• proteins
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins. (wikipedia.org)
  • Notably, alternative splicing allows the human genome to direct the synthesis of many more proteins than would be expected from its 20,000 protein-coding genes. (wikipedia.org)
  • citation needed] Pole plasm is organized by and contains the proteins and mRNA of the posterior group genes (such as oskar, nanos gene, Tudor, vasa, and Valois). (wikipedia.org)
  • Expression
  • In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes). (wikipedia.org)
  • At a molecular level, expression of the gene RUNX1 is upregulated by the RUNX1 intronic cis-regulatory element (+23 RUNX1 enhancer). (wikipedia.org)
  • The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation. (wikipedia.org)
  • Transcriptome instability correlates significantly with reduced expression level of splicing factor genes. (wikipedia.org)
  • The germ plasm effectively turns off gene expression to render the genome of the cell inert. (wikipedia.org)
  • The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. (wikipedia.org)
  • mRNA
  • Upstream of the coding sequence is the promoter region that contains sequences that regulate the transcription of the IFNA2 gene into a messenger RNA (mRNA). (wikipedia.org)
  • In this process, particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene. (wikipedia.org)
  • These genes play a role in germ line development to localize nanos mRNA to the posterior and localize germ cell determinants. (wikipedia.org)
  • transcripts
  • Examples of alternative splicing in immunoglobin gene transcripts in mammals were also observed in the early 1980s. (wikipedia.org)
  • RUNX1
  • RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. (wikipedia.org)
  • Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia including M2 AML. (wikipedia.org)
  • RUNX1 can bind DNA as a monomer, but its DNA binding affinity is enhanced by 10 fold if it heterodimerises with the core binding factor β (CBFβ), also via the runt domain. (wikipedia.org)
  • This +23 RUNX1 enhancer contains conserved motifs that encourage binding of various haematopoiesis related regulators such as Gata2, ETS factors (Fli-1, Elf-1, PU.1) and the SCL / Lmo2 / Ldb1 complex, as well as RUNX1 itself acting in an auto-regulatory loop. (wikipedia.org)
  • isoforms
  • There are two possible trancripts (due to alternative splicing) that encode 2 isoforms of STAT1 STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. (wikipedia.org)
  • family
  • It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). (wikipedia.org)
  • As a transcription factor (TF), its DNA binding ability is encoded by the runt domain (residues 50 - 177), which is homologous to the p53 family. (wikipedia.org)
  • Family history: Smoking: Smoking tobacco increases the risk of AMD by two to three times that of someone who has never smoked, and may be the most important modifiable factor in its prevention. (wikipedia.org)
  • Besides EGF itself other family members include: Heparin-binding EGF-like growth factor (HB-EGF) transforming growth factor-α (TGF-α) Amphiregulin (AR) Epiregulin (EPR) Epigen Betacellulin (BTC) neuregulin-1 (NRG1) neuregulin-2 (NRG2) neuregulin-3 (NRG3) neuregulin-4 (NRG4). (wikipedia.org)
  • Basic fibroblast growth factor, also known as bFGF, FGF2 or FGF-β, is a member of the fibroblast growth factor family. (wikipedia.org)
  • phosphorylation
  • This recognition induces the activation of specific serine kinases, enzymes which activate by phosphorylation the IFN regulatory factors (IRF), IRF3 and IRF7. (wikipedia.org)
  • promoter
  • The gene can be transcribed from 2 alternative promoters, promoter 1 (distal) or promoter 2 (proximal). (wikipedia.org)
  • role
  • STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. (wikipedia.org)
  • mice
  • Stress hormones in mice such as serum corticotropin releasing factor, adrenal corticotropin releasing hormone, and corticosterone were reduced after psoralidin administration. (wikipedia.org)
  • This gene is presently in use for producing transgenic mice. (wikipedia.org)
  • growth
  • In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. (wikipedia.org)
  • the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikipedia.org)