• interacts
  • Thus for instance, c-Abl interacts with the transcription factor RXF1, which binds to the palindromic EP sequence in the hepatitis virus B enhancer, and can also be recruited to an E2FDNA binding complex, through a direct interaction with the retinoblastoma protein (RB). (genetex.com)
  • pathways
  • Differential binding of adapter proteins may impart some signal specificity, since many of the receptors use the same adapter proteins, and may also link the activation of the receptor to multiple pathways. (genetex.com)
  • Antibodies reacting specifically with c-Abl are useful tools in the study of the detailed mechanisms of the signaling pathways involving c-Abl. (genetex.com)
  • leukemia
  • We show that ectopic expression of ERG in fetal hematopoietic progenitors promotes megakaryopoiesis and that ERG alone acts as a potent oncogene in vivo leading to rapid onset of leukemia in mice. (aacrjournals.org)
  • These data suggest that ERG is a hematopoietic oncogene that may play a direct role in myeloid leukemia pathogenesis. (aacrjournals.org)
  • Therefore, we wished to establish if ERG could act as an oncogene in myeloid leukemia and if the elevated expression of ERG in AMKL has functional significance. (aacrjournals.org)
  • The Abl oncogen is implicated in several human leukemias including the majority of chronic myelocytic leukemia (CML), one fourth of adult acute lymphoblastic leukemia (ALL) and few of pediatric ALL. (genetex.com)
  • Oncogenes were first discovered in retroviruses ( viruses containing the enzyme reverse transcriptase, and RNA , rather than DNA ) that were found to cause cancer in many animals (e.g., feline leukemia virus, simian sarcoma virus). (encyclopedia.com)
  • sequences
  • c-Ret/dok fusion proteins, in which Y1062 of c-Ret is deleted and replaced by the sequences of dok-4 or dok-5, induce ligand-dependent axonal outgrowth of PC12 cells, whereas a c-Ret fusion containing dok-2 sequences does not elicit this response. (rupress.org)
  • These docking proteins contain NH 2 -terminal membrane-targeting elements, pleckstrin homology (PH) domains or myristylation sites, and receptor-targeting sequences, PTB or PTB-like domains. (rupress.org)
  • Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. (springer.com)
  • While c-Abl does not select DNA sequences, it can be recruited to specific DNA-binding complexes through protein-protein interactions. (genetex.com)
  • receptor
  • The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocytic growth factor, CSF-1. (springer.com)
  • Sap J, Munoz A, Damm K, The c-erb-A protein is a high-affinity receptor for thyroid hormone. (springer.com)
  • The p53-related protein p73, is also a substrate of the non-receptor tyrosine kinase c-Abl, in response to DNA damage. (genetex.com)
  • Publications] Ueno, H.: 'Antisense repression of proto-on-cogene c-CBL enhances activation of the JAK-STAT pathway but not the Ras pathwayin epidermal growth factor receptor sig-nalling. (nii.ac.jp)
  • thus
  • Although these data imply that ERG might be a hematopoietic oncogene, no explicit evidence for this has thus far been shown. (aacrjournals.org)
  • putative
  • Waterfield MD, Scrace G, Whittle N,Platelet-derived growth factor is structurally related to the putative transforming protein of simian sarcoma virus. (springer.com)
  • Antibodies
  • These antibodies detected the MLL/MEN fusion protein of 230 kD,truncated form of the MLL Without the zinc finger domain and its downstream sequence(tMLL)of 180kD,and MEN protein of 70kD in Cos1 cells transfected with the corresponding cDNAs. (nii.ac.jp)
  • Synthesis
  • Irvin, "Purification and Partial Characterization of the Antiviral Protein from Phytolacca americana Which Inhibits Eukaryotic Protein Synthesis," Archives of Biochemistry and Biophysics 169: 522-528, 1975. (patentgenius.com)
  • Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
  • Purification
  • Purification and Propeties of a Second Antiviral Protein from Phytolacca americana which inactivates Eukaryotic Ribosomes," Archives of Biochemistry and Biophysics 200(2): 418-425, 1980. (patentgenius.com)
  • Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed)," Biochem. (patentgenius.com)
  • tumour
  • Oncogenes (Teilungsfoerdernde Chromosomen) that become amplified (im permanenten Übergewicht) during tumour development. (wikipedia.org)
  • Human
  • Reddy EP, Reynolds RK, Santos E, Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. (springer.com)
  • Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce C. Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. (springer.com)
  • Persson H, Leder P. Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. (springer.com)
  • Since the 1970s, dozens of oncogenes have been identified in human cancer. (wikipedia.org)
  • regulates
  • The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
  • binds
  • Sambucetti LC, Curran T. The fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. (springer.com)
  • fusion
  • In both EWS-ERG and TLS-ERG, the fusion protein contains a truncated form of ERG that retains the ETS domain. (aacrjournals.org)
  • Using immunostaining assay and subcellular fractionation of Cos1 cells expressing the MLL/MEN fusion, tMLL,and MEN proteins, we ha … More ve demonstrated that all these proteins exist in the nucleus of the cells. (nii.ac.jp)
  • Cells
  • The T315I mutation confers resistance in cells as it prevents other Bcr-Abl inhibitors from binding to the Abl kinase. (drugbank.ca)
  • To demonstrate the transforming activity of the MEN protein, the MEN cDNA was introduced retrovirally into Ratl cells. (nii.ac.jp)
  • The c-Fos protein expression and AP-1 activity were elevated in the MEN-expressing cells, which might be part of the responsible mechanism for the transformation. (nii.ac.jp)
  • humans
  • In 1976 Drs. Dominique Stehelin, J. Michael Bishop and Harold E. Varmus of the University of California, San Francisco demonstrated that oncogenes were activated proto-oncogenes, found in many organisms including humans. (wikipedia.org)
  • expression
  • however, it is unclear if expression of ERG per se has a leukemogenic activity. (aacrjournals.org)
  • Combining ectopic expression experiments in fetal hematopoietic progenitors and RNA interference in AMKL cell lines, we show, for the first time, that full-length ERG is a myeloid oncogene. (aacrjournals.org)
  • The unregulated expression of this protein activates other proteins that are involved in cell cycle and cell division which can cause a cell to grow and divide uncontrollably (the cell becomes cancerous). (wikipedia.org)