Gangliosides. Medical search. Frequent questions

Guillain-Barré syndrome, which has been linked to the production of anti-ganglioside antibodies. (wikipedia.org)
Many therapeutic treatments of tumor cells are being investigated using antibodies to target cells that express these elevated levels of gangliosides. (matreya.com)
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS. (loinc.org)
In adults with GBS, serum ganglioside antibodies directed against GM1, GM1b, GD1a, and GalNAc-GDIa have been associated with Campylobacter jejuni infection, acute motor axonal neuropathy, a more severe course, and more residual neurologic deficits. (medscape.com)
In this study, we apply our previously developed site mapping technique to investigate the recognition of cancer-related gangliosides by anti-ganglioside antibodies. (edu.au)
The results reveal a potential ganglioside-binding motif in the four antibodies studied, suggesting the possibility of structural convergence in the anti-ganglioside immune response. (edu.au)
The presence of antibodies to the gangliosides GM1, Asialo-GM1, and GD1a has been associated with motor neuropathies. (bloodtestslondon.com)
We hypothesised that generation of anti-ganglioside antibodies would control micrometastases and improve outcomes in sarcoma patients who were disease-free after metastasectomy. (wustl.edu)
For a more comprehensive ganglioside antibody panel when evaluating patients with autoimmune neuropathies, refer to Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies ( 0051033 ). (aruplab.com)
For example, IgG antibodies against GM1, GD1a, and related gangliosides are frequently present in patients with post-Campylobacter acute motor axonal neuropathy (AMAN) variant of GBS, and immunization of rabbits with GM1 has produced a model of AMAN. (johnshopkins.edu)
However, the role of anti-ganglioside antibodies in GBS continues to be debated because of lack of a passive transfer model. (johnshopkins.edu)
We recently have raised several monoclonal IgG anti-ganglioside antibodies. (johnshopkins.edu)
We passively transfer these antibodies by intraperitoneal hybridoma implantation and by systemic administration of purified anti-ganglioside antibodies in mice. (johnshopkins.edu)
In contrast to hybridoma implantation, passive transfer with systemically administered anti-ganglioside antibodies did not cause nerve fiber degeneration despite high titre circulating antibodies. (johnshopkins.edu)
Blood-nerve barrier studies indicate that animals implanted with hybridoma had leaky blood-nerve barrier compared to mice that received systemically administered anti-ganglioside antibodies. (johnshopkins.edu)
Immunohistochemistry was performed using specific antibodies for the major brain gangliosides (GM1, GD1a, GD1b, GT1b) and PSA NCAM and analysed in different brain regions. (veterinarska-stanica-journal.hr)
Antibodies to gangliosides, no. (cdc.gov)
An individual suffering from MS produces increased levels of antibodies that target cell membrane components, such as phospholipids, gangliosides, and membrane proteins. (nih.gov)
Among them, anti-ganglioside antibodies are considered as important biomarkers to differentiate MS from other diseases that exhibit similar symptoms. (nih.gov)
We report here a label-free method for detecting a series of antibodies against gangliosides in serum by surface plasmon resonance imaging (SPRi) in combination with a carbohydrate microarray. (nih.gov)

GD1s are the most abundant ganglioside species in the mammalian brain and consist of two structural isomers, GD1a and GD1b.Traditionally, the only way to analyze these isomers by mass spectrometry involved extraction and thus the researcher loses information about the location of the isomers in tissue. (nih.gov)
The imaging of [M-H](-) and [M-H2O-H](-) mass peaks for GD1 gangliosides showed different distribution, most likely reflecting the different spatial distribution of GD1a and GD1b species in the brain. (nih.gov)
Open VEGFC in another window Figure 1 Anti-GM1 IgG immunostaining patterns of individual sera.An assortment of GA1, GM1, GD1a, GD1b and GT1b gangliosides was separated on thin-layer chromatogram plates and immunostained with a 1/200 dilution of sera as described in Strategies. (antiviralbiologic.com)
Background Reactivity against terminal NeuNAc(α2-3)Gal, common to several gangliosides such as GD1a, GT1b and GM3, has rarely been reported. (bmj.com)
Results Reactivity against NeuNAc(α2-3)Gal, shared by GM3, GD1a and GT1b gangliosides, was detected in 10 patients: isolated in one patient, and concomitant with reactivity against other gangliosides in the remaining patients. (bmj.com)

