Function models biological. Medical search. Frequent questions

Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
Workshop recommendations highlighted the need for utilizing and developing improved approaches to methodically evaluate the function and phenotypic outcomes of genomic variation. (nih.gov)

Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes. (biomedcentral.com)
They form the intricately shaped compartments of life and are involved in cell recognition, cell communication, and numerous other biological processes. (mpg.de)
Visible Body offers a health and life science library that contains over 24,000 assets, including 3D gross and microanatomy models, virtual animal dissection models, diagnostic images, animations, and interactive simulations of biological processes. (visiblebody.com)
With the recognition of the involvement of the gut microbiota in brain processes, mental health and cognitive function, exciting opportunities to produce benefits for brain function by manipulating the microbiota have come into focus. (nature.com)
GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
Microfluidic systems are well-suited for studying mixed biological communities for improving industrial processes of fermentation, biofuel production, and pharmaceutical production. (springer.com)
What biological functions do cognitive processes consist of? (lu.se)
However, since the compartmental model does not possess a physiological structure, it is often not possible to incorporate a description of these non-linear biochemi- cal processes in a biologically appropriate context. (cdc.gov)
The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)

We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
The combination of the two offers the opportunity to map gene functions and gene networks in vivo at single-cell resolution using cell tracking and quantification of cellular phenotypes. (nih.gov)
Here we present Digital Development (http://www.digital-development.org), a database of cell lineage differentiation with curated phenotypes, cell-specific gene functions and a multiscale model. (nih.gov)
This information includes lineage differentiation phenotypes, cell-specific gene functions, differentiation landscapes and fate choices, and a multiscale model of lineage differentiation. (nih.gov)
One of the central problems in biology is understanding how genomic variation affects genome function to influence phenotypes. (nih.gov)

Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. (biomedcentral.com)
The biological system is complex with many regulatory features such as DNA, mRNA, proteins, metabolites, and epigenetic features such as DNA methylation and histone post-translational modifications (PTMs). (rsc.org)
A machine-learning model computationally breaks down how segments of amino acid chains determine a protein's function, which could help researchers design and test new proteins for drug development or biological research. (sciencedaily.com)
To do so, they use known structural similarities of proteins to supervise their model, as the model learns the functions of specific amino acids. (sciencedaily.com)
They trained their model on about 22,000 proteins from the Structural Classification of Proteins (SCOP) database, which contains thousands of proteins organized into classes by similarities of structures and amino acid sequences. (sciencedaily.com)

The Molecular Biophysics Group determines the functional mechanisms of biologically relevant molecular systems by employing high-performance computer simulations and data-driven predictive modeling. (ornl.gov)
Uncovering hidden patterns from such a huge and heterogeneous amount of omics data allows the creation of predictive models for real-life applications. (degruyter.com)
Thus, we develop a predictive model that is tested against existing data. (lu.se)
Computational techniques, including predictive algorithms and mathematical models that describe a selected process (e.g., skin permeation) by means of analytical or numerical methods. (cdc.gov)

Biophysical computational models of the heart provide a quantitative framework for mapping changes in anatomy to whole heart function. (plos.org)

Pharmacokinetics is the study of the time course for the Of course the actual nature of the relationship between tis- absorption, distribution, metabolism, and excretion of a sue exposure and response, particularly across species, may chemical substance in a biological system. (cdc.gov)
Although ChAT plays a crucial role in acetylcholine metabolism and the functioning of the nervous system, there is still much to be discovered about its regulation and recognition of substrates and inhibitors. (lu.se)

Importantly, the proposed theory can be tested experimentally, using a combination of behavioral paradigms, computational modelling, and neuroimaging. (frontiersin.org)
Therefore, new paradigms are needed to deal with omics data, for its annotation and integration and finally for inferring knowledge, answering biological questions and making it available to biologists. (degruyter.com)
Drosophila melanogaster is an apt model organism to decipher these behavioural paradigms. (who.int)

