ChromosomalPhosphatidicProteinsPhosphatidylinositolPLA2ProteinCharacterizationProteasesReceptorVirulence factorsEnzymesLysosomalHomologyStrainsMutationsPolymorphismsVenomGillsAdherenceCloningMechanismsMolecularActivityPathwayExpressionDrosophilaClassificationVivoClinicalRegulationMembraneSpeciesTargetFormationSignalImportantDisease
Chromosomal2
- Peruzzi D, Calabrese G, Faenza I, Manzoli L, Matteucci A, Gianfrancesco F, Billi AM, Stuppia L, Palka G, Cocco L: Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1). (smpdb.ca)
- The virulence of this bacterium results from the 32 Y pestis chromosomal genes and two Y pestis -specific plasmids, constituting the only new genetic material acquired since its evolution from its predecessor. (medscape.com)
Phosphatidic3
- Phosphatidic acid phospholipase A1 mediates ER-Golgi transit of a family of G protein-coupled receptors. (academictree.org)
- Phospholipase Dδ is Involved in WoundingInduced Phosphatidic Acid Formation in Arabidopsis[J]. Plant Diversity, 2015, 37(4): 428-438. (kib.ac.cn)
- LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2). (smpdb.ca)
Proteins2
- Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (wikigenes.org)
- Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)
Phosphatidylinositol2
- Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. (smpdb.ca)
- The Gαq/11 subunit activates phospholipase C (PLC) which cleaves the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into the secondary messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). (smpdb.ca)
PLA21
- Trimeresurus flavoviridis venom gland phospholipase A2 (PLA2) genes pgPLA 1a and pgPLA 2a encode Asp-49-PLA2 and genes pgPLA 1b and pgPLA 2b encode an isozyme of Asp-49-PLA2. (elsevierpure.com)
Protein8
- Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene. (wikipedia.org)
- In addition, heterozygote mutations in certain 'recessive' genes have been associated with late onset disease, possibly because of partial expression of the corresponding protein. (acnr.co.uk)
- He integrates several fields in his works, including Gene and Heat shock protein. (research.com)
- Glycoprotein Ib (platelet), beta polypeptide ( GP1BB ) also known as CD42c ( C luster of D ifferentiation 42c ), is a protein that in humans is encoded by the GP1BB gene. (wikidoc.org)
- Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein. (microbiologyresearch.org)
- Sequence analysis, expression, and deletion of a vaccinia virus gene encoding a homolog of profilin, a eukaryotic actin-binding protein. (microbiologyresearch.org)
- Our data show that the stable knockdown of HIPK2 led to wtp53 misfolding, as detected by p53 immunoprecipitation with conformation-specific antibodies, and that p53 protein misfolding impaired p53 DNA binding and transcription of target genes. (aacrjournals.org)
- TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
Characterization2
- Characterization of two dominant alleles of the major rhodopsin-encoding gene ninaE in Drosophila. (academictree.org)
- Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC: Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). (smpdb.ca)
Proteases2
- Phospholipases (e.g., phospholipase B) and proteases (e.g., he yeast Candida is the fourth most common cause of secreted aspartyl proteases [SAPs]) are two of the best- hospital-related bloodstream infections (1). (cdc.gov)
- Genes belonging to proteases, bacterial exporters and DNA stabilization were found to be under strong positive selection, thus facilitating pathogenicity and survival of the outliers. (frontiersin.org)
Receptor2
- Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% cholic acid. (jci.org)
- In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
Virulence factors3
- Our understanding of fungal virulence factors is limit- tory aspartic protease [SAP] and phospholipase). (cdc.gov)
- Many genes and characteristics were investigated for the staphylococcal species S. aureus and S. epidermidis , and the distribution of potential virulence factors among infectious isolates have been studied extensively. (biomedcentral.com)
- Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
Enzymes2
- Ivanušec A, Šribar J, Križaj I. Secreted Phospholipases A 2 - not just Enzymes: Revisited. (ijbs.com)
- Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
Lysosomal1
- The phospholipid bilayers are digested by lysosomal phospholipases, whereas clodronate is not digested and remains in the macrophage. (zhscience.com)
Homology1
- Dissociation of progeny vaccinia virus from the cell membrane is regulated by a viral envelope glycoprotein: effect of a point mutation in the lectin homology domain of the A34R gene. (microbiologyresearch.org)
Strains3
- AB then compared adhesion ability, biofilm production, and where E is the number of bands common to both strains, a secretion of SAP and phospholipase B of the outbreak iso- is the number of bands unique to strain A, and b is the lates and our clinical strains. (cdc.gov)
- While S. saprophyticus strains from animal sources have prerequisites for colonization of the urinary tract like the D-serine-deaminase, out findings suggested that they need to acquire new genes e.g. (biomedcentral.com)
- Virulence genotype analysis revealed that strain CR1 lacked hemolytic phospholipase C and D, three genes for LPS biosynthesis and had reduced antibiotic resistance genes when compared with clinical strains. (frontiersin.org)
Mutations4
- Although this depends on many factors, in this position paper we show three categories that stand out: gene mutations, food resources, and cognitive and behavioral stimulation. (ocl-journal.org)
- Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)
