• Additionally, our findings are the first to suggest a role and mechanism for Shh signaling as it relates to the metastatic potential of gastric cancer, thereby indicating potential therapeutic molecular targets to decrease metastasis. (korea.ac.kr)
  • ESD is now approved as the standard treatment for gastric dysplasia and early gastric cancer (EGC), having a negligible risk of lymph node metastasis. (e-ce.org)
  • Postoperative outcome of the patients with primary gastric carcinoma in Japan have apparently improved in advanced cases and among the aged population when compared with the archival data. (nih.gov)
  • Gastric carcinoma is one of the most common and mortal types of malignancy worldwide. (tmu.edu.tw)
  • It is known that the activation of hedgehog (Hh) signaling is involved in the progression and invasion of various tumors, including gastric carcinoma. (korea.ac.kr)
  • Microsatellite instability (MSI) is observed in 13-44% of gastric carcinoma. (elsevierpure.com)
  • The etiology of MSI in gastric carcinoma has not been clearly defined. (elsevierpure.com)
  • Although larger studies are needed, BAT-26 appears to be a sensitive and specific marker for the MSI-H phenotype in gastric carcinoma. (elsevierpure.com)
  • A 76-year-old male was diagnosed with stage IV (cT4, cN2, cP0, cH0, cM0) gastric carcinoma with a type 3 tumor in the cardia with lymph node metastases, determined by gastrofiberscope and abdominal computed tomography (CT). (elsevierpure.com)
  • Thus, the chemo-radiation treatment regimen described here may be a potent tool to control advanced gastric carcinoma. (elsevierpure.com)
  • Epstein-Barr virus (EBV)-positive gastric carcinoma represents one of the four subtypes of gastric carcinoma recently defined by The Cancer Genome Atlas. (medscape.com)
  • One-hundred and sixty-nine Japanese and 137 U.S. patients with localized gastric adenocarcinoma were enrolled. (qub.ac.uk)
  • Constitutive expression of Notch2 intracellular domain (N2IC), the activated form of Notch2 receptor, promoted both cell proliferation and xenografted tumor growth of human stomach adenocarcinoma SC-M1 cells. (tmu.edu.tw)
  • METHODS:This investigation was performed on gastric tumors obtained from 66 (46 men and 20 women) patients with documented gastric adenocarcinoma who underwent total or partial gastrectomy and regional lymphadenectomy from 2003 till 2011. (duke.edu)
  • Methods: We utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results registry to identify Korean-Americans with gastric adenocarcinoma treated with curative-intent gastrectomy between 1988 and 2008. (houstonmethodist.org)
  • Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated. (e-ce.org)
  • The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. (ox.ac.uk)
  • OBJECTIVE: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). (ox.ac.uk)
  • We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. (ox.ac.uk)
  • The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. (ox.ac.uk)
  • Helicobacter pylori infection is a principal cause of chronic active gastritis and peptic ulcer disease as well as gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma ( 1 ). (cdc.gov)
  • Gastric adenocarcinoma is the second leading cause of cancer death worldwide, following lung cancer. (medscape.com)
  • Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)
  • Since inflammation plays a significant role in gastric carcinogenesis, it has been suggested that polymorphisms in genes involved in inflammatory response may partly explain why only a subgroup of patients infected with H. pylori develop gastric cancer. (psu.edu)
  • This study aimed to evaluate the changes in epigenetic and genetic expression of multiple Rho GTPases in Helicobacter pylori -related gastric carcinogenesis by comparing H. pylori -positive GCs and negative controls. (gutnliver.org)
  • Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. (ox.ac.uk)
  • Further investigation is needed to clarify the role of iron in gastric carcinogenesis. (ox.ac.uk)
  • Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. (ox.ac.uk)
  • Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (ox.ac.uk)