Denial of basic biological functions and cellular makeup. (urbandictionary.com)
We primarily focus on a intracellular signaling pathway known as the mitochondrial unfolded protein response (or UPR mt ), which allows cells to monitor the function of the entire cellular pool of mitochondria and adapt transcription accordingly. (umassmed.edu)
Straight CR, Ringham OR, Bartley JM, Keilich SR, Kuchel GA, Haynes L, Miller MS. Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice. (umass.edu)
Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive, older adults with knee osteoarthritis. (umass.edu)

At the " Biomembrane Days", experts from all over the world inform about recent advances in understanding the morphology and molecular organizat ion of biomimetic and biological membranes. (mpg.de)
Understanding the physical and molecular cues that initiate the formation and function of branching structures and resolve the underlying mechanisms of growth and transport in branched tissues will benefit relevant industries including those involved in fermentation, biofuel production, and health care. (springer.com)
My research goal is to understand how structural and functional alterations at the molecular and single fiber levels affect whole skeletal muscle contraction and whole body function, primarily to find potential countermeasures to the loss of skeletal muscle performance under a variety of conditions, including aging, obesity, fatigue and illness (influenza). (umass.edu)
An important aspect of my research is the ability to measure the fundamental molecular determinants of contractile function, such as myosin-actin cross-bridge kinetics. (umass.edu)
By identifying the specific molecular mechanisms that lead to alterations in whole muscle function, my findings will impact clinical care by providing novel information about the treatment of conditions that reduce skeletal muscle performance. (umass.edu)
CRGs had important potential molecular functions and prognostic significance in gynecological cancers, especially in UCEC. (bvsalud.org)
This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)
You will gain knowledge and understanding of how plants function at different levels of organisation, from the molecular to the eco-physiological level. (lu.se)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
The model was investigated experimentally in two setups. (spie.org)

Using both C. elegans and mammalian models, we have significant progress in understanding the signal transduction mechanism as well its biological roles. (umassmed.edu)
Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)

The progress in the study of neuroscience makes it possible to study the cognitive function of the neuro-physiological roots - and also, create models that can simulate animal and human abilities to think, plan and solve problems by using computers. (lu.se)

The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
R 0 is affected by numerous biological, sociobehavioral, and environmental factors that govern pathogen transmission and, therefore, is usually estimated with various types of complex mathematical models, which make R 0 easily misrepresented, misinterpreted, and misapplied. (cdc.gov)
Although R 0 is a biological reality, this value is usually estimated with complex mathematical models developed using various sets of assumptions. (cdc.gov)

In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
NHGRI considered this problem in part through a workshop entitled "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease" as part of its strategic planning efforts . (nih.gov)

Indeed, the research did show that the SSRI fluoxetine as well as a glycine-tryptophan supplement improved cognitive function in SARS-CoV-2-infected rodent models, which were used in a portion of the study. (medscape.com)

The three-dimensional architectures of biological macromolecules determine their biological function. (ornl.gov)

August 19, 2020 - Notice of Pre-Application Webinars for the Impact of Genomic Variation on Function (IGVF) Consortium FOAs. (nih.gov)
Journal of Gerontology, Biological Sciences, 2020. (umass.edu)

Although much has been known about the TGF-β signaling pathway since the discovery of Smads 15 years ago, remarkable progress has been made in revealing details of different regulatory mechanisms that afford a full range of control of the biological functions of these factors in the TGF-β family. (biomedcentral.com)
The scale, resolution and richness of biological information presented here facilitate exploration of gene-specific and systems-level mechanisms of lineage differentiation in Metazoans. (nih.gov)
Our laboratory is interested in the neurobiological and genetic mechanisms of social behavior development, as well as biological mechanisms underlying social motivation, social learning, and social skill acquisition and generalization. (upenn.edu)
While supported by empirical evidence from multiple clinical trials, the cognitive mechanisms behind the effectiveness of MBCT are not well understood in computational (information processing) or biological terms. (frontiersin.org)
This article offers a novel perspective on potential mechanisms of MBCT that derive from computationally inspired theories of brain function. (frontiersin.org)
This analysis discriminates between different biological mechanisms to achieve a transient signal from a sustained TGF-b input, where one mechanism is to use a negative feedback to turn the signal off. (lu.se)
David F. Putrino, PhD, who runs the long COVID clinic at Mount Sinai Health System in New York City, said the research is helping "to paint a biological picture" that's in line with other research on the mechanisms that cause long COVID symptoms. (medscape.com)
Understanding these mechanisms is important for manipulating ChAT's function and its involvement in various diseases such as Alzheimer's disease, schizophrenia, and congenital myasthenic syndromes (CMF). (lu.se)
An understanding of the mechanisms that underlie these features is of fundamental importance for all biological disciplines. (lu.se)

