• GIST
  • This continuous activation leads to uncontrolled growth cell and an abolition of apoptosis, and is regarded as the main cause of GIST. (isciii.es)
  • 1. A method for the treatment of a subject with Gastrointestinal Stromal Tumours (GIST), wherein said method comprises the administration of an effective amount of masitinib or a pharmaceutically acceptable salt thereof to said subject. (patentsencyclopedia.com)
  • imatinib
  • Indeed, dramatic tumor responses achieved with imatinib mesylate or dasatinib, two small molecule inhibitors of KIT, were observed, including cases of two patients with melanoma arising from the anorectal mucosa, one harboring an exon 13 K624E mutation and one harboring a seven-codon duplication of exon 11. (skincancer.org)
  • 20. The method of claim 1, wherein masitinib or a pharmaceutically acceptable salt thereof, in particular masitinib mesylate, inhibits the growth of imatinib-resistant cells. (patentsencyclopedia.com)
  • frequent
  • Globally, both men are remembered as fathers of neuroscience, but Spaniards of the 1920s also knew Ramón y Cajal as a frequent visitor to the museum, especially to the paintings of the famed Francisco de Goya. (visionlearning.com)
  • nerves
  • a collection of specialized cells that make up the main parts of the nervous system - the brain, spinal cord, and nerves of the body. (visionlearning.com)
  • Second-order neurons of the NTS comprise neurochemically and biophysically distinct neurons that receive sensory information conveyed by vagal, aortic depressor and glossopharyngeal nerves from the subdiaphragmatic gastrointestinal viscera, as well as from gustatory, oesophageal and cardiorespiratory areas 4 , 12 - 14 . (pubmedcentralcanada.ca)
  • mice
  • Her group is using cells and serum from both mice and primary specimens from healthy and diseased patients for these studies and using a variety of exciting new tools and methods to unlock future discoveries. (stanford.edu)
  • signals
  • Historically, vagovagal neurocircuits and reflexes were believed to be 'static' in their contribution to the control of gastrointestinal functions, whereby sensory signals conveyed from the gut to the brainstem generate a motor response that is relayed back to the gut in a reflexive manner (that is, the synaptic signal is not modulated by input from other neurocircuits). (pubmedcentralcanada.ca)
  • Molecular
  • Bastian and colleagues identified the existence of several distinct molecular subtypes of melanoma, each with a corresponding clinical subgroup and each characterized by a unique frequency of key genetic alterations.4,5 While KIT mutations or amplification were not observed in melanoma arising from non-chronically sun-damaged skin (non- CSD), these changes were observed in 29 percent of mucosal, 18 percent of acral, and 23 percent of CSD-melanomas. (skincancer.org)
  • biology
  • Although a recent recruit, she previously spent a decade on the Farm as a Stanford undergraduate, medical student and graduate student and completed her PhD work with Prof. Irv Weissman one of the great leaders in stem cell biology. (stanford.edu)
  • clinical
  • Her primary clinical interest is in bone marrow failure and aplastic anemia, and in other diseases commonly neccessitating stem cell transplantation. (stanford.edu)
  • Clinical presentation is variable, and the most common symptoms are diffuse abdominal pain, gastrointestinal bleeding, fever, and a palpable mass or even obstruction. (isciii.es)
  • group
  • APUD cells [ a mine p recursor u ptake and d ecarboxylation] a group of cells that manufacture polypeptides and biogenic amines serving as hormones or neurotransmitters. (thefreedictionary.com)
  • they arise from the classic leiomyosarcomas of the gut as a group of sarcomas with different immunohistochemical features. (isciii.es)
  • diagnostic
  • This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach. (readbyqxmd.com)
  • function
  • Cells are highly variable and specialized in both structure and function, although all must at some stage replicate proteins and nucleic acids, use energy, and reproduce themselves. (thefreedictionary.com)
  • growth
  • This anomaly causes a permanent activation of the receptor and uncontrolled cell growth. (isciii.es)
  • highly
  • Confirmatory diagnosis is based on immunohistochemical features such as those of a highly cellular, spindle cell or epitheloid mesenchymal tumor that expresses the kit protein (7). (isciii.es)
  • cases
  • Most of these cases are described as idiopathic, or without a clear objective cause, and the array of potential causes or contributors is large. (acupunctureintegrated.com)
  • include
  • Though proposed 13 years prior, the idea that body tissues were composed of individual cells was not widely accepted among biologists, nor did cell theory even include the basic concept that all cells come from pre-existing cells. (visionlearning.com)
  • features
  • It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical reactivity for melanocytic markers. (readbyqxmd.com)
  • However
  • However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. (stanford.edu)
  • He might have gone unnoticed in El Prado, however, alongside his Spanish counterpart whom museumgoers easily recognized as Santiago Ramón y Cajal. (visionlearning.com)
  • By the mid the 19th century, however, due to improvements both stains and microscope lenses, biologists were starting to see cells everywhere. (visionlearning.com)
  • however, it was flawed with the idea that many of the cells within organisms arose through a crystallization process from material outside the organism. (visionlearning.com)
  • types
  • The different types of cells in breast cancer impacts the way individuals respond to various treatments. (stanford.edu)
  • amacrine cell any of five types of retinal neurons that seem to lack large axons, having only processes that resemble dendrites. (thefreedictionary.com)
  • unit
  • Consequently, cells could not be seen in all biological tissues, and science was not ready for the idea of the cell as the basic unit of life. (visionlearning.com)
  • blood
  • In the following decades, biologists had observed individual bacteria , and also cells within animal fluids , such as red blood cells and sperm. (visionlearning.com)