• Diseases
  • Both drugs can be given orally, concentrate in lung tissue, and have been used safely in humans for treatment of other diseases. (clinicaltrials.gov)
  • Sometimes, as in the Great Irish Famine of 1845-1849, fungal diseases of plants, in this case potato blight caused by Phytophthora, result in large-scale human suffering. (wikipedia.org)
  • Losses of crops due to fungal diseases (e.g., rice blast disease) or food spoilage can have a large impact on human food supplies and local economies. (wikipedia.org)
  • Injections
  • However, the concurrent treatment of ADA injections may impair the success of gene therapy, since transduced cells will have no selective advantage to proliferate if untransduced cells can survive in the presence of the injected ADA. (wikipedia.org)
  • pulmonary
  • for example, infants, adults with chronic conditions (such as chronic obstructive pulmonary disease), senior citizens, alcoholics and others with compromised immune systems are more likely to develop CAP from Haemophilus influenzae or Pneumocystis carinii. (wikipedia.org)
  • Candida
  • Screening of natural products of fungal fermentation in the 1970s led to the discovery of echinocandins, a new group of antifungals with broad-range activity against Candida spp. (wikipedia.org)
  • Medical
  • Although the symptoms receded temporarily following drug treatments in 1975,[medical citation needed] the symptoms later grew considerably worse. (wikipedia.org)
  • organisms
  • Many less-common organisms can cause CAP in adults, and are identified from specific risk factors or treatment failure for common causes. (wikipedia.org)
  • immune
  • Pattern recognition receptors (PRRs) play an important role in inducing an immune response by recognizing specific fungal pathogens and initiating an immune response. (wikipedia.org)
  • resistance
  • Additional objectives are to examine the effect of these treatments in controlling time to cytomegalovirus (CMV) retinitis progression and to examine the antiviral activity of combined and alternating ganciclovir/foscarnet treatment and development of antiviral resistance. (clinicaltrials.gov)
  • Compounds with this fungal-specific target have several attractive features: Lack of mechanism-based toxicity Potential for fungicidal activity Activity against strains with intrinsic or acquired resistance mechanisms for existing antimycotics. (wikipedia.org)
  • High levels of HIV-1 (often HAART-resistant) develop if treatment is stopped, if compliance with treatment is inconsistent, or if the virus spontaneously develops resistance to an individual's regimen. (wikipedia.org)
  • people
  • It appears to be an alternative to the more traditional treatment with melphalan in people who are ill-suited for autologous stem cell transplant. (wikipedia.org)
  • common
  • The most common treatment for SCID is bone marrow transplantation, which has been successful using either a matched related or unrelated donor, or a half-matched donor, who would be either parent. (wikipedia.org)
  • therapy
  • Treatment consists of either combined sequential daily maintenance therapy of both foscarnet and ganciclovir or alternating daily treatment with ganciclovir one day and foscarnet the following day. (clinicaltrials.gov)
  • eventually
  • After numerous tests and unsuccessful treatments, she eventually returned home to her cottage on a fjord in November 1977, where her long-time female partner (a nurse) cared for her. (wikipedia.org)