• Objective We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGAL pre-op ) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. (bmj.com)
  • Background and aims To investigate the value of urinary neutrophil gelatinase associated lipocalin (NGAL) kidney injury molecular-1 (KIM-1) and interleukin-18 (IL-18) in the diagnosis of acute kidney injury (AKI) following childhood cardiopulmonary bypass (CPB). (bmj.com)
  • Neutrophil gelatinase-associated lipocalin (NAGL): a novel biomarker for acute kidney injury]. (biu.ac.il)
  • Dive into the research topics of '[Neutrophil gelatinase-associated lipocalin (NAGL): a novel biomarker for acute kidney injury]. (biu.ac.il)
  • Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients? (wustl.edu)
  • Our aim was to study the predictive value of plasma neutrophil gelatinase-associated lipocalin (NGAL) at admission as a biomarker for AKI progression during the first 48 h of ICU admission in an unselected, heterogeneous ICU patient population. (hanze.nl)
  • Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein that in humans is encoded by the LCN2 gene. (wikipedia.org)
  • Use of Urinary Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis of Acute Kidney Injury Among Stroke Patients. (aacc.org)
  • Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis. (nih.gov)
  • The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) using both Meso Scale Discovery and Luminex-based analytical approaches. (genomeweb.com)
  • Combining the Renal Angina Index and measurement of urinary Neutrophil Gelatinase Associated Lipocalin can improve predictions of severe acute kidney injury in critically ill children. (asn-online.org)
  • Urinary neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine, urine protein, serum and urine catalytic iron, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and tissue lipid peroxidation were assayed. (alliedacademies.org)
  • One of these biomarkers is Neutrophil Gelatinase-Associated Lipocalin (NGAL). (pediatrmedchir.org)
  • Shoaib M, Mahmud SN, Safdar M. Early diagnosis of acute kidney injury by urinary neutrophil gelatinase-associated lipocalin in adult critically ill patients. (pediatrmedchir.org)
  • Meta-analysis of the diagnostic value of serum, plasma and urine neutrophil gelatinase-associated lipocalin for the detection of acute kidney injury in patients with sepsis. (pediatrmedchir.org)
  • Neutrophil gelatinase-associated lipocalin (ngal) and kidney injury molecule 1 (kim1) in patients with diabetic nephropathy: A cross-sectional study and the effects of lisinopril. (pediatrmedchir.org)
  • Buy Neutrophil Gelatinase Associated Lipocalin (NGAL) Detection Kit (Latex Enhanced Immunoturbidimetric Product on Nanjing Vazyme Biotech Co.,Ltd. (vazymemedical.com)
  • Neutrophil gelatinase associated lipocalin (NGAL) is an early and sensitive marker of acute kidney injury. (vazymemedical.com)
  • Delfino Duarte PA, Fumagalli AC, Wandeur V, Becker D. Urinary neutrophil gelatinase-associated lipocalin in critically ill surgical cancer patients. (ijccm.org)
  • Background and Aims: Neutrophil gelatinase-associated lipocalin (N-GAL) is an early biomarker of acute kidney injury (AKI) due to various etiologies. (ijccm.org)
  • Neutrophil gelatinase-associated lipocalin: Pathophysiology and clinical applications. (ijccm.org)
  • The search for early diagnostic methods revealed the Neutrophil gelatinase-associated lipocalin (NGAL) as a novel biomarker for detecting acute tubular injury (ATI). (fortuneonline.org)
  • On the other hand, the biomarker Neutrophil gelatinase-associated lipocalin (NGAL) can detect active tubular injury (ATI) from two hours after the start of the inducing event [1,2] which shows the precocity of NGAL in comparison to the traditional markers. (fortuneonline.org)
  • The Investigation Team led by Prof. Breithardt have assesed the potential benefit of bio-marker Neutrophil Gelatinase-Associated lipocalin (NGAL). (medicoinvestor.com)
  • Neutrophil gelatinase-associated lipocalin (NGAL) is a diagnostic marker for acute kidney injury (AKI). (biomedcentral.com)
  • However, there are no reports of urine neutrophil gelatinase-associated lipocalin (uNGAL) levels after open esophagectomy. (biomedcentral.com)
  • The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. (nih.gov)
  • Neutrophil gelatinase-associated lipocalin (NGAL), a 25-kDa protein, is released from the secondary granules of neutrophils and is covalently bound to neutrophil gelatinase. (e-cep.org)
  • Clinical Utility of Rapid Plasma Neutrophil Gelatinase-Associated Lipocalin Assays for Diagnosing Acute Kidney Injury in Critically Ill Newborn Infants. (neo-med.org)
  • Cystatin C, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, liver-type fatty acid binding protein, selected urinary enzymes (e.g. (paom.pl)
