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  • Alginate
  • In vitro evaluation showed good cell adherence and proliferation of bone marrow derived mesenchymal stem cells seeded on covalently crosslinked alginate dialdehyde-gelatin (ADA-GEL) hydrogel films with and without 0.1% nano-Bioglass ® (nBG). (mdpi.com)
  • The ability to form hydrogels in the presence of calcium ions that can be easily modulated into various shapes, the good in vitro and in vivo biocompatibility, low toxicity and its low price make alginate apromising candidate for tissue engineering applications[ 1 - 4 ]. (mdpi.com)
  • Important considerations in printability include: Uniformity in filament diameter Angles at the interaction of filaments "Bleeding" of filaments together at intersects Maintenance of shape fidelity after printing but before cross-linking Printing pressure and nozzle diameter Alginate is a naturally derived biopolymer from the cell wall of brown algae that has been widely used as a biomaterial. (wikipedia.org)
  • scaffold
  • This enables fabrication of cell-laden hydrogels with precise control over the architecture of the scaffold and the location of cells, growth factors, and other biological cues of interest. (springer.com)
  • The hydrogel scaffold facilitated early inflammatory cell infiltration that led to its rapid degradation, promoting the infiltration of angiogenic cells into the healing wounds. (pnas.org)
  • The potential advantages of hydrogel porogens include better rheological properties during injection, eventual elimination of the porogen leaching step, and the ability to load and deliver cells, bioactive molecules, or both within the hydrogel phase at the time of scaffold injection into the defective tissue site. (pubmedcentralcanada.ca)
  • In addition, the viability and adhesion of neonatal rat cardiomyocytes (NRCM) seeded onto the hydrogels was examined by in vivo imaging of NRCM-mediated scaffold contraction as well as by histological evaluation after immunostaining. (artificial-organs.com)
  • stiffness
  • Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. (ru.nl)
  • Increase in the ratio of thiol-modified gelatin reduced gel stiffness by diluting the effective concentration of the HA component. (wiley.com)
  • poly
  • Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. (springer.com)
  • regeneration
  • To address this, biomaterial therapy is being investigated as an approach to improve regeneration in the infarcted heart, as they can possess the potential to control cell function in the infarct environment and limit the adverse compensatory changes that occur post-MI. (frontiersin.org)
  • This review will provide a summary on the biomaterials developed to enhance cardiac regeneration and remodeling post-MI with a focus on how they control macrophages, cardiomyocytes, fibroblasts, and endothelial cells. (frontiersin.org)
  • A better understanding of how a biomaterial interacts with the different cell types in the heart may lead to the development of a more optimized biomaterial therapy for cardiac regeneration. (frontiersin.org)
  • Chemistries
  • Differences from traditional 3D printing materials Printed at a much lower temperature (37 °C or below) Mild cross-linking conditions Natural derivation Bioactive Cell manipulatable Bioink compositions and chemistries are often inspired and derived from existing hydrogel biomaterials. (wikipedia.org)
  • tissue-engineered
  • Doris Taylor's heart in a jar Tissue-engineered airway Tissue-engineered vessels Artificial skin constructed from human skin cells embedded in a hydrogel, such as in the case of bioprinted constructs for battlefield burn repairs. (wikipedia.org)
  • biocompatibility
  • Furthermore, renewable hydrogels display unique properties such as biodegradability, biocompatibility, stimuli-responsive characteristics and biological functions. (springer.com)
  • Extensive work has been done using alginates which are regarded as the most suitable biomaterials for cell microencapsulation due to their abundance, excellent biocompatibility and biodegradability properties. (wikipedia.org)
  • ionic
  • Bakarich SE, in het Panhuis M, Beirne S, Wallace GG, Spinks GM (2013) Extrusion printing of ionic-covalent entanglement hydrogels with high toughness. (springer.com)
  • Silicate nanoparticles (SiNP) are used for ionic crosslinking of gelatin to form stable hydrogel at body temperature (credit: Alberto Purwada et al. (cryonics.org)
  • Unlike the thermoplastics that are often utilized in traditional 3D printing, the chain entanglements and ionic interactions within the hydrogel-like bioink rather than temperature dominate shape fidelity. (wikipedia.org)
  • proteins
  • These hydrogels encompass light-sensitive naturally-derived proteins, shear-thinning biomaterial gels, and surgical sealants, each of which has opened new horizons for tissue engineering, minimally invasive medical procedures, and advanced biomedicine. (wikipedia.org)
  • Many biopolymers - proteins, carbohydrates, glycoproteins, and mucopolysaccharides - may be used to form hydrogels that contribute to temporary adhesion. (wikipedia.org)
  • shear
  • A second class of hydrogels pioneered by the group is a nanosilicate-based shear thinning gel that could be easily injected in a minimally invasive medical procedure. (wikipedia.org)
  • shape fidelity
  • Transparent crosslinked ultrashort peptide hydrogel dressing with high shape-fidelity accelerates healing of full-thickness excision wounds" (PDF). (wikipedia.org)
  • novel
  • In current study, we propose a novel concept of using hydrogel microparticles (MPs) as porogens to reproducibly form well-interconnected pore networks. (pubmedcentralcanada.ca)
  • Structural
  • Peppas N, Huang Y, Torres-Lugo M, Ward J, Zhang J (2000) Physicochemical foundations and structural design of hydrogels in medicine and biology. (springer.com)
  • physiological
  • Hydrogel MPs are incorporated into the injectable paste, they swell during mixing and injection to retain water in the pores, and instead of leaching out, the porogens create pores as they can degrade in physiological condition. (pubmedcentralcanada.ca)
  • However, at physiological temperatures, the viscosity of gelatin drops significantly. (wikipedia.org)
  • enables
  • The possibility to use the hydrogel with robotic dispensers enables its use in high throughput screening (HTS) formats. (wikipedia.org)
  • approaches
  • We then explain the different crosslinking methods commonly used in hydrogel printing and approaches to alter bioink crosslinking mechanisms. (springer.com)