• VEGF
  • VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. (wikipedia.org)
  • Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). (wikipedia.org)
  • axon
  • Here, we demonstrate that Sema3D is required for correct formation of the early axon pathways in the zebrafish brain and that different functions of Sema3D may require different neuropilin components. (jneurosci.org)
  • tumors
  • When the tumor burden was increased by implantation of 3 orthotopic tumors, successive primed ablation of 2 discrete lesions resulted in survival of 60% of treated mice as compared with 25% of mice treated with immunotherapy alone. (jci.org)
  • discoidin
  • In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. (wikipedia.org)
  • elegans
  • Studies in C. elegans revealed a possible mechanism for Netrin acting as a chemorepulsive agent (Fig.2). (wikipedia.org)
  • vitro
  • CCBE1 deficient mice were generated to understand the function of CCBE1 in cardiovascular development, and CCBE1 recombinant protein was used in both in vivo and in vitro settings to gain insight into the molecular function of CCBE1. (ahajournals.org)
  • These studies suggest that binding capability in vitro does not necessarily reveal ligand-receptor function in vivo . (jneurosci.org)
  • metastasis
  • 2 , 3 Thus, it is not surprising if guidance molecules contribute to tumor growth, activation of the microenvironment and metastasis. (pubmedcentralcanada.ca)
  • interactions
  • Robo3 has two isoforms, 3.1 and 3.2, and these isoforms interact with Robo1 and Robo2 (Robo1/2) through cis interactions at the leading edge of the growth cone. (wikipedia.org)
  • functional
  • The phenotypic differences between human DCs and macrophages are discernible by immunohistochemistry 1 - 2 and a clear functional distinction is the ability of DCs to leave tissues while macrophages remain fixed. (biomedsearch.com)
  • netrin
  • Netrin-2 is expressed broadly in the ventral two thirds of the spinal cord, but not in the floor plate. (wikipedia.org)
  • protein
  • Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. (wikipedia.org)
  • Xenopus laevis embryonic protein UVS.2, which is expressed during dorsoanterior development. (wikipedia.org)
  • Two mouse models of CMT2D have been used to better understand the disease, identifying that the disorder is caused by a toxic gain-of-function of the mutant glycine-tRNA ligase protein. (wikipedia.org)
  • soluble
  • Transmembrane TNF (tmTNF) and TNF receptor 2 are important for remyelination in experimental MS models, but it is unknown whether soluble TNF (solTNF), a major proinflammatory factor, is involved in regeneration processes. (jci.org)
  • mice
  • Some of the pathways active during ontogeny also regulate pancreatic growth during adulthood, and we are studying the role of these genetic pathways in growth control and function of the mature pancreas in mice. (stanford.edu)
  • neurons
  • They originate from pioneer neurons, and have the main function of laying down the initial growing path that subsequent growing axons, dubbed follower axons, from other neurons will eventually follow. (wikipedia.org)
  • expression
  • The expression patterns of Npn-1 and Npn-2 in developingneurons of the central and peripheral nervous systems are largely, though notcompletely nonoverlapping. (creativebiomart.net)
  • cellular
  • The term co-receptor is prominent in literature regarding signal transduction, the process by which external stimuli regulate internal cellular functioning. (wikipedia.org)
  • The key to optimal cellular functioning is maintained by possessing specific machinery that can carry out tasks efficiently and effectively. (wikipedia.org)
  • cell
  • Recent studies indicate that SEMA3F has biological effects in other cell types, however its mechanism(s) of function is poorly understood. (harvard.edu)
  • Many vital organs derive from the endodermal and mesodermal germ layers to form the gastrointestinal and respiratory tracts, yet little is known about the genetic programs that coordinate steps culminating in proper organ morphogenesis and axial position, cell differentiation and physiologic function. (stanford.edu)
  • In turn, we expect that these studies will identify important conserved functions that govern islet cell biology. (stanford.edu)
  • family
  • At the amino acid sequence level, Npn-1and Npn-2 share 44%identity Npn-1 and Npn-2 show different binding specificities for different membersof the semaphorin family. (creativebiomart.net)
  • The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. (wikipedia.org)