TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
Stat3-mediated alterations in lysosomal membrane protein composition. (uni-bielefeld.de)
Plasma membrane5
Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Protein7
Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)
Specific protein function and abnormalities are discussed below with each LGMD. (medscape.com)
Productive folding of the protein moiety is facilitated during this period by the calnexin/calreticulin cycle in mammalian cells, which relies on G1M9-specific lectin-type chaperones (calnexin and calreticulin) associated with the oxidoreductase ERp57, and UDP-glucose:glycoprotein glucosyltransferases 1 and 2, which are capable of re-adding glucose to M9 if the protein moiety is not yet folded. (elifesciences.org)
Bullfrog sialic acid-binding lectin (cSBL) is a multifunctional protein that has carbohydrate-binding and ribonuclease activities. (bvsalud.org)
Structures2
Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder. (uni-bielefeld.de)
Furthermore, we observed that SAL promoted the formation of lysosome-like structures, which are LAMP1 positive but not acidic in HeLa cells, which can trap sunitinib. (bvsalud.org)
Macrophages2
Accordingly, cell surface expression of LAMP1 is seen in cells with migratory or invasive functions, such as cytotoxic T cells, platelets and macrophages. (wikipedia.org)
Cell surface expression of LAMP1 can serve as a ligand for selectins and help mediate cell-cell adhesion. (wikipedia.org)
The structure of LAMP1 correlates with differentiation and metastatic potential of tumor cells as it is thought to help mediate cell-cell adhesion and migration. (wikipedia.org)
Phenotype1
However, this makes the determining the precise function of LAMP1 difficult, because while the LAMP1 deficient phenotype is little different than the wild type due to LAMP2 up regulation, the LAMP1/LAMP2 double deficient phenotype leads to embryonic lethality. (wikipedia.org)
Mannose3
Sequential mannose trimming of N -glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). (elifesciences.org)
This study demonstrates the details of mannose trimming in the ER by EDEM1 and EDEM3, filling an important gap in how mannose trimming creates an ERAD signal and shunts glycoproteins to the ERAD pathway. (elifesciences.org)
Quantitative Proteome Analysis of Mouse LiverLysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. (uni-bielefeld.de)
Extracellular2
Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules. (wikipedia.org)
Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)
Glycosylation is an important post-translational modification of proteins, and glycoproteins are widely involved in various important cellular biological processes and diseases ( 1 ). (frontiersin.org)
Different glycans of proteins can result in different immunogenicities and immune functions ( 2 ). (frontiersin.org)
These include proteins associated with the sarcolemma (see image below), proteins associated with the contractile apparatus (see image below), and various enzymes involved in muscle function. (medscape.com)
These functionally inappropriate proteins are somehow detected in the ER lumen and then transferred to the retrotranslocational channel embedded within the ER membrane, termed the retrotranslocon, followed by ubiquitin-dependent degradation by the proteasome in the cytoplasm. (elifesciences.org)
Immune1
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
Pancreatic3
LAMP1 expression on the surface of tumor cells has been observed for a number of different cancer types, particularly in highly metastatic cancers such as pancreatic cancer, colon cancer and melanoma. (wikipedia.org)
Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
Lysosomes in nutrient signalling: A focus on pancreatic β-cells. (uni-bielefeld.de)
Progression2
These glycoproteins are widely involved in important biological processes, such as antigen presentation, cytokine production and glycosylation progression. (frontiersin.org)
Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
Occur1
Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
Functional2
Supportive care is essential to preserve muscle function, maximize functional ability, and prolong life expectancy. (medscape.com)
No specific treatment is available for any of the LGMD syndromes, though aggressive supportive care is essential to preserve muscle function, maximize functional ability, and prolong life expectancy. (medscape.com)
Cell1
Cell surface expression of LAMP1 and LAMP2 is also often seen in cancer cells, particularly cancers with high metastatic potential, such as colon carcinoma and melanoma, and has been shown to correlate with their metastatic potential. (wikipedia.org)
Complex1
Here, we report the molecular architecture of the ESX-5 membrane complex from Mycobacterium xenopi determined at 13 resolution by electron microscopy. (regenerativemedicine.net)
Provide1
It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
Cancer1
This study briefly reviews the above information and explores the potential value of lysosomes in cancer therapy. (biomedcentral.com)
Signal1
Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)
Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. (uni-bielefeld.de)
Transport2
The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)
Lysosomes play a crucial role in intracellular transport. (biomedcentral.com)