• chelator
  • DTPA has also been used as a chelator for other metals, such as plutonium. (curehunter.com)
  • In ibritumomab tiuxetan, the chelator tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group. (wikipedia.org)
  • In capromab pendetide and satumomab pendetide, the chelator pendetide (GYK-DTPA) is a modified DTPA containing a peptide linker used to connect the chelate to an antibody. (wikipedia.org)
  • body's
  • After that time has elapsed both calcium-DTPA and zinc-DTPA are similarly effective in reducing internal contamination with plutonium, americium or curium, and zinc-DTPA is less likely to deplete the body's normal levels of zinc and other metals essential to health. (wikipedia.org)
  • Imaging
  • Both biodistribution and micro-SPECT/CT (single-photon emission computed tomography/computed tomography) imaging studies with 111In-[DTPA(1), Lys(3), Tyr(4)]-BN demonstrated the highest uptake at 8 hours postinjection. (curehunter.com)
  • Arterial spin labelling (ASL): Magnetic labeling of arterial blood below the imaging slab, without the need of gadolinium contrast. (wikipedia.org)
  • plutonium
  • DTPA has been considered for treatment of radioactive materials such as plutonium, americium, and other actinides. (wikipedia.org)
  • In August, 2004 the US Food and Drug Administration (USFDA) determined zinc-DTPA and calcium-DTPA to be safe and effective for treatment of those who have breathed in or otherwise been contaminated internally by plutonium, americium, or curium. (wikipedia.org)
  • Cine
  • CMR in the 4 chamber view comparing the cine (left) with the late gadolinium image using inversion recovery (right). (wikipedia.org)
  • images
  • The T1W image before Gd-DTPA was subtracted from the images at each time point after Gd-DTPA. (bmj.com)
  • Accurate measurement of T1 is required for some pharmacokinetic models, which can be estimated from 2 pre-gadolinium images of varying excitation pulse flip angle, though this method is not intrinsically quantitative. (wikipedia.org)
  • toxic
  • Gadolinium based agents may cause a toxic reaction known as nephrogenic systemic fibrosis (NSF) in patients with severe kidney problems. (wikipedia.org)
  • greater
  • Subjects with more white matter hyperintensities had greater signal increase after Gd-DTPA, whether diabetic or not (p=0.001). (bmj.com)
  • time
  • The signal intensity/time curves showed that brain signal intensity increased more in the diabetic group than controls during the first 15 minutes after Gd-DTPA, particularly in the basal ganglia (p=0.018). (bmj.com)
  • At this time, the use of other non-radioactive isotopes, such as gadolinium, has been limited, and to date, it has not been used clinically. (wikipedia.org)
  • When used to chelate iron fertilizer DTPA ensures that the iron is kept in the ferrous state (Fe2+) over time so it can be utilized by aquatic plants without expending valuable energy. (wikipedia.org)
  • metal
  • Like the more common EDTA, DTPA is mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide, which is used to bleach pulp in paper making. (wikipedia.org)
  • Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions. (wikipedia.org)
  • iron
  • DTPA is also used as a chelate for aquarium plant fertilizer, specifically iron, an essential micronutrient typically needed in substantial quantities by all plants. (wikipedia.org)