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  • hydrogels
  • Engineering cell matrix interactions in assembled polyelectrolyte fiber hydrogels for mesenchymal stem cell chondrogenesis. (nus.edu.sg)
  • Increasing mesh size of the hydrogels resulted in an increase in cellular proliferation exhibiting the strong correlation between mesh size and cell growth, while mesh size had a differential effect on ECM accumulation and expression of cartilage specific markers. (springer.com)
  • Hydrogels are considered as a preferred scaffold for cartilage tissue engineering due to their structural similarities and enhanced mass transport abilities. (springer.com)
  • Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical (especially drug delivery and stem cell engineering) and mechanical fields. (wikipedia.org)
  • The platelets act as cross-links to modify molecular functions to enable the hydrogels to have superior elasticity and toughness that resembles closely that of biological tissue. (wikipedia.org)
  • Nanocomposite hydrogels that are enforced with carbon-based nanomaterials are mechanically tough and electrically conducive, which make them suitable for use in biomedicine, tissue engineering, drug delivery, biosensing, etc. (wikipedia.org)
  • The electrical conducting property of these hydrogels allow them to mimic the characteristic of nerve, muscle, and cardiac tissues. (wikipedia.org)
  • However, even though these nanocomposite hydrogels demonstrate some functions of human tissue in lab environments, more research is needed to ensure their utility as tissue replacement. (wikipedia.org)
  • Nanocomposite hydrogels incorporated with polymeric nanoparticles are tailored for drug delivery and tissue engineering. (wikipedia.org)
  • Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content. (wikipedia.org)
  • Common uses for hydrogels include: Scaffolds in tissue engineering. (wikipedia.org)
  • When used as scaffolds, hydrogels may contain human cells to repair tissue. (wikipedia.org)
  • Sustained-release drug delivery systems Providing absorption, desloughing and debriding of necrotic and fibrotic tissue Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors, as well as in DDS. (wikipedia.org)
  • Ways of forming artificial superstructure include the use of thermo-responsive hydrogels, longitudinally oriented channels, longitudinally oriented fibers, stretch-grown axons, and nanofibrous scaffolds. (wikipedia.org)
  • In order to get around these difficulties, thermo-responsive hydrogels have been engineered to undergo solution-gelation (sol-gel) transitions, which are caused by differences in room and physiological temperatures, to facilitate implantation through in situ gelation and conformation to cavity shape caused, allowing them to be injected in a minimally invasively manner. (wikipedia.org)
  • polymer scaffold
  • Artistic rendering of human stem cells on the polymer scaffold. (nih.gov)
  • After refining the techniques and building on the work of Robert Langer at MIT, in 1997 Vacanti and colleagues at the University of Massachusetts controversially and with much media attention grew a cartilage structure resembling a human ear on the back of a nude mouse - dubbed the Earmouse, Auriculosaurus or Vacanti mouse - using a polymer scaffold and cow knee chondrocyte cells. (wikipedia.org)
  • fibrous
  • Collagens are fibrous proteins that serve as the building blocks of skin, tendon, bone, and other connective tissues. (nih.gov)
  • A non-woven fibrous scaffold was fabricated by electrospinning, surface modified using ammonia plasma, followed by scaffold surface biofunctionalisation with the latent TGF-β1. (bl.uk)
  • The extracellular matrix, which is mainly responsible for directing tissue growth and formation, has a complex superstructure created by many interwoven fibrous molecules. (wikipedia.org)
  • proteins
  • Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification. (semanticscholar.org)
  • After 4 weeks, WJ-MSC, embedded in a three-dimensional environment, were able to adapt to their environment and express specific cartilage-related genes and matrix proteins. (biomedcentral.com)
  • These materials consist of a complex mixture of ECM structural and decorating proteins specific to their tissue origin. (wikipedia.org)
  • ELPs can be engineered to recognize specific proteins in solution. (wikipedia.org)
  • Although engineered and modified in a laboratory setting, ELPs share structural characteristics with intrinsically disordered proteins (IDPs) naturally found in the body, such as tropoelastin, from which ELPs were given their name. (wikipedia.org)
  • Proteins are made from amino acids, which contain various functional groups. (wikipedia.org)
  • knee
  • 300 British orthopaedic surgeons specialising in knee surgery and soft tissue injury were invited to participate. (hindawi.com)
