• PPIs
  • Objective Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy, particularly in Helicobacter pylori (HP)-infected subjects. (bmj.com)
  • We determined the association between PPIs use and gastric cancer (GC) among HP-infected subjects who had received HP therapy. (bmj.com)
  • Previous studies have shown that the risk of gastric cancer was increased by 43% among PPIs users but the major confounding factor, H. pylori , was not adjusted in these analyses and the causal relationship may be biased. (bmj.com)
  • Long-term PPIs use was associated with a 2.4-fold increase in gastric cancer risk in H. pylori -infected subjects who had received eradication therapy. (bmj.com)
  • The risk of gastric cancer increases with the dose and duration of PPIs use. (bmj.com)
  • Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+/K+ ATPase) and inhibit gastric acid secretion. (wikipedia.org)
  • endoscopy
  • Tytgat GN, Mathus-Vliegen EM, Offerhaus J: Value of endoscopy in the surveillance of high-risk groups for gastrointestinal cancer. (cancer.gov)
  • Nondysplastic and low-grade patients are generally advised to undergo annual observation with endoscopy, with radiofrequency ablation as a therapeutic option. (wikipedia.org)
  • Genetic
  • When a cancer cell divides, both daughter cells inherit the genetic and epigenetic abnormalities of the parent cell, and may also acquire new genetic and epigenetic abnormalities in the process of cellular reproduction. (wikipedia.org)
  • Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation. (wikipedia.org)
  • Besides understanding the underlying genetic mechanisms that initiate or drive cancer progression, oncogenomics targets personalized cancer treatment. (wikipedia.org)
  • sporadic
  • In 1971, Knudson published the 2-hit hypothesis for mutation and cancer based on statistical analysis of inherited and sporadic cases of retinoblastoma. (wikipedia.org)
  • surgery
  • He did not limit himself to surgery only, and conducted extensive research on an ailment that affected many surgery patients at the time: wound fever. (wikipedia.org)
  • The group focuses on pancreatic cancer, other gastrointestinal and hepatobiliary malignancies, vascular disease, and transplant surgery. (wikipedia.org)
  • Pancreatic cancer and pancreatic disease Other gastrointestinal and hepatobiliary malignancies Vascular disease Transplant surgery and transplant psychology Investigating factors that affect surgical outcomes for diverse specialties including colorectal, cardiovascular, transplant, plastic and reconstructive, and minimally invasive surgery Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. (wikipedia.org)
  • See also: Beth Israel Deaconess Medical Center website SOAR researchers use national health services and administrative databases as well as prospective institutional tissue-linked databases to investigate factors contributing to disease outcomes for pancreatic cancer, hepato biliary disease, vascular disease, colorectal disease, plastic and reconstructive surgery, and transplant medicine. (wikipedia.org)
  • pathways
  • Conclusion: We identified some downregulated miRNAs involved in gastric cancer pathways and mechanisms of drug resistance that should manage to determine a predictable miRNA signature to perform a correct patient selection for GC treatments. (aacrjournals.org)
  • They did have potential functions in metabolic pathways that suggested mechanisms by which they could act to promote cancer (KNDC1, GPR124, EB12, GRINC1B) These genes are involved in pathways known to contribute to cancer pathogenesis, but before this study most would not have been candidates for targeted gene therapy. (wikipedia.org)
  • 2017
  • With approvals for two cancers in 2017, our companies have made tremendous progress with avelumab on behalf of patients this year, and we are confident that our broad clinical development program in both monotherapy and combinations across a range of cancers will continue to bring new potential treatment options to patients. (perssupport.nl)
  • In 2017, it is estimated that 28,000 Americans will be diagnosed with gastric cancer and 10,960 will die of it. (cancer.gov)
  • Oncology
  • Gastric cancer is a leading cause of cancer death globally with clear unmet needs, and the results provide important insights as we continue to investigate the role of avelumab for the treatment of gastric cancer," said Chris Boshoff, M.D., Ph.D., Senior Vice President and Head of Immuno-Oncology, Early Development and Translational Oncology, Pfizer Global Product Development. (perssupport.nl)
  • treatment
  • There may be some benefit with this treatment in patients with node-positive disease and higher N-ratio. (springer.com)
