GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome. (wikipedia.org)
Knockout of both GATA3 genes in mice is fatal: these animals die at embryonic days 11 and 12 due to internal bleeding. (wikipedia.org)
The GATA3 transcription factor regulates the expression of genes involved in the development of various tissues as well as genes involved in physiological as well as pathological humoral inflammatory and allergic responses. (wikipedia.org)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
One of the potential effects of TEs is the generation of new gene sequences [ 3 , 6 , 7 ] such as the envelope (env) genes of retroviral origin found in several mammals. (ecancer.org)
The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
With the development of high-throughput sequencing, genome-wide association studies (GWAS) and RNA sequencing (RNA-seq) have been extensively used in recent years to identify genomic regions and candidate genes associated with a variety of pork traits [ 3 - 5 ]. (animbiosci.org)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
Gene4
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. (wikipedia.org)
The GATA3 gene is located close to the end of the short arm of chromosome 10 at position p14. (wikipedia.org)
Expression of GATA3 may be regulated in part or at times by the antisense RNA, GATA3-AS1, whose gene is located close to the GATA3 gene on the short arm of chromosome 10 at position p14. (wikipedia.org)
Gene-deletion studies in mice indicate that Gata3 (mouse gene equivalent to GATA3) is critical for the embryonic development and/or function of various cell types (e.g. fat cells, neural crest cells, lymphocytes) and tissues (e.g. kidney, liver, brain, spinal cord, mammary gland). (wikipedia.org)
Protein5
GATA3 variant 1 is a linear protein consisting of 444 amino acids. (wikipedia.org)
GATA3 variant 2 protein is an identically structured isoform of, but 1 amino acid shorter than, GATA3 variant 1. (wikipedia.org)
The other zinc finger, ZNF1, is at the protein's N-terminus and interacts with various nuclear factors, including Zinc finger protein 1 (i.e. (wikipedia.org)
In addition, the peroxisome proliferator-activated receptor, phosphatidylinositol-3-kinase-protein kinase B, and mammalian target of rapamycin pathways were enriched in the pathway analysis. (animbiosci.org)
Unlike miRNAs whose central function is to restrain mRNA translation by inducing degradation, lncRNAs can act as numerous roles to exert their functions by directly or indirectly interacting with DNA, RNA or protein, even can encode some short peptides (Fig. 3 a-d) [ 6 ]. (biomedcentral.com)
Variant1
In many of these cases, a single exon is involved, and its transcription yields a variant mRNA [ 5 ]. (ecancer.org)
Chromosome1
The location of GATA3 borders that of other critical sites on chromosome 10, particularly a site located at 10p14-p13. (wikipedia.org)
Differences1
Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors . (biomedcentral.com)
20201
Animals: Client-owned cats with IRIS stage 3 CKD (n = 134), evaluated between 2017 and 2020. (preprints.org)
Diseases1
Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma. (wikipedia.org)
Regulatory factors1
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Differentiation1
Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)
Expression1
Statistical tools are required to analyze the large and hybridized as described previously (3, 10, 11) and according to standard amount of expression data generated by this methodology. (lu.se)
Animals2
Studies in humans implicate GATA3 in the following: 1) GATA3 is required for the development of the parathyroid gland, sensory components of the auditory system, and the kidney in animals and humans. (wikipedia.org)
Comparable studies in animals implicate GATA3 in the development of lymphocytes that mediate allergic and humoral immunity as well as allergic and humoral immune responses. (wikipedia.org)
Breast1
All three of these interleukins serve to promote allergic responses, 4) GATA3 induces the maturation of precursor cells into breast epithelial cells and maintains these cells in their mature state in mice and possibly humans. (wikipedia.org)
Clinical1
To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)
Responsible1
5) In mice, GATA3 is responsible for the normal development of various tissues including the skin, fat cells, the thymus, and the nervous system. (wikipedia.org)
Hundreds1
Hundreds of examples have been identified in which individual exons possess sequences that are similar or identical to TE fragments [ 3 , 4 ]. (ecancer.org)
Complex1
Large-scale deletions in GATA3 may span into the DiGeorge syndrome 2 area and thereby cause a complex syndrome with features of the Barakat syndrome combined with some of those of the DiGeorge syndrome 2. (wikipedia.org)
Mice3
Gene-deletion studies in mice indicate that Gata3 (mouse gene equivalent to GATA3) is critical for the embryonic development and/or function of various cell types (e.g. fat cells, neural crest cells, lymphocytes) and tissues (e.g. kidney, liver, brain, spinal cord, mammary gland). (wikipedia.org)
All three of these interleukins serve to promote allergic responses, 4) GATA3 induces the maturation of precursor cells into breast epithelial cells and maintains these cells in their mature state in mice and possibly humans. (wikipedia.org)
5) In mice, GATA3 is responsible for the normal development of various tissues including the skin, fat cells, the thymus, and the nervous system. (wikipedia.org)
Immune4
The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. (wikipedia.org)
Group 2 ILCs and Th2 cells, and thereby GATA3, are critical for the development of allergic and humoral immune responses in humans. (wikipedia.org)
Comparable studies in animals implicate GATA3 in the development of lymphocytes that mediate allergic and humoral immunity as well as allergic and humoral immune responses. (wikipedia.org)
The correlation between immune cells and the NDRG family was evaluated by the Tumor Immune Estimation Resource (TIMER) database. (nih.gov)
Pathological1
Several lncRNAs are recognized as key factors in the physiological and pathological processes of IS. (springer.com)
MRNA2
The mRNA of the NDRG family was investigated in The Cancer Genome Atlas (TCGA). (nih.gov)
N6-methyladenosine (m6A) was first discovered in eukaryotic messenger RNA (mRNA) [ 2 , 3 ] and viral nuclear RNA [ 4 , 5 ] in the 1970s and has been identified as one of the most common and abundant RNA modifications. (biomedcentral.com)
Signaling pathway1
Previous studies have established that the transforming growth factor β-mothers against decapentaplegic homolog 4 (SMAD4) signaling pathway is required for effective epithelial wound healing, and a conditional deletion of SMAD4 in the epidermis causes defects in skin wound healing, which are accompanied by spontaneous skin inflammation and SCC ( 6 ). (spandidos-publications.com)
Cells2
2) In humans, GATA3 is required for the development and/or function of innate lymphoid cells (ILCs), particularly Group 2 ILCs as well as for the development of T helper cells,(Th cells), particularly Th2 cells. (wikipedia.org)
3) GATA3 promotes the secretion of IL-4, IL-5, and IL-13 from Th2 cells in humans and has similar actions on comparable mouse lymphocytes. (wikipedia.org)
Pathways1
Additionally, talin 1 and laminin alpha 3, which participate in signaling pathways associated with adhesion and migration, have been previously observed to be overexpressed in SCC ( 9 ). (spandidos-publications.com)
Proteins1
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Plays1
GATA3 plays central role in allergy and immunity against worm infections. (wikipedia.org)
Studies1
Studies in humans implicate GATA3 in the following: 1) GATA3 is required for the development of the parathyroid gland, sensory components of the auditory system, and the kidney in animals and humans. (wikipedia.org)
Role1
However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear. (wikipedia.org)
Development1
Exposure to ultraviolet radiation, a potent mutagen and DNA-damaging agent, is considered to be a significant risk factor for the development of SCC ( 5 , 6 ). (spandidos-publications.com)
Alpha1
Following functional annotation, three upregulated transcription factors (TFs), including hypoxia inducible factor 1, alpha subunit (HIF1A), and six downregulated TFs were identified. (spandidos-publications.com)