  • There are treatments for cartilage damage and arthritis, but typically these treatments are focused either on relieving symptoms by smoothing down the damaged cartilage, or replacing the joint surface with an artificial implant, such as with knee replacement or hip replacement surgery. (verywell.com)
  • His group has directed his attention to tissue engineering the jaw joint disc (TMJ disc) and the knee meniscus, whose degradation is responsible for a large number of debilitating problems. (wikipedia.org)
  • Cartilage: lab-grown tissue was successfully used to repair knee cartilage. (wikipedia.org)
  • Anterior cruciate ligament reconstruction (ACL reconstruction) is a surgical tissue graft replacement of the anterior cruciate ligament, located in the knee, to restore its function after an injury. (wikipedia.org)
  • approaches
  • 3D bioprinting is based on three main approaches: Biomimicry, autonomous self-assembly and mini-tissue building blocks. (wikipedia.org)
  • mammalian
  • The idea for what would later be called STAP cells ("stimulus-triggered acquisition of pluripotency") came from Vacanti, who with his brother Martin, known as Marty, believed that adult mammalian tissues contained tiny pluripotent cells that were released when the tissue was injured or stressed. (wikipedia.org)
  • Decellularized extracellular matrix based bioinks can be derived from nearly any mammalian tissue. (wikipedia.org)
  • Vacanti
  • Charles Alfred Vacanti (born 1949/50, also known as Chuck) is an American researcher in tissue engineering and stem cells and the Vandam/Covino Professor of Anesthesiology, Emeritus, at Harvard Medical School. (wikipedia.org)
  • He is known for the Vacanti mouse, a mouse created with Linda Griffith and Joseph Upton with cartilage shaped like a human ear on its back, and for being the senior author on the first of two retracted articles on STAP cells, a concept proposed by his brother and himself, and co-authored with Haruko Obokata. (wikipedia.org)
  • Vacanti and his brother Joseph successfully used the same technique to grow a chest plate for a 12-year-old boy, Sean McCormack, who had been born without cartilage or bone over his heart and left lung. (wikipedia.org)
  • In 1998, the team at Massachusetts led by Vacanti grew a replacement thumb bone using a scaffold of coral for a man, Raul Murcia, whose thumb had been crushed. (wikipedia.org)
  • Vacanti says that he coined the term tissue engineering in 1991 in the context of organ replacement, though it had been used earlier for other uses and his coining is disputed (for example, the term was used in 1984 in the same context by an ophthalmic surgeon). (wikipedia.org)
  • synthetic
  • Whether the conduit is in the form of a biologic tube, synthetic tube or tissue-engineered conduit, it should facilitate neurotropic and neurotrophic communication between the proximal and distal ends of the nerve gap, block external inhibitory factors, and provide a physical guidance for axonal regrowth. (wikipedia.org)
  • Synthetic tissue for ACL reconstruction has also been developed, but little data exists on its strength and reliability. (wikipedia.org)
  • donor
  • in this instance, the donor tendon is taken from a cadaver, but the disadvantages associated with this include scarcity of suitable tissue, the risk of the recipient contracting a disease from the donor, or tissue rejection [ 8 , 9 ]. (hindawi.com)
  • Creating functional and durable tissue has the potential to shift the paradigm in reconstructive surgery by obviating the need for donor sites. (biomedcentral.com)
  • Due to the limited availability of donor tissue and functional recovery in autologous nerve grafting, neural tissue engineering research has focused on the development of bioartificial nerve guidance conduits as an alternative treatment, especially for large defects. (wikipedia.org)
  • Three sources of replacement material for ACL reconstruction are commonly used: Autografts (employing bone or tissue harvested from the patient's body) Allografts (using bone or tissue from another body, either a cadaver or a live donor). (wikipedia.org)
  • citation needed] An accessory hamstring or part of the patellar ligament are the most common donor tissues used in autografts. (wikipedia.org)
  • physiological
  • Methacrylation of gelatin is a common approach for the fabrication of gelatin scaffolds that can be printed and maintain shape fidelity at physiological temperature. (wikipedia.org)
  • The LCST must not exceed physiological temperature (37 °C) if the scaffold is to gel upon implantation, creating a minimally invasive delivery. (wikipedia.org)
  • organs
  • Decellularization of tissues and organs. (semanticscholar.org)
  • Currently, bioprinting can be used to print tissues and organs to help research drugs and pills. (wikipedia.org)
  • The main goal of this approach is to create fabricated structures that are identical to the natural structure that are found in the tissues and organs in the human body. (wikipedia.org)
