
  • important roles
  • We conclude that many genes playing important roles in seed formation are regulated without detectable DNA methylation events and suggest that selective action of TFs, as well as chromatin epigenetic events, play important roles in making a seed. (pnas.org)
  • The genes Oskar, nanos and germ cell-less (gcl) have important roles. (wikipedia.org)
  • regulators
  • BABY BOOM ( BBM ), transcription factors of the AP2/ERF family are key regulators of plant cell totipotency. (springer.com)
  • Ectopic expression of the BBM gene, originally identified in Brassica napus , has diverse functions in plant cell proliferation, growth and development without exogenous growth regulators. (springer.com)
  • The production of miRNA is regulated by certain transcription factors (TFs) that are also key regulators in gene expression. (hindawi.com)
  • This +23 RUNX1 enhancer contains conserved motifs that encourage binding of various haematopoiesis related regulators such as Gata2, ETS factors (Fli-1, Elf-1, PU.1) and the SCL / Lmo2 / Ldb1 complex, as well as RUNX1 itself acting in an auto-regulatory loop. (wikipedia.org)
  • human
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (aacrjournals.org)
  • The present study demonstrates for the first time the constitutive gene expression of VPF in normal and neoplastic human ovaries. (aacrjournals.org)
  • Human CBFB genome location and CBFB gene details page in the UCSC Genome Browser. (wikipedia.org)
  • regulatory
  • Hypothesizing that the Amazonian water system differences would affect the expression of muscle growth-related genes in juvenile tambaqui Colossoma macropomum (Cuvier 1818), this study aimed to analyze the morphometric data and expression of myogenic regulatory factors (MRFs) in the white and red muscle from tambaqui obtained from clear and black Amazonian water systems. (hindawi.com)
  • No such relation was found for the growth regulatory factors (p-trend = 0.94). (aacrjournals.org)
  • They are known to join together with transcription factors and downstream gene, forming a complex and highly interconnected regulatory network. (hindawi.com)
  • To recognize a few overrepresented motifs which are expected to perform important elementary regulatory functions, we constructed a computational model of miRNA-mediated feedforward loops (FFLs) in which a transcription factor (TF) regulates miRNA and targets gene. (hindawi.com)
  • Experimental data have demonstrated that gene regulatory networks are often constituted of some basic subcircuits involving feedforward or feedback loops [ 18 ], which are often called motif [ 19 ]. (hindawi.com)
  • These studies focused on FFLs at the transcriptional level, in which gene expression is controlled by two regulatory TFs. (hindawi.com)
  • This recognition induces the activation of specific serine kinases, enzymes which activate by phosphorylation the IFN regulatory factors (IRF), IRF3 and IRF7. (wikipedia.org)
  • At a molecular level, expression of the gene RUNX1 is upregulated by the RUNX1 intronic cis-regulatory element (+23 RUNX1 enhancer). (wikipedia.org)
  • vitro
  • Bandupriya HDD, Gibbings JG, Dunwell JM (2014) Overexpression of coconut AINTEGUMENTA - like gene, CnANT , promotes in vitro regeneration in transgenic Arabidopsis . (springer.com)
  • hypoxia
  • To investigate the transcriptional component of hypoxia-inducible PlGF expression, we cloned and sequenced a 1350-bp fragment of the 5′-flanking region of the mouse gene. (aacrjournals.org)
  • In the present study, we show that the induction of PlGF expression by hypoxia is dependent on the presence of the metal response element-binding transcription factor 1 (MTF-1). (aacrjournals.org)
  • Together, these findings demonstrate that the PlGF gene is responsive to hypoxia and that this response is mediated by MTF-1. (aacrjournals.org)
  • Serum
  • Stress hormones in mice such as serum corticotropin releasing factor, adrenal corticotropin releasing hormone, and corticosterone were reduced after psoralidin administration. (wikipedia.org)
  • proteins
  • Previously, we showed that several genes essential for seed development, including those encoding storage proteins, fatty acid biosynthesis enzymes, and transcriptional regulators (e.g. (pnas.org)
  • In a nested case-control study of 839 prevalent breast cancer cases and 1040 controls (frequency matched to cases on year of birth in 5-year strata), we evaluated 19 SNPs in eight genes coding for base excision repair (BER), BRCA1 interacting proteins and growth regulatory pathways for associations with breast cancer risk. (aacrjournals.org)
  • For BRCA1 interacting proteins and BER genes, the p-values for trend were 0.008 and 0.09, respectively. (aacrjournals.org)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins. (wikipedia.org)
  • Notably, alternative splicing allows the human genome to direct the synthesis of many more proteins than would be expected from its 20,000 protein-coding genes. (wikipedia.org)