The name ganglioside was first applied by the German scientist Ernst Klenk in 1942 to lipids newly isolated from ganglion cells of the brain. (wikipedia.org)
Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues. (afcdb.ca)
2,6-Dihydroxyacetophenone (DHA) matrix has been shown to provide efficient ionization of lipids, especially gangliosides. (nih.gov)
The project aims to clarify the therapeutic role of gangliosides, a family of glycolipid molecules that have properties of both lipids and carbohydrates, in the brain. (eurekalert.org)
These include bilayers with complex lipids (e.g., gangliosides and phosphoinositides), other components including cholesterol, sugars such as trehalose, viral fusion peptides, and bacterial toxins. (nih.gov)

Wikipedia] Particularly, Ganglioside GT1b (d18:1/16:0) is a GT1b ganglioside, A glycosphingolipid (ceramide and oligosaccharide) or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. (afcdb.ca)

Order our Ganglioside Antibody Profile with 3 Biomarkers Online & Attend near Oxford St, London. (bloodtestslondon.com)
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Approximately half the animals implanted with an intraperitoneal clone of anti-ganglioside antibody-secreting hybridoma developed a patchy, predominantly axonal neuropathy affecting a small proportion of nerve fibers. (johnshopkins.edu)
A plate was stained with orcinol reagent for chemical substance recognition of gangliosides (A). Desk 1 Serum antibody cross-reactivities and scientific top features of Guillain-Barr syndrome sufferers. (antiviralbiologic.com)

The DotDiver Ganglioside screen is an immunodot for the qualitative determination of IgG/IgM autoantibodies to gangliosides in human serum or plasma. (eaglebio.com)
Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging. (nih.gov)

A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. (wikipedia.org)
The oligosaccharide groups on gangliosides extend well beyond the surfaces of the cell membranes, and act as distinguishing surface markers that can serve as specific determinants in cellular recognition and cell-to-cell communication. (wikipedia.org)
The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin. (loinc.org)
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. (loinc.org)
Ganglioside is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid, NANA) linked on the sugar chain. (afcdb.ca)
1] Gangliosides are more complex glycosphingolipids in which oligosaccharide chains containing N-acetylneuraminic acid (NeuNAc) are attached to a ceramide. (afcdb.ca)

It has been found that tumor formation can induce the synthesis of a new complement of ganglioside, and very low concentrations of a specific ganglioside can induce differentiation of cultured neuronal tumor cells. (wikipedia.org)
Cholera Tetanus Botulism Leprosy Obesity, where inadequate ganglioside expression in mediobasal hypothalamic neurons deregulates neuronal leptin and insulin signaling. (wikipedia.org)
2014). Polysialic acid neural cell adhesion molecule (PSA NCAM) and gangliosides are molecules that play important roles in neuronal development and cell adhesion in the nervous system. (veterinarska-stanica-journal.hr)
Gangliosides are a type of glycolipid found mainly in the outer leaflet of cell membranes, including neuronal membranes, and are involved in cell signalling, cell adhesion, and other cellular processes (Lopez and Schnaar, 2009) while PSA NCAM refers to a polysialic acid modification of the neural cell adhesion molecule (NCAM), a glycoprotein that plays a critical role in neurogenesis and neuron migration (Gascon et al . (veterinarska-stanica-journal.hr)
Considering the roles of gangliosides on neuronal function, findings described here can contribute to the knowledge of the potential neuroprotective mechanisms of genistein against Aβ-induced alterations in the frontal cortex of rats and provide a novel view in the multifaceted scenario associated with its beneficial effects. (nih.gov)
1 Gangliosides 2 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. (matreya.com)

Recently, gangliosides have been found to be highly important molecules in immunology. (wikipedia.org)
Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. (wikipedia.org)
Here, we show that gangliosides in the HIV-1 membrane are the key molecules for mDC uptake. (plos.org)
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. (loinc.org)
Although different molecules, both gangliosides and PSA NCAM can be considered components of sialoglycoconjugates as they contain sialic acid residues in their structures. (veterinarska-stanica-journal.hr)
From NCBI Gene: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 gangliosideM2activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. (nih.gov)

Belongs to the class of organic compounds known as gangliosides. (afcdb.ca)
Sialic acid-containing glycolipids, known as gangliosides, play important structural and functional roles. (frontiersin.org)

Thus, in addition to the well-known function of gangliosides as host cell receptors that mediate virus (e.g., polyoma and SV40) attachment and transport from the plasma membrane to the ER, we now demonstrate that they can also act as determinants for capture by mDCs. (plos.org)

Hence, these results demonstrate that gangliosides can act as viral attachment factors, in addition to their well known function as cellular receptors for certain viruses. (plos.org)
In this study we demonstrate that gangliosides from human granulocytes, the second most abundant cells in peripheral blood, can serve as receptors for influenza viruses A/PR/8/34 (H1N1), A/X-31 (H3N2), and a parainfluenza virus Sendai virus (HNF1, Z-strain). (uni-bielefeld.de)

