Functional imidazoles. Medical search. Frequent questions

As a result, the goal of this article is to examine published research on the introduction, chemistry, synthesis, properties, industrial, biological and medicinal applications with efficacy of imidazole derivatives in order to better understand and explore their various properties and pharmacological potentials. (tsijournals.com)
A new strategy for the enantioselective synthesis of tetrahydrofuran imidazole based human histamine H3 and H4 receptor potential agonists was designed based on the lead structures imifuramine and OUP-16. (uni-regensburg.de)
In the first part of thesis application of y-butyrolactones for the synthesis of analogues of imifuramine (histamine H3 receptor agonist) and OUP-16 (histamine H4 receptor agonist) was shown with an extended side chain as well as additional functional groups to gain insight into structure-activity relationship. (uni-regensburg.de)
Furthermore, microwave-assisted aminocarbonylation using Mo(CO)6 as a solid carbon monoxide source was investigated in the synthesis of MAP amides and for coupling of imidazoles with amino acids. (avhandlingar.se)

In the first, histamine N-methyltransferase metabolizes most of the histamine to NMH, and monoamine oxidase (MAO) then metabolizes NMH to M-methyl imidazole acetic acid. (medscape.com)
In the second, diamine oxidase metabolizes 15%-30% of the histamine to imidazole acetic acid. (medscape.com)

Polysubstituted imidazoles , five-membered nitrogen-containing heterocyclic compounds, are found in various bioactive natural products and pharmaceuticals. (chemistryviews.org)
Imidazole is a five-membered planar ring that is solvable in water and other polar diluents. (tsijournals.com)
In the arena of five membered heterocyclic structures, the imidazole nucleus exhibits a range of properties. (tsijournals.com)
The imidazole ring is a five-membered ring structure with 3C and 2N atoms, with N present in the first and third positions and containing a hydrogen attachment sphere and an electron contributor nitrogen system [ 1 ]. (tsijournals.com)

Thiazoles are members of the azoles, heterocycles that include imidazoles and oxazoles. (wikipedia.org)
2-Imidazolidinone is a class of 5-membered ring heterocycles structurally related to imidazole. (atamanchemicals.com)

Thiazole can also be considered a functional group when part of a larger molecule. (wikipedia.org)
In this study we explored the enzymatic capabilities of a synthetic functional molecule attached to various polymer supports which could be capable of overcoming the obstacles faced by traditional enzymes. (ucsb.edu)
After attaching a triad-functionalized molecule consisting of an acid, imidazole, and hydroxyl functional groups to various polymeric platforms using the Azide-Alkyne Huisgen Cycloaddition reaction, we employed UV spectroscopy to monitor the real-time breakdown of assorted lipid substrates under exposure to these polymers. (ucsb.edu)
Molecular imprinting is a process in which functional and crosslinking monomers are co-polymerized in the presence of the target analyte, the imprint molecule. (intechopen.com)
When both domains bind the same DNA molecule the two halves interact to form functional β-lactamase, causing a measurable color changing reaction with nitrocefin. (willamette.edu)

We observe this catalytic enhancement not only with standard laboratory buffers, but also with diverse biological small molecules, including imidazole, amino acids, and amino sugars. (psu.edu)

To further clarify the influence of methyl substituents, we investigated a series of Cu( I ) complexes with (1-(2-pyridyl) pyrazole/imidazole and bis[2-(diphenylphosphino)phenyl]ether mixed ligands)[Cu(N^N)(P^P)] based on density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. (rsc.org)

Herein, we disclose how previously intractable aromatic imidazole rings, equipped with removable methylidene malononitrile activating handle, could be involved as competent cycloaddends with ß-aryl enals in efficient eliminative [4+2] cycloadditions under mild organocatalytic conditions. (bvsalud.org)

Here, we engineer reporter systems that allow the screening for defined conditions that induce molecular and functional features of human naive pluripotency. (janelia.org)
density functional theory and molecular mechanics. (lu.se)

Further transformation of acid chloride to imidazole can be achieved vai bromomethyl ketone. (uni-regensburg.de)
2-Imidazolidinone is composed of an imidazolidine core ( fully saturated imidazole) with a ketone function on the carbon between the two nitrogen atoms. (atamanchemicals.com)

1) A bis-cyclometalated chiral-at-metal rhodium complex (designated as RhS) in combination with the photoredox catalyst [Ru(bpy)3](PF6)2 enables visible-light-activated asymmetric α-amination and α-alkylation of 2-acyl imidazoles with aryl azides or α-diazo carboxylic esters as radical precursors, respectively (Chapter 3.1). (uni-marburg.de)
Additionally, aryl thioethers, also known as aryl sulfides, are a versatile synthetic platforms because they can be easily converted in a variety of other functional groups and find also applications as directing groups in chemistry of C-H functionalization. (uni-goettingen.de)

Moreover, the C-terminal functional group should preferably be a primary amide. (avhandlingar.se)
2-Imidazolidinone feature a saturated C3N2 backbones, except for the presence of a urea or amide functional group in the 2 or 4 positions. (atamanchemicals.com)

The chemistry of imidazole and its synthetic derivatives is reviewed in this article. (tsijournals.com)
A review of the literature on several research papers and other publications that give thorough information on the chemistry of imidazole. (tsijournals.com)
Beside peptide chemistry the synthetic work included the development of a fast and convenient microwave-assisted protocol for direct arylation of imidazoles. (avhandlingar.se)

substitution of the parazole with an imidazole group could reduce the ratio of 3 MLCT involved in emission transition. (rsc.org)
introduced two modifications to the traditional Bethesda assay (BA) for stabilization during the 2-hour incubation at 37°C: (i) buffering of normal pooled plasma (NPP) in the test and control mixtures with imidazole and (ii) substitution of FVIII-deficient plasma (FVIIIDP) for imidazole buffer (IB) in the control mixture and for specimen predilution. (cdc.gov)

