• AMPA
  • GluN1) (GluN2A) and of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors . (cura-cancer.com)
  • A number of biochemical and electrophysiological studies suggest that the synapse between the ipsilateral vestibular (VIIIth) nerve and the brainstem vestibular nucleus (VN) is mediated by an EAA acting predominantly on kainate or α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. (springer.com)
  • gamma-amin
  • Contributing to this effect is the activity that alcohol induces in the gamma-aminobutyric acid (GABA) system. (wikipedia.org)
  • calcium
  • summarly define how a calcium channel blocker 'block' (disrupt) GABA receptor from processing visual signals properly in the fore-brain (ie: hippocampus) through a signal transduction cascade. (openwetware.org)
  • Burgoyne R. D., Pearce I. A., and Cambray-Deakin M. (1988) N -methyl- d -aspartate raises cytosolic calcium concentration in rat cerebellar granule cells in culture. (springer.com)
  • Due to its hydrophilic character, IP3 can travel to the endoplasmic reticulum, where it induces, via fixation on its receptor, the opening of calcium channels increasing in this way the cytosolic calcium concentrations. (wikipedia.org)
  • In addition, pregnenolone sulfate has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release. (wikipedia.org)
  • tissues
  • Viral tropism for the decidua and placenta is then dependent on viral entry receptor expression in these tissues as well as on the maternal immune response to the virus. (jci.org)
  • ligands
  • Davies S. N., Martin D., Millar J. D., Aram J. A., Church J., and Lodge D. (1988) Differences in results from in vivo and in vitro studies on the use-dependency of N -methylaspartate antagonism by MK801 and other phencyclidine receptor ligands. (springer.com)
  • chloride
  • Additionally, in the absence of GABA the presence of benzodiazepines alone does not open the chloride channel. (wikipedia.org)
  • membrane
  • Like other metabotropic receptors, mGluRs have seven transmembrane domains that span the cell membrane. (wikipedia.org)
  • Stimulating the receptors causes the associated enzyme phospholipase C to hydrolyze phosphoinositide phospholipids in the cell's plasma membrane. (wikipedia.org)
  • The lipophilic diacylglycerol remains in the membrane, acting as a cofactor for the activation of protein kinase C. These receptors are also associated with Na+ and K+ channels. (wikipedia.org)
  • These receptors are involved in presynaptic inhibition, and do not appear to affect postsynaptic membrane potential by themselves. (wikipedia.org)
  • selective
  • Dememes D., Raymond J., and Sans A. (1984) Selective retrograde labelling of neurons of the cat vestibular ganglion with [ 3 H] d -Aspartate. (springer.com)
  • signals
  • It has been asserted that GABA signals interfere with the registration and consolidation stages of memory formation. (wikipedia.org)
  • The binding of SP to the NK1 receptor has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. (wikipedia.org)
  • hypothesis
  • Engineering Deceit with the Clouds: The H3 receptor site is an inducible metabolic promoter for orthogonal drug delivery and prokariotic gene regulation using Lactose derived repressors: An hypothesis. (openwetware.org)
  • effects
  • GABA is metabolized by successive transamination and oxidation to yield succinic semialdehyde and succinic acid respectively via the catalyzing effects of GABA transaminase. (wikipedia.org)
  • found
  • As the GABA system is found in the hippocampus (among other areas in the CNS), which is thought to play a large role in memory formation, this is thought to be possible. (wikipedia.org)
  • The NK1 receptor can be found in both the central and peripheral nervous system. (wikipedia.org)
  • include
  • Other diseases in which the NK1 receptor system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders. (wikipedia.org)
  • different
  • Nonetheless, these results suggest that EAA receptors may be important in many different parts of the vestibular reflex pathways. (springer.com)
  • The function of the receptor is different according to how the pentameric complex is put together. (wikipedia.org)
  • function
  • All of the electrophysiological studies conducted so far have used in vitro preparations, and it is possible that denervation of the VN during the preparation of an explant or slice causes changes in EAA receptor function. (springer.com)
  • When NK1 receptors are stimulated, they can generate various second messengers, which can trigger a wide range of effector mechanisms that regulate cellular excitability and function. (wikipedia.org)
  • type
  • A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40% of striatal MSNs expressing both DRD1 and DRD2 mRNA. (wikipedia.org)
  • These mixed-type NAcc MSNs with both D1-type and D2-type receptors are mostly confined to the NAcc shell. (wikipedia.org)
  • activity
  • Receptor types are grouped based on receptor structure and physiological activity. (wikipedia.org)
  • Receptors in groups II and III reduce the activity of postsynaptic potentials, both excitatory and inhibitory, in the cortex. (wikipedia.org)
  • The 3β-methyl ether of pregnenolone, 3β-methoxypregnenolone (MAP-4343), retains similar activity to pregnenolone in regards to interaction with MAP2, and is under development for potential clinical use for indications such as the treatment of brain and spinal cord injury and depressive disorders. (wikipedia.org)
  • channel
  • The channel conductance is not higher in the presence of benzodiazepine and GABA than the conductance with the presence of only high GABA concentrations. (wikipedia.org)