• CMVR
  • Although much effort has been put into dealing with CMV retinitis secondary to acquired immunodeficiency syndrome (AIDS), the few reports which have been published have mainly focused on treatment of CMVR after HSCT. (bjmu.edu.cn)
  • kinases
  • These kinases are present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells compared to uninfected human cells, allowing ganciclovir triphosphate to concentrate in infected cells. (wikipedia.org)
  • triphosphate
  • Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP). (wikipedia.org)
  • Ganciclovir triphosphate serves as a poor substrate for chain elongation. (wikipedia.org)
  • Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. (wikipedia.org)
  • In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route. (wikipedia.org)
  • HCMV
  • Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions, CMV infects around 40% of the population worldwide. (wikipedia.org)
  • Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals. (wikipedia.org)
  • liver
  • The L-valyl ester is cleaved by esterases in the intestines and the liver, leaving ganciclovir to be absorbed by the virus-infected cells. (wikipedia.org)