• activity
  • In vitro enzymatic assay revealed that metadoxine reduced the activity of the GABA transaminase enzyme, responsible for the degradation of GABA. (wikipedia.org)
  • present
  • Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with GABA modulators is not present in ramelteon. (wikipedia.org)
  • However, they have no effect if GABA or another agonist is not present. (wikipedia.org)