• These SNPs, however, are still thought to account for less than half of all genetic susceptibility to IS, with a number of yet to be discovered genes also contributing to the development of IS. (hindawi.com)
  • Genetic Basis of Olfactory Cognition: Extremely High Level of DNA Sequence Polymorphism in Promoter Regions of the Human Olfactory Receptor Genes Revealed Using the 1000 Genomes Project Dataset. (helix.com)
  • To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. (escholarship.org)
  • NUCLEAR LOCALIZATION SIGNALGREEN FLUORESCENT PROTEIN/b-GLUCURONIDASE reporter lines throughout the life cycle, which predicted functional divergence in the paralogous genes per clade. (unical.it)
  • However, partial overlap was observed for many TET genes across the clades, correlating with few phenotypes in single mutants and, therefore, requiring double mutant combinations for functional investigation. (unical.it)
  • Sequences of previously described binding sites were collected for these five factors present in the cis-regulatory regions of known target genes. (sdbonline.org)
  • Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (snpedia.com)
  • Nucleosome occupancy (white corresponding to large occupancy values) for the 2000 shortest S. Cerevisiae genes ordered by increasing length from top to bottom and aligned on the promoter (null distance). (ens-lyon.fr)
  • Identification and in silico characterization of structural and functional impacts of genetic variants in milk protein genes in the Zebu breeds Guzerat and Gyr. (fiocruz.br)
  • Whole genome sequencing of bovine breeds has allowed identification of genetic variants in milk protein genes. (fiocruz.br)
  • Although laborious, this multistep procedure for classifying variants allowed the identification of potentially functional variants for milk protein genes. (fiocruz.br)
  • Publishing on January 20th in The Journal of Neuroscience, researchers cast the lipid-binding ApoE4 in an entirely new light, showing that it is a transcription factor that enters the nucleus and binds DNA with high affinity, including the promoter regions of 1700 different genes. (buckinstitute.org)
  • When the genes whose promoters bind ApoE4 are considered in functional groups, their relationship to Alzheimer's disease is striking," said co-senior author Dale Bredesen, MD, Buck Institute faculty and a professor at the Easton Laboratories for Neurodegenerative Disease Research at UCLA, "ApoE4 targets genes associated with sirtuins and aging, insulin resistance, inflammation and oxidative damage, accumulation of amyloid plaques and tangled tau among others. (buckinstitute.org)
  • Limited analysis to our knowledge, no published studies have examined of 2 genes important to the innate immune response found the association between specifi c host genetic variants and no association between genetic variants and fatal infl uenza severe infl uenza disease outcomes. (cdc.gov)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
  • Additionally, a genetic network for the MKRN3 gene, mimicking a holistic regulatory depiction of the crosstalk between MKRN3 and other genes was designed. (frontiersin.org)
  • The sex-biased lincRNA genes are enriched for nearby and correspondingly sex-biased accessible chromatin regions, as well as sex-biased binding sites for growth hormone-regulated transcriptional activators (STAT5, hepatocyte nuclear factor 6 [HNF6], FOXA1, and FOXA2) and transcriptional repressors (CUX2 and BCL6). (omicsdi.org)
  • Genes in active, inactive, and poised chromatin states exhibited differential responsiveness to ligand-activated nuclear receptors and distinct enrichments for functional gene categories. (omicsdi.org)
  • These domestication traits likely consisted of a few major genes controlling dramatic changes in crop physiology, as is suggested by genetic studies comparing maize to its ancestor teosinte (Doebley et al. (springer.com)
  • Genetic variations in four genes have been directly linked to the pathogenesis of AD. (bmj.com)
  • Along with the complex arrangement of genetic material in a cell's nucleus, human genes also demonstrate their own unique organization. (jove.com)
  • A strand of DNA is comprised of genes and intergenic regions. (jove.com)
  • These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)
  • F3 contains 770 variants as a validation set including 70 SNVs in 'positive' set in non-coding regions of protein-coding genes newly reported and 700 randomly sampled common human variants, matched per type of region to the 'positive' set. (lu.se)
  • We report evidence of a polymorphism in the promoter region of IFNGR1 (encoding interferon-gamma receptor 1) that has opposite functional effects in different cellular contexts. (ox.ac.uk)
