Gemcitabine metastatic bladder cancer urinary bladder neoplasms. Medical search. Frequent questions

Bladder cancer Metastasis Staging Radical cystectomy Uro-oncology Urothelial carcinoma Computed tomography Urothelial carcinoma of the bladder (UCB) ranks globally as the 11th most common. (karger.com)

Inhibitors of programmed cell death 1 (PD-1) protein and its ligands PD-L1 and PD-L2, are first-line agents in patients with metastatic urothelial carcinoma who are not candidates for platinum-containing chemotherapy, and second-line agents for those with disease progression despite cisplatin-based chemotherapy. (medscape.com)
GTC (gemcitabine, paclitaxel and cisplatin) is a new chemotherapeutic regimen, which has shown promise in clinical trials. (edu.kz)
Phase 1 Trial of Concurrent Gemcitabine and Cisplatin with Image Guided Intensity Modulated Radiation Therapy for Locoregionally Advanced Cervical Carcinoma. (ucsd.edu)

Surgical removal of the bladder and bladder preservation are discussed, as well as updates on the use of chemotherapy and immunotherapy in localised and metastatic disease. (bvsalud.org)
Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)
Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. (biomedcentral.com)
Over the past three decades, surgical tumor debulking, followed by platinum-based chemotherapy is the standard treatment for advanced ovarian cancer. (biomedcentral.com)
Urothelial bladder cancer (BC) represents a highly heterogeneous disease with regard to natural history, ranging from non-muscle invasive BC (NMIBC), which represents 75% of primary diagnoses and is characterized by frequent recurrence but a low risk of mortality, to muscle invasive BC (MIBC), which requires platinum-based chemotherapy followed by radical surgery, to metastatic disease [ 1 ]. (e-crt.org)
Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
Current status of hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer in the United States. (ucsd.edu)
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
Treatment of patients with advanced and metastatic LC presents a significant challenge as malignant cells use different mechanisms to resist chemotherapy. (preprints.org)

The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
One patient who had 50-gene panel only also had his metastatic site (esophagus) of his tumor tested with FoundationOne. (cancerindex.org)
The p53 tumor suppressor plays a pivotal role in cancer and infectious disease. (encyclopedia.pub)
These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma , endometrial adenocarcinoma , and urothelial carcinoma based on Acrivon's OncoSignature® test status. (ucsd.edu)

As with most epithelial cancers, physical irritation has been associated with increased risk of malignant transformation of the urothelium. (wikipedia.org)
The origin and pathogenesis of epithelial ovarian cancer (EOC) have long been investigated but still poorly understood. (biomedcentral.com)
Studies have shown that epithelial ovarian cancer is not a single disease but is composed of a diverse group of tumors that can be classified based on distinctive morphologic and molecular genetic features [ 1 ]. (biomedcentral.com)
Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85-90% of adult renal malignancies [ 1 ]. (biomedcentral.com)
Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)

Some particular examples are listed below: Certain drugs, such as cyclophosphamide, via the metabolites acrolein and phenacetin, may predispose to the development of transitional cell carcinomas (the latter especially with respect to the upper urinary tract). (wikipedia.org)
Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. (jsco-cpg.jp)
14 j Habuchi T. Origin of multifocal carcinomas of the bladder and upper urinary tract: molecular analysis and clinical implications. (jsco-cpg.jp)
Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract. (jsco-cpg.jp)
Comparing the joint effect of arsenic exposure, cigarette smoking and risk genotypes of vascular endothelial growth factor on upper urinary tract urothelial carcinoma and bladder cancer. (jsco-cpg.jp)
Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma. (jsco-cpg.jp)

Transitional cell carcinoma, also called urothelial carcinoma, is a type of cancer that typically occurs in the urinary system. (wikipedia.org)
H&E stain Papillary transitional cell carcinoma, low grade Histopathology of urothelial carcinoma of the urinary bladder, showing a nested pattern of invasion. (wikipedia.org)

Bladder perforation Neoplasm Urothelial carcinoma Transurethral resection Clinical Data Warehouse. (karger.com)

