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  • Proton
  • Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. (clinicaltrials.gov)
  • The use of antacids or drugs that decrease gastric acid production (such as H2-receptor antagonists) or transport (such as proton pump inhibitors). (wikipedia.org)
  • In a 2009 meta-analysis comparing the net benefit of proton pump inhibitors and ranitidine to reduce the risk of aspiration before anesthesia, ranitidine was found to be more effective than proton pump inhibitors in reducing the volume of gastric secretions. (wikipedia.org)
  • In comparison to other acid-suppressing medications, such as histamine-2 (H2) receptor antagonists, proton pump inhibitors (PPI) are considered to be more potent at effectively inhibiting acid secretion. (freece.com)
  • Proton pump inhibitors are now FDA approved for healing erosive esophagitis (EE), maintenance of healed EE, risk reduction for development of gastric ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs), short-term treatment and maintenance of duodenal ulcers, pathological hypersecretory diseases such as Zollinger-Ellison (ZE) syndrome, and as a part of a multidrug regimen for Helicobacter pylori eradication. (freece.com)
  • Rabeprazole is a proton pump inhibitor that suppresses gastric acid production in the stomach. (wikipedia.org)
  • Like other medications in the proton pump inhibitor class, rabeprazole's mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. (wikipedia.org)
  • Rabeprazole, like other proton pump inhibitors such as omeprazole, is used for the purposes of gastric acid suppression. (wikipedia.org)
  • Rabeprazole-based products, like other proton pump inhibitor products, have to be formulated in delayed-release tablets to protect the active medication from being degraded by the acid of the stomach before being absorbed. (wikipedia.org)
  • Drugs to Treat Heartburn and Stomach Acid Reflux: The Proton Pump Inhibitors - Comparing Effectiveness, Safety, and Price" (PDF). (wikipedia.org)
  • Evidence emerged by the end of the 1970s that the newly discovered proton pump (H+/K+ ATPase) in the secretory membrane of the parietal cell was the final step in acid secretion. (wikipedia.org)
  • Optimization of substituted benzimidazoles and their antisecretory effects were studied on the newly discovered proton pump to obtain higher pKa values of the pyridine, thereby facilitating accumulation within the parietal cell and increasing the rate of acid-mediated conversion to the active mediate. (wikipedia.org)
  • This very large (>106-fold) H+ gradient is generated by the gastric H+/K+ ATPase which is an ATP-driven proton pump. (wikipedia.org)
  • A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). (wikipedia.org)
  • Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. (wikipedia.org)
  • The medication used to decrease acid is usually either a proton pump inhibitor (PPI) or an H2 blocker with four weeks of treatment initially recommended. (wikipedia.org)
  • Omeprazole is a proton-pump inhibitor and as such blocks the release of stomach acid. (wikipedia.org)
  • sold under the brand names Nexium or Nexum, among others) is a proton-pump inhibitor which reduces stomach acid. (wikipedia.org)
  • Gastrointestinal
  • Finally, by suppressing acid-mediated breakdown of proteins, ranitidine may lead to an elevated risk of developing food or drug allergies, due to undigested proteins then passing into the gastrointestinal tract, where sensitisation occurs. (wikipedia.org)
  • Now, all major gastrointestinal societies agree that H. pylori is the primary nondrug cause of PUD worldwide, and advocate its eradication as essential to treatment of gastric and duodenal ulcers. (wikipedia.org)
  • More than 50% of the world's population have H. pylori in their upper gastrointestinal tract. (wikipedia.org)
  • esophageal
  • A complete 24-hour profile of gastric acid secretion is best obtained during an esophageal pH monitoring study. (wikipedia.org)
  • A lower prevalence of Barrett's metaplasia and esophageal adenocarcinoma has also been described in individuals who were H. pylori positive [ 5,6 ]. (uptodate.com)
  • Some studies suggested that H. pylori strains positive for Cag A (strains strongly associated with the development of corpus gastritis) may be particularly protective against the development of esophageal adenocarcinoma [ 7-9 ]. (uptodate.com)
  • treatment
  • CONCLUSIONS: The acid-secreting mucosa in the fundus expanded in most cases with fundic atrophic gastritis after H pylori eradication, which could be responsible for the increase in acid secretion after the treatment. (biomedsearch.com)
  • For ulcer treatment, a night-time dose is especially important - as the increase in gastric/duodenal pH promotes healing overnight when the stomach and duodenum are empty. (wikipedia.org)
  • Vonoprazan: A Novel and Potent Alternative in the Treatment of Acid-Related Diseases. (atgcchecker.com)
  • Recently, the efficacy and safety of a new acid suppressant named vonoprazan in the treatment of acid-related diseases have been evaluated by a series of studies. (atgcchecker.com)
  • As a safe and effective acid inhibitor, vonoprazan might be a novel alternative in the treatment of acid-related diseases. (atgcchecker.com)
  • Treatment involves acid suppression, eradication of H. pylori (if present), and avoidance of NSAIDs. (merckmanuals.com)
  • Rabeprazole is also useful alongside antibiotic therapy for the treatment of the pathogen Helicobacter pylori, which otherwise thrives in acidic environments. (wikipedia.org)
  • 1868 Kussmaul suggests using bismuth compounds, an antibacterial agent, to treat peptic ulcers (bismuth subsalicylate has since been used in many commercial drugs, including Pepto Bismol as part of antibacterial H. pylori treatment). (wikipedia.org)