  • Conclusions: A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis. (northumbria.ac.uk)
  • In addition, a number of different genetic determinants of IS risk have been identified in genome-wide association studies, with single-nucleotide polymorphisms (SNPs) in 9p21, PITX2, HDAC9, ABO, NINJ2, ALDH2, and TSPAN2, all being linked with stroke susceptibility [ 2 ]. (hindawi.com)
  • PMID 17482701 ] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. (snpedia.com)
  • Genetic polymorphisms lead to individual differences. (frontiersin.org)
  • The aim of this study was to investigate the association of polymorphisms in the promoter region of miR-17-92 cluster with the risk of colorectal cancer (CRC). (oncotarget.com)
  • Three polymorphisms (i.e., rs9588884, rs982873 and rs1813389) in the promoter of miR-17-92 were analyzed among 874 cases and 1132 controls using a TaqMan allelic discrimination assay or a polymerase chain reaction-restriction fragment length polymorphism method. (oncotarget.com)
  • We performed functional characterization of NR3C1 variants in the 5´-regulatory region and investigate polymorphisms wtih respect to behavioral traits and disorders. (uni-trier.de)
  • C, one of IL-6 functional polymorphisms in the promoter region, has been reported as influencing IL-6 gene transcription and has been associated with elevated CRP levels. (ijbls.org)
  • We therefore studied the association of two polymorphisms - R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region - with FVIIc levels in 176 healthy Tunisians. (who.int)
  • Sequencing of a distal IL1RL1 promoter region demonstrated that SNPs rs6543115(C) and rs6543116(A) are associated with increased sST2 in UC patients on corticosteroids. (uandes.cl)
  • The most stringent authentication criteria proposed for ancient DNA, such as independent replication, amino-acid analysis, quantitation of template molecules, multiple extractions and cloning of PCR products, have been followed to obtain reliable sequences from the mtDNA hypervariable region 1 (HVR1), as well as some haplogroup diagnostic SNPs. (blogspot.com)
  • Prediction of functional regulatory SNPs in monogenic and complex disease. (lu.se)
  • Mammalian Odorant Receptors: Functional Evolution and Variation. (helix.com)
  • Analysis of 5' promoter deletion mutants revealed that the region from -441 to +118, relative to the transcription initiation site, is sufficient to establish high level promoter activity. (nih.gov)
  • We examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reduction in expression of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. (ox.ac.uk)
  • Here, we characterize epigenetic features of active promoter proximal regions and candidate distal regulatory elements to construct high-resolution chromatin interaction maps for maize via long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). (nature.com)
  • Many promoter proximal regions are involved in chromatin loops with distal regulatory elements, which regulate important agronomic traits. (nature.com)
  • In this study, we explore the regulatory role of mutations occurring in distal regulatory elements related to gene expression and phenotypic variations with adapted long-read ChIA-PET, and construct high-resolution chromatin interaction maps of maize promoter proximal regions and distal regulatory elements associated with RNA polymerase II occupancy and histone mark H3K4me3. (nature.com)
  • The resulting maps are analyzed to identify and assess the roles of promoter proximal-proximal interaction (PPI) and proximal-distal interaction (PDI). (nature.com)
  • We therefore tested whether genetic variants in the IL1RL1 distal promoter are involved in UC and affect glucocorticoid-mediated ST2 expression. (uandes.cl)
  • Serum ST2 levels and genetic variants in the IL1RL1 distal promoter were examined by ELISA and PCR sequencing in UC patients receiving corticosteroids. (uandes.cl)
  • Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activated cells. (nature.com)
  • Both enhancers are antagonized by RUNX/CBFβ complexes, and SATB1 further mediates the long-distance interaction of the distal enhancer with the promoter. (nature.com)
  • The relative differences in methylation among neighboring CpGs in the generally hypomethylated APC promoter may not only reflect stochastic fluctuations but also depend on the tissue type. (uni-wuerzburg.de)
  • Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma. (nih.gov)
  • The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation. (uni-trier.de)
  • By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
