• proton
  • Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. (clinicaltrials.gov)
  • The use of antacids or drugs that decrease gastric acid production (such as H2-receptor antagonists) or transport (such as proton pump inhibitors). (wikipedia.org)
  • In comparison to other acid-suppressing medications, such as histamine-2 (H2) receptor antagonists, proton pump inhibitors (PPI) are considered to be more potent at effectively inhibiting acid secretion. (freece.com)
  • Proton pump inhibitors are now FDA approved for healing erosive esophagitis (EE), maintenance of healed EE, risk reduction for development of gastric ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs), short-term treatment and maintenance of duodenal ulcers, pathological hypersecretory diseases such as Zollinger-Ellison (ZE) syndrome, and as a part of a multidrug regimen for Helicobacter pylori eradication. (freece.com)
  • SUBSTANCE: what is described is a microdispersed histo-equivalent bioplastic material containing hyaluronic acid, a buffer system, clarithromycin and a proton pump inhibitor. (russianpatents.com)
  • Rabeprazole is a proton pump inhibitor that suppresses gastric acid production in the stomach. (wikipedia.org)
  • Like other medications in the proton pump inhibitor class, rabeprazole's mechanism of action involves the permanent inhibition of proton pumps in the stomach, which are responsible for gastric acid production. (wikipedia.org)
  • Rabeprazole-based products, like other proton pump inhibitor products, have to be formulated in delayed-release tablets to protect the active medication from being degraded by the acid of the stomach before being absorbed. (wikipedia.org)
  • Drugs to Treat Heartburn and Stomach Acid Reflux: The Proton Pump Inhibitors - Comparing Effectiveness, Safety, and Price" (PDF). (wikipedia.org)
  • Evidence emerged by the end of the 1970s that the newly discovered proton pump (H+/K+ ATPase) in the secretory membrane of the parietal cell was the final step in acid secretion. (wikipedia.org)
  • Optimization of substituted benzimidazoles and their antisecretory effects were studied on the newly discovered proton pump to obtain higher pKa values of the pyridine, thereby facilitating accumulation within the parietal cell and increasing the rate of acid-mediated conversion to the active mediate. (wikipedia.org)
  • This very large (>106-fold) H+ gradient is generated by the gastric H+/K+ ATPase which is an ATP-driven proton pump. (wikipedia.org)
  • In a 2009 meta-analysis comparing the net benefit of proton pump inhibitors and ranitidine to reduce the risk of aspiration before anesthesia, ranitidine was found to be more effective than proton pump inhibitors in reducing the volume of gastric secretions. (wikipedia.org)
  • Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. (wikipedia.org)
  • The medication used to decrease acid is usually either a proton pump inhibitor (PPI) or an H2 blocker with four weeks of treatment initially recommended. (wikipedia.org)
  • sold under the brand names Nexium or Nexum, among others) is a proton-pump inhibitor which reduces stomach acid. (wikipedia.org)
  • bicarbonate
  • The bicarbonate buffer system is an acid-base homeostatic mechanism involving the balance of carbonic acid (H2CO3), bicarbonate ion (HCO− 3), and carbon dioxide (CO2) in order to maintain pH in the blood and duodenum, among other tissues, to support proper metabolic function. (wikipedia.org)
  • HCO− is the concentration of bicarbonate in the blood [H2COis the concentration of carbonic acid in the blood This is useful in arterial blood gas, but these usually state pCO2, that is, the partial pressure of carbon dioxide, rather than H2CO3. (wikipedia.org)
  • Bismuth chelate may also stimulate the synthesis of prostaglandin and increase the secretion of the bicarbonate and mucus. (medicalrealm.net)
  • strains
  • Tzelepi E, Mentis AF, Spiliadis C, Tzouvelekis LS: Antibiotic susceptibility and plasmid content of Helicobacter pylori strains isolated in Greece. (springer.com)
