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  • diagnostic
  • Gd-DTPA often increased diagnostic confidence in the identification and staging of tumours confined to the bladder wall and was necessary to assess depth of bladder wall invasion when T2-weighted images were suboptimal. (openrepository.com)
  • 0.001
  • Subjects with more white matter hyperintensities had greater signal increase after Gd-DTPA, whether diabetic or not (p=0.001). (bmj.com)
  • body's
  • After that time has elapsed both calcium-DTPA and zinc-DTPA are similarly effective in reducing internal contamination with plutonium, americium or curium, and zinc-DTPA is less likely to deplete the body's normal levels of zinc and other metals essential to health. (wikipedia.org)
  • bound
  • In vitro incubations with human plasma, followed by high-pressure liquid chromatography (HPLC) separation of the Gd-DTPASA and Mn-DTPASA liposomes showed that after an incubation period of 24 hours, only 4% of the gadolinium was bound to the plasma proteins, whereas, with the Mn-DTPASA liposomes, a transfer of 40% manganese was seen. (uzh.ch)
  • Compare the image orientation (4 chamber) with the short axis view of the movie above Scar is best seen after giving a contrast agent, typically one containing gadolinium bound to DTPA. (wikipedia.org)
  • tumours
  • Gd-DTPA may therefore be useful in selected patients with tumours of Stage T3a or less in whom information about depth of bladder wall invasion is inadequately shown on pre-contrast sequences. (openrepository.com)
  • Imaging
  • Both biodistribution and micro-SPECT/CT (single-photon emission computed tomography/computed tomography) imaging studies with 111In-[DTPA(1), Lys(3), Tyr(4)]-BN demonstrated the highest uptake at 8 hours postinjection. (curehunter.com)
  • Arterial spin labelling (ASL): Magnetic labeling of arterial blood below the imaging slab, without the need of gadolinium contrast. (wikipedia.org)
  • plutonium
  • DTPA has been considered for treatment of radioactive materials such as plutonium, americium, and other actinides. (wikipedia.org)
  • In August, 2004 the US Food and Drug Administration (USFDA) determined zinc-DTPA and calcium-DTPA to be safe and effective for treatment of those who have breathed in or otherwise been contaminated internally by plutonium, americium, or curium. (wikipedia.org)
  • pharmacokinetic
  • Pharmacokinetic modelling of gadolinium in DCE-MRI is complex, and requires choice of a model. (wikipedia.org)
  • Accurate measurement of T1 is required for some pharmacokinetic models, which can be estimated from 2 pre-gadolinium images of varying excitation pulse flip angle, though this method is not intrinsically quantitative. (wikipedia.org)
  • liver
  • Gadolinium liposomes accumulated in the liver of rats at a peak concentration 4 hours after application and at a higher concentration compared with the manganese liposomes. (uzh.ch)
  • images
  • Artefacts due to variable and inhomogeneous urine signal intensity, however, often degraded post-Gd-DTPA images of the bladder. (openrepository.com)
  • The T1W image before Gd-DTPA was subtracted from the images at each time point after Gd-DTPA. (bmj.com)
  • toxic
  • Gadolinium based agents may cause a toxic reaction known as nephrogenic systemic fibrosis (NSF) in patients with severe kidney problems. (wikipedia.org)
  • time
  • The signal intensity/time curves showed that brain signal intensity increased more in the diabetic group than controls during the first 15 minutes after Gd-DTPA, particularly in the basal ganglia (p=0.018). (bmj.com)
  • At this time, the use of other non-radioactive isotopes, such as gadolinium, has been limited, and to date, it has not been used clinically. (wikipedia.org)
  • metal
  • Like the more common EDTA, DTPA is mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide, which is used to bleach pulp in paper making. (wikipedia.org)
  • Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions. (wikipedia.org)
  • form
  • In the form of the methylglucamine salt meglumine gadobenate (INNm) or gadobenate dimeglumine (USAN), it is used as a gadolinium-based MRI contrast medium. (wikipedia.org)
  • Cell