  • Using CIS-ANALYST, the distribution of Bcd, Cad, Hb, Kr, and Kni binding sites were examined in a 1-Mb genomic region surrounding the well-characterized eve locus at a site_p value of 0.0003. (sdbonline.org)
  • Recently, we have broaden our studies of genomic sequences to encompass scales of the order of chromosome lengths (Mbp) while considering alternative codings with a clear functional significance. (ens-lyon.fr)
  • We further performed gene-based analysis as well as in silico bioinformatics analysis for CRC-relevant functional genomic annotation of identified loci. (bvsalud.org)
  • The NT gene (NTS) was sequenced for potential functional variants, evaluating its entire genomic and. (lu.se)
  • The NT gene (NTS) was sequenced for potential functional variants, evaluating its entire genomic and potentially regulatory regions, in DNA from 28 individuals, stratified by low and high pro-NT levels. (lu.se)
  • Here, we report the isolation and analysis of 5' flanking genomic DNA regions upstream to the CAD gene, from two conifers, i.e. white spruce (Picea glauca (Moench) Voss) and loblolly pine (Pinus taeda L.). Sequence comparisons with available CAD gene promoters from angiosperms highlighted the conservation of cis-elements matching MYB, WRKY and bHLH binding sites. (ox.ac.uk)
  • The maps indicate that chromatin loops are formed between regulatory elements, and that gene pairs between promoter proximal regions tend to be co-expressed. (nature.com)
  • At 19p12, the chromatin interaction of a putative regulatory element with the ZNF100 promoter region correlated with candidate outcome variants. (escholarship.org)
  • Regulation of gene expression involves post-translational modifications to histones which cause chromatin decondensation and recruit transcription factors at the promoter to initiate transcription. (utexas.edu)
  • Using the chromatin immunoprecipitation assay followed by real-time quantitative PCR, I show that the slowpoke promoter has a distinct spatio-temporal pattern of histone acetylation following a single sedative dose of ethanol. (utexas.edu)
  • Refinement of promoter regions using open chromatin and H3K4me3-marked regions provided insight into transcriptional regulation. (inrae.fr)
  • showed that the GAS5 rs55829688 promoter polymorphism alters the ability of the Yin-Yang 1 (YY1) transcription factor to bind to this region, thereby increasing GAS5 expression and elevated colorectal cancer risk [ 13 ]. (hindawi.com)
  • We conducted the first large genome-wide association study to identify novel genetic variants that predict better (or poorer) prognosis in colorectal cancer patients receiving standard first-line oxaliplatin-based chemotherapy vs chemotherapy without oxaliplatin. (bvsalud.org)
  • Strikingly, we found that liver-specific lincRNA gene promoters are more highly species conserved and have a significantly higher frequency of proximal binding by liver transcription factors than liver-specific protein-coding gene promoters. (omicsdi.org)
  • Sequence analysis and functional characterization of the promoter of the Picea glauca Cinnamyl Alcohol Dehydrogenase gene in transgenic white spruce plants. (ox.ac.uk)
  • Functional characterization of the P. glauca CAD promoter used P. glauca seedlings stably transformed with a DNA fragment of 1,163 base pairs (PgCAD) fused to the beta-glucuronidase (GUS) gene. (ox.ac.uk)
  • Kumsta R.*, Moser D.*, Streit F., Koper J.W., Meyer J. and Wüst S. (accepted for publication 6/2008): Characterization of a glucocorticoid receptor gene ( GR, NR3C1 ) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance. (uni-trier.de)
  • However, these intergenic regions carry important elements that regulate gene activity, for instance, the promoter where transcription starts, and enhancers and silencers that fine-tune gene expression. (jove.com)
  • These LRC are the signature of the DNA-histone proteins interactions within the nucleosomes, the basic units for DNA compaction in eukaryotic cell nuclei, that constitute a regulatory factor for accessibility to genetic material. (ens-lyon.fr)
  • We find that the IFNGR1-470del allele acts to suppress binding of nuclear proteins to the IFNGR1 promoter region in a manner that is specific for cell type. (ox.ac.uk)
  • In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control. (cnr.it)
  • Since this RNA will be used to generate proteins, exons are denoted as coding regions, whereas introns are another example of non-coding material. (jove.com)
  • Proteins called repressors bind to these regions, preventing polymerase-promoter association, inhibiting transcription. (jove.com)