  • Treatment includes stopping smoking, stopping NSAIDs, stopping alcohol and giving medications to decrease stomach acid. (wikipedia.org)
  • Prevention
  • Prevention of acid-aspiration pneumonitis during surgery: ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. (wikipedia.org)
  • peptides
  • Acidic environment of stomach helps conversion of pepsinogen into pepsin which is most important to digest the protein into smaller component like complex protein into simple peptides and amino acids inside stomach which is later absorbs by gastro intestinal tract. (wikipedia.org)
  • pathogenesis
  • In this article, we present an overview of recent advances in the understanding of H. pylori-commensal interactions in the pathogenesis and clinical evolution of H. pylori-associated gastric malignancies. (deepdyve.com)
  • stomach acid
  • Even without bacterial overgrowth, low stomach acid (high pH) can lead to nutritional deficiencies through decreased absorption of basic electrolytes (magnesium, zinc, etc.) and vitamins (including vitamin C, vitamin K, and the B complex of vitamins). (wikipedia.org)
  • Chloride, sodium, potassium, zinc and/or iodine deficiency, as these elements are needed to produce adequate levels of stomach acid (HCl). (wikipedia.org)
  • The "Heidelberg test" is an alternative way to measure stomach acid and diagnose hypochlorhydria/achlorhydria. (wikipedia.org)
  • Ranitidine , sold under the trade name Zantac among others, is a medication which decreases stomach acid production. (wikipedia.org)
  • Famotidine, sold under the trade name Pepcid among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. (wikipedia.org)
  • By inhibiting the functioning of this transporter, the drug prevents formation of stomach acid. (wikipedia.org)
  • inhibitory effect
  • 4. Rossowski WJ, Zacharia S, Mungan Z, Ozmen V, Ertan A, Baylor LM, Jiang NY, Coy DH:Reduced gastric acid inhibitory effect of a pGIP(1-30) NH2 fragment with potent pancreatic amylase inhibitory activity. (wikipedia.org)
  • ranitidine
  • Ranitidine is an H 2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach. (wikipedia.org)
  • Helicobacter pylori eradication protocols In the United States, all four FDA-approved members of the group-cimetidine, ranitidine, famotidine, and nizatidine-are available over the counter in relatively low doses. (wikipedia.org)
  • dyspepsia
  • We aimed to observe SPA and oxidative stress in nonulcer dyspepsia (NUD) infected with and without H. pylori among eastern Indians. (hindawi.com)
  • Due to its different prevalence and diversity of strains, we aimed to observe oxidative stress and serum prolidase activity in patients with H. pylori infected nonulcer dyspepsia among Indian subjects. (hindawi.com)
  • carcinogenesis
  • At meetings arranged by the PPI manufacturer, with most experts within gastric pathology and gastroenterology present, it was concluded that the ECL cell did not play any appreciable role in human gastric carcinogenesis. (bmj.com)
  • Moreover, the claim that the ECL cell was insignificant in gastric carcinogenesis was flawed. (bmj.com)
  • Suppression
  • Rabeprazole, like other proton pump inhibitors such as omeprazole, is used for the purposes of gastric acid suppression. (wikipedia.org)
  • In the setting of gastroesophageal reflux disease (GERD), whose pathophysiology is characterized by prolonged exposure to gastric acid in the esophagus (often due to changes in stomach and/or esophagus anatomy, such as those induced by abdominal obesity), acid suppression can provide symptomatic relief. (wikipedia.org)
  • eradicate
  • Combined treatment with antibiotics (amoxicillin and clarithromycin) directed eradicate H. pylori in patients with ulcers in stomach and duodenum requires Protonix 40 mg daily divided in two doses: take one tablet before breakfast and before supper, do not chew or crash it, eat it whole with a glass of water. (asiapharm.net)
  • cytokines
  • Toll-like receptors were first discovered in Drosophila and trigger the synthesis and secretion of cytokines and activation of other host defense programs that are necessary for both innate or adaptive immune responses. (wikipedia.org)
  • Interaction of TLRs with their specific PAMP is mediated through either MyD88- dependent pathway and triggers the signaling through NF-κB and the MAP kinase pathway and therefore the secretion of pro-inflammatory cytokines and co-stimulatory molecules or TRIF - dependent signaling pathway. (wikipedia.org)
  • carcinogenic
  • As the carcinogenic potential of viral agents and H. pylori has been reviewed extensively elsewhere, it will not be included here. (biomedcentral.com)
  • Activation of β -catenin by carcinogenic Helicobacter pylori ," Proceedings of the National Academy of Sciences of the United States of America , vol. 102, no. 30, pp. 10646-10651, 2005. (hindawi.com)
  • exocrine
  • Mungan Z, Ertan A, Hammer RA, Arimura A: Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion. (wikipedia.org)
  • pancreatic
  • Adrenergic modulation of interdigestive pancreatic secretion in humans. (ik-h.de)
  • 4. Rossowski WJ, Zacharia S, Mungan Z, Ozmen V, Ertan A, Baylor LM, Jiang NY, Coy DH:Reduced gastric acid inhibitory effect of a pGIP(1-30) NH2 fragment with potent pancreatic amylase inhibitory activity. (wikipedia.org)
  • Structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction. (wikipedia.org)
  • acidic
  • In acidic solution, the sulfenic acid is isolated before reaction with one or more cysteines accessible from the luminar surface of the enzyme, a tetracyclic sulfenamide. (wikipedia.org)
  • amino acids
  • The catalytic α subunit has ten transmembrane segments with a cluster of intramembranal carboxylic amino acids located in the middle of the transmembrane segments TM4, TM5, TM6 and TM8. (wikipedia.org)