Functions antigens cd38. Medical search. Frequent questions

This can be sidelined by either pretreatment of the erythrocytes with dithiothreitol (DTT) or by using an anti-CD38 antibody neutralizing agent, e.g. (wikipedia.org)
Then the section was stained with 5 µg/ml of Alexa Fluor® 647 anti-mouse CD38 (red) (Clone 90), 5 µg/ml Alexa Fluor® 488 anti-mouse CD3ε (green) (clone 145-2C11), and 5 µg/ml of Alexa Fluor® 594 anti-mouse F4/80 Antibody (blue) (Clone BM8) overnight at 4°C. The image was captured by 10X objective. (biolegend.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
The following product was used in this experiment: CD38 Monoclonal Antibody (90), eFluor™ 450, eBioscience™ from Thermo Fisher Scientific, catalog # 48-0381-82, RRID AB_11218302. (thermofisher.com)
Description: The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. (thermofisher.com)
Expi 293 cell line transfected with irrelevant protein (left) and human CD38 (right) were surface stained with Rabbit anti-CD38 monoclonal antibody 1μg/ml (clone: DM30) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody. (dimabio.com)
Flow cytometry data of serially titrated Rabbit anti-CD38 monoclonal antibody ( clone: DM30 ) on Raji cells. (dimabio.com)
The FLEX-NK TM multifunctional engager antibody CYT-338 directed against NKp46 and CD38 demonstrated in vitro activity against multiple myeloma tumor targets. (biospace.com)
Description: The G8.8 monoclonal antibody reacts with the 40 kDa mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. (thermofisher.com)
Secondary B lymphopoiesis is an antigen-dependent process and occurs in the germinal center of peripheral lymphoid organs with specific antibody production. (medscape.com)
The human immune system is capable of producing up to 10 9 different antibody species to interact with a wide range of antigens. (medscape.com)
All patients treated with NXC-201 were triple-class refractory (to at least 1 immunomodulatory drug, 1 proteasome inhibitor and 1 anti-CD38 antibody). (tmcnet.com)
A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. (cdc.gov)
and had received prior PI, IMiD, and anti-CD38 antibody therapy (ie, Darzalex or Sarclisa). (themmrf.org)
The production of such "class switched" antibodies is important for optimizing the immune response to particular antigens, since the antibody class defines its effector functions, such as complement activation, opsonization, neutralization of bacterial toxins and mast cell activation. (fu-berlin.de)
[ 13 ] are the most active regimens for transplant-ineligible patients, although addition of the anti-CD38 monoclonal antibody daratumumab to these regimens to drive deeper response is likely to become the new standard of care. (medscape.com)

Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19, CD138, signaling lymphocytic activation molecule 7 (SLAM7), and immunoglobulin light chains. (biomedcentral.com)
B-cell maturation antigen (BCMA), a member of the tumor necrosis issue receptor superfamily, is universally expressed by regular and neoplastic plasma cells and performs a essential function within the proliferation, survival and tumor development in a number of myeloma (MM). B-cell activating issue (BAFF) and a proliferation-inducing ligand (APRIL) have been acknowledged as proliferation ligands for BCMA within the bone marrow microenvironment. (bd-academy.org)

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. (biolegend.com)
CD38 is a type II transmembrane glycoprotein and the receptor of CD31. (cusabio.com)
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)

As a receptor, CD38 can attach to CD31 on the surface of T cells, thereby activating those cells to produce a variety of cytokines.CD38 activation cooperates with TRPM2 channels to initiate physiological responses such as cell volume regulation. (wikipedia.org)
CD31 on endothelial cells binds to the CD38 receptor on natural killer cells for those cells to attach to the endothelium. (wikipedia.org)
CD31 is the ligand of CD38. (biolegend.com)
The primary ligands for CD31 have been reported to be CD38 and the vitronectin receptor (α v β 3 integrin, CD51/CD61). (biolegend.com)
Other reported functions of CD31 are neutrophil emigration to sites of inflammation, and angiogenesis. (biolegend.com)
The combination of CD38 and CD31 plays an important role in cell migration and receptor-mediated adhesion. (cusabio.com)
Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. (nih.gov)
CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation. (thermofisher.com)