  • Many genetic variations outside protein-coding regions are associated with maize phenotypes. (nature.com)
  • Our results highlight the significance of 3D organization of regulatory elements and suggest that the topology of long-range genetic variations may affect gene expression as well as phenotype variation. (nature.com)
  • The aim of this study is to uncover genetic variations that influence differences in cooperative behavior. (repec.org)
  • A total of seven sequence variations across the NTS gene, none of them located in coding regions, were identified. (lu.se)
  • Introduction DNA microarrays are powerful tools for analysing gene expression patterns, detecting DNA mutations, and identifying genetic variations. (tutorialspoint.com)
  • Mendelian regulatory variations including 42 enhancer, 142 promoter, 153 5' UTR, 43 3' UTR, 65 RNA gene, 3 imprinting control region, and 5 microRNA gene variations. (lu.se)
  • 4462 functional sequence variations in regulatory DNA regions in training dataset F1 and 1116 functional SNVs in test datasets F2. (lu.se)
  • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
  • At 1q22, putative regulatory elements enhanced MEF2D promoter activity and haplotypes containing candidate outcome variants modulated these effects. (escholarship.org)
  • Among them a promoter, exons, introns, and regulatory elements, which together help to determine protein expression in a cell. (jove.com)
  • The current research is aimed at assessing the correlation between two functional GAS5 variants (rs145204276 and rs55829688) and susceptibility to IS in a Han Chinese population. (hindawi.com)
  • Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. (ox.ac.uk)
  • Genetic variation of the GR might be one of the factors underlying individual susceptibility to stress related disorders. (uni-trier.de)
  • Large scale genetic studies have offered up some interesting insights into how our sense of smell works, though, including evidence that genetic variation in the OR2M7 gene can help determine if a person noticed an unpleasant smell in their urine after eating asparagus 3 . (helix.com)
  • Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (snpedia.com)
  • COMT genetic variation confers risk for psychotic and affective disorders: a case control study. (snpedia.com)
  • PMID 16786032 ] Impact of complex genetic variation in COMT on human brain function. (snpedia.com)
  • Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. (snpedia.com)
  • In conclusion, our data suggest that genetic variation in the OLR1 gene may modify the risk of AD. (bmj.com)
  • citation needed] VMAT gene sequence analysis demonstrates that four aspartic acid residues in the middle region of TMDs I, VI, X, and XI and one lysine residue in TMD II have highly conserved gene sequences, suggesting these residues play a critical role in transporter structure and function. (wikipedia.org)
  • The bar coding sequence is under control of Arabidopsis thaliana ribulose-1,5-bisphosphate carboxylase small subunit ( rbcS ) protomer and A. tumefaciens transcript 7 gene 3' untranslated region. (cbd.int)
  • When further modeling DNA as a semifexible polymer explicitly taking into account the structural disorder induced by the sequence, we have provided some evidence that the observed LRC favor the spontaneous formation as well as the cooperative positioning of nucleosomes along the chromosomes including the nucleosome free regions experimentally observed at gene promoters (see figure below). (ens-lyon.fr)
  • Note that the organization of the nucleosomal assembly results from the confinement of nucleosomes between sequence induced high energy barriers corresponding to the nucleosome free regions observed at the promoters and gene ends. (ens-lyon.fr)
  • Because these approaches will rely on novel data types such as DNA sequences and high-throughput phenotyping images, Breeding 4 will call for analyses that are complementary to traditional quantitative genetic studies, being based on machine learning techniques which make efficient use of sequence and image data. (springer.com)
  • The polymerase then traverses the genetic material, and continues to yield RNA until it identifies a gene's transcription termination sequence, stopping the process. (jove.com)
  • A range of causative genetic alterations within the protein C promoter region and splice sites as well as in the coding sequence of the protein C gene itself have been reported. (medscape.com)
  • When the 1-Mb region surrounding eve was searched for dense clusters of predicted high-affinity sites (at least 13 Bcd, Cad, Hb, Kr, or Kni sites in a 700-bp window), three discrete regions were identified. (sdbonline.org)