  • citation needed] Pole plasm is organized by and contains the proteins and mRNA of the posterior group genes (such as oskar, nanos gene, Tudor, vasa, and Valois). (wikipedia.org)
  • mutations
  • These studies are very important because the assisted reproduction techniques (mainly intracytoplasmic sperm injection) bypass the natural selection process and some classical chromosomal abnormalities, microdeletions of AZF genes or some deleterious genic mutations could pass through generations. (scielo.br)
  • Mutations in this gene have been associated with multifocal stenosing ulceration of the small intestine. (wikipedia.org)
  • 2002
  • Chugh A, Khurana P (2002) Gene expression during somatic embryogenesis-recent advances. (springer.com)
  • Genes referred to as early or primary auxin response genes can undergo transcriptional alterations within minutes of exposure to auxin, and fall into three major classes- Aux/IAA s, SAURs , and GH3 s ( Hagen and Guilfoyle, 2002 ). (frontiersin.org)
  • platelet-derive
  • Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNa), Interferon gamma (IFNg), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF) or Interleukin 6 (IL-6) Type I interferons (IFN-a, IFN-b) bind to receptors, cause signaling via kinases, phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. (wikipedia.org)
  • receptor
  • Díez JJ, Hernanz A, Medina S, Bayón C, Iglesias P. Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function. (springer.com)
  • The current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor (VEGF) gene (rs2010963) and its receptor, kinase insert domain-containing receptor (KDR) gene polymorphism (rs2071559), and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). (hindawi.com)
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (wikipedia.org)
  • All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. (wikipedia.org)
  • After binding to its receptor, type I IFNs activate multiple cellular factors that transduce the signal from the cell surface into the nucleus. (wikipedia.org)
  • The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene. (wikipedia.org)
  • Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR. (wikipedia.org)
  • EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. (wikipedia.org)
  • Epidermal growth factor has been shown to interact with epidermal growth factor receptor. (wikipedia.org)
  • In this study, bFGF was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. (wikipedia.org)
  • mRNA
  • Upstream of the coding sequence is the promoter region that contains sequences that regulate the transcription of the IFNA2 gene into a messenger RNA (mRNA). (wikipedia.org)
  • In this process, particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene. (wikipedia.org)
  • These genes play a role in germ line development to localize nanos mRNA to the posterior and localize germ cell determinants. (wikipedia.org)
  • polymorphisms
  • Impact of TNF-α and LTα gene polymorphisms on genetic susceptibility in Indian SLE patients. (springer.com)
  • Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. (springer.com)
  • 1 studied polymorphisms in the tumour necrosis factor (TNF) and lymphotoxin A genes with respect to their effect on lung function of smokers, and failed to find any association with chronic obstructive pulmonary disease (COPD) phenotypes. (ersjournals.com)
  • As part of a European Union collaborative project, we have studied polymorphisms within the TNF gene in a large collection of well-characterised Caucasian COPD patients (n = 1,018) and control subjects (n = 911). (ersjournals.com)
  • The fact that we see no association with any of the tumour necrosis factor single nucleotide polymorphisms or haplotypes makes it highly unlikely that polymorphisms in this gene play a major role in the susceptibility to chronic obstructive pulmonary disease. (ersjournals.com)
  • Several environmental and genetic factors (i.e., hypoxia, hyperglycemia, oxidative stress, ischemia, and gene polymorphisms of VEGF) influence plasma VEGF levels [ 12 - 16 ]. (hindawi.com)
  • Among several polymorphisms of the VEGF gene, the rs2010963 (−634C/G polymorphism of the VEGF gene) and few others were reported to affect serum VEGF levels [ 13 - 15 ]. (hindawi.com)
  • Single nucleotide polymorphisms (SNPs) in genes coding for highly conserved cellular pathways may cause subtle functional deficiencies (or proficiencies) in those pathways that could increase (or decrease) susceptibility to breast cancer. (aacrjournals.org)
  • encodes
  • It encodes a protein known as CGRP (calcitonin gene related peptide). (wikipedia.org)
  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. (wikipedia.org)
  • This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. (wikipedia.org)
  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. (wikipedia.org)
  • glycoprotein
  • Vascular permeability factor (VPF), also known as vascular endothelial growth factor, is a homodimeric glycoprotein that acts on vascular endothelium as a potent permeability-inducing agent and mitogen. (aacrjournals.org)