To that end, we develop computational methods in statistics, probabilistic modeling, and bioinformatics, and work in a close collaboration with experimental labs to design and perform high-throughput experiments. (tau.ac.il)
This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. (cdc.gov)

We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. (imperial.ac.uk)
it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity. (imperial.ac.uk)
BECC researchers study how direct and indirect human impacts on the climate and ecosystems influence biodiversity and ecosystem functioning from local to global scales, and how knowledge about these dynamics may inform mitigation and adaptation decisions in the face of such changes. (lu.se)

Classical ethology, together with recent developments in Behavioral Biology, can supply a broad biological basis for relationship research, however, the ethologically oriented attitudes concerning systems theory, description, classification, theorizing and integration of knowledge are probably the most important contribution of classical ethology to relationship research. (bvsalud.org)

Each method specifically integrates a subset of omics data using approaches such as conceptual integration, statistical integration, model-based integration, networks, and pathway data integration. (rsc.org)
Through a clever multi-omics design, the authors were able to use three major types of integrated analyses to identify differences in encoded and expressed microbial functions that were involved in the BPA-degrading microbial community. (rsc.org)
We have strong interests in incorporating omics information into our modeling, in using supercomputing in our research, and in using simulation to interpret neutron scattering experiments. (ornl.gov)

The DACC will serve as the coordinating center for the Impact of Genomic Variation on Function (IGVF) Consortium and will be responsible for establishing a resource of consortium generated data, metadata, analyses, methods, and tools, and coordination of consortium activities. (nih.gov)
It provides an ensemble of high quality solutions, which are analyzed with clustering methods and display a hierarchical structure highlighting distinct parameter subspaces with biological interpretations. (lu.se)
In unsupervised methods, providing explanatory insights into addition, we predict the response of the system when varying the data and related biological interpretations. (lu.se)
We test the olf413 loss of function mutants for food preference between two fruit extracts using CAFE and horizontal box methods. (who.int)

Yet, for these models to be useful and trustworthy in performing the necessary extrapolations (spe- cies, doses, exposure scenarios), they must be thoughtfully constructed in accordance with known biology and pharmacokinetics, doc- umented in a form that is transparent to risk assessors, and shown to be robust using diverse and appropriate data. (cdc.gov)

Using the structures and functions of living organisms as models for the design and engineering of materials and machines. (imperial.ac.uk)
They discuss current approaches - both experimental and computational - that use big data to identify genetic interactions both in humans and model organisms [ 1 ]. (degruyter.com)

In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. (plos.org)
Simulations of cardiac electrical activation and mechanical pump function in hearts with shapes described by different combinations of shape components were performed. (plos.org)
This highlights the need to have high fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a large impact on cardiac function. (plos.org)

Incidence of respiratory symptoms and chronic disease in a non-smoking population as a function of long-term cumulative exposure to ambient air pollutants (Adventist health study of smog follow-up study). (cdc.gov)
1997. Lung function and long term exposure to air pollutants in Switzerland. (cdc.gov)
Documentation of the threshold limit values and biological exposure indices. (cdc.gov)
1994. Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)
Three statistical learning models were developed to predict noiseinduced hearing loss (NIHL) from an archive of animal noise exposure data, which contains 936 chinchillas exposed to various noise environments. (cdc.gov)
In addition to frequency-specific energy metrics, noise exposure parameters and biological metrics such as kurtosis, noise type, and pre/ postexposure hearing thresholds were used as inputs to the model. (cdc.gov)
This model also allows for incorporation of exposure information as an independent variable, which will be important for risk variants associated with specific exposures. (cdc.gov)