  • This 5' flanking region is a functional promoter of the PDGF alpha R gene as concluded from its capacity to drive luciferase reporter gene expression in an orientation dependent way. (nih.gov)
  • DNA constructs were cloned into a pGL3 promoter vector for luciferase gene reporter assays. (cdc.gov)
  • Currently, few genetic determinants of children with CPP have been described. (frontiersin.org)
  • We previously identified associations with ovarian cancer outcome at five genetic loci. (escholarship.org)
  • Whenever individuals from around the world are clustered based on a large number of loci, invariably the major races emerge as clusters of genetic similarity. (blogspot.com)
  • 7948 control SNVs used for training and testing, 4044 control SNVs from HepG2, 2693 SNVs of dsQTL, 51 deSNVs and 156 enhancer SNVs in B-cells from NHGRI GWAS Catalog, 56497 GM12878 enhancer SNVs and 2029 variants in training set of dsQTL model within hotspot DHS region of non-blood cell. (lu.se)
  • [ 9 ] These mutations are divided into 2 types-type I and type II-on the basis of whether they cause a quantitative (type I) or functional (type II) deficiency of protein C. (medscape.com)
  • In plants, functional information is limited to one of the 17 members of the Arabidopsis (Arabidopsis thaliana) TET gene family and to expression data in reproductive stages. (unical.it)
  • Exploiting the functional genomics and bioinformatics studies paved the way in understanding the relationship between genotype and phenotype of an organism suffering from environmental stress. (intechopen.com)
  • Bioinformatic and functional genetic analyses indicated that MEF2D and ZNF100 are targets of candidate outcome variants at 1q22 and 19p12, respectively. (escholarship.org)
  • Genetic systems often behave unpredictably due to structural interactions between DNA, RNA and protein components as well as functional interactions with host factors and metabolites. (universityofcalifornia.edu)
  • The brain circuits and regions associated with anxiety disorders are beginning to be understood with the development of functional and structural imaging. (medscape.com)
  • discovered that the rs145204276 indel polymorphism in the GAS5 promoter area alters GAS5 transcript activity, thereby increasing hepatocellular carcinoma (HCC) risk [ 12 ]. (hindawi.com)
  • Transcriptional activity of 5-HT 1A receptor promoter containing rs198585630 C/T allele was determined in vitro . (frontiersin.org)
  • We demonstrated that transcriptional activity of 5-HT 1A receptor promoter containing rs198585630 C allele was higher than that of 5-HT 1A receptor promoter containing T allele. (frontiersin.org)
  • The transcriptional activity of 5-HT 1A receptor promoter was stimulated by 30 mW/cm 2 microwave exposure, and rs198585630 C allele was more sensitive to microwave exposure, as it showed stronger transcriptional activation. (frontiersin.org)
  • A study from the Buck Institute and UCLA offers an explanation for why a particular genetic form (allele) of apolipoprotein E (ApoE) poses the most significant genetic risk for Alzheimer's disease. (buckinstitute.org)
  • the data represent a hypothesis-generating resource for further functional analyses. (unical.it)
  • Phylogeographic analyses show that the haplogroup composition of the ancient Iberians was very similar to that found in modern Iberian Peninsula populations, suggesting a long-term genetic continuity since pre-Roman times. (blogspot.com)
  • Adult Drosophila acquire rapid functional tolerance to ethanol after a single sedation due in part to a transcriptional up-regulation of the slowpoke message. (utexas.edu)
  • Using the binary GAL4/UAS system to express slowpoke in different parts of the Drosophila nervous system I show that slowpoke induction in the mushroom bodies of the adult fly brain, a region critical for olfactory learning and memory, is important for ethanol tolerance. (utexas.edu)
  • In addition, the morphogen retinoic acid, alone or in combination with dibutyryl cAMP, gives a 22-fold induction of PDGF alpha R gene promoter activity in human teratocarcinoma cells. (nih.gov)
  • These findings indicate that the rs9588884 GG and the rs982873 CC in the promoter of miR-17-92 may protect against CRC, possibly by decreasing transcriptional activity and eventually resulting in lower levels of miR-20a and miR-17. (oncotarget.com)
  • Research has shown that people with ALDH5A1 gene variants that result in a lack of functional succinic semialdehyde dehydrogenase tend to have more severe signs and symptoms than people who have gene variants that impair protein activity. (medlineplus.gov)