  • The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. (wikipedia.org)
  • protein
  • Here we explore a novel approach to neurotrophic factor-based therapy by engineering zinc finger protein transcription factors (ZFP TFs) that activate the expression of the endogenous glial cell line-derived neurotrophic factor (GDNF) gene. (jneurosci.org)
  • Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the STAT protein family. (wikipedia.org)
  • In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. (wikipedia.org)
  • Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. (wikipedia.org)
  • Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. (wikipedia.org)
  • Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. (wikipedia.org)
  • Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. (wikipedia.org)
  • The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation. (wikipedia.org)
  • Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene. (wikipedia.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1, RPL6 and ribosomal protein S19. (wikipedia.org)
  • Continuing his research at the institute, Deo and his colleagues, discovered an Enhancing Factor (EF), a 14 kDa protein, isolated from the small intestine of mice. (wikipedia.org)
  • Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. (wikipedia.org)
  • Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene. (wikipedia.org)
  • variants
  • Two transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
  • Abnormal splicing variants are also thought to contribute to the development of cancer, and splicing factor genes are frequently mutated in different types of cancer. (wikipedia.org)
  • The "record-holder" for alternative splicing is a D. melanogaster gene called Dscam, which could potentially have 38,016 splice variants. (wikipedia.org)
  • tumor
  • The stimulatory effect of oncogenic Ras on the induction of PlGF expression in hypoxic cells suggests that PlGF could be an important proangiogenic factor in the tumor microenvironment. (aacrjournals.org)
  • Fragoso JM, Vargas-Alarcón G, Jiménez-Morales S, Reyes-Hernández OD, Ramírez-Bello J. Tumor necrosis factor alpha (TNF-α) in autoimmune diseases (AIDs): molecular biology and genetics. (springer.com)
  • Tumor necrosis factor. (springer.com)
  • It is a tumor suppressor gene. (wikipedia.org)
  • subunit
  • In fact, the RUNX family is often referred to as α-subunits, together with binding of a common β-subunit CBFβ, RUNX can behave as heterodimeric transcription factors collectively called the core binding factors (CBFs). (wikipedia.org)
  • isoforms
  • There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
  • vascular
  • Placenta growth factor (PlGF) is a mitogen for endothelial cells that can potentiate the growth and permeabilizing effects on endothelium of vascular endothelial growth factor. (aacrjournals.org)
  • Marino and coworkers have recently reported that both circulating and intraplaque polymorphonuclear neutrophil leukocytes from subjects with carotid atherosclerosis are active producers of different inflammatory mediators including the vascular endothelial growth factor (VEGF) [ 11 ]. (hindawi.com)
  • Genetic
  • Hirankarn N, Avihingsanon Y, Wongpiyabovorn J. Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism -863, but not -308 and -238, in Thai population. (springer.com)
  • These analyses suggest a genetic complexity that may be under estimated when SNPs in single genes are analyzed or when pathway coverage is incomplete. (aacrjournals.org)
  • Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. (wikipedia.org)
  • Genetic factors and smoking also play a role. (wikipedia.org)
  • interaction
  • While previous studies have identified members of this family, a recent spurt in gene expression data coupled with genome update and reannotation calls for a reassessment of the prevalence of ARF genes and their interaction networks in M. truncatula . (frontiersin.org)
  • functional
  • Comparison of transcription factor genes of C. elegans and Caenorhabditis briggsae was therefore carried out and revealed very few examples of functional gene duplication since the divergence of these species for most, but not all, transcription factor gene families. (harvard.edu)
  • In summary, this study not just shines new light on an important gene family, but also provides a guideline for identification of new members of gene families and their functional characterization through network analyses. (frontiersin.org)
  • Oskar is sufficient to recruit the other genes to form functional germ plasm. (wikipedia.org)
  • GDNF
  • We assessed the effectiveness of glial cell line-derived neurotrophic factor (GDNF) gene therapy to restore TIDA neuron function in senile female rats and reverse their chronic hyperprolactinemia. (biomedsearch.com)
  • GDNF is a potent neurotrophic factor, and small changes in its expression levels can have profound effects on neuronal survival. (jneurosci.org)
