• GIST
  • This continuous activation leads to uncontrolled growth cell and an abolition of apoptosis, and is regarded as the main cause of GIST. (isciii.es)
  • imatinib
  • Indeed, dramatic tumor responses achieved with imatinib mesylate or dasatinib, two small molecule inhibitors of KIT, were observed, including cases of two patients with melanoma arising from the anorectal mucosa, one harboring an exon 13 K624E mutation and one harboring a seven-codon duplication of exon 11. (skincancer.org)
  • frequent
  • Globally, both men are remembered as fathers of neuroscience, but Spaniards of the 1920s also knew Ramón y Cajal as a frequent visitor to the museum, especially to the paintings of the famed Francisco de Goya. (visionlearning.com)
  • subtypes
  • Bastian and colleagues identified the existence of several distinct molecular subtypes of melanoma, each with a corresponding clinical subgroup and each characterized by a unique frequency of key genetic alterations.4,5 While KIT mutations or amplification were not observed in melanoma arising from non-chronically sun-damaged skin (non- CSD), these changes were observed in 29 percent of mucosal, 18 percent of acral, and 23 percent of CSD-melanomas. (skincancer.org)
  • tissue
  • Arias-Stella cells columnar cells in the endometrial epithelium which have a hyperchromatic enlarged nucleus and which appear to be associated with chorionic tissue in an intrauterine or extrauterine site. (thefreedictionary.com)
  • An astrocytic cell from rat brain grown in tissue culture and stained with antibodies to GFAP (red) and vimentin (green). (wikipedia.org)
  • They perform many functions, including biochemical support of endothelial cells that form the blood-brain barrier , provision of nutrients to the nervous tissue, maintenance of extracellular ion balance, and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. (wikipedia.org)
  • biology
  • Although a recent recruit, she previously spent a decade on the Farm as a Stanford undergraduate, medical student and graduate student and completed her PhD work with Prof. Irv Weissman one of the great leaders in stem cell biology. (stanford.edu)
  • clinical
  • Her primary clinical interest is in bone marrow failure and aplastic anemia, and in other diseases commonly neccessitating stem cell transplantation. (stanford.edu)
  • Clinical presentation is variable, and the most common symptoms are diffuse abdominal pain, gastrointestinal bleeding, fever, and a palpable mass or even obstruction. (isciii.es)
  • group
  • Her group is using cells and serum from both mice and primary specimens from healthy and diseased patients for these studies and using a variety of exciting new tools and methods to unlock future discoveries. (stanford.edu)
  • APUD cells [ a mine p recursor u ptake and d ecarboxylation] a group of cells that manufacture polypeptides and biogenic amines serving as hormones or neurotransmitters. (thefreedictionary.com)
  • they arise from the classic leiomyosarcomas of the gut as a group of sarcomas with different immunohistochemical features. (isciii.es)
  • walls
  • This type often has "vascular feet" that physically connect the cells to the outside of capillary walls when they are in proximity to them. (wikipedia.org)
  • diagnostic
  • This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach. (readbyqxmd.com)
  • studies
  • On the basis of several studies it is now believed that this model also applies to macroglial cell specification. (wikipedia.org)
  • cases
  • Most of these cases are described as idiopathic, or without a clear objective cause, and the array of potential causes or contributors is large. (acupunctureintegrated.com)
  • growth
  • This anomaly causes a permanent activation of the receptor and uncontrolled cell growth. (isciii.es)
  • Just as with neuronal cell specification, canonical signaling factors like Sonic hedgehog (SHH), Fibroblast growth factor (FGFs), WNTs and bone morphogenetic proteins (BMPs), provide positional information to developing macroglial cells through morphogen gradients along the dorsal-ventral, anterior-posterior and medial-lateral axes. (wikipedia.org)
  • structure
  • Cells are highly variable and specialized in both structure and function, although all must at some stage replicate proteins and nucleic acids, use energy, and reproduce themselves. (thefreedictionary.com)
  • A few simple dyes helped improve cell visibility , but early microscopists lacked stains that could elucidate cell structure. (visionlearning.com)
  • That was a major insight, though it would take another decade or so for cell theory to be accepted widely, and still more time before the idea of cells as building blocks would be applied to the most elusive biological structure, the brain. (visionlearning.com)
  • include
  • Though proposed 13 years prior, the idea that body tissues were composed of individual cells was not widely accepted among biologists, nor did cell theory even include the basic concept that all cells come from pre-existing cells. (visionlearning.com)
  • material
  • however, it was flawed with the idea that many of the cells within organisms arose through a crystallization process from material outside the organism. (visionlearning.com)
  • features
  • Confirmatory diagnosis is based on immunohistochemical features such as those of a highly cellular, spindle cell or epitheloid mesenchymal tumor that expresses the kit protein (7). (isciii.es)
  • However
  • However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. (stanford.edu)
  • He might have gone unnoticed in El Prado, however, alongside his Spanish counterpart whom museumgoers easily recognized as Santiago Ramón y Cajal. (visionlearning.com)
  • By the mid the 19th century, however, due to improvements both stains and microscope lenses, biologists were starting to see cells everywhere. (visionlearning.com)
  • made
  • Thus, a series of discoveries by Theodor Schwann and Matthias Jakob Schleiden led to the idea in the 1830s that all organisms were made up of cells. (visionlearning.com)
  • blood
  • In the following decades, biologists had observed individual bacteria , and also cells within animal fluids , such as red blood cells and sperm. (visionlearning.com)
  • unit
  • Consequently, cells could not be seen in all biological tissues, and science was not ready for the idea of the cell as the basic unit of life. (visionlearning.com)
  • present
  • Müller cells of the retina and Bergmann glia cells of the cerebellar cortex represent an exception, being present still during adulthood. (wikipedia.org)