  • Biomimicry requires duplication of the shape, framework, and the microenvironment of the organs and tissues. (wikipedia.org)
  • human
  • Human cartilage was physically shattered, then decellularized sequentially with use of hypotonic buffer, TritonX-100, and a nuclease solution and made into a suspension. (semanticscholar.org)
  • She is also a faculty in the Irving Comprehensive Cancer Center and in the Center for Human Development at Columbia University, an honorary professor at the Faculty of Technology and Metallurgy at the University of Belgrade, honorary professor at the University of Novi Sad, and an adjunct professor at the Department of Biomedical Engineering at Tufts University. (wikipedia.org)
  • In ways not achieved by any other research team, Prof. Vunjak-Novakovic's group has succeeded to control cell growth, metabolism and function of engineered human tissues. (wikipedia.org)
  • The continued success of tissue engineering, and the eventual development of true human replacement parts, will grow from the convergence of engineering and basic research advances in tissue, matrix, growth factor, stem cell, and developmental biology, as well as materials science and bio informatics. (wikipedia.org)
  • biomedical
  • Gordana Vunjak-Novakovic is a Serbian American biomedical engineer. (wikipedia.org)
  • She was a Fulbright Fellow at Massachusetts Institute of Technology's Harvard-MIT Division of Health Sciences and Technology from 1986 to 1987 and held joint appointments as research scientist at the Whitaker College of Health Sciences and Technology at MIT (1993-1998) and as adjunct professor in the Department of Biomedical Engineering at Tufts University (1994-2004). (wikipedia.org)
  • In 1998 she became a full-time principal research scientist with the Harvard-MIT Division of Health Science and Technology at MIT, where she collaborated, among others, with renowned biomedical engineer Robert S. Langer. (wikipedia.org)
  • In 2005, she accepted a position as full professor with the Department of Biomedical Engineering at Columbia University. (wikipedia.org)
  • In addition, Vunjak-Novakovic is the current Chair of Fellows of the American Institute for Medical and Biological Engineering, a fellow of the Biomedical Engineering Society, a fellow of AAAS, and a founding fellow of TERMIS. (wikipedia.org)
  • He joined UCI from the University of California, Davis where he also served as the Chair of the Biomedical Engineering department. (wikipedia.org)
  • In the Summer of 2002, Professor Athanasiou was elected President of the Biomedical Engineering Society. (wikipedia.org)
  • These 3D all-carbon scaffolds/architectures may be used for the fabrication of the next generation of energy storage, supercapacitors, field emission transistors, high-performance catalysis, photovoltaics, and biomedical devices and implants. (wikipedia.org)
  • blood vessels
  • Play media While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • vitro
  • In this study, we explored the influence of radial shockwaves on human bone marrow MSCs using a floating model in vitro and evaluated the healing effects of these cells on cartilage defects in vivo using a rabbit model. (paperity.org)
  • Conclusions In the present study, we found that radial shockwaves significantly promoted the proliferation and self-renewal of MSCs in vitro and safely accelerated the cartilage repair process in vivo, indicating favorable clinical outcomes. (paperity.org)
  • Collagen-hyaluronic acid (CHyA) scaffolds, recently developed in our laboratory for in vitro chondrogenesis, were fabricated with three distinct mean pore sizes (94, 130, and 300? (jove.com)
  • m) stimulated significantly higher cell proliferation, chondrogenic gene expression, cartilage-like matrix deposition, and resulting bulk compressive modulus after in vitro culture, relative to scaffolds with smaller mean pore sizes (94, 130? (jove.com)
  • The technical development of the Minusheet perfusion culture system was driven by the idea to create under in vitro conditions an environment resembling as near as possible the situation of specialized tissues found within the organism. (wikipedia.org)
  • Under natural conditions a prerequisite for an optimal tissue development is a cell-specific interaction with the extracellular matrix, while under in vitro conditions a substitute for the extracellular matrix has to be selected. (wikipedia.org)
  • In vitro meat: Edible artificial animal muscle tissue cultured in vitro. (wikipedia.org)
  • polymer
  • For example, a series of 5 papers on bioreactors, seeding of polymer scaffolds for cartilage tissue engineering, cultivation parameters, and tissue construct characterization, published in 1998 and 1999 have been cited over a 2,000 times. (wikipedia.org)