Present characterization of ganglioside standards quantifies only the fatty acid content by gas chromatography-flame ionization detection (GC-FID) analysis of the ganglioside mixture and does not parse out the percentages of the individual mono-sialo ganglioside components. (omicsonline.org)
We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. (srce.hr)

More than 60 gangliosides are known, which differ from each other mainly in the position and number of NANA residues. (wikipedia.org)
Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. (loinc.org)
The 60+ known gangliosides differ mainly in the position and number of NANA residues. (afcdb.ca)
The peptides are shown to act as structural mimics of gangliosides by interacting with many of the same binding site residues as the cognate carbohydrate epitopes. (edu.au)
Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16-C24) in ceramide portions. (srce.hr)

Anti-ganglioside GD2 (anti-GD2) is very useful in the identification of disialoganglioside GD2 and in immunotargeting cells expressing disialoganglioside GD2. (matreya.com)

7. Electrospray Ionization Ion Mobility Mass Spectrometry of Human Brain Gangliosides. (nih.gov)

2020). The specific ganglioside profile may vary among brain regions and cell types. (veterinarska-stanica-journal.hr)

The usual multiple reaction monitoring (MRM) liquid chromatography-tandem mass spectrometry (LC-MS/MS) of gangliosides, which monitors the dehydrated sialic acid fragment (m/z 290), cannot differentiate between the individual iso-molecular weight components C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)
1. Gangliosides of Human Glioblastoma Multiforme: A Comprehensive Mapping and Structural Analysis by Ion Mobility Tandem Mass Spectrometry. (nih.gov)
8. Chip-nanoelectrospray quadrupole time-of-flight tandem mass spectrometry of meningioma gangliosides: a preliminary study. (nih.gov)
12. Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry. (nih.gov)

GD1b was the most prominent ganglioside expressed in all brain structures, while GM1 showed varying distribution between the species. (veterinarska-stanica-journal.hr)
The Aβ-infused animals showed a significant decrease in ganglioside concentration and relative reduction of GD1b and GQ1b species. (nih.gov)
Representative types of sera displaying reactivity solely with GM1 (B), or sera displaying yet another reactivity with GA1 (C), GD1b (D) or with both gangliosides (Electronic) are proven. (antiviralbiologic.com)

NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides. (wikipedia.org)
Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. (loinc.org)
NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of Gangliosides anionic. (afcdb.ca)
Deficiencies in lysosomal enzymes that degrade the carbohydrate portions of various gangliosides are responsible for a number of lysosomal storage diseases such as Tay-Sachs disease, Sandhoff disease, and GM1 gangliosidosis. (afcdb.ca)
The carbohydrate portion of the ganglioside GM1 is the site of attachment of cholera toxin, the protein secreted by Vibrio cholerae. (afcdb.ca)
Viruses were found to exhibit specific adhesion to terminal Neu5Acalpha2-3Gal and/or Neu5Acalpha2-6Gal sequences as well as depending on the chain length of ganglioside carbohydrate backbones from human granulocytes, these important effector cells which represent the first line of defence in immunologically mediated reactions. (uni-bielefeld.de)

AP-MALDI Mass Spectrometry Imaging of Gangliosides Using 2,6-Dihydroxyacetophenone. (nih.gov)
The structures of gangliosides from human granulocytes were elucidated by fast atom bombardment mass spectrometry and by gas chromatography/mass spectrometry as their partially methylated alditol acetates. (uni-bielefeld.de)
2. Electrospray ionization ion mobility mass spectrometry provides novel insights into the pattern and activity of fetal hippocampus gangliosides. (nih.gov)
4. Ion mobility mass spectrometry of human melanoma gangliosides. (nih.gov)
5. Cerebrospinal fluid: Profiling and fragmentation of gangliosides by ion mobility mass spectrometry. (nih.gov)
6. Profiling and sequence analysis of gangliosides in human astrocytoma by high-resolution mass spectrometry. (nih.gov)
9. High resolution mass spectrometry provides novel insights into the ganglioside pattern of brain cavernous hemangioma. (nih.gov)
10. Aberrant ganglioside composition in glioblastoma multiforme and peritumoral tissue: A mass spectrometry characterization. (nih.gov)
11. Assessment of the molecular expression and structure of gangliosides in brain metastasis of lung adenocarcinoma by an advanced approach based on fully automated chip-nanoelectrospray mass spectrometry. (nih.gov)
13. Ion mobility mass spectrometry provides novel insights into the expression and structure of gangliosides in the normal adult human hippocampus. (nih.gov)
14. Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. (nih.gov)
15. Assessment of ganglioside age-related and topographic specificity in human brain by Orbitrap mass spectrometry. (nih.gov)
17. Profiling and sequencing of gangliosides from human caudate nucleus by chip-nanoelectrospray mass spectrometry. (nih.gov)
This deuterated ganglioside is ideal for the identification of gangliosides in samples and biological systems using mass spectrometry. (matreya.com)

