• regulates
  • Binding of 14-3-3 has little effect on Cdc25C activity, and it is believed that 14-3-3 regulates Cdc25C by sequestering it to the cytoplasm, thereby preventing the interactions with CycB-Cdk1 that are localized to the nucleus at the G2/M transition. (wikipedia.org)
  • 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation. (sinobiological.com)
  • FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. (wikipedia.org)
  • In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. (wikipedia.org)
  • interactions
  • citation needed] 14-3-3 proteins can be considered evolved members of the Tetratrico Peptide Repeat (TPR) superfamily, generally have 9 or 10 alpha helices, and usually form homo- and/or hetero-dimer interactions along their amino-termini helices. (wikipedia.org)
  • binds
  • 14-3-3 gamma binds and may regulate CDK11 during the cell cycle and apoptosis. (acris-antibodies.com)
  • The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. (acris-antibodies.com)
  • specifically, the C2 domain of PKCε at amino acids 14-21 (also known as εV1-2) binds RACK2, and peptide inhibitors targeting εV1-2 inhibit PKCε translocation and function in cardiomyocytes, while peptide agonists augment translocation. (wikipedia.org)
  • Molecular
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • apoptosis
  • CHOP also induces apoptosis during endoplasmic reticulum stress by activating growth arrest and DNA damage-inducible protein GADD34. (wikipedia.org)
  • receptors
  • α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. (wikipedia.org)
  • These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. (wikipedia.org)
  • This process involves the transport of cargo proteins, like endocytosed receptors, to endosome recycling complexes and subsequently to the plasma membrane. (wikipedia.org)
  • amino
  • Protein primary structure is the linear sequence of amino acids in a peptide or protein. (wikipedia.org)
  • By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. (wikipedia.org)
  • Protein sequence is typically notated as a string of letters, listing the amino acids starting at the amino-terminal end through to the carboxyl-terminal end. (wikipedia.org)
  • In particular, the L-amino acids normally found in proteins can spontaneously isomerize at the C α {\displaystyle \mathrm {C^{\alpha }} } atom to form D-amino acids, which cannot be cleaved by most proteases. (wikipedia.org)
  • The N-terminal amino group of a polypeptide can be modified covalently, e.g., acetylation − C ( = O ) − C H 3 {\displaystyle \mathrm {-C(=O)-CH_{3}} } The positive charge on the N-terminal amino group may be eliminated by changing it to an acetyl group (N-terminal blocking). (wikipedia.org)
  • The net charge on a protein is based on the sum charge of its amino acids, and the pH of the buffer. (wikipedia.org)
  • The amino acid sequence of "heavy chain disease" protein ZUC. (wikipedia.org)
  • tissue
  • It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. (genecards.org)
  • Rab11FIP5 has also been implicated as a protein involved in the creation of tissue polarity during development. (wikipedia.org)
  • Expression
  • Consistent with these findings, L-165,041 increased 14-3-3ε mRNA and protein level, whereas PPARδ small interfering RNA suppressed both basal and L-165,041-dependent YWHAE transcription and 14-3-3ε protein expression. (ahajournals.org)
  • Intriguingly, activation or knock down of endogenous PPARδ regulated C/EBPβ protein expression. (ahajournals.org)
  • FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. (wikipedia.org)
  • receptor
  • 3-5 Exciting new evidence also suggests that PPARδ agonists may possess antiatherosclerotic properties in vivo by decreasing the amount of nonliganded PPARδ receptor and releasing the transcriptional repressor BCL-6 in foam cells. (ahajournals.org)
  • The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. (wikipedia.org)
  • ROS generated via pharmacologic activation of the mitochondrial potassium-sensitive ATP channel (mitoK(ATP)) and the endogenous G-protein coupled receptor ligand, apelin. (wikipedia.org)
  • Some of the proteins that are regulated through Rab11FIP5 mediated vesicle trafficking are microtubule proteins and the TfR receptor. (wikipedia.org)
  • regulate
  • This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. (wikipedia.org)
  • Rab11FIP5 aids in this sorting process by binding to kinesin II and forming a protein complex to regulate vesicular trafficking. (wikipedia.org)
  • bound
  • Alpha-1 antitrypsin has an SG group and thiol compounds may be bound to the protein altering their mobility. (wikipedia.org)