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  • AIDS
  • Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those infected with AIDS. (wikipedia.org)
  • Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions, CMV infects around 40% of the population worldwide. (wikipedia.org)
  • either
  • The retinitis is detected with ophthalmoscopy as either a perivascular yellow-white retinal lesion frequently associated with retinal hemorrhage or as a focal white granular infiltrate, often without hemorrhage. (annals.org)
  • Often individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir. (wikipedia.org)
  • kinases
  • These kinases are present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells compared to uninfected human cells, allowing ganciclovir triphosphate to concentrate in infected cells. (wikipedia.org)
  • triphosphate
  • Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP). (wikipedia.org)
  • Ganciclovir triphosphate serves as a poor substrate for chain elongation. (wikipedia.org)
  • Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. (wikipedia.org)
  • In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route. (wikipedia.org)
  • disease
  • Before 1982, CMV retinitis was a very rare disease occurring usually after chemotherapy as a consequence of immunological depression (7). (scielo.br)
  • Cox proportional hazards models did not reveal any statistically significant relationships between development of CMV retinitis in the fellow eye and baseline age ( P =0.45), sex ( P =0.67), CD4 count ( P =0.28), or posterior pole (zone 1) disease in the first eye ( P =0.12). (arvojournals.org)
  • About 90% of plasma ganciclovir is eliminated unchanged in the urine, with a half-life of 2-6 hours, depending on renal function (elimination takes over 24 hours in end-stage renal disease). (wikipedia.org)
  • HCMV
  • Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions, CMV infects around 40% of the population worldwide. (wikipedia.org)
  • Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals. (wikipedia.org)
  • viral
  • Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. (wikipedia.org)
  • Once incorporated into viral DNA due to its structure similarity to dGTP, chain termination occurs once a single nucleotide is added to the distal hydroxyl group of the incomplete deoxyribose ring of ganciclovir. (wikipedia.org)
  • liver
  • The L-valyl ester is cleaved by esterases in the intestines and the liver, leaving ganciclovir to be absorbed by the virus-infected cells. (wikipedia.org)