• angiogenesis
  • Knocking down HIF-1α or HIF-2α individually inhibited the xenograft tumor angiogenesis and growth, and knocking them down simultaneously revealed a better inhibitory effect than knocking down either unit alone. (aacrjournals.org)
  • As such, we suggest that therapeutic outcome in terms of inhibiting tumor growth and angiogenesis may benefit from nonselectively targeting HIF-1α and HIF-2α in OSCC. (aacrjournals.org)
  • glucose
  • The detrimental skeletal effects of glucose toxicity, insulin deficiency, and diabetes complications might partly explain the association between type 1 diabetes and osteoporosis ( 3 - 5 ). (diabetesjournals.org)
  • In order to be diagnosed with Type 2 Diabetes, an individual must present with all of the following: 1) Classic symptoms of diabetes mellitus, including polyuria, polydipsia, polyphagia, weight loss, and random plasma glucose ≥ 200 mg/dL, 2) Fasting plasma glucose ≥126 mg/dL, and 3) Two hour post glucose load (75g) plasma glucose ≥200 mg/dL, and confirmed by repeat test. (wikidot.com)
  • gene
  • The PAI-1 gene is SERPINE1, located on chromosome 7 (7q21.3-q22). (wikipedia.org)
  • The purpose of this study is to clarify the biologic actions of extremely low-frequency (ELF) alternate-current (AC) high magnetic fields, especially their effects on gene functions including DNA replication, repair and transcription. (nii.ac.jp)
  • deficiency
  • Quantitative computed tomography analysis showed that PAI-1 deficiency protected against streptozotocin-induced bone loss in female mice but not in male mice. (diabetesjournals.org)
  • PAI-1 deficiency blunted the changes in the levels of Runx2, osterix, and alkaline phosphatase in tibia as well as serum osteocalcin levels suppressed by the diabetic state in female mice only. (diabetesjournals.org)
  • Furthermore, the osteoclast levels in tibia, suppressed in diabetes, were also blunted by PAI-1 deficiency in female mice. (diabetesjournals.org)
  • 12 ) previously reported that PAI-1 deficiency partially protected against bone loss in estrogen-deficient mice. (diabetesjournals.org)
  • In the current study, we examined the effects of PAI-1 deficiency on streptozotocin-induced diabetic bone loss by using wild-type and PAI-1-deficient mice. (diabetesjournals.org)
  • vitro
  • In vitro study demonstrated that treatment with active PAI-1 suppressed the levels of osteogenic genes and mineralization in primary osteoblasts from female mouse calvaria. (diabetesjournals.org)
  • activity
  • Direct antigonadal activity of cannabinoids: suppression of rat granulosa cell functions. (springer.com)
  • The irregular atrial discharge typical of AF may result from an irregular atrial response to a rapidly discharging regularly firing driver resulting from either local ectopic firing ( Figure 1 A) or a single localized reentry circuit ( Figure 1 B). Alternatively, fibrillatory activity may be caused directly by multiple functional reentry circuits varying in time and space ( Figure 1 C). (ahajournals.org)
  • Paroxysmal AF usually involves a driver in the cardiac muscle sleeve around ≥1 pulmonary veins (PVs) caused by rapid focal activity or local reentry. (ahajournals.org)
  • type 1 diabet
  • Type 1 diabetes is a disease in which patients have little or no insulin secretion and hyperglycemia. (diabetesjournals.org)
  • A decrease in bone mineral density (BMD) and a marked increase in fracture risk have been described in patients with type 1 diabetes ( 1 , 2 ). (diabetesjournals.org)
  • diabetic patients
  • However, the pathogenesis of this skeletal fragility and markers for the evaluation of bone metabolism in type 1 diabetic patients remain to be fully clarified. (diabetesjournals.org)
  • Several reports have shown that circulating PAI-1 levels are elevated in type 1 and type 2 diabetic patients and in animal models ( 8 , 9 ). (diabetesjournals.org)
  • Congenital
  • The principal features include congenital heart defect (typicall pulmonary valve stenosis with dysplastic pulmonary valve also atrial septal defect and hypertrophic cardiomyopathy), short stature, learning problems, pectus excavatum, impaired blood clotting, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge. (wikipedia.org)
  • tumor
  • Despite these differences, both HIF-1α and HIF-2α showed promoting roles in tumor growth, and simultaneously knocking down HIF-1α and HIF-2α would produce a better inhibitory effect than knocking down HIF-1α or HIF-2α individually. (aacrjournals.org)