  • A hamartoma is a mostly benign, local malformation of cells that resembles a neoplasm of local tissue but is usually due to an overgrowth of multiple aberrant cells, with a basis in a systemic genetic condition, rather than a growth descended from a single mutated cell (monoclonality), as would typically define a benign neoplasm/tumor. (wikipedia.org)
  • The DNA Polymerase β (Pol β) variant Asp160Asn (D160N) was first identified in a gastric tumor. (psu.edu)
  • The suicide gene therapy group (14 rats) was subjected to in situ gene transfer with a recombinant adenovirus vector carrying the HSV-TK gene driven by CAG promoter (Ad.CAGHSV-TK) in gastric tumor, followed by the antiviral drug ganciclovir (GCV). (fujita-hu.ac.jp)
  • We hypothesized that gastric cancers associated with Epstein-Barr virus infection (EBV+) or microsatellite instability (MSI), both of which are known to harbor such tumor microenvironment, are associated with increased PD-L1 expression. (johnshopkins.edu)
  • Positive PD-L1 expression (PD-L1+), defined as membranous staining in either tumor cells or tumor immune infiltrates, was seen in 32 (72%) gastric cancers. (johnshopkins.edu)
  • In summary, EBV+ or MSI gastric cancers are more likely to express PD-L1 and have increased CD8 T cells at tumor invasive front than EBV-/MSS cancers. (johnshopkins.edu)
  • Family history of malignant tumor is a predictor of gastric cancer prognosis: Incorporation into a nomogram. (cdc.gov)
  • Factors that are correlated with an improved prognosis include a gastric location, a diameter of less than 2 cm, a low mitotic index, and an absence of tumor spillage with complete gross resection. (medscape.com)
  • Gastric gastrointestinal stromal tumor (GIST) en face. (medscape.com)
  • From 208 participating hospitals, 53 items including surgical procedures, pathological diagnosis, and survival outcomes of 13,626 patients with primary gastric cancer treated in 2002 were collected retrospectively. (nih.gov)
  • The spread of primary gastric non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT) to the perigastric lymph nodes is a very important step concerning the prognosis of these tumours. (nih.gov)
  • We suggest that the depth of infiltration should be included in the pathological reports concerning primary gastric lymphomas of the MALT. (nih.gov)
  • Recent studies in Western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (PGL). (hku.hk)
  • However, the clinical characteristics of metachronous gastric neoplasms (MGN) following ESD have not yet been thoroughly studied with respect to the various tiers of primary gastric neoplasms. (e-ce.org)
  • Background Metastatic gastric cancer and cancer of the esophagogastric junction (GC/EGJ) is an aggressive disease with poor prognosis. (gencat.cat)
  • PURPOSE: The aim of this study was to evaluate if the occurrence of neutropenia is correlated with response to ramucirumab plus paclitaxel for metastatic gastric cancer. (bath.ac.uk)
  • abstract = "PURPOSE: The aim of this study was to evaluate if the occurrence of neutropenia is correlated with response to ramucirumab plus paclitaxel for metastatic gastric cancer.METHODS: This is a retrospective study of patients treated with ramucirumab plus paclitaxel.RESULTS: Fifty-three patients were evaluated. (bath.ac.uk)
  • How much do you know about advanced and metastatic gastric cancer? (medscape.com)
  • report a case of a patient with metastatic gastric cancer with a meaningful response to the anti-programmed death-ligand 1 (PD-L1) antibody avelumab. (medscape.com)
  • We identified the association between garlic intake and reduced risk of gastric and colorectal cancers and hypothesized that the active ingredients in garlic may act on multiple pathways to reduce the risk of gastrointestinal tumors according to published papers. (spandidos-publications.com)
  • PURPOSE:Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors diagnosed at advanced stage. (duke.edu)
  • Gastric tumors were induced by MNNG in 38/73 (52%) of Wistar strain rats. (fujita-hu.ac.jp)
  • We examined 117 gastric carcinomas for MSI and observed instability at one or more loci in 19 (16%) of these tumors. (elsevierpure.com)
  • The drug, which earned Breakthrough Therapy designation from the US Food and Drug Administration (FDA) earlier this year, is designed to target fibroblast growth factor receptor 2b (FGFR2b), overexpressed in about 30% of patients with HER2-negative gastric cancer and other solid tumors. (medscape.com)
  • EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)
  • Predictive value of rodent forestomach and gastric neuroendocrine tumours in evaluating carcinogenic risks to humans / views and expert opinions of an IARC working group, Lyon, 29 November - 1 December 1999. (who.int)
  • Background: A recent Intergroup trial demonstrated a significant survival advantage of postgastrectomy chemoradiation in gastric cancer patients, primarily because of a reduction of a relative locoregional recurrence (LRR) rate exceeding 70% in control patients. (elsevierpure.com)
  • Schwarz, RE & Zagala-Nevarez, K 2002, ' Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy ', Annals of Surgical Oncology , vol. 9, no. 4, pp. 394-400. (elsevierpure.com)
  • However, the remaining stomach harbors the possibility of metachronous neoplasm recurrence. (e-ce.org)
  • 1 , 2 Even after surgery for gastric cancer, 3.0% to 5.4% of patients experience recurrence during follow-up. (e-ce.org)
  • 3 , 4 Following ESD for EGC, recurrence develops in completely preserved stomachs at a rate of approximately 3% annually. (e-ce.org)
  • In this study, we aimed to determine the characteristics of metachronous recurrence after ESD for gastric dysplasia and EGC. (e-ce.org)
  • Despite the declining incidence and mortality, gastric cancer remains the third leading cause of cancer-related mortality in the world ( 1 , 3 ). (spandidos-publications.com)
  • Although age-adjusted mortality from gastric cancer has been decreasing in Japan, the crude incidence of gastric cancer shows a slight increase. (elsevierpure.com)
  • We have observed trends in the incidence of gastric cancer by sex and 20-year age groups over the past two decades (1976-1996). (elsevierpure.com)
  • Simultaneously, we observed changes in the prevalence of Helicobacter pylori infection and in serological atrophy of the gastric mucosa, and compared the results with those involving changes hi the incidence of gastric cancer. (elsevierpure.com)
  • The marked decline in gastric cancer incidence observed in the young population will also begin to occur in the elderly population in the future. (elsevierpure.com)
  • The annual incidence of gastric cancer is 0.6% for mild-to-moderate dysplasia, and 6% for severe dysplasia within 5 years after diagnosis. (e-ce.org)
  • Georgia also reports a high annual incidence of gastric cancer, 17/100,000 population in 2002 (National Center for Disease Control, Tbilisi, unpub. (cdc.gov)
  • We found that higher concentrations of N-Shh enhanced cell motility and invasiveness in gastric cancer cells, whereas no increase was observed in cells that were treated with KAAD-cyclopamine (a Shh signaling inhibitor) or anti-Shh blocking antibodies. (korea.ac.kr)
  • In addition, the N-Shh-induced migration and invasiveness of gastric cancer cells were reduced by treatment with anti-TGF-β blocking antibody or TGF-β1 small interfering RNA (siRNA) in presence of N-Shh when compared with control groups. (korea.ac.kr)
  • In summary, these results indicate that Shh promotes motility and invasiveness of gastric cancer cells through TGF-β-mediated activation of the ALK5-Smad 3 pathway. (korea.ac.kr)
  • Recently, Peritoneal Surface Oncology Group International (PSOGI) developed a novel comprehensive treatment consisting of cytoreductive surgery (CRS) and perioperative chemotherapy (POC) for the treatment of peritoneal metastases (PM) from gastric cancer with curative intent. (lu.se)
  • Scholars@Duke publication: The Chicago Consensus on Peritoneal Surface Malignancies: Management of Gastric Metastases. (duke.edu)
  • This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. (elsevierpure.com)
  • Predictors of survival were identified that can guide physicians selecting personalized treatment approaches for patients with brain metastases from gastric cancer. (elsevierpure.com)
  • Brain metastases from gastric cancer are rare and are diagnosed in less than 1% of patients with gastric cancer. (scielo.org.pe)
  • We analyzed the endoscopic images of 43 patients who underwent endoscopic submucosal dissection for early gastric cancer after HP eradication and 119 patients with an HP eradication history who underwent esophagogastroduodenoscopy for a medical checkup. (biomedcentral.com)