CD38 can function either as a receptor or as an enzyme. (wikipedia.org)
There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. (biomedcentral.com)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)
CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. (thermofisher.com)
CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. (thermofisher.com)
Scientists have screened neutralizing antibodies utilizing the virus receptor-binding area (RBD) as an antigen, indicating that RBD accommodates a number of conformational neutralizing epitopes, that are the primary structural domains for inducing neutralizing antibodies and T-cell immune responses. (bd-academy.org)
NXC-201 (formerly HBI0101) is a BCMA-targeted investigational chimeric antigen receptor T (CAR-T) cell therapy that is being studied in a comprehensive clinical development program for the treatment of patients with relapsed or refractory multiple myeloma and AL amyloidosis. (tmcnet.com)

Thus, a screening assay for irregular antibodies against red blood cell antigens or a direct immunoglobulin test can produce false-positive results. (wikipedia.org)
Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)
These vaccines can stimulate the production of corresponding antibodies in the body, thereby altering the fate of MIC proteins being cleaved, increasing the levels of MICA/MICB proteins on the tumor surface, and enhancing the antigen-presenting ability of classical dendritic cells (cDC) as well as the cytotoxic function of T cells [6]. (kactusbio.com)

Daratumumab (Darzalex) which targets CD38 has been used in treating multiple myeloma. (wikipedia.org)
With this feature, CD38 has become a popular target for the treatment of multiple myeloma (MM). (cusabio.com)
The data presented at AACR supports the advancement of our lead GPC3-targeting hepatocellular carcinoma (HCC) program towards clinical trials and our differentiated CD38-targeting multiple myeloma program to IND-enabling studies. (biospace.com)
These data support further development of CYT-338 as a therapeutic for targeting CD38 expressing multiple myeloma cells. (biospace.com)

To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. (exbio.cz)

Interferon gamma strongly induces CD38 expression on monocytes. (wikipedia.org)
We investigated the effects of monocyte-activating stimuli (IFN-gamma, IL-2, LPS, TNF-alpha, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. (nih.gov)
Treatment with IFN-gamma produced a dose- and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. (nih.gov)
These findings identify IFN-gamma as a modulator of monocytic CD38 expression and indicate that CD38 plays a specific role in the activation and adhesion processes performed by monocytes. (nih.gov)
CD38 expression and functional activities are up-regulated by IFN-γ on human monocytes and monocytic cell lines. (southernbiotech.com)
Reduced total and CD38 Monocytes, cells that drive age-related tissue NAD depletion. (foresight.org)

Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)

CD38 is a multifunctional enzyme that catalyzes the synthesis of ADP ribose (ADPR) (97%) and cyclic ADP-ribose (cADPR) (3%) from NAD+. (wikipedia.org)
CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. (dimabio.com)

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. (wikipedia.org)
By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. (biolegend.com)
CD38 is a gene providing instruction of making a protein named ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also abbreviated as ADPRC1 or CD38) in human and belongs to ADP-ribosyl cyclase family. (cusabio.com)
CD38 is also a complex ectoenzyme featuring ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities, leading to the synthesis and degradation of cADPR, a Ca+-mobilizing agent. (nih.gov)

CD38 occurs not only as an ectoenzyme on cell outer surfaces, but also occurs on the inner surface of cell membranes, facing the cytosol performing the same enzymatic functions. (wikipedia.org)