  • Balkanay enrolled adult patients undergoing CABG found a significant difference between high dose group (8 μg/kg) and low dose group (4 μg/kg) for the 24th postoperative hour in the mean values of neutrophil gelatinase-associated lipocalin (NGAL), [ 17 ] indicating that dexmedetomidine had marked effects on renoprotection in a dose-dependent fashion. (medscape.com)
  • Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study. (bmj.com)
  • Costs and outcomes of acute kidney injury in critically ill patients with cancer. (ijccm.org)
  • Postoperative AKI within 72 hours was defined using the International Kidney Disease: Improving Global Outcomes classification. (bmj.com)
  • The nomogram developed in this study was found to be sensitive and specific for the preoperative prediction of AKI in VLBW infants, as per the Kidney Disease: Improving Global Outcomes (KDIGO) criteria modified for neonates. (frontiersin.org)
  • Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)
  • Partly based on the AKIN and RIFLE criteria, Kidney Disease: Improving Global Outcomes (KDIGO) published the KDIGO standard for the evaluation and management of AKI in 2012. (hindawi.com)
  • The international Kidney Disease: Improving Global Outcomes (KDIGO) work group classified AKI in three stages of ascending severity [ 7 ], according to a quantitative increase in serum creatinine (SCr) or a decrease in urine output (UO). (biomedcentral.com)
  • Ostermann M. Diagnosis of acute kidney injury: Kidney Disease Improving Global Outcomes criteria and beyond. (paom.pl)
  • Diagnosis of CKD at early stages will allow earlier intervention for the treatment of kidney disease, and the prevention of further kidney damage. (randox.com)
  • therefore, early diagnosis of kidney injury is important for preventing AKI. (wikipedia.org)
  • Early diagnosis of acute kidney injury (AKI) is a major challenge in the intensive care unit (ICU). (biomedcentral.com)
  • Subclinical Acute Kidney Injury (AKI) describes patients who did not fulfill the classical criteria for AKI diagnosis but showed elevated levels of new biomarkers reflecting tubular injury. (pediatrmedchir.org)
  • Roy JP, Devarajan P. Acute kidney injury: Diagnosis and management. (pediatrmedchir.org)
  • Denker B, Robles-Osorio ML, Sabath E. Recent advances in diagnosis and treatment of acute kidney injury in patients with cancer. (ijccm.org)
  • In the context of neurocritical care, AKI diagnosis holds significance for acute brain injury (ABI) management. (beds.ac.uk)
  • This stimulated continuous research on novel biochemical markers suitable for diagnosis and monitoring of acute kidney injury (AKI) and chronic kidney disease (CKD). (paom.pl)
  • Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
  • The presence of this protein in blood and urine is an early biomarker of acute kidney injury. (nih.gov)
  • In view of the definition for AKI using conventional tests such as the blood urea nitrogen, serum creatinine levels, urine output quantity and creatinine clearance rate, it may result in delay in the timely detection of kidney injury and can lead to false-negative results, and dexmedetomidine for the prevention of AKI may be more effective than the current results. (medscape.com)
  • Acute kidney injury (AKI) occurs in up to 20% of patients admitted to hospital and results in significant morbidity and mortality [ 1 ]. (karger.com)
  • Amongst the survivors of an episode of AKI, there is an increasing understanding of long-term consequences that may include an increased mortality risk, the development of chronic kidney disease (CKD), and the progression from CKD to end-stage renal disease (ESRD) [ 2,3 ]. (karger.com)
  • Acute kidney injury (AKI) is recognized as an independent predictor for mortality in very-low-birth-weight (VLBW) infants and is reported to have a high incidence. (frontiersin.org)
  • Acute kidney injury and mortality in hospitalized patients. (bmj.com)
  • Acute kidney injury (AKI) causes significant morbidity and mortality. (alliedacademies.org)
  • Abstract Background: Septic patients with acute kidney injury (AKI) are associated with increased morbidity and mortality compared to septic patients without AKI. (criticalcareshock.com)
  • 40-55%) are higher than the mortality rates due to ICU-related myocardial infarction (20%), sepsis without AKI (15-25%), or acute respiratory distress syndrome requiring mechanical ventilation (30-40%) [ 1 ]. (beds.ac.uk)
  • To predict AKI progression, a multivariant model with age, sex, diabetes mellitus, body mass index, admission type, Acute Physiology and Chronic Health Evaluation score and SCr at admission had an area under the receiver operating characteristics (ROC) curve of 0.765. (hanze.nl)
