• resection
  • Although the current treatment guideline for early-stage LA patients is composed mainly of follow-up without adjuvant therapy after resection, the current study raises an interesting possibility that additional clinical interventions might provide benefits for early-stage LA patients who have genomic alterations to the RB pathway. (aacrjournals.org)
  • PPIs
  • Objective Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy, particularly in Helicobacter pylori (HP)-infected subjects. (bmj.com)
  • We determined the association between PPIs use and gastric cancer (GC) among HP-infected subjects who had received HP therapy. (bmj.com)
  • Previous studies have shown that the risk of gastric cancer was increased by 43% among PPIs users but the major confounding factor, H. pylori , was not adjusted in these analyses and the causal relationship may be biased. (bmj.com)
  • Long-term PPIs use was associated with a 2.4-fold increase in gastric cancer risk in H. pylori -infected subjects who had received eradication therapy. (bmj.com)
  • The risk of gastric cancer increases with the dose and duration of PPIs use. (bmj.com)
  • Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+/K+ ATPase) and inhibit gastric acid secretion. (wikipedia.org)
  • prognosis
  • To refine the prediction of prognosis in patients with GC, two ratio-based nodal staging systems have been proposed: the lymph node ratio (LNR) [ 7 ], defined as the ratio between MLNs and THNs, and the log odds of metastatic lymph nodes (LODDS) [ 8 ], defined as the log of the ratio between the number of MLNs and number of negative lymph nodes (NLNs). (jcancer.org)
  • pathways
  • Conclusion: We identified some downregulated miRNAs involved in gastric cancer pathways and mechanisms of drug resistance that should manage to determine a predictable miRNA signature to perform a correct patient selection for GC treatments. (aacrjournals.org)
  • They did have potential functions in metabolic pathways that suggested mechanisms by which they could act to promote cancer (KNDC1, GPR124, EB12, GRINC1B) These genes are involved in pathways known to contribute to cancer pathogenesis, but before this study most would not have been candidates for targeted gene therapy. (wikipedia.org)
  • 2017
  • With approvals for two cancers in 2017, our companies have made tremendous progress with avelumab on behalf of patients this year, and we are confident that our broad clinical development program in both monotherapy and combinations across a range of cancers will continue to bring new potential treatment options to patients. (perssupport.nl)
  • pancreatic cancer
  • The group focuses on pancreatic cancer, other gastrointestinal and hepatobiliary malignancies, vascular disease, and transplant surgery. (wikipedia.org)
  • Pancreatic cancer and pancreatic disease Other gastrointestinal and hepatobiliary malignancies Vascular disease Transplant surgery and transplant psychology Investigating factors that affect surgical outcomes for diverse specialties including colorectal, cardiovascular, transplant, plastic and reconstructive, and minimally invasive surgery Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. (wikipedia.org)
  • See also: Beth Israel Deaconess Medical Center website SOAR researchers use national health services and administrative databases as well as prospective institutional tissue-linked databases to investigate factors contributing to disease outcomes for pancreatic cancer, hepato biliary disease, vascular disease, colorectal disease, plastic and reconstructive surgery, and transplant medicine. (wikipedia.org)
  • Electronic medical record: research tool for pancreatic cancer? (wikipedia.org)
  • surgery
  • He did not limit himself to surgery only, and conducted extensive research on an ailment that affected many surgery patients at the time: wound fever. (wikipedia.org)
  • intraperitoneal
  • Our search strategy consisted of combining the medical subject headings (MeSH) terms as well as using the standard PubMed syntax: "stomach neoplasm/" AND ("peritoneal lavage/" OR "positive peritoneal cytology.tw" OR "intraperitoneal free cancer cells.tw") NOT [(gastrointestinal stromal tum$).tw OR GIST.tw]. (springer.com)
  • Oncology
  • Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX ABSTRACT not differ between the cN0/ypN0 and cN? (deepdyve.com)
  • Gastric cancer is a leading cause of cancer death globally with clear unmet needs, and the results provide important insights as we continue to investigate the role of avelumab for the treatment of gastric cancer," said Chris Boshoff, M.D., Ph.D., Senior Vice President and Head of Immuno-Oncology, Early Development and Translational Oncology, Pfizer Global Product Development. (perssupport.nl)
  • curative
  • Preconditioning melanoma patients with total body irradiation (TBI) before adoptive transfer of T cells increases objective and curative responses. (aacrjournals.org)
  • Proton
  • This very large (>106-fold) H+ gradient is generated by the gastric H+/K+ ATPase which is an ATP-driven proton pump. (wikipedia.org)
  • treatment
  • There may be some benefit with this treatment in patients with node-positive disease and higher N-ratio. (springer.com)
  • In INT 0116[ 7 ], only 64% of the patients completed treatment protocol. (springer.com)
  • 0.05), and the recurrence rate among patients with previous anti-TB treatment was 18% (4/22) after gastric cancer diagnosis. (springer.com)
  • There is no universal consensus on the most appropriate treatment regimen for this particular patient group. (springer.com)
  • The accuracy of survival prediction for patients with GC is pivotal for postoperative treatment decisions and surveillance. (jcancer.org)
  • Avelumab is under clinical investigation for treatment of gastric/GEJ cancer and has not been demonstrated to be safe and effective for this indication. (perssupport.nl)
  • The success of targeted cancer therapies such as Gleevec, Herceptin and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment. (wikipedia.org)
  • Besides understanding the underlying genetic mechanisms that initiate or drive cancer progression, oncogenomics targets personalized cancer treatment. (wikipedia.org)
  • Identifying and targeting the mutations in an individual patient may lead to increased treatment efficacy. (wikipedia.org)
  • Gene
  • Utilising gene expression data coupled with in-vitro, in-vivo or clinical response data is a promising strategy that may enable clinicians to match the right drug to the right patient. (clinicaltrials.gov)
  • identify
  • therefore, whether CT or EUS can reliably identify patients eligible for preoperative therapy is still unclear. (amegroups.com)
  • Our purpose was to determine the accuracy of EUS and CT for preoperative staging of gastric cancer and to identify factors that may affect their usefulness in selecting patients for preoperative therapy. (amegroups.com)
  • All patients were checked against the registration system of the Centers for Disease Control (CDC) in Taiwan or by chart review to identify a case of active TB. (springer.com)
  • The initiative allows such exceptional patients (who have responded positively for at least six months to a cancer drug that usually fails) to have their genomes sequenced to identify the relevant mutations. (wikipedia.org)
  • pathological
  • Conventionally, the outcomes of radically resected GC are predicted based on the pathological tumour invasion depth and lymph node status, which are addressed in the American Joint Committee on Cancer (AJCC) TNM classification [ 4 ]. (jcancer.org)
  • regimen
  • Patients who failed this regimen, and those diagnosed to have GC within 12 months after HP therapy, or gastric ulcer after therapy were excluded. (bmj.com)
  • trials
  • trials) this searches for the phrase 'kidney cancer' in the title as well as either the word 'trial' or 'trials' in description. (medworm.com)
  • Data
  • The JAVELIN Gastric 300 data will be further examined in an effort to better understand the results and will also be submitted for presentation at an upcoming medical congress. (perssupport.nl)