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  • interacts
  • Thus for instance, c-Abl interacts with the transcription factor RXF1, which binds to the palindromic EP sequence in the hepatitis virus B enhancer, and can also be recruited to an E2FDNA binding complex, through a direct interaction with the retinoblastoma protein (RB). (genetex.com)
  • retroviruses
  • Oncogenes were first discovered in retroviruses ( viruses containing the enzyme reverse transcriptase, and RNA , rather than DNA ) that were found to cause cancer in many animals (e.g., feline leukemia virus, simian sarcoma virus). (encyclopedia.com)
  • putative
  • Waterfield MD, Scrace G, Whittle N,Platelet-derived growth factor is structurally related to the putative transforming protein of simian sarcoma virus. (springer.com)
  • thus
  • Although these data imply that ERG might be a hematopoietic oncogene, no explicit evidence for this has thus far been shown. (aacrjournals.org)
  • Synthesis
  • Irvin, "Purification and Partial Characterization of the Antiviral Protein from Phytolacca americana Which Inhibits Eukaryotic Protein Synthesis," Archives of Biochemistry and Biophysics 169: 522-528, 1975. (patentgenius.com)
  • Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
  • Purification
  • Purification and Propeties of a Second Antiviral Protein from Phytolacca americana which inactivates Eukaryotic Ribosomes," Archives of Biochemistry and Biophysics 200(2): 418-425, 1980. (patentgenius.com)
  • Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed)," Biochem. (patentgenius.com)
  • tumour
  • Oncogenes (Teilungsfoerdernde Chromosomen) that become amplified (im permanenten Übergewicht) during tumour development. (wikipedia.org)
  • chronic
  • The Abl oncogen is implicated in several human leukemias including the majority of chronic myelocytic leukemia (CML), one fourth of adult acute lymphoblastic leukemia (ALL) and few of pediatric ALL. (genetex.com)
  • HUMAN
  • Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce C. Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. (springer.com)
  • Persson H, Leder P. Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. (springer.com)
  • Since the 1970s, dozens of oncogenes have been identified in human cancer. (wikipedia.org)
  • leukemia
  • We show that ectopic expression of ERG in fetal hematopoietic progenitors promotes megakaryopoiesis and that ERG alone acts as a potent oncogene in vivo leading to rapid onset of leukemia in mice. (aacrjournals.org)
  • These data suggest that ERG is a hematopoietic oncogene that may play a direct role in myeloid leukemia pathogenesis. (aacrjournals.org)
  • Therefore, we wished to establish if ERG could act as an oncogene in myeloid leukemia and if the elevated expression of ERG in AMKL has functional significance. (aacrjournals.org)
  • regulates
  • The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
  • binds
  • Sambucetti LC, Curran T. The fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. (springer.com)
  • mechanisms
  • Antibodies reacting specifically with c-Abl are useful tools in the study of the detailed mechanisms of the signaling pathways involving c-Abl. (genetex.com)
  • humans
  • In 1976 Drs. Dominique Stehelin, J. Michael Bishop and Harold E. Varmus of the University of California, San Francisco demonstrated that oncogenes were activated proto-oncogenes, found in many organisms including humans. (wikipedia.org)
  • cancer
  • In silico target fishing identified maca's traditional effects on treatment and prevention of osteoporosis, prostate cancer, and kidney diseases, and its potential function of treating cardiovascular diseases, as the most important of this herb's possible activities. (biomedcentral.com)
  • Many cancer drugs target the proteins encoded by oncogenes. (wikipedia.org)
  • Later on the term "oncogene" was rediscovered in 1969 by National Cancer Institute scientists George Todaro and Robert Heubner. (wikipedia.org)