Surveillance is needed to monitor for recurrent cancer and functional outcomes. (bvsalud.org)

CONTEXT: We present an overview of the updated 2023 European Association of Urology (EAU) guidelines for muscle-invasive and metastatic bladder cancer (MMIBC). (bvsalud.org)

PATIENT SUMMARY: The European Association of Urology guidelines panel on muscle-invasive and metastatic bladder cancer has released an updated version of the guideline containing information on diagnosis and treatment of this disease. (bvsalud.org)

It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus. (wikipedia.org)
TCC can arise anywhere in the urinary tract, including the renal pelvis, ureter, bladder, and urethra, but it is usually found in the urinary bladder. (medscape.com)
Cigarette smoking and cancers of the renal pelvis and ureter. (jsco-cpg.jp)

It is the second most common type of kidney cancer, but accounts for only five to 10 percent of all primary renal malignant tumors. (wikipedia.org)
The 1973 WHO grading system for transitional cell carcinomas (papilloma, G1, G2 or G3) is most commonly used despite being superseded by the 2004 WHO grading for papillary types (papillary neoplasm of low malignant potential [PNLMP], low grade, and high grade papillary carcinoma). (wikipedia.org)
Pancreatic cancer (PC) is a malignant neoplasm with a high mortality rate. (oncotarget.com)

Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)

Practice patterns and survival in FIGO 2009 stage 3B endometrial cancer. (ucsd.edu)

To provide recommendations on appropriate clinical trial designs across disease settings in UC, the Society for Immunotherapy of Cancer (SITC) and the International Bladder Cancer Group (IBCG) convened a multidisciplinary, international consensus panel. (bvsalud.org)
Cancer Immunology, Immunotherapy. (elsevierpure.com)
Many oncology treatments are now calling on immunotherapy approaches, and scores of studies have investigated the role of p53 antibodies in cancer diagnosis and therapy. (encyclopedia.pub)

In the United States, the leading cause of cancer death in men is lung cancer, with lung cancer continuing to surpass breast cancer as the leading cause of cancer death in women. (health.am)
lung cancer incidence rates are approximately 400 per 100,000 women aged 60 to 79. (health.am)
There is a dose-response relationship for smoking and lung cancer, and the risk for lung cancer increases with smoking duration, number of cigarettes smoked, age at onset of smoking, use of unfiltered cigarettes, tar and nicotine content, and degree of inhalation. (health.am)
The pivotal trial by Doll and Hill in 1956 showed that smoking cessation reduces the risk of lung cancer compared to those who continue to smoke. (health.am)
in 1986 in a case control study of lung cancer in New Mexico, which compared cases and controls less than 65 years of age to those more than 65 years of age and additionally showed that one decline in lung cancer risk that occurs with smoking cessation in the older person is comparable to that of the young. (health.am)
This same study showed that the number of years of smoking is relatively less important than the number of cigarettes smoked per day in determining the risk for lung cancer in those persons 65 and older. (health.am)
A recent American Cancer Society study clarified the risk of lung cancer mortality in smokers and former smokers. (health.am)
examined and compared absolute and relative lung cancer death risk in former smokers as a function of age at cessation.7 In a prospective cohort study with 6 years of follow-up, the absolute risk of lung cancer mortality was compared in individuals who had never smoked and current and former smokers. (health.am)
As expected, there was a lower lung cancer death risk seen for those patients who quit smoking earlier in life, and the risk for those who were former smokers was significantly lower than for those who continued to smoke. (health.am)
If one quit between the ages of 50 and 64, the lung cancer death risk leveled off at the risk attained at the time of quitting until around age 75, when it increased significantly. (health.am)
For current smokers at age 75, the annual lung cancer mortality is estimated at 1 per 100 for males and 1 per 200 for females. (health.am)
Lung cancer (LC) is one of the leading causes of cancer occurrence and mortality worldwide. (preprints.org)

Urothelial carcinoma Bladder cancer Inflammatory biomarker Age Senescence Survival Cystectomy With around 593,393 newly diagnosed patients worldwide, bladder cancer. (karger.com)
They account for about 4% of newly diagnosed adult cancers and are among the leading causes of cancer mortality. (oncolink.org)