Gangliosides are complex glycosphingolipids and have been implicated in brain development, neuritogenesis, memory formation, synaptic transmission and aging. (nih.gov)

Gangliosides are glycosphingolipids. (afcdb.ca)

Furthermore, the sialyllactose molecule present in specific gangliosides was identified as the determinant moiety for mDC HIV-1 uptake. (plos.org)
Utilizing Tay-Sachs ganglioside labeled with (14)C in the N-acetylgalactosaminyl portion or (3)H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sachs ganglioside may be initiated by either the removal of the molecule of N-acetylgalactosamine or N-acetylneuraminic acid. (eurekamag.com)
The letter G refers to ganglioside, and the subscripts M, D, T and Q indicate that the molecule contains mono-, di-, tri and quatra-sialic acid. (afcdb.ca)
It has been recently reported that GD3, a b-series ganglioside, is a marker molecule for identifying and isolating mouse NSCs. (elsevierpure.com)

Glycolipid and ganglioside metabolism imbalances in Huntington's disease. (desplatslab.org)

In this study, an in vivo model of Aβ toxicity was used to investigate the effects of this peptide and the treatment with genistein on the lipid composition (gangliosides, phospholipids and cholesterol) in the frontal cortex of rats. (nih.gov)
The influence of ceramide composition on the rate of GM1 association to HeLa cells has been investigated by incubating the cells in the presence of either native ganglioside or molecular species carrying highly homogeneous long chain base moieties, fractionated from native GM1. (unimib.it)
Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. (srce.hr)
Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. (srce.hr)
16. Human gliosarcoma-associated ganglioside composition is complex and distinctive as evidenced by high-performance mass spectrometric determination and structural characterization. (nih.gov)

Here we show that gangliosides, basic components of the host cell's plasma membrane, have an important role in this process. (plos.org)
Gangliosides are known to be incorporated into the viral envelope membrane during the process of viral particle budding and here we show that they serve as viral attachment factors: they are recognized and enable HIV-1 uptake by mDCs. (plos.org)
Furthermore, we identify a moiety composed of sialyllactose on HIV-1 membrane gangliosides as the specific domain recognized by mDCs. (plos.org)

Gangliosides are also involved in several diseases: Influenza, in which haemagglutinin of influenza virus exploits certain gangliosides to enter and infect the cells expressing them. (wikipedia.org)

After having increased the GM1 cell content (65-fold) by incubation with the various ganglioside species, the cells were incubated with cholera toxin and the time course of cyclic AMP accumulation was monitored. (unimib.it)

Several gangliosides have been found to have elevated expressions in tumor cells. (matreya.com)
A vaccine consists of immunogenic tumor-associated antigens, shaped as peptides, recombinant proteins, gangliosides or whole tumor cells, always in combination with an adjuvant needed to potentiate the immune response. (medscape.com)

Disruptions in ganglioside metabolism has been linked to several diseases such as Niemann-Pick C, and Gaucher disease types II, Alzheimer disease and Guillain-Barre syndrome. (nih.gov)

The structural basis of the recognition of ganglioside-mimetic peptides is also investigated using site mapping and compared to ganglioside recognition. (edu.au)

GM2 is the second monosialo ganglioside characterized, thus the subscript 2. (afcdb.ca)

For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. (loinc.org)
In all Gangliosides, the ceramide is linked through its C-1 to a beta-glucosyl residue, which, in turn, is bound to a beta-galactosyl residue. (afcdb.ca)
The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). (srce.hr)

Both snake species showed expression of all four complex gangliosides with similar distribution patterns. (veterinarska-stanica-journal.hr)
In addition, it is important to note that the specific distribution of gangliosides and PSA NCAM may be influenced by factors such as brain region, developmental stage, and species-specific characteristics. (veterinarska-stanica-journal.hr)
The distribution of gangliosides and PSA NCAM varies among animal species. (veterinarska-stanica-journal.hr)
Further, different animal species may show variations in the types and proportions of gangliosides in their nervous systems. (veterinarska-stanica-journal.hr)
The GM1 gangliosideM1species carrying the unsaturated C18 long chain base moiety proved to have the fastest rate of association, whereas the saturated species carrying 20 carbon atoms had the slowest rate. (unimib.it)

