• stiffness
  • Increase in the ratio of thiol-modified gelatin reduced gel stiffness by diluting the effective concentration of the HA component. (wiley.com)
  • Using widely available materials, the module helps teachers lead students through an investigation of how the stiffness of tissues in the body vary based on their function, and about the importance of matching biomaterial and host tissue stiffness. (rochester.edu)
  • vivo
  • In addition, the viability and adhesion of neonatal rat cardiomyocytes (NRCM) seeded onto the hydrogels was examined by in vivo imaging of NRCM-mediated scaffold contraction as well as by histological evaluation after immunostaining. (artificial-organs.com)
  • physiological
  • Hydrogel MPs are incorporated into the injectable paste, they swell during mixing and injection to retain water in the pores, and instead of leaching out, the porogens create pores as they can degrade in physiological condition. (pubmedcentralcanada.ca)
  • By modulating the heating temperatures and healing times, the healed Gelatin/PAAm gels could achieve 53% healing efficiency at a physiological temperature range, which greatly expands their uses for biomedical applications. (rsc.org)
  • The combination of high strength, self-recovery, and self-healing properties makes Gelatin/PAAm gels promising candidates for further development and use as thermoresponsive biomaterials under physiological conditions. (rsc.org)
  • However, at physiological temperatures, the viscosity of gelatin drops significantly. (wikipedia.org)
  • Alginates
  • Extensive work has been done using alginates which are regarded as the most suitable biomaterials for cell microencapsulation due to their abundance, excellent biocompatibility and biodegradability properties. (wikipedia.org)
  • mechanical properties
  • The state of the art of the physical/chemical crosslinking methods of the gelatin-based hydrogels being used to overcome the weak mechanical properties is highlighted. (mdpi.com)
  • We tune the mechanical properties of the hydrogel using the chitin nanofiber content and show proof-of-concept applications in engineering vascular tissues. (rsc.org)
  • The final DOPA-modified, Fe 3+ ion-crosslinked gelatin hydrogels retained their hydrogel stability well at body temperature in an aqueous environment and exhibited appropriate mechanical properties. (rsc.org)
  • The optimized Gelatin/PAAm DN gels demonstrated high mechanical properties ( E of 84 kPa, σ f of 0.268 MPa, ε f of 40.69 mm mm −1 and W of 6.01 MJ m −3 ), large hysteresis (up to 1012 kJ m −3 at λ = 30), and rapid self-recovery properties (∼87% toughness recovery at room temperature). (rsc.org)
  • ionic
  • Silicate nanoparticles (SiNP) are used for ionic crosslinking of gelatin to form stable hydrogel at body temperature (credit: Alberto Purwada et al. (cryonics.org)
  • Unlike the thermoplastics that are often utilized in traditional 3D printing, the chain entanglements and ionic interactions within the hydrogel-like bioink rather than temperature dominate shape fidelity. (wikipedia.org)
  • proteins
  • These hydrogels encompass light-sensitive naturally-derived proteins, shear-thinning biomaterial gels, and surgical sealants, each of which has opened new horizons for tissue engineering, minimally invasive medical procedures, and advanced biomedicine. (wikipedia.org)
  • Many biopolymers - proteins, carbohydrates, glycoproteins, and mucopolysaccharides - may be used to form hydrogels that contribute to temporary adhesion. (wikipedia.org)
  • biomedical
  • Tissue Engineering and Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota. (pubmedcentralcanada.ca)
  • NFC hydrogel in 3D cell culture offers a platform for various biomedical applications. (wikipedia.org)
  • The chapter hopes that the module will be adopted by middle school science teachers, and that it will help encourage student engagement in science at the middle school level, and help increase widespread understanding of the field of biomaterials and biomedical engineering. (rochester.edu)
  • Khademhosseini has further expanded his contribution in the field of biomedical adhesives by developing an elastic and adhesive hydrogels for surgical applications. (wikipedia.org)
  • shear
  • A second class of hydrogels pioneered by the group is a nanosilicate-based shear thinning gel that could be easily injected in a minimally invasive medical procedure. (wikipedia.org)
  • elastic
  • Overall results suggest that the DOPA-Fe 3+ gelatin hydrogel, with its good elastic and hemostatic properties, is a promising tissue adhesive for use in a wide variety of surgical operations. (rsc.org)
  • Biomimetic
  • Biomimetic and enzyme-responsive dynamic hydrogels for studying cell-matrix interactions in pancreatic ductal adenocarcinoma. (annals.org)
  • fabrication
  • Recently, photo-fabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. (engineering.org.cn)
  • shape fidelity
  • Important considerations in printability include: Uniformity in filament diameter Angles at the interaction of filaments "Bleeding" of filaments together at intersects Maintenance of shape fidelity after printing but before cross-linking Printing pressure and nozzle diameter Alginate is a naturally derived biopolymer from the cell wall of brown algae that has been widely used as a biomaterial. (wikipedia.org)
  • Transparent crosslinked ultrashort peptide hydrogel dressing with high shape-fidelity accelerates healing of full-thickness excision wounds" (PDF). (wikipedia.org)
  • properties
  • This allows investigation into the relationship between the rate of drug diffusion and hydrogel properties such as mesh size. (rochester.edu)
  • This article is an overview of the intrinsic/extrinsic properties of the gelatin-based hydrogels in organ 3D bioprinting areas with advanced technologies, theories and principles. (mdpi.com)
  • However, simultaneously achieving high strength and self-healing properties in DN hydrogels still remains a challenge. (rsc.org)
  • These superior properties were largely attributed to effective energy dissipation via the rupture of the first gelatin network. (rsc.org)
  • Most interestingly, Gelatin/PAAm DN gels without any chemical crosslinkers in the second network enabled the achievement of both high mechanical strength and fast self-healing properties. (rsc.org)
  • ratio
  • The swelling ratio of ADA-GEL microcapsules of all compositions was significantly decreased, whereas the degradability was found to increase with the increase of gelatin ratio. (rsc.org)
  • natural
  • Differences from traditional 3D printing materials Printed at a much lower temperature (37 °C or below) Mild cross-linking conditions Natural derivation Bioactive Cell manipulatable Bioink compositions and chemistries are often inspired and derived from existing hydrogel biomaterials. (wikipedia.org)
  • cell
  • To address this, biomaterial therapy is being investigated as an approach to improve regeneration in the infarcted heart, as they can possess the potential to control cell function in the infarct environment and limit the adverse compensatory changes that occur post-MI. (frontiersin.org)
  • and various effects have been observed on different cell types depending on the biomaterial that is applied. (frontiersin.org)
  • A better understanding of how a biomaterial interacts with the different cell types in the heart may lead to the development of a more optimized biomaterial therapy for cardiac regeneration. (frontiersin.org)
  • GrowDex is NFC hydrogel for 3D cell culture commercialized by UPM, Finland. (wikipedia.org)
  • molecules
  • Upon the addition of Fe 3+ ions, the DOPA-modified gelatin formed a sticky hydrogel within seconds through complexation between the DOPA molecules and Fe 3+ ions. (rsc.org)
  • liver
  • The hemostatic ability of the DOPA-Fe 3+ gelatin hydrogels was explored using a hemorrhaging liver rat model. (rsc.org)
  • Shortly after the injection of the DOPA-Fe 3+ gelatin hydrogel, the bleeding was arrested in the hemorrhaging site of the liver. (rsc.org)
  • human
  • The tyrosine residues in human gelatin were converted into DOPA by enzymatic reaction with tyrosinase. (rsc.org)