• activates
  • Furthermore, when it was shown three decades ago that epinephrine activates blood platelets in an aggregometer, it was proposed that platelets could be the link between stress and cardiovascular disease. (ahajournals.org)
  • Thrombin, a well-known stimulator of P-selectin expression in platelets, activates a PI-specific phospholipase C. 9 10 Thrombin thus promotes PI turnover and PKC activation, resulting in increases in intracellular Ca 2+ and phosphorylation of substrate protein. (ahajournals.org)
  • infarction
  • Whether the thrombotic component of myocardial infarction is primary or secondary in a given patient, platelet function alterations can influence many mechanisms - operating at the microenvi-ronmental level - from which it depends if the thrombotic lesion grows or sends platelet emboli to the smaller myocardial vessels. (springer.com)
  • blood
  • The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the. (google.com)
  • Failure of the renal excretory function causes a moderate reduction of red cell life span, the impairment of the function of blood platelets, and suppression of marrow activity. (wordpress.com)
  • But the blood cells that eventually produced by these organs is still not functioning properly and the body finally experiencing anemia. (blogspot.com)
  • factor
  • The release of granular content (β-thromboglobulin and platelet factor 4) to the circulation in response to epinephrine was not significant. (ahajournals.org)
  • Secretion of platelet-derived growth factor may contribute to the smooth muscle hyperplasia of atherosclerotic lesions. (ahajournals.org)
  • Formation is influenced by growth factors, the most influential are the platelet derived growth factor (platelet-derived growth factor / PDGF), and expenditures described collagenase activity towards monocytes, macrophages and granulocytes. (blogspot.com)
  • patients
  • Decreased platelet sensitivity to prostacyclin in patients with myocardial ischaemia. (springer.com)
  • 9 Platelet activation may also play a significant role in patients with persistent unstable angina pectoris. (ahajournals.org)
  • Patients with altered level of consciousness also had poorer renal function. (ac.ke)
  • The majority of patients with altered level of consciousness also had systolic hypotension, severe metabolic acidosis and impaired renal function. (ac.ke)
  • Platelet transfusions are being used increasingly in patients with thrombocytopenia to improve hemostatic function before surgery and invasive procedures. (asahq.org)
  • Methods: Twenty-five patients with thrombocytopenia from ablation chemotherapy and total body irradiation (before bone marrow transplantation), were randomized to receive either 1-day (fresh) or 4-day stored platelets. (asahq.org)
  • Conclusions: In patients with chemotherapy-induced thrombocytopenia, platelet transfusion causes an immediate increase in number and function, which is independent of storage time. (asahq.org)
  • renal
  • This chapter analyzes the anemia of chronic renal disease as being caused by a failure of both renal excretory and endocrine function. (wordpress.com)
  • The failure of renal endocrine function is managed by replacement treatment with EPO. (wordpress.com)
  • activity
  • Because NO has been shown to inhibit protein kinase C (PKC) activity, we examined the hypothesis that the NO synthase inhibitor N G -nitro- l -arginine methyl ester ( l -NAME) stimulates P-selectin expression on platelets via PKC activation. (ahajournals.org)
  • release
  • Ristocetin-induced ATP release increased immediately after transfusion of fresh platelets only (0 plus/minus 0 to 69 plus/minus 17) and remained unchanged for 2 h. (asahq.org)
  • structure
  • The two main EGF-like domain subtypes hEGF and cEGF are not just distinct in their structure and conformation but also have different functions. (wikipedia.org)
  • cells
  • The most prominent of these was Holm Holmsen who made basic discoveries establishing platelets as secretory non-nucleated cells. (wikipedia.org)
  • risk
  • DNA sequencing will meet the challenge of elucidating the genetic predisposition for common polygenic diseases, especially in determining the function of the novel common genetic risk variants and identifying the rare variants, which may also partially ascertain the source of the missing heritability. (onlinejacc.org)