  • Gastric cancer remains difficult to cure , primarily because early gastric cancer has no associated symptoms and by the time most patients present with symptoms, it is with advanced disease . (medscape.com)
  • BACKGROUND: It is believed that the development of gastric cancer (GC) before the age of 50 has a hereditary basis. (mcmaster.ca)
  • Interestingly, our study showed a significant correlation between blood group O and the development of gastric cancer under the age of 50. (mcmaster.ca)
  • Chronic HP infection causes atrophic gastritis and intestinal metaplasia leading to dysplasia and the development of gastric cancer [ 3 , 4 ]. (biomedcentral.com)
  • Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for gastric neoplasms. (e-ce.org)
  • Bemarituzumab is being positioned as a potential frontline therapy for advanced gastric or gastroesophageal junction cancer. (medscape.com)
  • Prolonged complete response obtained by radiation and chemotherapy with paclitaxel in a case of recurrent gastric cancer in the rectovesical pouch]. (elsevierpure.com)
  • Dive into the research topics of '[Prolonged complete response obtained by radiation and chemotherapy with paclitaxel in a case of recurrent gastric cancer in the rectovesical pouch]. (elsevierpure.com)
  • Endoscopic severe gastric mucosal atrophy is useful to screen patients for gastric cancer after HP eradication. (biomedcentral.com)
  • Blood group A and history of gastric cancer in first-degree relatives have been shown to be risk factors for GC. (mcmaster.ca)
  • A history of gastric cancer is one of the strongest risk factors for the development of gastric neoplasms. (e-ce.org)
  • Five participants, of whom 3 were H. pylori -positive, reported a history of gastric surgery for peptic ulcer disease. (cdc.gov)
  • Receiver operating characteristic analysis showed that a score of A2 in the Kyoto classification of gastritis (open-type atrophic pattern in the Kimura-Takemoto classification) was an endoscopic marker for the presence of post-HP-eradication gastric cancer. (biomedcentral.com)
  • CEA and CA19-9 were assayed on cytosol obtained from multiple endoscopic biopsies of 41 patients with chronic superficial gastritis, 18 with chronic atrophic gastritis, and 9 with gastric cancer. (cnr.it)
  • Mucosal tissue concentrations of both CEA and CA19-9 increased from chronic superficial gastritis to chronic atrophic gastritis and to gastric cancer (p = 0.005 and p = 0.002, respectively). (cnr.it)
  • In conclusion, these data indicate that gastric mucosa of patients with chronic atrophic gastritis and intestinal metaplasia express high levels of both CA19-9 and CEA. (cnr.it)
  • METHODS: In this meta-analysis and prospective cohort study, we first did a fixed-effects meta-analysis of the association between genetic variants and gastric cancer in six independent genome-wide association studies (GWAS) with a case-control study design. (fry-it.com)
  • Methods: Information on patients undergoing gastrectomy for potentially curable gastric cancer between 1990 and 2000 was reviewed. (elsevierpure.com)
  • Background: There is ongoing debate whether extended lymphadenectomy improves survival in gastric cancer patients who undergo surgical resection. (houstonmethodist.org)
  • Our objective was to assess lymph node (LN) number and its impact on survival for Korean-American gastric cancer patients. (houstonmethodist.org)
  • Conclusions: Although examined LN number may impact survival for white patients, outcomes of Korean-American gastric cancer patients were independent of LN number. (houstonmethodist.org)
  • Our data suggest that survival of Korean-American gastric cancer patients are comparable with outcomes from East Asian hospitals and may be independent of surgical technique. (houstonmethodist.org)
  • Survival Prediction of Stomach Cancer Using Expression Data and Deep Learning Models with Histopathological Image. (cdc.gov)
  • The messenger RNA expression and methylation of Rho GTPases (RhoA, Rac1, DOCK180, ELMO1, and CDC42) were evaluated in H. pylori -negative (control) human gastric tissues and H. pylori -positive GCs by using real-time reverse transcription-polymerase chain reaction and the quantitative MethyLight assay, respectively. (gutnliver.org)
  • Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study. (fry-it.com)
  • INTERPRETATION: Chinese individuals at an increased risk of incident gastric cancer could be identified by use of our newly developed polygenic risk score. (fry-it.com)
