• tissue
  • Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). (wikipedia.org)
  • PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue. (wikipedia.org)
  • In inflammatory conditions in which fibrin is deposited in tissues, PAI-1 appears to play a significant role in the progression to fibrosis (pathological formation of connective tissue). (wikipedia.org)
  • Unfortunately, intravenously recombinant tissue plasminogen activator (rtPA) is so far the only approved thrombolytic by Food and Drug Administration for treating ischemic stroke within 4.5 hours of stroke onset [ 4 ]. (hindawi.com)
  • Compared with recombinant tissue-type plasminogen activator or urokinase monotherapy, combination therapy with these agents was associated with a lower need for acute intervention during the 1st 24 h after admission, but the difference did not reach statistical significance (14% for combination therapy vs. 21% for each agent alone, p = 0.30). (acc.org)
  • In conclusion, ω-3 fatty acids given in addition to simvastatin to patients with combined hyperlipemia reduced the free tissue factor pathway inhibitor fraction in the fasting state and inhibited the activation of factor VII occurring during postprandial lipemia, thus representing a potential beneficial effect on the hemostatic risk profile in this patient group. (ahajournals.org)
  • 2 Tissue factor (TF) is an integral membrane protein that functions as a cofactor to enhance the proteolytic activity of activated factor VII (FVII a ) toward factor IX and factor X, which leads to the formation of a fibrin clot. (ahajournals.org)
  • ALTERATION OF THE LOCAL ADAPTATION SYNDROME Selye (1) has shown that there is a local tissue adaptation to applied irritants. (scribd.com)
  • Targeting frail individuals with high levels of inflammation and SASP factors would necessitate identification of predictors of improvement with metformin in tissue inflammation and function. (clinicaltrials.gov)
  • 2. The method of claim 1 wherein the nitric oxide adduct is present in a matrix coating on a surface of the medical device which contacts a tissue within the patient, wherein the matrix coating is nylon or plastic. (google.com)
  • gene
  • The PAI-1 gene is SERPINE1, located on chromosome 7 (7q21.3-q22). (wikipedia.org)
  • The purpose of this study is to clarify the biologic actions of extremely low-frequency (ELF) alternate-current (AC) high magnetic fields, especially their effects on gene functions including DNA replication, repair and transcription. (nii.ac.jp)
  • glucose
  • The detrimental skeletal effects of glucose toxicity, insulin deficiency, and diabetes complications might partly explain the association between type 1 diabetes and osteoporosis ( 3 - 5 ). (diabetesjournals.org)
  • In order to be diagnosed with Type 2 Diabetes, an individual must present with all of the following: 1) Classic symptoms of diabetes mellitus, including polyuria, polydipsia, polyphagia, weight loss, and random plasma glucose ≥ 200 mg/dL, 2) Fasting plasma glucose ≥126 mg/dL, and 3) Two hour post glucose load (75g) plasma glucose ≥200 mg/dL, and confirmed by repeat test. (wikidot.com)
  • activity
  • Direct antigonadal activity of cannabinoids: suppression of rat granulosa cell functions. (springer.com)
  • The irregular atrial discharge typical of AF may result from an irregular atrial response to a rapidly discharging regularly firing driver resulting from either local ectopic firing ( Figure 1 A) or a single localized reentry circuit ( Figure 1 B). Alternatively, fibrillatory activity may be caused directly by multiple functional reentry circuits varying in time and space ( Figure 1 C). (ahajournals.org)
  • Paroxysmal AF usually involves a driver in the cardiac muscle sleeve around ≥1 pulmonary veins (PVs) caused by rapid focal activity or local reentry. (ahajournals.org)
  • Congenital
  • The principal features include congenital heart defect (typicall pulmonary valve stenosis with dysplastic pulmonary valve also atrial septal defect and hypertrophic cardiomyopathy), short stature, learning problems, pectus excavatum, impaired blood clotting, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge. (wikipedia.org)
  • diabetes
  • 10 ) reported that PAI-1 contributes to the development of diabetes. (diabetesjournals.org)
  • Diabetes was induced in male and female wild-type (PAI-1 WT) mice and PAI-1-deficient (PAI-1 KO) mice (10 weeks of age) by daily injections of streptozotocin (50 mg/kg body wt i.p. in saline [ 13 ]), a pancreatic β-cell cytotoxin, for 4 days. (diabetesjournals.org)
  • 1 ][ 2 ]Previously, it was referred to as non-insulin-dependent diabetes mellitus or adult-onset diabetes mellitus. (wikidot.com)
  • This study provided the opportunity to assess the association between endothelial vasodilation function and the incidence of diabetes in a cohort of apparently healthy postmenopausal women. (diabetesjournals.org)
  • Each 1-unit decrease of FMD was associated with a significant 32% (22-48%) increase in the multiple-adjusted RR of incident diabetes. (diabetesjournals.org)
  • activation
  • We evaluated the imbalances of the plasminogen activation system related to OSAS, and we assessed the effects of CPAP on the plasminogen activation system. (rcjournal.com)
  • Besides the differences in activation pattern, HIF-1α and HIF-2α exhibit distinct roles in hypoxic activation of target genes ( 5 - 11 ). (aacrjournals.org)
  • progression
  • Such hypoxic zones have been postulated to increase patient treatment resistance and favor tumor progression ( 1 , 3 ). (aacrjournals.org)
  • development
  • The periovulatory interval refers to that period bracketed by the gonadotropin surge and the development of an effective corpus luteum (Fig. 1). (springer.com)