  • Some studies suggested that H. pylori strains positive for Cag A (strains strongly associated with the development of corpus gastritis) may be particularly protective against the development of esophageal adenocarcinoma [ 7-9 ]. (uptodate.com)
  • Unfortunately, Cag A positive strains have also been associated with gastric adenocarcinoma. (uptodate.com)
  • It is also effective in the eradication of clarithromycin-resistant H. pylori strains. (atgcchecker.com)
  • H. pylori consists of a large diversity of strains, and hundreds of genomes have been completely sequenced. (wikipedia.org)
  • ulceration
  • However, endoscopy allows for biopsy or cytologic brushing of gastric and esophageal lesions to distinguish between simple ulceration and ulcerating stomach cancer. (merckmanuals.com)
  • 1728 Stahl hypothesizes that some fevers are related to gastric inflammation and ulceration. (wikipedia.org)
  • bacterium
  • H. pylori is a helix-shaped (classified as a curved rod, not spirochaete) Gram-negative bacterium about 3 μm long with a diameter of about 0.5μm. (wikipedia.org)
  • stomach acid
  • Even without bacterial overgrowth, low stomach acid (high pH) can lead to nutritional deficiencies through decreased absorption of basic electrolytes (magnesium, zinc, etc.) and vitamins (including vitamin C, vitamin K, and the B complex of vitamins). (wikipedia.org)
  • Chloride, sodium, potassium, zinc and/or iodine deficiency, as these elements are needed to produce adequate levels of stomach acid (HCl). (wikipedia.org)
  • The "Heidelberg test" is an alternative way to measure stomach acid and diagnose hypochlorhydria/achlorhydria. (wikipedia.org)
  • Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production. (wikipedia.org)
  • Famotidine, sold under the trade name Pepcid among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. (wikipedia.org)
  • Treatment includes stopping smoking, stopping NSAIDs, stopping alcohol and giving medications to decrease stomach acid. (wikipedia.org)
  • By inhibiting the functioning of this transporter, the drug prevents formation of stomach acid. (wikipedia.org)
  • bacteria
  • 1881 Klebs notes the presence of bacteria-like organisms in the lumen of the gastric glands. (wikipedia.org)
  • Like other typical Gram-negative bacteria, the outer membrane of H. pylori consists of phospholipids and lipopolysaccharide (LPS). (wikipedia.org)
  • Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). (wikipedia.org)
  • H. pylori can be diagnosed by testing the blood for antibodies, a urea breath test, testing the stool for signs of the bacteria, or a biopsy of the stomach. (wikipedia.org)
  • diseases
  • Vonoprazan: A Novel and Potent Alternative in the Treatment of Acid-Related Diseases. (atgcchecker.com)
  • Recently, the efficacy and safety of a new acid suppressant named vonoprazan in the treatment of acid-related diseases have been evaluated by a series of studies. (atgcchecker.com)
  • As a safe and effective acid inhibitor, vonoprazan might be a novel alternative in the treatment of acid-related diseases. (atgcchecker.com)
  • Review article: drug interactions with agents used to treat acid-related diseases" (pdf). (wikipedia.org)
  • urease
  • presented a comprehensive analysis of transcription at single-nucleotide resolution by differential RNA-seq that confirmed the known acid induction of major virulence loci, such as the urease (ure) operon or the cag pathogenicity island (see below). (wikipedia.org)
  • endoscopic
  • Currently modern trends in the treatment of gastric ulcer is aimed at developing methods that substitute surgical treatment is the creation of new medicines and technologies for minimally invasive endoscopic technique. (russianpatents.com)
  • inhibitory effect
  • 4. Rossowski WJ, Zacharia S, Mungan Z, Ozmen V, Ertan A, Baylor LM, Jiang NY, Coy DH:Reduced gastric acid inhibitory effect of a pGIP(1-30) NH2 fragment with potent pancreatic amylase inhibitory activity. (wikipedia.org)