Phenacetin and papillary necrosis: independent risk factors for renal pelvic cancer. (jsco-cpg.jp)

Prostate Cancer and Prostatic Diseases. (elsevierpure.com)
The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (worldsbest.rehab)

Survival rate of patients diagnosed with the invasive form of bladder cancer is low suggesting an urgent need to implement novel treatments. (edu.kz)
A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway. (biomedcentral.com)
[ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
Despite the advent of improved biochemical methods and imaging technology over the years, early detection of cancer remains a key to survival. (oncolink.org)

Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)
The primary objectives in a diagnostic evaluation for suspected cancer are determinations of the tissue type, the primary site of malignancy, the extent of disease within the body and the tumor's future recurrence potential. (oncolink.org)

Transitional cell bladder carcinomas associated with this sSMS are more aggressive and invasive than those not associated with it. (wikipedia.org)
Magnetic resonance imaging (MRI) of the bladder is superior to computed tomography (CT) for disease staging, specifically in differentiating T1 from T2 disease, and may lead to a change in treatment approach in patients at high risk of an invasive tumour. (bvsalud.org)
Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. (cancerindex.org)

Symptoms of urothelial carcinoma in the bladder include hematuria (blood in the urine). (wikipedia.org)

These findings suggest that these two different types of ovarian cancers develop along different molecular pathways. (biomedcentral.com)

Given that receptor tyrosine kinases of the ErbB family are overexpressed in a high proportion of metastatic bladder tumours, approaches involving small-molecule inhibitors of ErbB receptors in combination with conventional cytostatic drugs are of potential interest. (edu.kz)
Our data indicate that a combinatorial approach involving GTC and lapatinib may have therapeutic potential in a subset of bladder tumours depending on the genetic context. (edu.kz)
S. Family history of cancer among cases of upper urothelial tumours in a Balkan nephropathy area. (jsco-cpg.jp)

NENs account for approximately 0.4% of colorectal neoplasms. (biomedcentral.com)

Prognostic Value of Pretreatment Inflammatory Markers in Patients Receiving Radical Cystectomy for Urothelial Bladder Cancer: Does Age Matter? (karger.com)
Radical surgery was performed to remove his colon cancer on Feb 16th, 2013. (biomedcentral.com)

When the term "urothelial" is used, it specifically refers to a carcinoma of the urothelium, meaning a transitional cell carcinomas of the urinary system. (wikipedia.org)
Signs and symptoms of transitional cell carcinomas depend on the location and extent of the cancer. (wikipedia.org)
Thus, urothelial carcinomas are more common in the context of chronic urinary stone disease, chronic catheterization (as in patients with paraplegia or multiple sclerosis), and chronic infections. (wikipedia.org)

Diagnosis includes urine analysis and imaging of the urinary tract (cystoscopy). (wikipedia.org)

The uterus is located in the pelvis, between the bladder and rectum, and the vagina is located behind the urethra, which connects to the bladder. (cancer.net)
In this way, the urogenital sinus is divided by the orifices into two different portions: the cephalad one that will become the bladder and caudal one that will become the urethra. (esur2023.com)

Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

J Cancer Res Clin Oncol. (cancerindex.org)

These preliminary results paved the way for a vast number of studies on the role of cellular protein p53 in the cancer biology field, leading to the discovery that p53 mutations are the most common genetic alteration in human cancers. (encyclopedia.pub)

Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (ucsd.edu)
Positron Emission Tomography-Guided Bone Marrow-Sparing Radiation Therapy for Locoregionally Advanced Cervix Cancer: Final Results From the INTERTECC Phase II/III Trial. (ucsd.edu)
Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (worldsbest.rehab)

No blood tests are specific for bladder cancer, but a general evaluation is necessary prior to initiating therapy with intravesical bacillus Calmette-Guérin (BCG). (medscape.com)

