• expression
  • Gene expression of 11 beta-hydroxysteroid dehydrogenase in the mesenteric arteries of genetically hypertensive rats. (ahajournals.org)
  • Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression. (ahajournals.org)
  • Epigenetics is the study of heritable alterations in phenotypes and gene expression that occur without changes in the DNA sequence. (ahajournals.org)
  • Epigenetic mechanisms are flexible genomic factors that not only can change genome function under exogenous influence, but also can provide a molecular substrate that allows for the stable propagation of gene expression states from one generation of cells to the next. (ahajournals.org)
  • 6 , 12 , 13 Methylation within gene promoters and CpG-dense sequences (CpG islands, usually unmethylated) has long been held to have the highest functional relevance to gene expression control ( Figure 1 ). (ahajournals.org)
  • At that time, Allfrey et al had already demonstrated that histone acetylation and methylation contributed to gene expression control. (ahajournals.org)
  • Here, we analyzed for the first time whether the 11β-HSD2 expression is modulated by microRNAs (miRNAs). (ahajournals.org)
  • The aim of this study was to characterize the phenotype of adipose tissue in WOKW rats with regard to adipocyte metabolism, insulin resistance, and gene expression and thus to define the phenotype more precisely. (wiley.com)
  • The severe insulin resistance predominantly in epididymal adipose tissue of WOKW rats is associated with a 10-fold decrease in adipocyte adiponectin gene expression, decreased Pparγ , but increased Foxo1 gene expression compared to DA rats. (wiley.com)
  • Insulin resistance in adipose tissue is associated with altered adipocyte gene expression in WOKW rats, additionally completing the picture of the metabolic syndrome in this animal model. (wiley.com)
  • Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below. (jax.org)
  • Multivariable adjusted linear regression models were used to examine the relationship of candidate gene expression with arsenic exposure or with birth weight of the baby. (biomedcentral.com)
  • It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. (wikipedia.org)
  • protein
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • Downstream of DHSRS7B on the negative strand of chromosome 17p11.2 is the gene Transmembrane protein 11 (TMEM11), and on the positive strand is the gene Mitogen-activated protein kinase, kinase 3 (MAP2K3). (wikipedia.org)
  • The DHRS7B gene has a predicted protein product that is 325 amino acids, a molecular weight of 35.1 kDa, and an isoelectric point of 9.867. (wikipedia.org)
  • The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. (genecards.org)
  • GJA3 (Gap Junction Protein Alpha 3) is a Protein Coding gene. (genecards.org)
  • GJB5 (Gap Junction Protein Beta 5) is a Protein Coding gene. (genecards.org)
  • GDH/6PGL endoplasmic bifunctional protein is a protein that in humans is encoded by the H6PD gene. (wikipedia.org)
  • The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. (wikipedia.org)
  • Cortisol
  • Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. (wikipedia.org)
  • 11β-HSD2), that converts cortisol to inactive cortisone. (wikipedia.org)
  • Mineralocorticoid
  • Activation of the mineralocorticoid receptor, upon the binding of its ligand aldosterone, results in its translocation to the cell nucleus, homodimerization and binding to hormone response elements present in the promoter of some genes. (wikipedia.org)
  • proteins
  • According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. (genecards.org)
  • The hormone receptor without ligand binding interacts with heat shock proteins and prevents the transcription of targeted genes. (wikipedia.org)
  • tissues
  • Microarray and EST data indicates that the DHRS7B gene is highly expressed in the testes, thyroid, kidneys, and adipose tissues. (wikipedia.org)
  • Prednisolone functions as an irreversible glucorticoid receptor agonist, binding to alpha glucorticoid receptors (AlphaGRs) and beta glucorticoid receptors (BetaGRs) within bodily tissues to reduce inflammation. (mentalhealthdaily.com)
  • transcription
  • MED19 was found to interact with DHRS7B through a two hybrid screening approach and plays a role as a co-activator in regulated transcription of most RNA polymerase II dependent genes. (wikipedia.org)
  • In addition to being an anti-inflammatory agent, prednisone is an effective immunosuppressant drug, exerting effects by modifying gene transcription, reducing activity within the lymphatic system (e.g. (mentalhealthdaily.com)
  • This results in the complex recruitment of the transcriptional machinery and the transcription into mRNA of the DNA sequence of the activated genes. (wikipedia.org)
  • activity
  • To gain insight into potentially relevant miRNAs in vivo, we investigated 2 models with differential 11β-HSD2 activity linked with salt-sensitive hypertension. (ahajournals.org)
  • GO annotations related to this gene include gap junction channel activity . (genecards.org)
  • autosomal
  • The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder. (wikipedia.org)