About the same time, CD38 was discovered to be not simply a marker of cell types, but an activator of B cells and T cells. (wikipedia.org)
CD38 is most frequently found on plasma B cells, followed by natural killer cells, followed by B cells and T cells, and then followed by a variety of cell types. (wikipedia.org)
CD38 on leukocytes attaching to CD16 on endothelial cells allows for leukocyte binding to blood vessel walls, and the passage of leukocytes through blood vessel walls. (wikipedia.org)
The cytokine tumor necrosis factor strongly induces CD38 on airway smooth muscle cells inducing cADPR-mediated Ca2+, thereby increasing dysfunctional contractility resulting in asthma. (wikipedia.org)
CD38 is upregulated on plasmacytoid dendritic cells (pDCs) in vivo during human influenza infection and blocking CD38 prevents the ability of pDCs to produce type I interferon in vitro. (wikipedia.org)
On the surface of lymphoid cells, myeloid cells and other non-hematopoietic tissue cells, the expression of CD38 shows is lower, but on the surface of malignant plasma cells such as myeloma cells, CD38 shows high expression. (cusabio.com)
The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. (thermofisher.com)
Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. (thermofisher.com)
Affinity ranking of different Rabbit anti-CD38 mAb clones by titration of different concentration onto Raji cells. (dimabio.com)
These cells possessed strong effector function and intact proliferative capacity. (ox.ac.uk)
Individuals tested many years after infection exhibited lower frequencies of B19-specific cytotoxic T lymphocytes, typically 0.05%-0.5% of CD8+ T cells, which were perforin, CD38, and CCR7 low. (ox.ac.uk)
CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. (thermofisher.com)
Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. (thermofisher.com)
Antigen-specific CD4+ and CD8+ T cell responses were asynchronous, with the peak CD4+ T cell responses occurring 1 week post the second vaccination (boost), whereas CD8+ T cells peaked 2 weeks later. (stanford.edu)
8. Coccia MA, Brams P. High titer, prostate specific antigen-specific human IgG production by hu-PBL-SCID mice immunized with antigen-mouse IgG2a complex-pulsed autologous dendritic cells. (southernbiotech.com)
Second, the adjuvant is able to increase the adaptability of the recalled cells to give improved specificity to the new vaccine antigen. (nature.com)
Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
Secondary lymphopoiesis (SL) begins when mature B cells enter the extrafollicular area of lymphoid tissue and differentiate into short-lived plasma cells and memory cells after being stimulated by antigen-presenting cells. (medscape.com)
Leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) was expressed on some populations of hematopoietic cells and contributed to the proliferation by interacting with stromal cells. (elsevierpure.com)
Numerous studies have confirmed that MICA is highly expressed on the surface of various tumor cells, such as non-small cell lung cancer, colorectal cancer, and breast cancer, making it a tumor-associated antigen. (kactusbio.com)
During the immune response activated B cells migrate to the T cell zones within the secondary lymphoid organs and acquire help from the residing antigen-specific, activated T cells. (fu-berlin.de)
Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)

For the large number of hepatocellular cancer patients who currently have such limited, poor clinical options, a novel tumor antigen-directed NK engager is needed. (biospace.com)
It allows for synergistic attacks independent of tumor antigens and demonstrates efficacy against drug-resistant tumors, which is one of the reasons why immune cell therapy and immunotherapy combinations have garnered significant attention. (kactusbio.com)

Like CD38, CD157 is a member of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of cADPR from NAD+, although CD157 is a much weaker catalyst than CD38. (wikipedia.org)

Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)

CD44 is a single-pass type I transmembrane protein and functions as a cellular adhesion molecule for hyaluronic acid, a major component of the extracellular matrix. (bio-connect.nl)

In humans, the CD38 protein is encoded by the CD38 gene which is located on chromosome 4. (wikipedia.org)
The CD38 protein is a marker of cell activation. (wikipedia.org)
The product was purified to obtain the recombinant human CD38 protein carrying C-terminal hFc tag. (cusabio.com)
This CD38 protein migrated along the gel to a band of about 58-90 kDa molecular weight. (cusabio.com)

CD38 was first identified in 1980 as a surface marker (cluster of differentiation) of thymus cell lymphocytes. (wikipedia.org)
CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose. (southernbiotech.com)

In 1992 the enzymatic activity of CD38 was discovered, having the capacity to synthesize the calcium-releasing second messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). (wikipedia.org)

GCs are transient structures which arise after challenge with a T cell-dependent antigen within secondary lymphoid organs, such as the spleen and lymph nodes. (fu-berlin.de)

Concurrent administration of a neutralizing/effector function-positive bnAb through the airway and systemic routes confirmed elevated effectiveness. (bd-academy.org)