  • After refining the techniques and building on the work of Robert Langer at MIT, in 1997 Vacanti and colleagues at the University of Massachusetts controversially and with much media attention grew a cartilage structure resembling a human ear on the back of a nude mouse - dubbed the Earmouse, Auriculosaurus or Vacanti mouse - using a polymer scaffold and cow knee chondrocyte cells. (wikipedia.org)
  • mammalian
  • Decellularized extracellular matrix based bioinks can be derived from nearly any mammalian tissue. (wikipedia.org)
  • The idea for what would later be called STAP cells ("stimulus-triggered acquisition of pluripotency") came from Vacanti, who with his brother Martin, known as Marty, believed that adult mammalian tissues contained tiny pluripotent cells that were released when the tissue was injured or stressed. (wikipedia.org)
  • vascularization
  • Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. (jove.com)
  • In addition, in recent development, bioreactor technologies have allowed the rapid maturation of tissues, vascularization of tissues and the ability to survive transplants. (wikipedia.org)
  • simulate
  • Materials supple enough to simulate native cartilage have been too squishy and fragile to grow in a joint and withstand loading. (redorbit.com)
  • Moreover, to always offer fresh nutrition including respiratory gas and to simulate a tissue-specific fluid environment, the tissue carriers can be inserted into compatible perfusion culture containers. (wikipedia.org)
  • cells
  • NOVATACH™ is a series of peptide-coupled alginates which facilitate and promote interaction between cells and alginate-based scaffolds and matrices resulting in improved cell functionality and viability. (novamatrix.biz)
  • Orthotopic models have their limitations too, but with proper technique tumor cells of interest can be accurately engrafted into tissue that most closely mimics conditions in the human brain. (jove.com)
  • Human adipose tissue is a source of multipotent stem cells. (springer.com)
  • Marrow stromal cells as stem cells for nonhematopoietic tissues. (springer.com)
  • Since then, the challenge has been to develop the right medium to fill the empty spaces of the scaffold -- one that can sustain compressive loads, provide a lubricating surface and potentially support the growth of stem cells on the scaffold. (redorbit.com)
  • Once implanted, the bone cells weave into and through the porous microstructure of the bone graft to support the new tissue, blood cells and soft tissue as they grow to connect fractured bone segments. (google.com)
  • This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. (wikipedia.org)
  • These cells are held in place by a small piece of soft tissue from the tibia, called a periosteal flap, which is sutured over the area to serve as a watertight lid. (wikipedia.org)
  • citation needed] A variation on the Carticel technique, called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable tissue which is implanted via an open or arthroscopic procedure. (wikipedia.org)
  • The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. (wikipedia.org)
  • Recently, there have been several published case reports of successful cartilage growth in human knees using autologous cultured mesenchymal stem cells. (wikipedia.org)
  • Thus, on the one hand the system provides a highly adaptable basis for the culture of adherent cells and the generation of specialized tissues. (wikipedia.org)
  • In both cases a Minusheet tissue carrier prevents damage but supports development of contained cells or tissues during experimentation. (wikipedia.org)
  • A standard culture protocol with a tissue carrier can be initiated by seeding cells onto the upper side. (wikipedia.org)
  • When a tissue carrier is turned, cells can also be seeded on the other side so that co-culture experiments with two different cell types become possible. (wikipedia.org)
  • Not only single cells but also a thin slice of tissue can be mounted between two pieces of a woven net within a Minusheet tissue carrier. (wikipedia.org)
  • After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
  • In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
  • She is University Professor and The Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia University, where she directs the Laboratory for Stem Cells and Tissue Engineering. (wikipedia.org)
  • Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. (wikipedia.org)
  • Artificial bone marrow Artificial bone Laboratory-grown penis Oral mucosa tissue engineering Foreskin Tissue engineering utilizes living cells as engineering materials. (wikipedia.org)
  • Cells became available as engineering materials when scientists at Geron Corp. discovered how to extend telomeres in 1998, producing immortalized cell lines. (wikipedia.org)
  • Therefore, dECM-derived bioinks are particularly tailored to provide tissue-specific cues to cells. (wikipedia.org)
