• genome
  • These trVLPs can continuously infect cells expressing the Ebola virus proteins responsible for genome replication and transcription, allowing us to safely model multiple infectious cycles under biosafety level 2 conditions. (jove.com)
  • receptor
  • Due to the relatively conserved binding region of E2 to the CD81 receptor on the liver cells, this discovery is expected to pave the way to design a HCV vaccine which will stimulate antibody response with neutralizing effects on broad range of virus strains. (wikipedia.org)
  • polypeptide
  • The two 5-proximal ORFs encode the replicases, two internal ORFs encode movement proteins, and the 3-proximal ORF encodes a polypeptide (p37) which plays a dual role as capsid protein and as suppressor of RNA silencing. (jove.com)
  • gene
  • To date, several host- and virus-related factors have been implicated in the progression to MCII, such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene subfamilies, the involvement of complement factors and the specific role of some HCV proteins. (mdpi.com)
  • bind
  • In line, HBsAg preferentially bound to TLR9-triggered pDC demonstrating that once pDC are able to bind HBV/HBsAg, the virus exerts its immune regulatory effect. (jove.com)
  • complexes
  • In particular, about 60% of HCV-infected patients present cold-precipitable (cryoprecipitable) and noncryoprecipitable immune complexes that could be associated with the clinical onset of type II mixed cryoglobulinemia (MCII) [ 2 ]. (mdpi.com)
  • This immune complex-mediated vasculitis is characterized by a primary B-cell clonal proliferation accompanied by the deposition of immune complexes composed of complement factors, mono/oligoclonal IgMs with rheumatoid factor (RF) activity bound to oligo/polyclonal IgGs that, in the case of HCV infection, are mostly directed against HCV proteins [ 3 ]. (mdpi.com)
  • allosteric
  • Here, we aimed to provide some insight into the inhibitor binding mode and allosteric regulation mechanism of HCV NS3/4A protein by using computational methods. (jove.com)
  • promotes
  • NSs induces a shut-off of host transcription including interferon (IFN)-beta mRNA 7,8 and promotes degradation of double-stranded RNA-dependent protein kinase (PKR) at the post-translational level. (jove.com)
  • interaction
  • Further residue interaction network analysis suggests the communication of the domain-domain interface play an important role in the transition from closed to open conformation of HCV NS3/4A protein. (jove.com)
  • human
  • Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? (mdpi.com)
  • Therefore, HBV and HBV-derived proteins were examined for their effect on human pDC in vitro. (jove.com)
  • expression
  • The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. (blogspot.com)
  • contain
  • Negative-stain electron microscopy revealed that the particles were spherical (~40- to 75-nm diameter) and pleomorphic and that some of them contain HCV E2 protein and apolipoprotein E on their surfaces. (pubmedcentralcanada.ca)
  • time
  • Cell-free culture supernatants, protein lysates and total RNA were harvested at various time points post-transfection to assess HCV growth. (jove.com)