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  • duodenal
  • Pathologic gastrointestinal (GI) hypersecretory conditions such as Zollinger-Ellison syndrome Gastroesophageal reflux disease (GERD) Erosive esophagitis Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence Recurrent postoperative ulcer Upper GI bleeding Prevention of acid-aspiration pneumonitis during surgery: ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. (wikipedia.org)
  • orally
  • The intestinal epithelium is an important site for the absorption of orally administered drugs via paracellular and transcellular routes and is exposed to a variety of factors present in the intestinal lumen. (aspetjournals.org)
  • model
  • In this model, ranitidine permeability in the mucosal-to-serosal direction decreased by ≈95% as monolayer resistance increased from 150 to 500 Ω/cm 2 , indicating a primarily paracellular route of transport. (aspetjournals.org)
  • studies
  • Two studies were conducted in healthy volunteers to confirm the involvement of an excipient, SAPP (sodium acid pyrophosphate), and the mechanism of interaction, altered gastrointestinal transit. (springer.com)
  • system
  • The float formulation is an efficient approach to extend the residence time in stomach to increase the absorption of less soluble or less stable drugs in digestive system. (hindawi.com)
  • high
  • Robotic solid phase extraction and high performance liquid chromatography analysis of ranitidine in serum or plasma. (springer.com)
  • risk
  • Ranitidine can also be given with NSAIDs to reduce the risk of ulceration. (wikipedia.org)
  • Prevention of acid-aspiration pneumonitis during surgery: ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. (wikipedia.org)
  • cimetidine
  • Roxatidine acetate (TZU 0460/HOE 760) [N-(3-[3-(1-piperidinylmethyl)-phenoxy]-propyl)acetoxyacetamide hydrochloride] is a specific and competitive H2-receptor antagonist with a chemical structure different from those of cimetidine, ranitidine and famotidine. (semanticscholar.org)
  • Another champion of the approach of developing chemical analogues of known active substances was Sir David Jack at Allen and Hanbury's, later Glaxo, who pioneered the first inhaled selective beta2-adrenergic agonist for asthma, the first inhaled steroid for asthma, ranitidine as a successor to cimetidine, and supported the development of the triptans. (wikipedia.org)
  • Ranitidine causes fewer CNS adverse reactions and drug interactions compared to cimetidine. (wikipedia.org)
  • risk
  • Pathologic gastrointestinal (GI) hypersecretory conditions such as Zollinger-Ellison syndrome Gastroesophageal reflux disease (GERD) Erosive esophagitis Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence Recurrent postoperative ulcer Upper GI bleeding Prevention of acid-aspiration pneumonitis during surgery: ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. (wikipedia.org)
  • In a 2009 meta-analysis comparing the net benefit of proton pump inhibitors and ranitidine to reduce the risk of aspiration before anesthesia, ranitidine was found to be more effective than proton pump inhibitors in reducing the volume of gastric secretions. (wikipedia.org)