  • transcripts
  • Examples of alternative splicing in immunoglobin gene transcripts in mammals were also observed in the early 1980s. (wikipedia.org)
  • histone
  • Seed DMVs are enriched in transcription factor (TF) genes and are decorated with histone marks that fluctuate developmentally, resembling their animal counterparts in significant ways. (pnas.org)
  • Mice knockout for the histone acetyltransferase p300/CBP-associated factor (PCAF) develop a resistan. (biomedsearch.com)
  • somatic
  • Braybrook SA, Stone SL, Park S, Bui AQ, Le BH, Fischer RL, Goldberg RB, Harada JJ (2006) Genes directly regulated by LEAFY COTYLEDON2 provide insight into the control of embryo maturation and somatic embryogenesis. (springer.com)
  • The objective of the present study was to determine the frequency of somatic chromosomal anomalies and Y chromosomal microdeletions (azoospermia factor genes, AZF) in infertile males who seek assisted reproduction. (scielo.br)
  • important roles
  • We conclude that many genes playing important roles in seed formation are regulated without detectable DNA methylation events and suggest that selective action of TFs, as well as chromatin epigenetic events, play important roles in making a seed. (pnas.org)
  • The genes Oskar, nanos and germ cell-less (gcl) have important roles. (wikipedia.org)
  • regulators
  • BABY BOOM ( BBM ), transcription factors of the AP2/ERF family are key regulators of plant cell totipotency. (springer.com)
  • Ectopic expression of the BBM gene, originally identified in Brassica napus , has diverse functions in plant cell proliferation, growth and development without exogenous growth regulators. (springer.com)
  • The production of miRNA is regulated by certain transcription factors (TFs) that are also key regulators in gene expression. (hindawi.com)
  • This +23 RUNX1 enhancer contains conserved motifs that encourage binding of various haematopoiesis related regulators such as Gata2, ETS factors (Fli-1, Elf-1, PU.1) and the SCL / Lmo2 / Ldb1 complex, as well as RUNX1 itself acting in an auto-regulatory loop. (wikipedia.org)
  • human
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (aacrjournals.org)
  • The present study demonstrates for the first time the constitutive gene expression of VPF in normal and neoplastic human ovaries. (aacrjournals.org)
  • Human CBFB genome location and CBFB gene details page in the UCSC Genome Browser. (wikipedia.org)
  • regulatory
  • Hypothesizing that the Amazonian water system differences would affect the expression of muscle growth-related genes in juvenile tambaqui Colossoma macropomum (Cuvier 1818), this study aimed to analyze the morphometric data and expression of myogenic regulatory factors (MRFs) in the white and red muscle from tambaqui obtained from clear and black Amazonian water systems. (hindawi.com)
  • No such relation was found for the growth regulatory factors (p-trend = 0.94). (aacrjournals.org)
  • They are known to join together with transcription factors and downstream gene, forming a complex and highly interconnected regulatory network. (hindawi.com)
  • To recognize a few overrepresented motifs which are expected to perform important elementary regulatory functions, we constructed a computational model of miRNA-mediated feedforward loops (FFLs) in which a transcription factor (TF) regulates miRNA and targets gene. (hindawi.com)
  • Experimental data have demonstrated that gene regulatory networks are often constituted of some basic subcircuits involving feedforward or feedback loops [ 18 ], which are often called motif [ 19 ]. (hindawi.com)
  • These studies focused on FFLs at the transcriptional level, in which gene expression is controlled by two regulatory TFs. (hindawi.com)
  • This recognition induces the activation of specific serine kinases, enzymes which activate by phosphorylation the IFN regulatory factors (IRF), IRF3 and IRF7. (wikipedia.org)
  • At a molecular level, expression of the gene RUNX1 is upregulated by the RUNX1 intronic cis-regulatory element (+23 RUNX1 enhancer). (wikipedia.org)
  • vitro
  • Bandupriya HDD, Gibbings JG, Dunwell JM (2014) Overexpression of coconut AINTEGUMENTA - like gene, CnANT , promotes in vitro regeneration in transgenic Arabidopsis . (springer.com)
  • hypoxia
  • To investigate the transcriptional component of hypoxia-inducible PlGF expression, we cloned and sequenced a 1350-bp fragment of the 5′-flanking region of the mouse gene. (aacrjournals.org)
  • In the present study, we show that the induction of PlGF expression by hypoxia is dependent on the presence of the metal response element-binding transcription factor 1 (MTF-1). (aacrjournals.org)
  • Together, these findings demonstrate that the PlGF gene is responsive to hypoxia and that this response is mediated by MTF-1. (aacrjournals.org)
  • Serum
  • Stress hormones in mice such as serum corticotropin releasing factor, adrenal corticotropin releasing hormone, and corticosterone were reduced after psoralidin administration. (wikipedia.org)