  • Type II protein C deficiency is less common than type I disease and is associated with decreased functional activity and normal immunologic levels of protein C. A number of point mutations within the protein C gene giving rise to this disorder have been described. (medscape.com)
  • So, as new evolutionary optima have been set by environmental changes (e.g., domestication, management practices, biotic or abiotic pressures) or major shifts in genetic background, plant breeders have selected better-adapted genotypes while pursuing faster genetic gains through technological innovations and scientific breakthroughs. (springer.com)
  • Further, we investigated the impact of genetic variants on epigenomic signals and gene expression. (inrae.fr)
  • For example, the transcription, translation, and degradation of an mRNA is crucial to any gene expression event, and all three processes are controlled by a combination of elements including promoters, ribosome binding sites (RBSs), and cis -regulatory signals encoded in untranslated regions (UTRs). (universityofcalifornia.edu)
  • Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency. (medlineplus.gov)
  • To improve molecular detection of INH-R TB, we used whole genome sequencing (WGS) to analyze 52 phenotypically INH-R Mycobacterium tuberculosis complex (MTBC) clinical isolates that lacked the common katG S315T or inhA promoter mutations. (cdc.gov)
  • All such mutations would be detectable by sequencing more DNA adjacent to existing target regions. (cdc.gov)
  • Our functional genetic experiments have confirmed the role of seven suspected INH resistance mutations and discovered five novel INH resistance mutations. (cdc.gov)
  • PMID 16525418 ] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. (snpedia.com)
  • Results: NGS detected 130 risk variants associated with DA (3.1 × 10-6 to 6.21 × 10-4), 129 of which were located in noncoding regions. (cdc.gov)
  • Together, these datasets constitute a resource for functional element annotation in rice and indicate the central role of epigenomic information in understanding transcriptional regulation. (inrae.fr)
  • Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone. (omicsdi.org)
  • Positron emission tomography (PET) scanning has demonstrated increased flow in the right parahippocampal region and reduced serotonin type 1A receptor binding in the anterior and posterior cingulate and raphe of patients with panic disorder. (medscape.com)
  • The same clustering criteria that were successful for identifying CRMs in eve (700-bp regions with at least 13 predicted binding sites) identified clusters overlapping 14 of these 19 known CRMs (Berman, 2002). (sdbonline.org)
  • A 1.1-kb fragment containing this cluster was placed in a reporter construct containing the eve minimal promoter fused to a lacZ reporter gene. (sdbonline.org)
  • MRSA) co-infection compared with fatal cases with high- risk was not explained by shared exposure to infl uenza and intermediate-producing MBL2 genotypes (odds ratio virus and thus may have a genetic component. (cdc.gov)
  • This study describes the molecular cloning of the non-coding exon 1 and approximately 2 kb of 5' flanking region of the human PDGF alpha R gene. (nih.gov)
  • 10976 in exon 8 in the catalytic region of ing factors that may increase cardiovascu- the FVII gene and an insertion of a decanu- lar disease. (who.int)
  • Objective: The aim of this study was to identify DA-associated functional genetic variants through next-generation sequencing (NGS), bioinformatics, and functional assays. (cdc.gov)
  • Contrary to expectations, a fragment containing the entire region between the TBPH gene and the bgcn translational start drove strong HEG expression only during late spermatogenesis rather than in the germline stem cells and spermatogonia as expected. (plos.org)
  • Anxiety disorders appear to be caused by an interaction of biopsychosocial factors, including genetic vulnerability, which interact with situations, stress, or trauma to produce clinically significant syndromes. (medscape.com)
  • The genomes of eukaryotes can be structured in several functional categories. (jove.com)
  • The 5-HT receptor family includes at least 7 classes (5-HT 1−7 receptor) and 15 subtypes with different functional and transduction properties. (frontiersin.org)
  • Introduction Retrotransposons are genetic elements that are capable of replicating and inserting themselves into different parts of the genome. (tutorialspoint.com)
  • A decade later, molecular genetic tools have improved methods for protein identification. (wikipedia.org)
  • The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)