  • Compared with individuals at a high genetic risk who adopt an unhealthy lifestyle, those who adopt a healthy lifestyle could substantially reduce their risk of incident gastric cancer. (fry-it.com)
  • Because different predominant ER distributions link to breast and gastric cancer and little is known of the prognostic role of LMTK3 in gastric cancer, this study was carried out to clarify the prognostic role of these polymorphisms in gastric cancer. (qub.ac.uk)
  • The prognostic role of these polymorphisms may be negative in gastric cancer. (qub.ac.uk)
  • We compared relative frequencies of 17 single nucleotide polymorphisms (SNPs) in eight inflammation-related genes between 112 gastric cancer patients and 208 controls. (psu.edu)
  • Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals. (psu.edu)
  • Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. (ox.ac.uk)
  • Retrospective review of electronic medical records of patients who underwent gastric ESD at The Catholic University of Korea, Yeouido St. Mary's Hospital. (e-ce.org)
  • The PET scan reveals a hypermetabolic zone in the lesser curvature of the stomach, and the endoscopy reveals a lesion suggestive of gastric malignant neoplasia in the Borrmann I fundus. (scielo.org.pe)
  • In this scoring system, five endoscopic findings (atrophy, intestinal metaplasia, gastric fold hypertrophy, nodularity, diffuse redness) related to HP infection are scored to estimate the risk for gastric cancer. (biomedcentral.com)
  • One participant reported gastric cancer and was H. pylori -positive. (cdc.gov)
  • These findings suggest that the estrogen pathway may play a prognostic role in patients with gastric cancer but this may be dependent on the regional differences both in physiology and genetic alterations of gastric cancer. (qub.ac.uk)
  • In contrast to surgical gastrectomy, ESD can provide functional and structural preservation of the stomach, even after complete and curative resection. (e-ce.org)
  • Scholars@Duke publication: The expression of Claudin-4 in gastric cancer tissue: A single center experience. (duke.edu)
  • In the present study, we designed an antisense oligodeoxynucleotide of DNMT1 (AS/MT: 5′-CGGTAC GCGCCGGCATCT-3′) and demonstrated successful inhibition of DNMT1 expression by AS/MT at the protein level, using gastric cancer cell lines in vitro. (elsevierpure.com)
  • To assess the role of mismatch repair in the development of MSI in gastric cancer, expression of hMSH2 and hMLH1 was explored. (elsevierpure.com)
  • Forty-four resected gastric cancers including 7 EBV+, 16 MSI, and 21 microsatellite stable cancers without EBV (EBV-/MSS) were studied for PD-L1 expression and T-cell subpopulations by immunohistochemistry. (johnshopkins.edu)
  • Our data thus support the thesis that gastric MALT lymphomas show clinicopathologic similarities with gastric carcinomas. (nih.gov)
  • Gastric cancer is the fifth malignancy and the third cause of cancer death worldwide, according to the global cancer statistics presented in 2018. (unicatt.it)
  • Gastric cancer is the fifth leading cause of cancer-related deaths worldwide, with 1.09 million new cases and 769,000 deaths reported in 2020 . (medscape.com)
  • Identifying potential biomarkers of response to immunotherapy in different malignancies including gastric cancer has been a daunting task. (medscape.com)
  • In order to evaluate the parameters that influence the infiltration of the lymph nodes we retrospectively investigated 145 surgical specimens with gastric MALT lymphoma. (nih.gov)
  • At this time, no gastric cancer cells were detected in the resected specimen, including the primary lesion and lymph nodes, confirming a pathological complete response (CR grade 3). (elsevierpure.com)
  • BACKGROUND: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. (ox.ac.uk)
  • Gastrointestinal cancer is a health issue with worldwide concern, of which gastric and colorectal cancers are the most common types ( 1 , 2 ). (spandidos-publications.com)
  • Gastric cancer is one of the most common cancers, which causes the second largest deaths worldwide. (nottingham.edu.cn)
  • Low-grade dysplasia (LGD) and high-grade dysplasia (HGD) in the stomach are also significant risks for metachronous cancer development. (e-ce.org)