EVIDENCE SYNTHESIS: Patients should be counselled regarding risk factors for bladder cancer. (bvsalud.org)
Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. (health.am)
Except in a few cases, the vast majority of published work on p53 antibodies in cancer patients use wild-type p53 as the antigen to detect these antibodies and it is unclear that they can recognize p53 mutants carried by cancer patients at all. (encyclopedia.pub)
Laboratory data provide information on the functioning of specific organs and metabolic processes that may be affected in cancer patients or altered by subsequent cancer therapy. (oncolink.org)
Biopsy methods for accurate histologic or cytologic proof of malignancy are absolutely essential to workup and subsequent management of suspected cancer patients. (oncolink.org)

Assessment of malnutrition by unintentional weight loss and its implications on oncologic outcomes in patient with locally advanced cervical cancer receiving primary chemoradiation. (ucsd.edu)

Pancreatic cancer (PC) is one of the most common causes of cancer-related death. (oncotarget.com)

Participants in Arm 2 will receive the combination of ACR-368 and ultralow-dose gemcitabine. (ucsd.edu)

This is the first page of Cancer.Net's Guide to Ovarian, Fallopian Tube, and Peritoneal Cancer. (cancer.net)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
In this guide, this group of cancers is referred to as "ovarian/fallopian tube cancer" because peritoneal cancer is relatively rare. (cancer.net)
When the term "ovarian cancer" is used, it includes both fallopian tube and peritoneal cancers because it may be unclear where the cancer started. (cancer.net)
see more information below), and in most cases, the cancer actually starts in the tip, or outer end, of the fallopian tubes. (cancer.net)
Based on this updated knowledge, when discussing contraception to avoid future pregnancy, some doctors recommend removal of the fallopian tubes, rather than tying or banding the tubes, in order to lower the risk of ovarian/fallopian tube cancers. (cancer.net)
Rarely, peritoneal cancer can develop after ovaries and fallopian tubes have been removed. (cancer.net)
Just as with ovarian cancer, some peritoneal cancers may begin in the fallopian tubes and spread from the end of the fallopian tube into the peritoneal cavity. (cancer.net)

It has been demonstrated that numerous ncRNAs are dysregulated and involved in cancer initiation and progression. (biomedcentral.com)
Notably, expressions of some lncRNAs undergo significant changes in the initiation and progression of cancers. (oncotarget.com)

This study aimed to explore the genomic and transcriptomic landscape of bladder cancer (BC) and its implication for treatment with an immune checkpoint inhibitor (ICI). (e-crt.org)

One of the most investigated and promising molecular targeted drugs in ovarian cancer is bevacizumab, a monoclonal antibody directed against VEGF. (biomedcentral.com)

Cancer is a major burden of disease worldwide. (health.am)

Cite this: Nonsteroidal Antiinflammatory Drugs and Bladder Cancer - Medscape - Apr 01, 2011. (medscape.com)

No association was observed between regular aspirin use and bladder cancer risk (HR = 1.04, 95% CI: 0.94, 1.15). (medscape.com)
Results suggest that nonaspirin NSAIDs, but not aspirin, are associated with a reduction in risk of bladder cancer, particularly for nonsmokers. (medscape.com)

The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)

Anatomy2

Diseases10

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes1

Metastasis1

Cisplatin3

Chemotherapy12

Tumor4

Adenocarcinoma1

Epithelial5

Upper urinary tract6

Transitional Cell Carc2

Transurethral Resection1

Recurrent1

20231

Muscle-invasive1

Ureter3

Malignant3

Squamous Cell Carc1

Endometrial Cancer1

Immunotherapy3

Lung Cancer12

Newly diagnosed2

Papillary1

Prostate cancer2

Survival4

Recurrence2

Invasive3

Hematuria1

Ovarian cancers1

Tumours3

Colorectal1

RadiCal2

Carcinomas3

Diagnosis1

Urethra2

Chemotherapeutic2

Oncol1

Human cancers1

Radiation therapy3

Intravesical1

Patients5

Locally1

Pancreatic Cancer1

Dose1

Fallopian8

Initiation and progression2

Implication1

Molecular1

Burden1

Medscape1

Aspirin2

Curative1