- About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. (aacrjournals.org)
- Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS. (bvsalud.org)
Polymorphisms2
- Polymorphisms of Trimeresurus flavoviridis venom gland phospholipase A2 isozyme genes. (elsevierpure.com)
- 5 Moreover some of these genes contain polymorphisms which act as risk factors for the development of PD. (acnr.co.uk)
Venom1
- Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A 2 (Lys49-PLA 2 ) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. (biomedcentral.com)
Gills2
- The other two elongation factors, SseEF1A3 and SseEF1A4 , represent novel genes that are mainly expressed in gills and skin. (biomedcentral.com)
- The expression of CRH-BP and CRH-R1 genes in the gills and in the skin is downregulated after both infection and restraint. (silverchair.com)
Adherence1
- We described a broad analysis of animal and human S. saprophyticus isolates regarding virulence genes and phenotypic properties such as lipase activity, hydrophobicity, and adherence. (biomedcentral.com)
Cloning2
- Traditional linkage analysis, gene cloning and Genome Wide Association Studies (GWAS) have identified several loci and genes associated with monogenic PD. (acnr.co.uk)
- Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (atlasgeneticsoncology.org)
Mechanisms1
- Alternative (or coexisting) mechanisms of coronary artery vasospasm include enhanced phospholipase C activity. (medscape.com)
Molecular1
- chemicals in last dynamic gene in molecular mode phrase lungs: a specific synapse for Cheyne-Stokes care. (siriuspixels.com)
Activity1
- Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
Pathway1
- Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. (biologists.com)
Expression6
- Although phospholipase B expression has cent of patients who have had Candida isolated from their been well studied in C. albicans (18), the relationship intravenous catheters have underlying fungemia (2), and between C. parapsilosis virulence and phospholipase phe- the case-fatality rate for catheter-related candidemia notype is unclear. (cdc.gov)
- Expression of one copy of wild type Gap1 under control of the sev enhancer/ promoter cassette ( sevGap1 ) rescues the complete loss-of-function eye phenotype, while creating no phenotypic defects when placed in a wild type background containing two copies of the endogenous Gap1 gene. (sdbonline.org)
- Phylogenetic and tissue expression analyses allowed for the identification of SseEF1A1 and SseEF1A2 as the Senegalese sole counterparts of mammalian eEF1A1 and eEF1A2 , respectively, and of Sse42Sp50 as the ortholog of Xenopus laevis and teleost 42Sp50 gene. (biomedcentral.com)
- The expression profile of the five genes was also studied during larval development, revealing different behaviours. (biomedcentral.com)
- The five genes exhibit different expression patterns in tissues and during larval development. (biomedcentral.com)
- Inactivating Gene Expression with Antisense Modified Oligonucleotides. (yale.edu)
Drosophila3
- In his work, he performs multidisciplinary research in Gene and Drosophila melanogaster. (research.com)
- The head involution defective gene of Drosophila melanogaster functions in programmed cell death. (research.com)
- Mutants in the gene encoding the InsP 3 R ( itpr ) in Drosophila exhibit a range of defects including altered wing posture, increased spontaneous firing, and loss of rhythmic flight patterns in response to an air puff stimulus. (jneurosci.org)
Classification1
- This classification is imperfect as it contains both confirmed and unconfirmed loci (loci not replicated) and the causative gene remains unknown for many loci. (acnr.co.uk)
Vivo1
- We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. (aacrjournals.org)
Clinical3
- In total, 236 clinical isolates and 15 animal isolates of S. saprophyticus were characterized in respect of the occurrence of 9 potential virulence genes and four surface properties. (biomedcentral.com)
- Nearly 90% of the clinical isolates were found to possess the gene for the surface-associated lipase Ssp and 10% for the collagen binding MSCRAMM SdrI. (biomedcentral.com)
- Here 236 clinical isolates of S. saprophyticus and 15 isolates of animal origin were characterized regarding the existence of these genes and surface properties. (biomedcentral.com)
Regulation1
- To study the possible regulation of SseEF1A gene expressions by thyroid hormones (THs), larvae were exposed to the goitrogen thiourea (TU). (biomedcentral.com)
Membrane1
- Three systems are known to maintain OM lipid asymmetry: the OM phospholipase A 2 PldA 7 , the lipopolysaccharide (LPS) palmitoyl transferase PagP 8 and the Mla (maintenance of outer membrane lipid asymmetry) system. (nature.com)
Species1
- Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. (wikidoc.org)
Target1
- Here, we show, by microarray analysis, that wtp53 lost the target gene activation following stable knockdown of HIPK2 (HIPK2i) in colon cancer cell line. (aacrjournals.org)
Formation1
- Adhesion (15) and biofilm formation (14) may assay was used to quantitate phospholipase. (cdc.gov)
Signal1
- In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene. (wikidoc.org)
Important2
- These apparently important new genes or properties for virulence have to be further analyzed. (biomedcentral.com)
- With regard to this, Senegalese sole ( Solea senegalensis ) is a commercially important flatfish in which eEF1A gene remains to be characterized. (biomedcentral.com)
Disease1
- For instance, they can be applied in various models of autoimmune disease, transplantation, neurological disorders and gene therapy. (zhscience.com)