  • However, emerging innovations span from bioprinting of cells or extracellular matrix deposited into a 3D gel layer by layer to produce the desired tissue or organ. (wikipedia.org)
  • This aggregation of cells does not require a scaffold, and are required for placing in the tubular-like tissue fusion for processes such as extrusion. (wikipedia.org)
  • Given that every tissue in the body is naturally composed of different cell types, many technologies for printing these cells vary in their ability to ensure stability and viability of the cells during the manufacturing process. (wikipedia.org)
  • These stimulations send signals to the cells to control the remodeling and growth of tissues. (wikipedia.org)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • Charles Alfred Vacanti (born 1949/50, also known as Chuck) is an American researcher in tissue engineering and stem cells and the Vandam/Covino Professor of Anesthesiology, Emeritus, at Harvard Medical School. (wikipedia.org)
  • He is known for the Vacanti mouse, a mouse created with Linda Griffith and Joseph Upton with cartilage shaped like a human ear on its back, and for being the senior author on the first of two retracted articles on STAP cells, a concept proposed by his brother and himself, and co-authored with Haruko Obokata. (wikipedia.org)
  • He co-founded the Tissue Engineering Society, and holds a number of patents related to stem cells. (wikipedia.org)
  • Marty first identified what they believed were tiny stem cells in rat brain tissue that he had sliced and forced through small tubes. (wikipedia.org)
  • They published work in 2001 describing these "spore-like cells", and reported that these cells could survive anoxic conditions for days and that they were able to grow a variety of tissues including pancreas and lung from isolated spore-like cells. (wikipedia.org)
  • Laboratory
  • From a mechanical standpoint, this technology remedies the issues that other types of synthetic cartilage have had," says Zhao, founder of Duke's Soft Active Materials (SAMs) Laboratory. (redorbit.com)
  • biological
  • In a biological tissue, light scattering is based on the size and type of scatterers seen as refractive index variations that describe the optical properties shown. (spiedigitallibrary.org)
  • We have found that photoacoustic imaging at 1064 nm can identify brachytherapy seeds uniquely at laser penetration depths of 5 cm in biological tissue at the ANSI limit for human exposure with a contrast-to-noise ratio of 26.5 dB. (spiedigitallibrary.org)
  • Biomedical engineering students combine a study of fundamental physiological and biological fundamental processes with a study of engineering methods. (njit.edu)
  • In addition, Vunjak-Novakovic is the current Chair of Fellows of the American Institute for Medical and Biological Engineering, a fellow of the Biomedical Engineering Society, a fellow of AAAS, and a founding fellow of TERMIS. (wikipedia.org)
  • fibers
  • In this paper, we have implemented the variable incidence angle technique of multiple angle of illumination experiment on tendon and cartilage samples whose dominant constituents are genetically different types of collagen fibers, type I and type II, respectively. (spiedigitallibrary.org)
  • synthetic
  • A Duke research team has developed a better recipe for synthetic replacement cartilage in joints. (redorbit.com)
  • The team's next step will likely be to implant small patches of the synthetic cartilage in animal models, according to Guilak and Zhao. (redorbit.com)
  • Synthetic tissue for ACL reconstruction has also been developed, but little data exists on its strength and reliability. (wikipedia.org)
  • differentiation
  • Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes are cell-type specific and influence cellular shape, differentiation, and extracellular matrix secretion. (jove.com)
  • The preferential addition of heparan sulfate or chondroitin sulfate chains to domains I and V could have an effect on the differentiation of mesenchymal tissues into cartilage, bone or any number of tissues, but the regulatory mechanism of changing from heparan sulfate to chondroitin sulfate addition are not well understood. (wikipedia.org)
  • chondrocyte
  • Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. (wikipedia.org)
  • human
  • She is also a faculty in the Irving Comprehensive Cancer Center and in the Center for Human Development at Columbia University, an honorary professor at the Faculty of Technology and Metallurgy at the University of Belgrade, honorary professor at the University of Novi Sad, and an adjunct professor at the Department of Biomedical Engineering at Tufts University. (wikipedia.org)
  • In ways not achieved by any other research team, Prof. Vunjak-Novakovic's group has succeeded to control cell growth, metabolism and function of engineered human tissues. (wikipedia.org)
