• activates
  • Furthermore, when it was shown three decades ago that epinephrine activates blood platelets in an aggregometer, it was proposed that platelets could be the link between stress and cardiovascular disease. (ahajournals.org)
  • Thrombin, a well-known stimulator of P-selectin expression in platelets, activates a PI-specific phospholipase C. 9 10 Thrombin thus promotes PI turnover and PKC activation, resulting in increases in intracellular Ca 2+ and phosphorylation of substrate protein. (ahajournals.org)
  • membranes
  • Ten-minute incubation with either phorbol 12-myristate 13-acetate (PMA), thrombin, or l -NAME significantly increased P-selectin expression on platelets (as assessed by flow-cytometric analysis) and PKC activity of platelet membranes. (ahajournals.org)
  • 1978
  • They circulate as anucleate discs two to five microns in diameter: detailed measurements of a number of parameters of normal platelets have been provided by Stahl and associates (1978). (springer.com)
  • activity
  • Because NO has been shown to inhibit protein kinase C (PKC) activity, we examined the hypothesis that the NO synthase inhibitor N G -nitro- l -arginine methyl ester ( l -NAME) stimulates P-selectin expression on platelets via PKC activation. (ahajournals.org)
  • Failure of the renal excretory function causes a moderate reduction of red cell life span, the impairment of the function of blood platelets, and suppression of marrow activity. (wordpress.com)
  • renal
  • Patients with altered level of consciousness also had poorer renal function. (ac.ke)
  • The majority of patients with altered level of consciousness also had systolic hypotension, severe metabolic acidosis and impaired renal function. (ac.ke)
  • This chapter analyzes the anemia of chronic renal disease as being caused by a failure of both renal excretory and endocrine function. (wordpress.com)
  • The failure of renal endocrine function is managed by replacement treatment with EPO. (wordpress.com)
  • structure
  • A diagrammatic representation of platelet structure is provided in Figure 2.1. (springer.com)
  • The two main EGF-like domain subtypes hEGF and cEGF are not just distinct in their structure and conformation but also have different functions. (wikipedia.org)
  • primary
  • The primary function of insulin is to regulate or decrease blood glucose levels. (infobarrel.com)
  • non-primary source needed] FERMT3 deficiency on β(2) integrin function depend on both cell type (Natural killer cell or Leukocytes) and the integrin activation stimulus. (wikipedia.org)
  • walls
  • When platelets do not stick together and adhere to the walls of your arteries, this will improve your cholesterol levels. (infobarrel.com)
  • studies
  • Details of the ultrastructure of platelets have been revealed by electron microscopy studies and have provided information which helps to explain platelet behavior in the process of hemostasis. (springer.com)
  • cells
  • The most prominent of these was Holm Holmsen who made basic discoveries establishing platelets as secretory non-nucleated cells. (wikipedia.org)
  • cellular
  • They are essential in the organisation of focal adhesions that mediate cell-extracellular matrix junctions and are involved in other cellular compartments that control cell-cell contacts and nucleus functioning. (wikipedia.org)
  • excretory
  • Modulating Effects By Trichinella Spiralis Sensu Stricto Excretory/Secretory Antigens of Human Neutrophil Functions," Wiadomosci Parazytologizne 35:391-399 (1989). (patentgenius.com)
  • appear
  • When examined by light microscopy platelets appear to consist of organelles randomly distributed or clumped together in a water-clear cytoplasm (hyaloplasm) enclosed by a membrane. (springer.com)
  • risk
  • DNA sequencing will meet the challenge of elucidating the genetic predisposition for common polygenic diseases, especially in determining the function of the novel common genetic risk variants and identifying the rare variants, which may also partially ascertain the source of the missing heritability. (onlinejacc.org)