  • However, a highly proliferating mass of tumor cells develops faster than the vasculature, and tumor cells rapidly meet up with an avascular environment deficient in oxygen ( 1 ). (aacrjournals.org)
  • Such hypoxic zones have been postulated to increase patient treatment resistance and favor tumor progression ( 1 , 3 ). (aacrjournals.org)
  • diabetes
  • 10 ) reported that PAI-1 contributes to the development of diabetes. (diabetesjournals.org)
  • Diabetes was induced in male and female wild-type (PAI-1 WT) mice and PAI-1-deficient (PAI-1 KO) mice (10 weeks of age) by daily injections of streptozotocin (50 mg/kg body wt i.p. in saline [ 13 ]), a pancreatic β-cell cytotoxin, for 4 days. (diabetesjournals.org)
  • 1 ][ 2 ]Previously, it was referred to as non-insulin-dependent diabetes mellitus or adult-onset diabetes mellitus. (wikidot.com)
  • This study provided the opportunity to assess the association between endothelial vasodilation function and the incidence of diabetes in a cohort of apparently healthy postmenopausal women. (diabetesjournals.org)
  • Each 1-unit decrease of FMD was associated with a significant 32% (22-48%) increase in the multiple-adjusted RR of incident diabetes. (diabetesjournals.org)
  • development
  • The periovulatory interval refers to that period bracketed by the gonadotropin surge and the development of an effective corpus luteum (Fig. 1). (springer.com)
  • The maturational status of the oocyte and its embryonic potential, as well as establishment and ultimate function of the corpus luteum, are dependent upon the quality of antecedent follicular development. (springer.com)
  • 7 , 8 AF-related electric remodeling, resulting from altered expression and/or function of cardiac ion channels, favors the development of functional reentry substrates, 7 which are reversible on AF termination (reverse remodeling) and contribute to persistent AF. (ahajournals.org)
  • expression
  • The expression of PAI-1 in the liver and the sensitivity of bone cells to PAI-1 may be an underlying mechanism. (diabetesjournals.org)
  • We evaluated the correlations between HIF-1α and HIF-2α expression and the clinical-pathologic characteristics of 97 patients with OSCC by immunohistochemical staining. (aacrjournals.org)
  • HIF-1α expression was significantly associated with T stage ( P = 0.004), lymph node involvement ( P = 0.006), histologic differentiation ( P = 0.013), and microvessel density ( P = 0.014), whereas that of HIF-2α was associated with T stage ( P = 0.011) and microvessel density ( P = 0.005). (aacrjournals.org)
  • patients
  • Doctor Zhang Zhongjing (AD152-219), one of the most eminent Chinese physicians, has first applied RRR as one of the principal herbs in Fengyin Decoction to treat poststroke epilepsy patients induced evil-wind due to excessive heat [ 9 ]. (hindawi.com)
  • resistance
  • A fine glass micro-electrode tip diameter about 1 mm) filled with electrolyte forex rates feed is attached to the cell membrane by suction, forming a tight seal' resistance 1 G or more, i. (reliablebinaryoption.com)
  • significantly
  • PAI-1 and tPA were significantly higher in the subjects with OSAS compared with the controls, whereas TGF-β and uPA levels were lower. (rcjournal.com)
  • After the CPAP therapy, PAI-1 significantly decreased, whereas TGF-β showed a significant increase, although the values did not reach those of the controls. (rcjournal.com)
  • females
  • In conclusion, the current study indicates that PAI-1 is involved in the pathogenesis of type 1 diabetic osteoporosis in females. (diabetesjournals.org)
  • partial
  • 1 OSAS is characterized by the repetitive partial or complete closure of the upper airway during sleep that is caused by a collapse of the pharyngeal airway. (rcjournal.com)
  • cell
  • This study aimed to investigate the functional difference between hypoxia inducible factor (HIF)-1α and HIF-2α in oral squamous cell carcinomas (OSCC). (aacrjournals.org)
  • OSCC cell lines transfected with lentivirus encoding short hairpin RNA against HIF-1α/2α were used to investigate the HIF-1α/2α-dependent target genes. (aacrjournals.org)
  • In this study, we show that hypoxia inducible factor (HIF)-1α and HIF-2α correlated with different clinical-pathologic parameters, stabilized at different oxygen levels, contributed differently to cell proliferation, and regulated different target genes in oral squamous cell carcinomas (OSCC). (aacrjournals.org)
  • transcription
  • Two of the most important transcription factors mediating the cellular response to hypoxia are hypoxia inducible factor (HIF)-1α and HIF-2α ( 4 ). (aacrjournals.org)