Further absolute shrinkage and selection operator (LASSO) and multivariable COX regression yielded an autophagy genetic risk model consisting of eight genes. (hindawi.com)
Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
We obtained DEG (differentially expressed genes) between the two clusters, and constructed a risk model of RNA modification-related genes using DEGs. (bvsalud.org)
The differentially expressed genes between the two clusters were obtained, and these genes were used for modeling. (bvsalud.org)

We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
The second, on biological information and genetic theory, was edited by John C. Sanford, Courtesy Professor in the Department of Horticulture at Cornell, and notoriously the primary inventor of the gene gun. (evolutionnews.org)
Both self-organizational theorists and intelligent design (ID) theorists believe that natural selection operating on random genetic mutation is an insufficient basis on which to explain the origins of biological complexity and irrelevant to the origin of life. (evolutionnews.org)
DNA carries the genetic code of life, with different conformations associated with different biological functions. (lu.se)
We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. (cdc.gov)
The present model provided an opportunity to estimate the relative change in risk associated with multiple genetic variants. (cdc.gov)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

He has extensive experience in developing and interpreting output of ocean and climate models, but also specialises in developing and using ecosystem models, particularly those that describe aspects of the Southern Ocean marine ecosystem. (edu.au)
Species abundances directly affect the functioning of an ecosystem and its conservation value. (imperial.ac.uk)

Measurements of signal propagation in more than 23,000 pairs of neurons from nematode worms show that predictions of neural function made on the basis of anatomy are often incorrect, in part owing to the effects of extrasynaptic signalling. (nature.com)
The National Institutes of Health will fund six projects to identify biological factors that affect neural regeneration in the retina. (nih.gov)
AmphiBot's elegant motion in the water has come from the equivalent what are called central pattern generators (CPGs), which are sequences of neural circuits (the biological kind) that generate the sort of rhythms that you see in eel-like animals that rely on oscillations to move. (ieee.org)

Our study revealed the prognostic value of PRGs in PAAD and created a reliable model for predicting the prognosis of PAAD patients. (hindawi.com)
The motivation is to move away from specifically predicting structures, and move toward [finding] how amino acid sequences relate to function. (sciencedaily.com)
Rather than predicting structure directly -- as traditional models attempt -- the researchers encoded predicted protein structural information directly into representations. (sciencedaily.com)

The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. (aaai.org)
Collectively, these data highlight a biological role for SMRT in mediating DNA damage responses and suggest a model where p53 binding to the DAD limits HDAC3 interaction with this coregulator, thereby facilitating SMRT coactivation of p53-dependent gene expression. (nih.gov)
Input data were grouped into three primary meta-analytic classes: gray matter atrophy, increased function, and decreased function in patients with major depression relative to healthy control subjects. (psychiatryonline.org)
We applied a hierarchical model to camera- and live-trapping data from a region in Borneo, and estimated the relative abundance (controlling for imperfect detection) of 57 terrestrial mammal species, as a function of either categorical or continuous metrics of land-use change. (imperial.ac.uk)
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Genomic Variation and Function Data and Administrative Coordinating Center (DACC). (nih.gov)
You can: 1) explicitly model heterogeneous variance in each level of the categorical moderator or 2) simply do a subset analysis to model each level of a categorical moderator seperately (i.e, seperate models) and then apply the folded normal to the overall mean estimate of the model with the subsetted data in each group / level. (ethz.ch)
This current special issue aims to provide a forum for researchers to present the latest advances and state-of-the-art techniques, tools and applications in biological big data analysis. (degruyter.com)
Detecting sources of bias in transcriptomic data is essential to determine signals of biological significance. (degruyter.com)
However, analyzing such big data and deriving biological knowledge, applying it for predictions and further experimentation is becoming a challenging task. (degruyter.com)
Researchers can then use those representations as inputs that help machine-learning models predict the functions of individual amino acid segments -- without ever again needing any data on the protein's structure. (sciencedaily.com)
The model successfully describes the kinetics of experimental data and also correctly predicts the behavior in experiments where the system is perturbed. (lu.se)
A novel method in this context, simulated tempering, is used to fit the model parameters to the data. (lu.se)
2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
We compare the models meters where only a few (if any) have values that represent both to existing data (9,10) and to novel measurements first reliable estimates from experiments. (lu.se)
Our detailed model-building strategy and robust statistical validation protocols tackle the formidable challenge of working on small datasets, which is often the case in biological and medical data. (lu.se)
PBPK models are effective tools for integrating diverse dose-response and mechanistic data in order to more accurately predict human risk. (cdc.gov)
Based on the behavior of the data, a mathematical assessment is the assumption that the toxic effects in a par- model is selected which possesses a sufficient number of ticular tissue can be related in some way to the concentra- compartments (and therefore parameters) to describe the tion time course of an active form of the substance in that data. (cdc.gov)
The advantage of this modeling approach is that there is no limitation to fitting the model to the experimen- * tal data. (cdc.gov)
Since the model parameters do not possess any intrinsic meaning, they can be freely varied to obtain the best possible fit, and different parameter values can be used for each data set in a related series of experiments. (cdc.gov)