  • Chronic Kidney Disease is an abnormal kidney function and/ or structure, present for a minimum period of 3 months. (randox.com)
  • Utilising patented Biochip Technology, the Randox Chronic Kidney Disease (CKD) arrays could improve patient risk stratification whilst monitoring the effectiveness of treatment. (randox.com)
  • More than 10% of people in the United States will develop some kind of chronic kidney disease (CKD), with higher incidences for individuals that suffer from obesity, elevated cholesterol, and a family history of CKD. (wikipedia.org)
  • This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). (karger.com)
  • Among 1,018 children with newly diagnosed chronic kidney disease and 4,072 children with normal kidney function who were seen at primary care practices, 71% and 50%, respectively, received at least one medication that might be toxic to the kidneys over an average follow-up of 3.3 years. (asn-online.org)
  • The evaluation and treatment of SCD triggering factors and of underlying acute and chronic diseases will facilitate prevention and lower the risk of cardiac arrest. (jccm.ro)
  • Chin'ombe N, Msengezi O, Matarira H. Microalbuminuria in patients with chronic kidney disease at Parirenyatwa Hospital in Zimbabwe. (pediatrmedchir.org)
  • Results: A total of 22 patients were assessed (77% male, age 52.8 years, Acute Physiology and Chronic Health Evaluation II [APACHE II] 17.3) in whom the most frequent site of cancer was the gastrointestinal tract. (ijccm.org)
  • However, it may not be possible to maintain this feature under critical conditions or in the case of pre-existing chronic kidney disease (CKD). (fortuneonline.org)
  • We compared vital signs, PaO 2 /F I O 2 , serum C-reactive protein (CRP) levels, acute physiology and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and uNGAL levels between the sepsis group and the esophagectomy group. (biomedcentral.com)
  • Campbell D, Weir MR. Defining, treating and understanding chronic kidney disease - a complex disorder. (paom.pl)
  • KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. (paom.pl)
  • Yamaguchi J, Tanaka T, Nangaku M. Recent advances in understanding of chronic kidney disease. (paom.pl)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • Hospitalization discharge diagnoses for kidney disease: United States, 1980-2005. (bmj.com)
  • 2022 United States Renal Data System (USRDS) annual data report: epidemiology of kidney disease in the United States. (bmj.com)
  • Acute kidney injury (AKI) is one of the most serious complications, especially in end-stage liver disease. (hindawi.com)
  • The rate of such prescriptions was 4-times higher in patients with kidney disease than in those without. (asn-online.org)
  • Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with broccoli powder lessened kidney injury in the genetically altered mice. (asn-online.org)
  • Onconephrology: The latest frontier in the war against kidney disease. (ijccm.org)
  • Occupational heat stress increases the risk of acute kidney injury (AKI) and kidney disease. (cdc.gov)
  • Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
  • Clinical kidney journal , 13 (6), 994-1002. (hanze.nl)
  • KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
  • KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
  • Identifying new markers of kidney injury with clinical value has also become an increasing focus of research. (hindawi.com)
  • Canine patients needing surgical intervention are at risk of developing acute kidney injury, whose clinical manifestation it's late. (fortuneonline.org)
  • Owing continuing progress in nephrology laboratory diagnostics, novel biomarkers of kidney damage are likely to be introduced in routine clinical practice. (paom.pl)
  • Abelha FJ, Botelho M, Fernandes V, Barros H. Determinants of postoperative acute kidney injury. (ijccm.org)
  • Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
  • In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
  • Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
  • Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
  • Kidney health is most frequently measured by serum creatinine. (wikipedia.org)
  • AKI is difficult to diagnose since symptoms and elevated levels of markers of renal function (eg: creatinine) generally do not occur until the injury is quite advanced. (aaltoscientific.com)
  • To date, the optimal dose of dexmedetomidine to improve kidney function after cardiac surgery is unclear. (medscape.com)
  • Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
  • External validation for acute kidney injury severity scores: a multicenter retrospective study in 14 Japanese ICUs. (bmj.com)
  • Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)
  • Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