  • In INT 0116[ 7 ], only 64% of the patients completed treatment protocol. (springer.com)
  • The accuracy of survival prediction for patients with GC is pivotal for postoperative treatment decisions and surveillance. (jcancer.org)
  • Avelumab is under clinical investigation for treatment of gastric/GEJ cancer and has not been demonstrated to be safe and effective for this indication. (perssupport.nl)
  • The success of targeted cancer therapies such as Gleevec, Herceptin and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment. (wikipedia.org)
  • Identifying and targeting the mutations in an individual patient may lead to increased treatment efficacy. (wikipedia.org)
  • Proton
  • This very large (>106-fold) H+ gradient is generated by the gastric H+/K+ ATPase which is an ATP-driven proton pump. (wikipedia.org)
  • outcomes
  • Conventionally, the outcomes of radically resected GC are predicted based on the pathological tumour invasion depth and lymph node status, which are addressed in the American Joint Committee on Cancer (AJCC) TNM classification [ 4 ]. (jcancer.org)
  • Therefore, a major challenge for improving clinical outcomes is to understand the molecular mechanisms that may play essential roles in patients responses of GC treatments. (aacrjournals.org)
  • Outcomes Research evaluates the impact of health care on the health outcomes of patients and populations (see AHRQ for further details). (wikipedia.org)
  • SOAR members hope, as part of the surgical outcomes research community, to improve overall outcomes for patients with surgical diseases. (wikipedia.org)
  • Gene
  • Utilising gene expression data coupled with in-vitro, in-vivo or clinical response data is a promising strategy that may enable clinicians to match the right drug to the right patient. (clinicaltrials.gov)
  • increases
  • Preconditioning melanoma patients with total body irradiation (TBI) before adoptive transfer of T cells increases objective and curative responses. (aacrjournals.org)
  • accuracy
  • Our purpose was to determine the accuracy of EUS and CT for preoperative staging of gastric cancer and to identify factors that may affect their usefulness in selecting patients for preoperative therapy. (amegroups.com)
  • data
  • The JAVELIN Gastric 300 data will be further examined in an effort to better understand the results and will also be submitted for presentation at an upcoming medical congress. (perssupport.nl)
  • somatic
  • Somatic evolution is important in the process of aging as well as the development of some diseases, including cancer. (wikipedia.org)
  • Early mathematical modeling of cancer, by Armitage and Doll, set the stage for the future development of the somatic evolutionary theory of cancer. (wikipedia.org)
  • Access to cancerous and normal tissue samples from the same patient and the fact that most cancer mutations represent somatic events, allow the identification of cancer-specific mutations. (wikipedia.org)
  • mutations
  • Researchers hypothesized that cancer evolves in a sequence of chromosomal mutations and selection and that therapy may further select clones. (wikipedia.org)
  • Cancer develops due to DNA mutations and epigenetic alterations that accumulate randomly. (wikipedia.org)
  • Cancer mutations are cumulative and sometimes are related to disease stage. (wikipedia.org)
  • The remaining 8 were new mutations and all were single base changes: Four were in families that are strongly associated with cancer pathogenesis (PTPRT, CDH24, PCLKC and SLC15A1). (wikipedia.org)
  • The initiative allows such exceptional patients (who have responded positively for at least six months to a cancer drug that usually fails) to have their genomes sequenced to identify the relevant mutations. (wikipedia.org)
  • Once identified, other patients could be screened for those mutations and then be given the drug. (wikipedia.org)
  • disease
  • Access to methylation profiling is important to cancer research because: Epi-drivers, along with Mut-drivers, can act as immediate causes of cancers Cancer epimutations are cumulative and sometimes related to disease stage The first cancer genome was sequenced in 2008. (wikipedia.org)
  • Years
  • Over the last 15 years, large randomized controlled studies have validated the benefit of preoperative therapy for patients with resectable gastric cancer. (amegroups.com)
  • A notable overall increase in cardia cancer was evident in the Western population during the study period, with no similar change evident in the Japanese population over the last 15 years. (jcancer.org)
  • 1 ] Two-thirds of people diagnosed with gastric cancer are older than 66 years. (cancer.gov)