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  • vascular
  • P-selectin plays an important pro-inflammatory role in mediating interactions among neutrophils, platelets, and the vascular endothelium. (ahajournals.org)
  • Although periodontitis is a common condition (47% of U.S. dentate adults aged 30 years and older [ 9 ]) associated with chronic low-grade inflammatory state and atherosclerotic vascular disease [ 10 ], it is only sparsely investigated as a potential source of ongoing platelet activation. (biomedcentral.com)
  • activates
  • Furthermore, when it was shown three decades ago that epinephrine activates blood platelets in an aggregometer, it was proposed that platelets could be the link between stress and cardiovascular disease. (ahajournals.org)
  • Thrombin, a well-known stimulator of P-selectin expression in platelets, activates a PI-specific phospholipase C. 9 10 Thrombin thus promotes PI turnover and PKC activation, resulting in increases in intracellular Ca 2+ and phosphorylation of substrate protein. (ahajournals.org)
  • infarction
  • Whether the thrombotic component of myocardial infarction is primary or secondary in a given patient, platelet function alterations can influence many mechanisms - operating at the microenvi-ronmental level - from which it depends if the thrombotic lesion grows or sends platelet emboli to the smaller myocardial vessels. (springer.com)
  • respectively
  • Results: Platelet number increased similarly (21,000 plus/minus 2,000/mm 3 to 76,000 plus/minus 7,000/mm 3 and 20,000 plus/minus 1,000/mm 3 to 65,000 plus/minus 4,000/mm 3 ) after transfusion in the 1- and 4-day stored platelets, respectively. (asahq.org)
  • significantly
  • Ten-minute incubation with either phorbol 12-myristate 13-acetate (PMA), thrombin, or l -NAME significantly increased P-selectin expression on platelets (as assessed by flow-cytometric analysis) and PKC activity of platelet membranes. (ahajournals.org)
  • blood
  • The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the. (google.com)
  • Failure of the renal excretory function causes a moderate reduction of red cell life span, the impairment of the function of blood platelets, and suppression of marrow activity. (wordpress.com)
  • We hypothesized that circulating platelets and platelet-leukocyte complexes from peripheral blood of periodontitis patients become less reactive upon stimulation after the provision of non-surgical periodontal therapy. (biomedcentral.com)
  • But the blood cells that eventually produced by these organs is still not functioning properly and the body finally experiencing anemia. (blogspot.com)
  • factor
  • The release of granular content (β-thromboglobulin and platelet factor 4) to the circulation in response to epinephrine was not significant. (ahajournals.org)
  • Secretion of platelet-derived growth factor may contribute to the smooth muscle hyperplasia of atherosclerotic lesions. (ahajournals.org)
  • Formation is influenced by growth factors, the most influential are the platelet derived growth factor (platelet-derived growth factor / PDGF), and expenditures described collagenase activity towards monocytes, macrophages and granulocytes. (blogspot.com)
  • activation
  • 9 Platelet activation may also play a significant role in patients with persistent unstable angina pectoris. (ahajournals.org)
  • Because NO has been shown to inhibit protein kinase C (PKC) activity, we examined the hypothesis that the NO synthase inhibitor N G -nitro- l -arginine methyl ester ( l -NAME) stimulates P-selectin expression on platelets via PKC activation. (ahajournals.org)
  • increase
  • Conclusions: In patients with chemotherapy-induced thrombocytopenia, platelet transfusion causes an immediate increase in number and function, which is independent of storage time. (asahq.org)
  • patients
  • Decreased platelet sensitivity to prostacyclin in patients with myocardial ischaemia. (springer.com)
  • Patients with altered level of consciousness also had poorer renal function. (ac.ke)
  • The majority of patients with altered level of consciousness also had systolic hypotension, severe metabolic acidosis and impaired renal function. (ac.ke)
  • Platelet transfusions are being used increasingly in patients with thrombocytopenia to improve hemostatic function before surgery and invasive procedures. (asahq.org)
  • Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. (biomedcentral.com)
  • release
  • Ristocetin-induced ATP release increased immediately after transfusion of fresh platelets only (0 plus/minus 0 to 69 plus/minus 17) and remained unchanged for 2 h. (asahq.org)
  • renal
  • This chapter analyzes the anemia of chronic renal disease as being caused by a failure of both renal excretory and endocrine function. (wordpress.com)
  • The failure of renal endocrine function is managed by replacement treatment with EPO. (wordpress.com)
  • protein
  • A plurality of protein factors and also cellular components such as e.g. platelets (thrombocytes) are involved in regulating hemostasis. (google.com)
  • It is of note that only a small proportion of the transcribed RNAs are translated into protein with the remainder performing a host of functions, affecting those sequences (genes) that encode for protein. (onlinejacc.org)
  • formation
  • The flow and composition change in response to the formation of a platelet mass in the passageway. (google.com)
  • Formation of platelet-leukocyte complexes in response to P. gingivalis was also reduced at recall compared to baseline (1.2 ± 0.7 vs. 11.4 ± 50.5, P = 0.045). (biomedcentral.com)
  • cellular
  • They are essential in the organisation of focal adhesions that mediate cell-extracellular matrix junctions and are involved in other cellular compartments that control cell-cell contacts and nucleus functioning. (wikipedia.org)
  • structure
  • The two main EGF-like domain subtypes hEGF and cEGF are not just distinct in their structure and conformation but also have different functions. (wikipedia.org)
  • expression
  • Recently, N,N,N -trimethylsphingosine, an inhibitor of PKC, has been shown to attenuate thrombin-stimulated P-selectin expression in both platelets and ECs. (ahajournals.org)