Ganglionic hexamethonium. Medical search. Frequent questions

A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system, often by acting as a nicotinic receptor antagonist. (wikipedia.org)
The opposite of a ganglionic blocker is referred to as a ganglionic stimulant. (wikipedia.org)
In parallel experiments, rats received the ganglionic blocker hexamethonium before smoke exposure. (mcmaster.ca)
Pretreatment with the ganglionic blocker hexamethonium (2 mg/kg iv) completely abolished enhancing effect of L-NAME on airway responsiveness. (elsevierpure.com)

Nicotinic receptor antagonists: hexamethonium pentolinium mecamylamine trimetaphan tubocurarine pempidine benzohexonium chlorisondamine pentamine Nicotinic receptor agonists (acting through depolarization block): nicotine Blocking ACh release in autonomic ganglia (although these have many other actions elsewhere): botulinum toxin Ganglionic blockers are used less frequently now than they were in the past, because antihypertensives with fewer side effects are now available. (wikipedia.org)
Yet, in all groups, epibatidine-induced strip contractions were similarly inhibited by mecamylamine and hexamethonium (ganglionic nicotinic receptor antagonists), SR 16584 (α3β4 neuronal nicotinic receptor antagonist), atracurium and tubocurarine (neuromuscular nicotinic receptor antagonists), and atropine (muscarinic receptor antagonist), indicating that nicotinic receptors (particularly α3β4 subtypes), neuromuscular and muscarinic receptors play roles in bladder contractility. (jefferson.edu)

ML-1035 contractions were completely blocked by atropine and tetrodotoxin, while ganglionic blockade with hexamethonium was ineffective. (nih.gov)
The neurogenic pressor effect was assessed by ganglionic blockade with hexamethonium. (bvsalud.org)

Because ganglionic blockers block both the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system. (wikipedia.org)
A family of medications known as ganglionic blocking agents, also referred to as ganglionic blockers, affects the autonomic nervous system by preventing the transmission of nerve impulses at ganglia, which are collections of nerve cell bodies outside the central nervous system. (pharmacyfreak.com)
Ganglionic blockers were once used to address conditions like hypertension, angina, and some forms of autonomic dysfunction, but they are no longer frequently prescribed. (pharmacyfreak.com)

The nicotinic antagonist hexamethonium, for example, does this by blocking the transmission of outgoing signals across the autonomic ganglia at the postsynaptic nicotinic acetylcholine receptor. (wikipedia.org)

Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents. (lookformedical.com)

In atropine-treated rats, hexamethonium (antagonist of ganglionic nicotinic receptors) greatly attenuated the BIMP-induced increase in blood pressure without changing the BIMP-induced increase in heart rate. (inra.fr)
In rats treated with atropine plus hexamethonium, intravenous phentolamine (non-selective alpha-adrenergic receptor antagonist) plus propranolol (non-selective beta-adrenergic receptor antagonist) completely blocked the BIMP-induced increases in blood pressure and heart rate. (inra.fr)

Treatment with hexamethonium before smoking reversed the effect of the smoke on the colitis, improving all parameters. (mcmaster.ca)
This effect is reversed by hexamethonium, suggesting that a neural pathway is involved. (mcmaster.ca)

Because ganglionic blockers block both the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system. (wikipedia.org)
Nicotinic receptor antagonists: hexamethonium pentolinium mecamylamine trimetaphan tubocurarine pempidine benzohexonium chlorisondamine pentamine Nicotinic receptor agonists (acting through depolarization block): nicotine Blocking ACh release in autonomic ganglia (although these have many other actions elsewhere): botulinum toxin Ganglionic blockers are used less frequently now than they were in the past, because antihypertensives with fewer side effects are now available. (wikipedia.org)
Members of this group frequently act as ganglionic blockers and neuromuscular depolarizing agents. (bvsalud.org)

The results indicated that the pressor response was peripherally mediated because it persisted following ganglionic blockade with hexamethonium, and was attenuated by NMDAR antagonists, AP-5 or R-(+)-HA-966. (ecu.edu)
Since nicotinic receptors help transmit outgoing signals for the sympathetic and parasympathetic systems, nicotinic receptor antagonists such as hexamethonium interfere with the transmission of these signals. (wikipedia.org)
Nicotinic antagonists that block the receptor include mecamylamine, dihydro-β-erythroidine, and hexamethonium . (wikipedia.org)

A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system, often by acting as a nicotinic receptor antagonist. (wikipedia.org)
The nicotinic antagonist hexamethonium, for example, does this by blocking the transmission of outgoing signals across the autonomic ganglia at the postsynaptic nicotinic acetylcholine receptor. (wikipedia.org)

Quaternary ammonium compounds have been reported to be structurally analogous to decamethonium (a recognized muscular blocking agent) and hexamethonium (an established ganglionic blocking agent). (nih.gov)

It was reported that BTMAC may act at the same ganglionic site as acetylcholine. (nih.gov)