• Proteins
  • The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins. (biomedcentral.com)
  • We reconstructed a network formed by pairwise interactions between TBEV virion itself, viral RNA and viral proteins and 140 genes/proteins from TBEVHostDB. (biomedcentral.com)
  • Two genes/proteins ( CCR5 and IFNAR1 ) that had maximal number of interactions were revealed. (biomedcentral.com)
  • Among nine genes associated with severe forms of TBEV infection, three genes/proteins ( CCR5 , IL10 , ARID1B) were found to have protein-protein interactions within the network, and two genes/proteins ( IFNL3 and the IL10, that was just mentioned) were up- or down-regulated in response to TBEV infection. (biomedcentral.com)
  • 2001, Bui and Schreiber, 2007) RAG proteins are necessary for the recombination events necessary to produce TCRs and Igs, and as such RAG-2 deficient mice are incapable of producing functional T, B or NK cells. (wikipedia.org)
  • RAG-2 deficient mice were chosen over other methods of inducting immunodeficiency (such as SCID mice) as an absence of these proteins does not affect DNA repair mechanisms, which becomes important when dealing with cancer, as DNA repair problems can lead to cancers themselves. (wikipedia.org)
  • PCSK9 gene expression can be regulated by sterol-response element binding proteins (SREBP-1/2), which also controls LDLR expression. (wikipedia.org)
  • peptides
  • Later artificial cells have ranged from hundred-micrometer to nanometer dimensions and can carry microorganisms, vaccines, genes, drugs, hormones and peptides. (wikipedia.org)
  • Similarly, cathepsin B gene knockout and cathepsin B inhibitor treatment studies in traumatic brain injury mouse models have shown cathepsin B to be key to causing the resulting neuromuscular dysfunction, memory loss, neuronal cell death and increased production of pro-necrotic and pro-apoptotic cell death peptides. (wikipedia.org)
  • transgenic mice
  • This gene expression analysis reveals the immune events associated with prevention of tumor development and shows that HER-2/neu transgenic mice represent a good model of a poor-prognosis group of human breast tumors. (labome.org)
  • 2-free cholesterol and phospholipids are transferred from triglyceride rich particles to plasma lipoproteins by distinct mechanisms, and 3 - CETP also contributes to phospholipid transfer activity in human plasma but not in transgenic mice plasma, a species which has high levels of the specific phospholipid transfer protein activity. (biomedcentral.com)
  • C57BL
  • Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J- Tyr c-Brd background. (taconic.com)
  • Charles River Laboratories, Wilmington, MA), B6 × 129, C57BL/6J (The Jackson Laboratory, Bar Harbor, ME), C57BL/6J mutant mice and BALB/c CX3CR 1 -enhanced green fluorescent protein (EGFP) were used in these experiments, and all animal experimentation protocols were approved by the Northwestern University Animal Care and Use Committee. (jneurosci.org)
  • vitro
  • HSC population is then the ideal target for the correction of hematopoietic genetic diseases and also for the knockout of the responsible genes to in vitro and in vivo model those hematopoietic diseases. (intechopen.com)
  • Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs) Inhibits phospholipase A2 in vitro Binds phosphatidylcholine, phosphatidylinositol Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. (wikipedia.org)
  • inhibitor
  • Cathepsin B may enhance the activity of other protease, including matrix metalloproteinase, urokinase (serine protease urokinase plasminogen activator), and cathepsin D, and thus it has an essential position for in the proteolysis of extracellular matrix components, intercellular communication disruption, and reduced protease inhibitor expression. (wikipedia.org)
  • neurological
  • Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. (wikipedia.org)
  • Transcription
  • This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (genecards.org)
  • GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding . (genecards.org)
  • This complex then further binds to retinoic acid response elements (RARE) on DNA that regulates transcription of retinoid acid dependent null genes. (wikipedia.org)
  • human
  • Based on manual review and curation of scientific publications a catalog comprising 140 human genes involved in response to TBEV infection was developed. (biomedcentral.com)
  • A database comprising 140 human genes involved in response to TBEV infection was compiled and the TBEVHostDB web resource, providing access to all genes was created. (biomedcentral.com)
  • However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. (wikipedia.org)
  • embryos
  • However, this changed when the quail orthologue of Sulf1, QSulf1, was identified in a screen for Sonic hedgehog (Shh) response genes activated during somite formation in quail embryos. (wikipedia.org)
  • cytokine
  • citation needed] Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. (wikipedia.org)
  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. (wikipedia.org)
  • This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A, often referred to as IL-17, was originally discovered at transcriptional level by Rouvier et al. (wikipedia.org)
  • Accession
  • The HSulf1 gene (GenBank accession number AY101175) has an open reading frame of 2616 bp, encoding a protein of 871 amino acid (aa), and HSulf2 (GenBank accession number AY101176) has an open reading frame of 2613 bp, encoding a protein of 870 aa. (wikipedia.org)
  • Mutations
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis. (wikipedia.org)
  • Mutant Mice
  • A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed 129S5;B6 background. (taconic.com)
  • humans is encoded
  • Uteroglobin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene. (wikipedia.org)
  • Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. (wikipedia.org)
  • Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene. (wikipedia.org)
  • Pyruvate dehydrogenase lipoamide kinase isozyme 3, mitochondrial is an enzyme that in humans is encoded by the PDK3 gene. (wikipedia.org)
  • Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene. (wikipedia.org)
  • vivo model
  • In agreement with these findings, a second in vivo model, cardiac myosin light chain kinase (MYLK3) knockout (cMLCK neo/neo), showed depressed fractional shortening, progressing to left ventricular hypertrophy by 4-5 months of age. (wikipedia.org)
  • dependent
  • The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. (genecards.org)
  • Adult mice expressing a non-phosphorylatable cardiac RLC (TG-RLC(P-)) exhibited significant decreases in load-dependent and load-independent measures of contractility. (wikipedia.org)
  • cancer
  • The Trex1 Knockout Mouse was developed in the laboratories of Tomas Lindahl at the Clare Hall Laboratories, Imperial Cancer Research Fund (now Cancer Research UK). (taconic.com)
  • 2001
  • In 2001, it was shown that mice deficient in RAG-2 (Recombinase Activator Gene 2) were far less capable of preventing MCA induced tumours than were wild type mice. (wikipedia.org)
  • 2001) Another experiment involving IFN-γ−/− (Interferon γ) showed that these mice are more likely do develop certain types of cancers as well, and suggests a role of CD4+ T cells in tumor immunity, which produce large amounts of IFN-γ (Street et al. (wikipedia.org)
  • Mouse
  • However, comparing the nontransgenic (no CETP activity) with the CETP transgenic mouse plasma, no effect of CETP on the 14 C-PL distribution in mice lipoproteins was observed. (biomedcentral.com)
  • For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
  • A conditional knockout mouse line called Pdk3tm2a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. (wikipedia.org)
  • data
  • To provide access to data on all genes, the TBEVhostDB web resource ( http://icg.nsc.ru/TBEVHostDB/ ) was created. (biomedcentral.com)