• proteins
  • We conclude that rabbit gastric parietal cells possess functional A2BR proteins that are coupled to G s and stimulate HCl production upon activation. (physiology.org)
  • To fulfill these tasks in a regulated manner, the parietal cell is equipped with an exclusive collection of apical and basolateral ion transporter proteins that are exposed on the membrane whenever their functions are required (see e.g., review Ref. 45 ). (physiology.org)
  • This secretion system transports various molecules, from ions, drugs, to proteins of various sizes (20 - 900 kDa). (wikipedia.org)
  • Increased cAMP level results in increased protein kinase A. Protein kinase A phosphorylates proteins involved in the transport of H+/K+ ATPase from the cytoplasm to the cell membrane. (wikipedia.org)
  • ions
  • Chloride and hydrogen ions are secreted separately from the cytoplasm of parietal cells and mixed in the canaliculi. (wikipedia.org)
  • This creates a negative potential of -40 mV to -70 mV across the parietal cell membrane that causes potassium ions and a small number of sodium ions to diffuse from the cytoplasm into the parietal cell canaliculi. (wikipedia.org)
  • The hydrogen ions leave the cell through H+/K+ ATPase antiporter pumps. (wikipedia.org)
  • To prevent these disastrous effects, mucus and bicarbonate ions (HCO3−) are secreted by the foveolar cells. (wikipedia.org)
  • Hydrolysis of one ATP molecule is used to catalyse the electroneutral exchange of two luminal potassium ions for two cytoplasmic protons through the gastric membrane. (wikipedia.org)
  • Hydrogen ions are pumped out of the cell into the canaliculi in exchange for potassium ions, via the H+/K+ ATPase. (wikipedia.org)
  • This causes resorption of K+ ions and secretion of H+ ions. (wikipedia.org)
  • vagus nerves
  • Stretch activates two reflexes: a short reflex mediated through the myenteric nerve plexus, and a long reflex mediated through the vagus nerves and brainstem. (wikipedia.org)
  • 2.) Vagus nerves carry parasympathetic action potentials to the stomach (pink arrow), where enteric plexus neurons are activated. (prezi.com)
  • Action potentials generated by the chemoreceptors are carried by the vagus nerves to the medulla oblongata (green arrow), where they inhibit parasympathetic action potentials (pink arrow), thereby decreasing gastric secretions. (prezi.com)
  • peptide
  • The molecules secreted vary in size from the small Escherichia coli peptide colicin V, (10 kDa) to the Pseudomonas fluorescens cell adhesion protein LapA of 900 kDa. (wikipedia.org)
  • The vagus nerve (CN X) also releases gastrin releasing peptide onto G cells. (wikipedia.org)
  • These cells are stimulated by the hormones gastrin (not depicted in the adjacent diagram) and pituitary adenylyl cyclase-activating peptide. (wikipedia.org)
  • Enterochromaffin-like cells also produce pancreastatin and probably other peptide hormones and growth factors. (wikipedia.org)
  • membrane
  • The is a substantial increase (50-100 fold) in the surface area of the apical membrane of the parietal cell, as well as the appearance of microvilli. (slideserve.com)
  • To discover if HGT-1 cells have additional properties found in parietal cells, [3H]omeprazole and patch clamp recording techniques were used to evaluate specific omeprazole binding sites and K+ channels in the plasma membrane. (bmj.com)
  • Omeprazole
  • HGT-1 cells exhibited [3H]omeprazole binding in the non-stimulated state, which increased 100% in the presence of 1 mM histamine. (bmj.com)
  • Unpublished data from UC Davis found that administration of only two doses of omeprazole 18-24 hours apart in 10 cats resulted in a mean gastric pH of 7.2 compared to a pH of 2.8 with placebo administration. (vetbloom.com)