  • In tissues with healthy cells or a high cell density, gadolinium re-enters the vessels faster since it cannot pass the cell membranes. (wikipedia.org)
  • In damaged tissues or tissues with a lower cell density, the gadolinium stays in the extracellular space longer. (wikipedia.org)
  • study
  • This study suggests that Gd-DTPA diffuses rapidly into the extravascular space in epidural scar, with a slower, net movement toward the intravascular compartment as the agent is renally filtered. (ajnr.org)
  • chelate
  • These data support and confirm the hypothesis that the geometrical confinement of Gd3+-chelate compounds into porous structures offers MRI nanoconstructs with enhanced relaxivity (up to 6 times for [Gd(DTPA)(H2O)]2−, and 4 times for [GdTTHA]3−) and, potentially, improved stability, reduced toxicity and tissue specificity. (rice.edu)
  • DTPA is also used as a chelate for aquarium plant fertilizer, specifically iron, an essential micronutrient typically needed in substantial quantities by all plants. (wikipedia.org)
  • When used to chelate iron fertilizer DTPA ensures that the iron is kept in the ferrous state (Fe2+) over time so it can be utilized by aquatic plants without expending valuable energy. (wikipedia.org)
  • In capromab pendetide and satumomab pendetide, the chelator pendetide (GYK-DTPA) is a modified DTPA containing a peptide linker used to connect the chelate to an antibody. (wikipedia.org)
  • DTPA and derivatives are used to chelate gadolinium to form a MRI contrast agent, such as Magnevist. (wikipedia.org)
  • Interaction with the gadolinium (Gd) contrast agent (commonly a gadolinium ion chelate) causes the relaxation time of water protons to decrease, and therefore images acquired after gadolinium injection display higher signal in T1-weighted images indicating the present of the agent. (wikipedia.org)
  • Magnevist
  • Recently, the geometrical confinement of Gd3+-based contrast agents (CAs) within porous structures has been proposed as a novel, alternative strategy to improve relaxivity without chemical modification of the CA. Here, we have characterized and optimized the performance of MRI nanoconstructs obtained by loading [Gd(DTPA)(H2O)]2− (Magnevist®) into the pores of injectable mesoporous silicon particles. (rice.edu)
  • body's
  • After that time has elapsed both calcium-DTPA and zinc-DTPA are similarly effective in reducing internal contamination with plutonium, americium or curium, and zinc-DTPA is less likely to deplete the body's normal levels of zinc and other metals essential to health. (wikipedia.org)
  • initial
  • The recommended treatment is for an initial dose of calcium-DTPA, as this salt of DTPA has been shown to be more effective in the first 24 hours after internal contamination by plutonium, americium, or curium. (wikipedia.org)
  • DCE-MRI can also provide model independent parameters, such as T1 (which is not technically part of the contrast scan, and can be acquired independently) and (initial) area under the gadolinium curve (IAUGC, often given with number of seconds from injection, i.e. (wikipedia.org)
  • images
  • Accurate measurement of T1 is required for some pharmacokinetic models, which can be estimated from 2 pre-gadolinium images of varying excitation pulse flip angle, though this method is not intrinsically quantitative. (wikipedia.org)
  • administration
  • In August, 2004 the US Food and Drug Administration (USFDA) determined zinc-DTPA and calcium-DTPA to be safe and effective for treatment of those who have breathed in or otherwise been contaminated internally by plutonium, americium, or curium. (wikipedia.org)
  • high
  • Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions. (wikipedia.org)
  • In tissues with healthy cells or a high cell density, gadolinium re-enters the vessels faster since it cannot pass the cell membranes. (wikipedia.org)
  • metal
  • Like the more common EDTA, DTPA is mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide, which is used to bleach pulp in paper making. (wikipedia.org)
  • lower
  • ICC for change scores was lower for STIR (ICC 0.53) than for Gd-DTPA- enhanced sequences (ICC 0.79). (docme.ru)
  • materials
  • DTPA has been considered for treatment of radioactive materials such as plutonium, americium, and other actinides. (wikipedia.org)