After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)

Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)

The use of Daratumumab can interfere with pre-blood transfusion tests, as CD38 is weakly expressed on the surface of erythrocytes. (wikipedia.org)
An analysis of binding sites on CD38 indicates CYT-338 binds an epitope that is distinct from daratumumab. (biospace.com)

The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. (frontiersin.org)

In conclusion, our data suggest that NETs are selectively loaded with antigens recognized by P-ANCAs, and netting neutrophils provide a physiological substrate for ANCA detection in patients with AAV. (biotechnologyconsultinggroup.com)
The distinct ANCA-staining patterns are a result of the neutrophil fixation process with ethanol and do not represent the physiological antigen distribution. (biotechnologyconsultinggroup.com)

CD38 also functions in cell adhesion, signal transduction and calcium signaling. (wikipedia.org)
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)

The cytokine interferon gamma and the Gram negative bacterial cell wall component lipopolysaccharide induce CD38 expression on macrophages. (wikipedia.org)

AS03 and MF59 enhance innate immune responses by increasing antigen uptake and presentation in the local tissue. (nature.com)

Both continue their development in the bone marrow through an antigen-independent process called primary lymphopoiesis (PL). Recognized stages of PL are pro-B cell, pre-B cell, immature B cell, and mature B cell. (medscape.com)

Increased expression of CD38 is an unfavourable diagnostic marker in chronic lymphocytic leukemia and is associated with increased disease progression. (wikipedia.org)
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome. (thermofisher.com)

The results from the patient-reported outcomes showed statistically significant and clinically meaningful improvements in health-related quality of life including cognitive functioning, fatigue, and pain reduction for patients with RRMM who received Abecma compared with standard treatment regimens. (themmrf.org)

We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. (frontiersin.org)
The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. (frontiersin.org)

Adjuvants can enhance vaccine immunogenicity, allowing a reduction in the quantity of antigen per dose and a consequent increase in the number of doses that can be manufactured in a given time-period. (nature.com)

Antigens are foreign substances that evoke an immune response. (medscape.com)

The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. (wikipedia.org)

The likely explanation--analogous to that for cytomegalovirus infection--is that this persistent response is due to low-level antigen exposure. (ox.ac.uk)

CUSABIO synthesized the recombinant gene by integrating the C-terminal hFc tag sequence into the targeted gene encoding the 43-300aa of the human CD38. (cusabio.com)
The antigen is being used as a target for immunotherapy treatment of human carcinomas. (thermofisher.com)

CD38 is thought to be a major regulator of NAD+ levels, its NADase activity is much higher than its function as an ADP-rybosyl-cyclase: for every 100 molecules of NAD+ converted to ADP ribose it generates one molecule of cADPR. (wikipedia.org)

When nicotinic acid is present under acidic conditions, CD38 can hydrolyze nicotinamide adenine dinucleotide phosphate (NADP+) to NAADP. (wikipedia.org)

Secondary T lymphopoiesis is also an antigen-dependent process and occurs in the thymus. (medscape.com)

CD38 increases airway contractility hyperresponsiveness, is increased in the lungs of asthmatic patients, and amplifies the inflammatory response of airway smooth muscle of those patients. (wikipedia.org)
Our results indicate that IFN-gamma is a strong up-modulator of CD38, and IL-2 increases its expression only modestly. (nih.gov)

Future studies may address whether targeting NETs or neutrophil bodies triggers distinct functions in autoimmune disease and AAV. (biotechnologyconsultinggroup.com)

CD38 is a paralog of CD157, which is also located on chromosome 4 (4p15) in humans. (wikipedia.org)

Anatomy12

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Chemicals and Drugs95

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Antibody16

Maturation antigen2

Type II transmembrane glycoprotein3

CD318

Receptor7

Antibodies3

Multiple myeloma4

CD342

Monocytes6

BCMA1

Multifunctional2

Hydrolase4

Ectoenzyme1

Cells26

Tumor2

Cyclase family1

Ligand1

Transmembrane protein1

Protein4

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Cyclic ADP-ri1

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Daratumumab2

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NAADP1

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