• interacts
  • Thus for instance, c-Abl interacts with the transcription factor RXF1, which binds to the palindromic EP sequence in the hepatitis virus B enhancer, and can also be recruited to an E2FDNA binding complex, through a direct interaction with the retinoblastoma protein (RB). (genetex.com)
  • growth factor r
  • Publications] Ueno, H.: 'Antisense repression of proto-on-cogene c-CBL enhances activation of the JAK-STAT pathway but not the Ras pathwayin epidermal growth factor receptor sig-nalling. (nii.ac.jp)
  • pathways
  • Differential binding of adapter proteins may impart some signal specificity, since many of the receptors use the same adapter proteins, and may also link the activation of the receptor to multiple pathways. (genetex.com)
  • leukemia
  • Therefore, we wished to establish if ERG could act as an oncogene in myeloid leukemia and if the elevated expression of ERG in AMKL has functional significance. (aacrjournals.org)
  • The Abl oncogen is implicated in several human leukemias including the majority of chronic myelocytic leukemia (CML), one fourth of adult acute lymphoblastic leukemia (ALL) and few of pediatric ALL. (genetex.com)
  • cellular
  • Under nutrient-replete conditions, autophagy is thought to selectively degrade long-lived proteins and organelles as a means of recycling cell contents and maintaining cellular homeostasis and integrity. (biologists.org)
  • By contrast, the following studies were interpreted as indications of a negative role for Ena/VASP proteins in actin-dependent cellular processes. (biologists.org)
  • Neutrophils (whose function in the body is to remove hazardous microorganisms and inflammatory debris) are activated by the binding of the crystals to the neutrophil cellular membrane, which leads to respiratory burst activity, engulfment of the crystals and release of proteolytic enzymes. (ubc.ca)
  • Bishop and Varmus were awarded the Nobel Prize in Physiology or Medicine in 1989 for their discovery of the cellular origin of retroviral oncogenes. (wikipedia.org)
  • induce
  • c-Ret/dok fusion proteins, in which Y1062 of c-Ret is deleted and replaced by the sequences of dok-4 or dok-5, induce ligand-dependent axonal outgrowth of PC12 cells, whereas a c-Ret fusion containing dok-2 sequences does not elicit this response. (rupress.org)
  • Synthesis
  • Irvin, "Purification and Partial Characterization of the Antiviral Protein from Phytolacca americana Which Inhibits Eukaryotic Protein Synthesis," Archives of Biochemistry and Biophysics 169: 522-528, 1975. (patentgenius.com)
  • The present invention is directed to substituted pyrimidine compounds of formula (I): ##STR00001## and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition. (patentsencyclopedia.com)
  • Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
  • receptor
  • These docking proteins contain NH 2 -terminal membrane-targeting elements, pleckstrin homology (PH) domains or myristylation sites, and receptor-targeting sequences, PTB or PTB-like domains. (rupress.org)
  • Purification
  • Purification and Propeties of a Second Antiviral Protein from Phytolacca americana which inactivates Eukaryotic Ribosomes," Archives of Biochemistry and Biophysics 200(2): 418-425, 1980. (patentgenius.com)
  • Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed)," Biochem. (patentgenius.com)
  • tumour
  • A decrease in tumour size expressing native or T315I mutant BCR-ABL have been observed in rats. (drugbank.ca)
  • Oncogenes (Teilungsfoerdernde Chromosomen) that become amplified (im permanenten Übergewicht) during tumour development. (wikipedia.org)
  • regulates
  • The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
  • fusion
  • In both EWS-ERG and TLS-ERG, the fusion protein contains a truncated form of ERG that retains the ETS domain. (aacrjournals.org)
  • Using immunostaining assay and subcellular fractionation of Cos1 cells expressing the MLL/MEN fusion, tMLL,and MEN proteins, we ha … More ve demonstrated that all these proteins exist in the nucleus of the cells. (nii.ac.jp)
  • known
  • A majority of the known protein kinases are localized at or near the plasma membranes. (genetex.com)
  • The function of another elongation factor, elongin, is known to be inhibited by VHL tumor suppressor protein in vitro, suggesting the possible relationship of aberrant transcriptional elongation to oncogenesis. (nii.ac.jp)
  • novel
  • Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as `anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments. (biologists.org)
  • Cells
  • The T315I mutation confers resistance in cells as it prevents other Bcr-Abl inhibitors from binding to the Abl kinase. (drugbank.ca)
  • To demonstrate the transforming activity of the MEN protein, the MEN cDNA was introduced retrovirally into Ratl cells. (nii.ac.jp)
  • The c-Fos protein expression and AP-1 activity were elevated in the MEN-expressing cells, which might be part of the responsible mechanism for the transformation. (nii.ac.jp)
  • expression
  • however, it is unclear if expression of ERG per se has a leukemogenic activity. (aacrjournals.org)
  • The unregulated expression of this protein activates other proteins that are involved in cell cycle and cell division which can cause a cell to grow and divide uncontrollably (the cell becomes cancerous). (wikipedia.org)
  • roles
  • In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. (biologists.org)
  • cell
  • In the past three years a number of studies on Ena/VASP proteins have appeared to arrive at contradictory conclusions as to the function of these proteins in actin dynamics and cell motility. (biologists.org)
  • contains
  • The c-Abl protein contains three high mobility group-like domains that bind to A+T-rich DNA in a cooperative manner. (genetex.com)
  • The central proline-rich domain contains binding sites for SH3 and WW domains as well as for the G-actin binding protein profilin. (biologists.org)
  • ETV6 protein contains 3 domains: a) the pointed N-terminal (i.e. (wikipedia.org)
  • humans
  • In 1976 Drs. Dominique Stehelin, J. Michael Bishop and Harold E. Varmus of the University of California, San Francisco demonstrated that oncogenes were activated proto-oncogenes, found in many organisms including humans. (wikipedia.org)
  • domain
  • Furthermore, p73 and c-Abl can associate with each other, and this binding is mediated by PxxP motif in p73 and the SH3 domain of c-Abl. (genetex.com)
  • The domain structure of the Ena/VASP proteins along with their binding partners and functions are shown. (biologists.org)