Gangliosides are very similar to globosides except that they also contain N-acetyl neuraminic acid (NANA) in varying amounts. (afcdb.ca)

Within lysosomes, beta-hexosaminidase A helps break down a fatty substance called GM2 gangliosideM2found in cell membranes. (nih.gov)

Ganglioside GD3 carries a net-negative charge at pH 7.0 and is acidic. (afcdb.ca)

3. T. Kolter, R. Proia, K. Sandhoff "Combinatorial Ganglioside Biosynthesis" J. Biol. (matreya.com)

We propose that this novel recognition moiety might be crucial for inducing immune responses, but also critical to disseminate HIV-1 and other ganglioside-containing viruses. (plos.org)

Several authors have reported molecular similarities among these gangliosides and bacterial lipopolysaccharides, mainly Campylobacter iejuni. (nih.gov)

Damage caused by the buildup of GM2 gangliosideM2leads to the dysfunction and eventual death of these neurons, which causes the signs and symptoms of Tay-Sachs disease. (nih.gov)

Gobburi ALP, Zhang R, Willard B, Inman D, Anderson DJ (2015) Heterogeneous Ganglioside Standards in LC-MS/MS: Sensitive Method for Quantifying the Major Molecular Components in Mono-Sialo Ganglioside Standards. (omicsonline.org)
Gangliosides, specifically GM1, are markers of these heterogeneous sites. (rcsb.org)

Frontal cortex was homogenized with chloroform:methanol for lipid extraction and ganglioside, phospholipid and cholesterol levels were evaluated. (nih.gov)

During aging and in some cases of neurodegenerative diseases, including Huntington's disease and Parkinson's disease, the level of some of the gangliosides is lower in the patient's brain," says Sipione. (eurekalert.org)
Previously, Sipione's team was able to slow down neurodegeneration in a mouse model of Huntington's disease through injection of a type of ganglioside called GM1 into the mouse brain. (eurekalert.org)

Immune responses against gangliosides are strongly implicated in the pathogenesis of some variants of Guillain-Barré syndrome (GBS). (johnshopkins.edu)

HEXA gene variants affect the ability of the beta-hexosaminidase A enzyme to break down GM2 gangliosideM2 (nih.gov)

A commercially-available mono-sialo (GM1) ganglioside standard consists of three major components with different ceramide structures: C18:0 fatty acid/C18-sphingosine, C18:0 fatty acid/C20-sphingosine and C20:0 fatty acid/C18-sphingosine. (omicsonline.org)

Mutations in genes coding for these enzymes leads to the accumulation of partially broken down gangliosides in lysosomes, which results in a group of diseases called gangliosidosis. (wikipedia.org)
Vascular Diseases and Gangliosides. (nih.gov)

Also, gangliosides are considered as important regulatory elements in cell-cell recognition and cell signaling. (rcsb.org)

The catabolism of Tay-Sachs ganglioside, N-acetylgalactosaminyl- (N-acetylneuraminosyl) -galactosylglucosylceramide, has been studied in lysosomal preparations from normal human brain and brain obtained at biopsy from Tay-Sachs patients. (eurekamag.com)
Methods: We conducted a randomised phase II trial of the immunological adjuvant OPT-821 with a KLH-conjugated ganglioside vaccine targeting GM2, GD2 and GD3, versus OPT-821 alone in patients with metastatic sarcoma following complete metastasectomy. (wustl.edu)

Anatomy1

Organisms1

Diseases6

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes4

Disciplines and Occupations1

Information Science4

Antibodies20

GD1a5

Lipids5

GT1b1

Antibody4

Serum2

Oligosaccharide6

Neuronal6

Molecules6

Known as gangliosides2

Function of gangliosides1

Demonstrate that gangliosides2

Characterization of ganglioside2

Residues5

Anti-ganglioside1

Brain gangliosides1

Specific ganglioside1

Tandem mass spectro4

GD1b3

Carbohydrate6

Mass spectrometry14

Complex glycosphingolipids1

Glycosphingolipids1

Molecule4

Glycolipid1

Composition5

Membrane3

Influenza virus1

Cholera1

Tumor2

Metabolism1

Peptides1

Monosialo1

Residue3

Species5

Globosides1

Cell membranes1

Acidic1

Sandhoff1

Moiety1

Campylobacter1

Neurons1

Heterogeneous2

Cholesterol1

Huntington's2

Immune1

Variants1

Fatty1

Diseases2

Recognition1

Patients2