Humans have immense linguistic and cognitive capabilities: we acquire tens of thousands of words effortlessly, combine them in multiple ways to form novel constructions and use them for a broad range of communicative functions. (fu-berlin.de)
These results demonstrate the feasibility of developing such models for the prediction of NIHL in humans. (cdc.gov)

By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)

There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
The biological function of this gene is yet to be unravelled. (who.int)
Here we propose this gene function in taste recognition, food preference and feeding activity. (who.int)
Thus implying that olf413 gene function is required for taste recognition, starvation driven initiation and execution of feeding behaviour of the flies. (who.int)

Several bioinformatic approaches were used to analyze the biological functions of DEPRGs and to identify prognostic DERPGs. (hindawi.com)
Examples are provided to illustrate approaches for selecting a ``preferred'' model from multiple alternatives. (cdc.gov)

The systems tend to have many para- about its dynamics and function. (lu.se)

The consistent thread through Stuart's career has been using computational models to describe a physical system and then use that knowledge to understand the impacts of that change on social, biological and ecological systems. (edu.au)
If a particular model is unable to describe the Corresponding author. (cdc.gov)

Once developed, these models are useful for interpola- tion and limited extrapolation of the concentration profiles which can be expected as experimental conditions are var- ied. (cdc.gov)

These concepts regard the brain as embodying a model of its environment (including the external world and the body) which predicts future sensory inputs and is updated by prediction errors, depending on how precise these error signals are. (frontiersin.org)
The interpretation of R 0 estimates derived from different models requires an understanding of the models' structures, inputs, and interactions. (cdc.gov)

Cardiac anatomy plays a crucial role in determining cardiac function. (plos.org)

We have deployed a host of machine learning algorithms, including the popular state-of-the-art LightGBM (a gradient boosting model), for building prediction models. (lu.se)

Here, we tackle this challenge by combining crowdsourcing and phylogenetic modelling to approximate actual rates of a rarely obs. (researchgate.net)
R 0 is rarely measured directly, and modeled R 0 values are dependent on model structures and assumptions. (cdc.gov)

Stuart's research expertise is focused computational modelling. (edu.au)
His research interests include climate change, climate modelling and understanding how our changing climate impacts on ecological and social systems. (edu.au)
My main focus is on translational research, or applying basic research findings to improve human health, and I use both human and model systems in this work. (umass.edu)
The investigation of ontogeny, evolution, function and causation is still important for re- lationship research. (bvsalud.org)

This process improves access to microfluidics for controlling biological microenvironments, and further enabling visual and quantitative analysis of fungal cultures. (springer.com)
To reduce the uncertainty inherent in such extrapolations, there has been considerable interest in the development of physiologically based pharmacokinetic (PBPK) models of toxic chemicals for application in quantitative risk assessments. (cdc.gov)

Hydrogen sulfide is produced in small amounts by some cells of the mammalian body and has a number of biological signaling functions. (wikipedia.org)