  • The continued success of tissue engineering, and the eventual development of true human replacement parts, will grow from the convergence of engineering and basic research advances in tissue, matrix, growth factor, stem cell, and developmental biology, as well as materials science and bio informatics. (wikipedia.org)
  • The main goal of this approach is to create fabricated structures that are identical to the natural structure that are found in the tissues and organs in the human body. (wikipedia.org)
  • tendon
  • It is found that tendon displays a much greater angular anisotropy in its optical backscattering coefficient than the healthy cartilage. (spiedigitallibrary.org)
  • The development of bio-devices for complete regeneration of ligament and tendon tissues is presently one of the biggest challenges in tissue engineering. (frontiersin.org)
  • The peculiar hierarchical structure of the tendon, a highly anisotropic tissue, in which collagen fibrils assemble in parallel bundles, is difficult to restore since it is organized as an ensemble of structural units at increasing size levels, responsible for its remarkable biofunctional properties. (frontiersin.org)
  • woven
  • He and Guilak began working together to integrate the hydrogel into the fabric of the 3-D woven scaffolds in a process Zhao compares to pouring concrete over a steel framework. (redorbit.com)
  • mechanical
  • It has all the mechanical properties of native cartilage and can withstand wear and tear without fracturing. (redorbit.com)
  • Often, the tissues involved require certain mechanical and structural properties for proper functioning. (wikipedia.org)
  • Athanasiou received his bachelor's degree in Mechanical Engineering from New York Institute of Technology at Old Westbury in 1984. (wikipedia.org)
  • approaches
  • 3D bioprinting is based on three main approaches: Biomimicry, autonomous self-assembly and mini-tissue building blocks. (wikipedia.org)
  • artificial
  • And though the resulting material did not quite meet the standards of natural cartilage, it easily outperformed all other known potential artificial replacements across the board, including the hydrogel and scaffolding by themselves. (redorbit.com)
  • It's a very promising candidate for artificial cartilage in the future. (redorbit.com)
  • toxicity
  • We think we have demonstrated that these DNA nanotrains are a promising targeted drug transport platform for delivery of cancer chemotherapeutics with very low toxicity to healthy tissues, and that the platform has wide application for many different cancer types, Tan said. (regenerativemedicine.net)
  • successfully
  • Vacanti and his brother Joseph successfully used the same technique to grow a chest plate for a 12-year-old boy, Sean McCormack, who had been born without cartilage or bone over his heart and left lung. (wikipedia.org)
  • metabolism
  • Again, in partic- ular drug delivery, it is very important to investigate pharmacokinetic aspects, start- ing from the administration of the nanovector-drug complexes to their distribution via the blood circulation, reaching of the target tissue, metabolism in the liver, and elimination via the kidneys or the biliary pathway. (iforexprofit.com)
  • development
  • In consequence, regarding an optimal generation of specialized tissues a powerful strategy has to exclude as much as possible harmful parameters, while factors supporting the process of tissue development must be intensified . (wikipedia.org)
  • For an easy handling and to prevent damage during development the selected specimens are placed in the base part of a Minusheet tissue carrier (Fig. 1b). (wikipedia.org)
  • His first company Osteobiologics, founded in 1993, was based, among other inventions, on the development of acellular scaffolds for the treatment of focal cartilage lesions. (wikipedia.org)
  • fabrication
  • Methacrylation of gelatin is a common approach for the fabrication of gelatin scaffolds that can be printed and maintain shape fidelity at physiological temperature. (wikipedia.org)
  • regeneration
  • Although his background is in anesthesiology, Vacanti began work in tissue engineering in the late 1980s with his brother Joseph, also known as Jay, who was working on liver regeneration. (wikipedia.org)
  • parameters
  • To meet parameters positively influencing cell adhesion and communication, the technical concept is based on a Minusheet tissue carrier (Fig. 1). (wikipedia.org)
  • compression
  • Hyaluronic acid in the extracellular space confers upon tissues the ability to resist compression by providing a counteracting turgor (swelling) force by absorbing significant amounts of water. (wikipedia.org)
  • organ
  • Vacanti says that he coined the term tissue engineering in 1991 in the context of organ replacement, though it had been used earlier for other uses and his coining is disputed (for example, the term was used in 1984 in the same context by an ophthalmic surgeon). (wikipedia.org)