• bowel
  • Impaired (i.e., slowed) motility of the gastrointestinal system, which can be involved in gastroesophageal reflux disease, gastroparesis (e.g., diabetic and postsurgical), irritable bowel syndrome and constipation, is one of the largest health care burdens of industrialized nations. (patentsencyclopedia.com)
  • Despite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a paucity of information regarding the ability of IBS patients to respond to acute experimental stress. (cambridge.org)
  • Gum chewing, an inexpensive intervention, is theorized to activate the cephalic- vagal reflex and increase the production of gastrointestinal hormones associated with bowel motility. (clinicaltrials.gov)
  • It has been researched for enhancing gastrointestinal motility, especially in gastroparesis and in aiding recovery of bowel function following gastrointestinal surgery, where opioid analgesic drugs used for post-operative pain relief may worsen existing constipation. (wikipedia.org)
  • doi: 10.1007/s00268-011-1335-9 PMID 22072430 Shaw M, Pediconi C, McVey D, Mondou E, Quinn J, Chamblin B, Rousseau F. Safety and efficacy of ulimorelin administered postoperatively to accelerate recovery of gastrointestinal motility following partial bowel resection: results of two randomized, placebo-controlled phase 3 trials. (wikipedia.org)
  • Peptides
  • doi: 10.1016/j.peptides.2011.03.014 PMID 21453735 Bochicchio G, Charlton P, Pezzullo JC, Kosutic G, Senagore A. Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data. (wikipedia.org)
  • They are discriminated from other cells of the gastrointestinal epithelial crypts by the presence of basally located granulations that contain serotonin and other peptides. (wikipedia.org)
  • physiological
  • The purpose of this study was to determine whether intravenous administration of CRH affects human gastrointestinal motility and whether CRH discriminates physiological responses in normal control subjects from those in IBS patients. (bmj.com)
  • However, this is incorrect, as it was discovered that these effects are achieved only with higher-than-normal physiological level, and that these results naturally occur in the body through a similar hormone, secretin. (wikipedia.org)
  • corticotropin releasi
  • 5 6 These phenomena in rats are mimicked by intracerebroventricular 6-9 or intravenous 9 administration of corticotropin releasing hormone (CRH) and are blocked by the CRH antagonist, α helical CRH 9-41 . (bmj.com)
  • insulin
  • Octreotide (trade name Sandostatin, among others) is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. (wikipedia.org)
  • The most frequent adverse effects (more than 10% of patients) are headache, hypothyroidism, cardiac conduction changes, gastrointestinal reactions (including cramps, nausea/vomiting and diarrhoea or constipation), gallstones, reduction of insulin release, hyperglycemia or hypoglycemia, and (usually transient) injection site reactions. (wikipedia.org)
  • receptors
  • Ghrelin and synthetic ghrelin mimetics (growth hormone secretagogues) increase body weight and fat mass by triggering receptors in the arcuate nucleus that include the orexigenic neuropeptide Y (NPY) and agouti-related protein (AgRP) neurons. (wikipedia.org)
  • growth
  • The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. (patentsencyclopedia.com)
  • Growth, reproduction, control of metabolic processes, sexual attributes, and even mental conditions and personality traits are dependent on hormones. (thefreedictionary.com)
  • Octreotide can also be used in the treatment of Acromegaly, a disorder of excessive growth hormone (GH). (wikipedia.org)
  • The receptor for ghrelin, the ghrelin/growth hormone secretagogue receptor (GHS-R), is found on the same cells in the brain as the receptor for leptin, the satiety hormone that has opposite effects from ghrelin. (wikipedia.org)
  • Ulimorelin (INN, USAN) (developmental code name TZP-101) is a drug with a modified cyclic peptide structure which acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). (wikipedia.org)
  • Unlike many related drugs, ulimorelin is peripherally selective and has little or no effect on growth hormone (GH) release, instead having a specific laxative effect. (wikipedia.org)
  • function
  • This Phase 2 trial is designed to evaluate the effects of RM-131 on symptoms and lower gastrointestinal (GI) function in patients with significant chronic constipation. (biospace.com)
  • The total number of hormones is still unknown, but each has its unique function and its own chemical formula. (thefreedictionary.com)
  • Through these cross connections, the gut can provide sensory information to the CNS, and the CNS can affect gastrointestinal function. (wikipedia.org)
  • inflammatory
  • The overproduction of cytokines [ 1 ] and inflammatory mediators may account for systemic inflammatory response once the onset of disease of AP, which might cause multiple organ dysfunctions and/or failures if the inflammatory response was out of control, including the gastrointestinal dysfunction and acute lung injury (ALI) at the early stage [ 2 ]. (hindawi.com)
  • As well as herbal formula, the effect of acupuncture on the inflammatory response and gastrointestinal motility was also explored. (hindawi.com)
  • reduce
  • The extent to which screening procedures reduce the incidence of gastrointestinal cancer or mortality depends on the rate of precancerous and cancerous disease in that population. (wikipedia.org)
  • symptoms
  • The test does not directly detect colon cancer but is often used in clinical screening for that disease, but it can also be used to look for active occult blood loss in anemia or when there are gastrointestinal symptoms. (wikipedia.org)
  • rats
  • The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and large intestine are interior exteriorly related" in traditional Chinese medicine. (hindawi.com)
  • estrogen
  • and the sex hormones, estrogen from the ovaries and androgen from the testes. (thefreedictionary.com)
  • Estrogen, or oestrogen, is the primary female sex hormone. (wikipedia.org)
  • The estrogen:ER complex binds to specific DNA sequences called a hormone response element to activate the transcription of target genes (in a study using an estrogen-dependent breast cancer cell line as model, 89 such genes were identified). (wikipedia.org)
  • Conclusion
  • CONCLUSION: The fact that the patient improved during pregnancy and breast feeding, would seem to indicate the involvement of factors in the physiology of pregnancy and breast feeding that are of importance for gastric motility. (biomedsearch.com)
  • chronic
  • Testoni P, Bagnolo F, Masci E, Colombo E, Tittobello A (1993) Different interdigestive antroduodenal motility patterns in chronic antral gastritis with and without Helicobacter pylori infection. (springer.com)