With this step and recent successful electron transfer site designs within this scaffold, we are one step closer to a fully functional de novo designed nitrite reductase. (janelia.org)

Post-cycloaddition chemical editing provided imidazole-based ring systems with diverse oxidation state and functional groups. (bvsalud.org)

Initially, the functional monomer forms a complex and, after polymerization, their functional groups are held by the highly crosslinking polymeric structure. (intechopen.com)

Apart from its usage in pharmaceuticals, imidazole has a variety of industrial uses [ 4 ]. (tsijournals.com)

The process of developing a working synthetic enzyme with a triad of functional groups has never been successfully attempted before. (ucsb.edu)

The enzyme breaks down urocanic acid, a natural constituent of skin and other tissues of the body, into the metabolite imidazole propionate. (lu.se)

These could be helpful to improve biosorbents through modification of surface reactive sites via surface grafting and/or exchange of functional groups. (iwaponline.com)

Participants were assigned to twice-daily doses of imidazole dipeptide formula ( n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo ( n = 17). (frontiersin.org)

Imidazole is used in the decontamination of His-tagged proteins using restrained Metal Attraction Chromatography (IMAC). (tsijournals.com)

The functional group transformation of bromo to azide by SN2 reaction and subsequent reduction to amine furnished the key intermediate having tetrahydrofuran and amine functionality. (uni-regensburg.de)
This reaction occurred under environmentally benign and external oxidant-free reaction conditions with good functional group compatibility. (organic-chemistry.org)
Unfortunately, no activity was detected possibly due to imidazole being a reducer inhibiting the assay reaction. (willamette.edu)

Cellular small molecules provide a simple way to overcome the limited functional diversity of RNA and have the potential to participate in the catalytic mechanisms of many ribozymes in vivo. (psu.edu)

Functional recombinant FRβ protein was produced in insect cells and used as antigen to isolate a mAb, m909, from a human naïve Fab phage display library. (biomedcentral.com)

1-Vinylimidazole is a very important imidazole derivative and an important great chemical resources. (zhishangchemical.com)

The effect of the NPP preparation used in the control mixture on its stability was evaluated using NPP (Precision Biologic) unbuffered and buffered with imidazole (Sigma-Aldrich) or with 4-(2-hydroxyethy l)-1-piperazineethanesulfonic acid (HEPES) (Acros Organics, Fairfield, NJ, USA) to pH 7.4 and mixed 1:1 with FVIIIDP, BSA or an inhibitor- negative patient plasma in duplicate. (cdc.gov)

Imidazole is observed in a variety of key genetic compounds. (tsijournals.com)

We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans. (frontiersin.org)

In addition, this sustainable approach tolerates a broad range of functional groups. (organic-chemistry.org)

Imidazole-containing medicines have a greater reach in clinical medicine for treating a variety of conditions. (tsijournals.com)

The most prevalent amino acid is 'histidine,' which has an imidazole on the side chain [ 3 ]. (tsijournals.com)

Alterations in its activity or functional connectivity have been found in many disease states characterized by disturbed cognitive or psychological function ( Dennis and Thompson, 2014 ). (frontiersin.org)
Comparing these constructs, we reaffirm a previous result in which a blue shift in the 1s to 4p transition energy determined by Cu(I) X-ray absorption spectroscopy is correlated with an enhanced activity within imidazole-based constructs. (janelia.org)
Imidazole-buffered NPP (Precision Biologic) (IB-NPP) was used in control and test mixtures, and naturally deficient FVIIIDP (George King Biomedical) was used in control mixtures and for predilution of those specimens requiring dilution (<25% residual activity, >2.0 NBU). (cdc.gov)

Treatment of lactol with bisprotected imidazole in the presence of n-butyl lithium afforded diols as two diastereomers. (uni-regensburg.de)

Structure of imidazole. (tsijournals.com)

This comprehensive review describes the detailed profile of high-value nutrients and bioactives along with pharmacological and phyto-medicinal attributes of this multipurpose food plant with the aim to exploring its potential uses as ingredients for functional foods and nutraceutical/pharmaceutical industry. (scialert.net)
Additionally, the protocol demonstrated a high functional group tolerance. (uni-goettingen.de)

To create imidazole, he employed glyoxal and formaldehyde in ammonia. (tsijournals.com)

This method allowed the efficient and direct preparation of scantly represented 6,7-dihydrobenzo[d]imidazoles with optimal enantio- and regioselectivities. (bvsalud.org)

Hemophilia A is an X-linked, recessive disorder caused by deficiency of functional plasma clotting factor VIII (FVIII), which may be inherited or arise from spontaneous mutation. (medscape.com)

99% ee with broad functional group compatibility. (uni-marburg.de)

Heinrich Debus synthesised imidazole for the first time in 1858, but several imidazole products had been found as young as the 1840's. (tsijournals.com)

We analyzed resting state functional connectivity with the FSL fMRI analysis package. (frontiersin.org)

Imidazole is a component of theophylline, which is present in tea leaves and coffee beans and activates the central nervous system. (tsijournals.com)

The product is a functional copolymer utilized as an additive in oilfield chemicals and cosmetics. (zhishangchemical.com)

Anatomy1

Organisms8

Diseases3

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes27

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Synthesis4

Histamine2

Five-membered4

Heterocycles2

Molecule5

Amino acids1

Ligands1

Aromatic1

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Ketone2

Aryl2

Amide2

Chemistry3

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Reaction3

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Activity3

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