  • The maturational status of the oocyte and its embryonic potential, as well as establishment and ultimate function of the corpus luteum, are dependent upon the quality of antecedent follicular development. (springer.com)
  • 7 , 8 AF-related electric remodeling, resulting from altered expression and/or function of cardiac ion channels, favors the development of functional reentry substrates, 7 which are reversible on AF termination (reverse remodeling) and contribute to persistent AF. (ahajournals.org)
  • active
  • In vitro study demonstrated that treatment with active PAI-1 suppressed the levels of osteogenic genes and mineralization in primary osteoblasts from female mouse calvaria. (diabetesjournals.org)
  • Alternatively, proteases may be classified by the optimal pH in which they are active: Acid proteases Neutral proteases involved in type 1 hypersensitivity. (wikipedia.org)
  • effects
  • Effects of indomethacin on ovulation and luteal function in gilts. (springer.com)
  • The effects of marijuana extract and delta-9-tetrahydrocannabinol on luteal function in the rhesus monkey. (springer.com)
  • Metformin by reducing effects of cellular senescence and improving glycemic control may improve the functioning of older adults. (clinicaltrials.gov)
  • 1. A method for preventing adverse effects associated with the use of a medical device in a patient comprising introducing into said patient a medical device of which at least a portion includes a nitric oxide adduct, wherein said nitric oxide adduct comprises a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite or a nitrosated amino acid. (google.com)
  • found
  • Annonacinone is a naturally occurring PAI-1 inhibitor found in plants of the Annonaceae family. (wikipedia.org)
  • Product Name: Native Soybean Trypsin InhibitorDescription: Trypsin inhibitors are found in a variety of sources, such as soybean, human plasma, lima bean, and bovine pancreas. (dna-pkinhibitor.com)
  • patients
  • We evaluated the correlations between HIF-1α and HIF-2α expression and the clinical-pathologic characteristics of 97 patients with OSCC by immunohistochemical staining. (aacrjournals.org)
  • Doctor Zhang Zhongjing (AD152-219), one of the most eminent Chinese physicians, has first applied RRR as one of the principal herbs in Fengyin Decoction to treat poststroke epilepsy patients induced evil-wind due to excessive heat [ 9 ]. (hindawi.com)
  • resistance
  • A fine glass micro-electrode tip diameter about 1 mm) filled with electrolyte forex rates feed is attached to the cell membrane by suction, forming a tight seal' resistance 1 G or more, i. (reliablebinaryoption.com)
  • significantly
  • PAI-1 and tPA were significantly higher in the subjects with OSAS compared with the controls, whereas TGF-β and uPA levels were lower. (rcjournal.com)
  • After the CPAP therapy, PAI-1 significantly decreased, whereas TGF-β showed a significant increase, although the values did not reach those of the controls. (rcjournal.com)
  • HIF-1α expression was significantly associated with T stage ( P = 0.004), lymph node involvement ( P = 0.006), histologic differentiation ( P = 0.013), and microvessel density ( P = 0.014), whereas that of HIF-2α was associated with T stage ( P = 0.011) and microvessel density ( P = 0.005). (aacrjournals.org)
  • however
  • However, a highly proliferating mass of tumor cells develops faster than the vasculature, and tumor cells rapidly meet up with an avascular environment deficient in oxygen ( 1 ). (aacrjournals.org)
  • combination
  • or combination therapy with urokinase, 1.5 x 106 U over 1 hour plus rt-PA, 1 mg/kg (10% given as a bolus and a maximum dose of 90 mg) over 1 hour. (acc.org)
  • 15. The method of claim 1 which comprises administering the nitric oxide adduct in combination with an anti-thrombogenic agent. (google.com)
  • partial
  • 1 OSAS is characterized by the repetitive partial or complete closure of the upper airway during sleep that is caused by a collapse of the pharyngeal airway. (rcjournal.com)
  • cell
  • This study aimed to investigate the functional difference between hypoxia inducible factor (HIF)-1α and HIF-2α in oral squamous cell carcinomas (OSCC). (aacrjournals.org)
  • OSCC cell lines transfected with lentivirus encoding short hairpin RNA against HIF-1α/2α were used to investigate the HIF-1α/2α-dependent target genes. (aacrjournals.org)
  • In this study, we show that hypoxia inducible factor (HIF)-1α and HIF-2α correlated with different clinical-pathologic parameters, stabilized at different oxygen levels, contributed differently to cell proliferation, and regulated different target genes in oral squamous cell carcinomas (OSCC). (aacrjournals.org)
  • transcription
  • Two of the most important transcription factors mediating the cellular response to hypoxia are hypoxia inducible factor (HIF)-1α and HIF-2α ( 4 ). (aacrjournals.org)
  • short
  • Arms Assigned interventions Placebo Comparator: Metformin Chronic metformin administration through augmentation of cellular regeneration and reduction of senescence will improve frailty and physical functioning as studied by the short physical performance battery (SPPB) test. (clinicaltrials.gov)
  • levels
  • Streptozotocin markedly elevated the levels of PAI-1 mRNA in liver in female mice only. (diabetesjournals.org)
  • PAI-1 has been of particular focus in cardiovascular disease because of strong positive correlations between serum PAI-1 levels and cardiovascular risk ( 7 ). (diabetesjournals.org)
  • PAI-1 is present in increased levels in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. (wikipedia.org)