3. Analyze the behavior of the model for extracted param- too large for modeling, since there are a sufficient number of eter values. (lu.se)

Simultaneously, the model predicts a "contact map" for each embedding, which basically says how far away each amino acid is from all the others in the protein's predicted 3-D structure -- essentially, do they make contact or not? (sciencedaily.com)
Our model predicts that multiple disease variants broaden the risk distribution, facilitating the identification of susceptible populations. (cdc.gov)

Researchers recently reported a technique that increases the regenerative capacity of retinal axons in a mouse model of optic nerve injury, a model commonly used to study glaucoma and other optic neuropathies. (nih.gov)
Researchers are beginning to use machine-learning models to predict protein structures based on their amino acid sequences, which could enable the discovery of new protein structures. (sciencedaily.com)
In the future, the model could be used for improved protein engineering, by giving researchers a chance to better zero in on and modify specific amino acid segments. (sciencedaily.com)
The model might even steer researchers away from protein structure prediction altogether. (sciencedaily.com)
The researchers then fed their model random pairs of protein structures and their amino acid sequences, which were converted into numerical representations called embeddings by an encoder. (sciencedaily.com)
Biological researchers had pretty much decided that CPGs explained the extent of wiggly animal motion, until it was discovered you can chop an eel's spinal cord in half, and it'll somehow maintain its coordinated undulatory swimming performance. (ieee.org)

This pre-packaging approach provides a simple, one step process to initiate microfluidics in any setting for fungal studies, bacteria-fungal interactions, and other biological inquiries. (springer.com)

Therefore, we aimed to explore the prognostic value of HS6ST2 in 33 cancer types and investigate its potential immune function. (bvsalud.org)
Our study reveals that HS6ST2 can function as a prognostic marker in various malignant tumors because of its role in tumorigenesis and tumor immunity. (bvsalud.org)

Membranes play a cent ral role for the structure and function of all cells. (mpg.de)

This allowed us to show that some shape components that explain a large amount of electrical and mechanical function variance only explain a small amount of anatomical variance. (plos.org)
The obtained results confirmed that the proposed model can explain most of the observed variance during image derived biomass estimation [ 7 ]. (degruyter.com)

Two of the experiments are used to fit the model parameters sets, where these sets subsequently are clustered with and the other two are left as ``blind test'' experiments. (lu.se)
This paper describes the process of PBPK model development and highlights issues related to the specification of model structure and parameters, model eval- uation, and consideration of uncertainty. (cdc.gov)

An interactive introduction to the structures and functions of each body system. (visiblebody.com)

Decline curve analysis (DCA) shows that the risk model combined with other indicators produces better clinical efficacy. (hindawi.com)
It is used to simulate the Monte Carlo method, ST naturally provides ensembles of kinetics of large signaling networks, where one cannot only solutions rather than single ones, subject to analysis by rely on biological intuition. (lu.se)

ID theorists also believe that the self-organizational capacities of physical systems are limited, falling far short of the order we observe, so the ultimate source of information for the origin of life and hierarchically integrated morphogenesis in both organismal development and speciation must be extrinsic to biological systems and their physical environments. (evolutionnews.org)

Anatomy1

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Information Science1

Phenotypic2

Processes9

Phenotypes5

Proteins5

Predictive4

Biophysical1

Metabolism2

Paradigms3

Cellular4

Molecular8

Experimentally2

Signal transduction2

Physiological1

Mathematical models3

Phenotype2

Cognitive function1

Macromolecules1

20202

Mechanisms9

Probabilistic2

Biodiversity3

Behavioral1

Omics3

Methods4

Biology1

Organisms2

Simulations3

Exposure7

Genes4

Genetic7

Ecosystem2

Neural3

Predicting3

Data19

Humans2

Datasets1

Gene4

Approaches2

Dynamics1

Describe2

Experimental1

Inputs2

Plays a crucial role1

Algorithms1

Rarely2

Research4

Quantitative2

Mammalian1

Analyze1

Predicts2

Researchers6

Interactions1

Prognostic2

Cells1

Variance2

Parameters2

Structures and functions1

Analysis2

Systems1