  • Early Outcomes of Pharmacomechanical Thrombectomy in Acute Deep Vein Thrombosis Patients. (groupflorence.com)
  • Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. (beds.ac.uk)
  • This article summarizes the epidemiology and outcomes of AKI in neurocritically ill adults admitted to the ICU, focusing on prevalent ABI conditions like traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and acute stroke. (beds.ac.uk)
  • Mehta RL, Kellum JA, Shah SV, Mehta RL, Palevsky P. Acute kidney injury network: report on an initiative to improve outcomes in acute kidney injury. (paom.pl)
  • Recently, to diagnose UTI noninvasively, several studies have reported that some urinary biomarkers of acute kidney injury (AKI) may be associated with UTI. (e-cep.org)
  • Background The study of novel urinary biomarkers of acute kidney injury has expanded exponentially. (uthscsa.edu)
  • Cystatin C is well recognised marker of kidney filtration dysfunction and injury. (randox.com)
  • Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. (springeropen.com)
  • Both pulmonary and non-pulmonary sepsis can lead to ARDS with pulmonary sepsis (due to pneumonia or aspiration of gastric contents) resulting in direct injury to the lung and non-pulmonary sepsis resulting in indirect injury to the lung [ 22 ]. (springeropen.com)
  • In a mouse model of non-pulmonary sepsis, glycocalyx degradation contributed to acute lung injury, and human studies have shown an association between glycocalyx degradation and development of pulmonary edema [ 27 , 28 ], findings that support an association between glycocalyx degradation and ARDS. (springeropen.com)
  • From NCBI Gene: This gene encodes a protein that belongs to the lipocalin family. (nih.gov)
  • Acute kidney injury: prevention, detection and management. (bmj.com)
  • Urbschat A, Obermuller N, Haferkamp A. Biomarkers of kidney injury. (paom.pl)
  • Apoptotic pathways in ischemic acute renal failure. (bmj.com)
  • Non-steroidal anti-inflammatory drugs (NSAIDs), even at therapeutic doses, can cause ischemic kidney injury [11]. (fortuneonline.org)
  • Acute kidney injury (AKI), which initially affects the renal tubules, is characterized by rapid deterioration of renal function caused by nephrotoxic substances or renal ischemia. (fortuneonline.org)
  • Kidney injury by ischemia can occur by any factor that provokes renal blood perfusion alterations and cellular death [7]. (fortuneonline.org)
  • Dexmedetomidine is widely used for perioperative anesthesia/analgesia, and may have a more profound renal protection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury. (medscape.com)
  • Results The incidence of AKI was 34%, including 15 cases with Risk stage AKI, 4 cases with Injury stage AKI, 3 cases with Failure stage AKI, 1 cases with Loss stage AKI. (bmj.com)
  • Incidence of acute kidney injury in cancer patients: A Danish population-based cohort study. (ijccm.org)
  • Acute renal failure requiring renal replacement therapy: incidence and outcome. (paom.pl)
  • The success of a biomarker-guided therapy for the prevention of kidney damage questions are currently studied - and results are eagerly awaited. (medicoinvestor.com)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • His presentation carried the stunning title: New Biomarkers improve the prediction of acute renal damage significantly in patients who suffer from heart failure (HF). (medicoinvestor.com)
  • Renal biomarkers are gaining in importance because they can simplify the prediction of acute kidney injury. (medicoinvestor.com)
  • Ventricular septal rupture is a potentially fatal complication of acute myocardial infarction. (jccm.ro)
  • Septic acute kidney injury: Molecular mechanisms and the importance of stratification and targeting therapy. (ijccm.org)
  • The Acute Dialysis Quality Initiative (ADQI) group first proposed the RIFLE diagnostic criteria in 2004. (hindawi.com)
  • Management of acute kidney injury: core curriculum 2018. (bmj.com)
  • Very-low-birth-weight (VLBW) infants have underdeveloped kidneys, and they are easily affected by nephrotoxic drugs ( 3 , 4 ). (frontiersin.org)
  • IL-8 endothelial-derived chemokine involved in recruiting neutrophils to sites of injury and stimulating their response. (randox.com)
  • It is expressed in neutrophils and in low levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. (wikipedia.org)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • In a similar study with 330 patients with dyspnea (2 / 3 HF patients) neopterin, another promising biomarkers was meaured, Also in this case occurrence of acute renal damage was predicted in advance. (medicoinvestor.com)
  • The kidneys have an intrinsic physiological mechanism of protection and regulation of renal blood flow, mediated by eicosanoid derivatives, the prostacyclin [6]. (fortuneonline.org)