Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
The plasma membrane is made up of two layers of phospholipids with many proteins embedded in it. (helpwriteanessay.com)
The activity and function of GBA is regulated by several accessory proteins including lysosomal integral membrane protein 2 (LIMP2) and progranulin (PGRN). (biomedcentral.com)
The resistance mechanism involved complexation of cadmium in polyphosphate granules, changes in the structure of the cell membrane and induction of three cysteine-rich, low molecular weightproteins (3500-7000) containing 4 to 7 g-atoms per mole of cadmium, zinc, and copper. (nih.gov)
Transfer of the genetic information encoded in DNA to cells where it expresses identified individual proteins, has permitted investigation of the function of such proteins on a cellular level, and of the underlying cell physiology. (justia.com)
e.Compare and contrast the sorting of proteins to lysosomes to the packaging of proteins into regulated secretory granules such as those containing insulin. (wizedu.com)
The AP-1B clathrin adaptor complex plays a key role in the recognition and intracellular transport of many membrane proteins destined for the basolateral surface of epithelial cells. (rupress.org)
Expression of a constitutively activated GTP hydrolysis mutant selectively inhibited basolateral (but not apical) transport of newly synthesized membrane proteins. (rupress.org)
To a large extent, plasma membrane proteins are delivered to and maintained at the appropriate cell surface domain by distinct targeting signals that control polarized transport on the secretory and endocytic pathways ( Mellman, 1996 ). (rupress.org)
The proteins and lipids allow cell communication, and carbohydrates (sugars and sugar chains), which decorate both the proteins and lipids and help cells recognize each other. (microbenotes.com)
The lipids and glycoproteins also help in the transportation of substances into the cell and out of the cell. (jotscroll.com)
Cytoplasm6
In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
Animal cell as eukaryotic cells has membrane-bound organelles in the cytoplasm which is enveloped by a plasma membrane, unlike the prokaryotic cells . (jotscroll.com)
This is a spherical structured organelle found majorly at the center of a cell surrounded by a double-layered nuclear membrane separating it from the cytoplasm. (microbenotes.com)
Protein11
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. (wikipedia.org)
Online Mendelian Inheritance in Man (OMIM): Lysosome-associated membrane protein 2 - 309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)
ER functions in protein modification and lipid synthesis. (thesciencenotes.com)
Niemann-Pick C1 protein (NPC1) is a membrane protein that primarily resides in late endosomes and lysosomes, and plays an important role in cholesterol homeostasis in the cell. (bvsalud.org)
CLN7/MFSD8 gene encodes a lysosomal membrane glycoprotein, but the biochemical processes affected by CLN7-loss of function are unexplored thus preventing development of potential treatments. (nature.com)
As noted earlier, animal cells are eukaryotic cells with a membrane-bound nucleus. (microbenotes.com)
Nucleus9
The nucleus is enclosed by a nuclear envelope which consists of the outer and inner membrane and is permeable to ions, molecules and RNA materials. (thesciencenotes.com)
Cis face is a forming face that faces the plasma membrane whereas Trans face is a maturing face that faces the nucleus. (thesciencenotes.com)
Prokaryotic cells - These have no central nucleus, rather, genetic information is located within the nucleoid, no membrane-bound organelles, the cell is simple and much smaller than a eukaryotic cell. (helpwriteanessay.com)
Prokaryotic cells include archaea and bacteria and lack a central nucleus and other membrane-bound organelles. (helpwriteanessay.com)
and transport to and through the nuclear membrane into the nucleus of the cell where transcription of the genetic material can take place. (justia.com)
The animal cell has a membrane-bound nucleus which possesses the presence of DNA in the nucleus. (jotscroll.com)
Brown's observations of orchid cells led to the identification and description of the cell nucleus, a pivotal component of cellular function and organization. (microbiologynote.com)
Endoplasmic3
Endoplasmic reticulum is a network of tubes and membranes that carry material through the cell. (thesciencenotes.com)
The defective enzyme leads to lipid product accumulation, resulting in dysfunction of cellular organelles with a common storage place being the lysosome. (medscape.com)
The cellular parts and membrane-bound organelles of an animal cell carry out specific functions needed for the cell to work properly. (jotscroll.com)
They also have several structural organelles within the plasma membrane which perform various specific functions for proper cell function and generally to maintain the body normal mechanisms. (microbenotes.com)
The animal cell is made up of several structural organelles enclosed in the plasma membrane, that enable it to function properly, eliciting mechanisms that benefit the host (animal). (microbenotes.com)
Within this vast array of cells, each possesses specialized organelles that execute distinct functions vital for the organism's survival. (microbiologynote.com)
Endosome2
The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components. (justia.com)
Rab8-GFP was localized to membranes in the TGN-recycling endosome, together with AP-1B complexes and the closely related but ubiquitously expressed AP-1A complex. (rupress.org)
Permeable1
Making the membrane even less permeable to water-soluble ions and molecules. (jotscroll.com)
The comprehensive characterization of surface glycoproteins remains a great challenge and is often underrepresented in proteomics. (bvsalud.org)
Surface glycoproteins are captured by chemical oxidation of glycans or click chemistry for carbohydrate metabolic labeling. (bvsalud.org)
These techniques offer a wide range of applications for studying the function of cell surface receptors and identifying markers for diagnostic and therapeutic development. (bvsalud.org)
Why are carbohydrate groups of glycoproteins always exposed on the surface of the cell? (wizedu.com)
iii) descrivere una serie di nuovi meccanismi simil-autofagici che permettono alle cellule di riprendersi da stress (recovER-phagy) e di eliminare aggregati proteici tossici (ER-to-lysosomes-associated degradation) che sono un tratto distintivo di molte malattie rare provocate dall'accumulo di prodotti genici difettosi. (usi.ch)
Molecules5
Plasma membrane or cell membrane or cytoplasmic membrane helps in the exchange of molecules in and out of the cell. (thesciencenotes.com)
The role of the plasma membrane is to regulate entry and exit of molecules through osmosis, and diffusion among other transport processes. (helpwriteanessay.com)
It creates an image as a result of a phospholipid bilayer, 2 layers of phospholipid molecules, which are all oriented with their water-soluble (hydrophilic) ends toward the outside and their fat-soluble portions(hydrophobic) toward the inside of the membrane. (jotscroll.com)
This feature gives the membrane flexibility and allows the phospholipid molecules to move freely sideways within their own monolayer. (jotscroll.com)
To also regulate the molecules that pass into and out of the cell, through the plasma membrane. (microbenotes.com)
Hydrophobic1
The cell membrane is described as being amphipathic because it contains hydrophilic heads as well as the hydrophobic tails. (helpwriteanessay.com)
Components2
This article describes the components of the human cell, detailing their structure and function. (researchgate.net)
Because glycosphingolipids are essential components of all cell membranes, inability to degrade these substances and their subsequent accumulation results in physiologic and morphologic alterations of specific tissues and organs that lead to characteristic clinical manifestations. (medscape.com)
Gene1
The highest expression level of the zp1 gene was found in the liver, followed by the tibia and yolk membrane, while no expression was detected in the heart and eggshell gland. (bvsalud.org)
Degrade1
Some of this is done via acid hydrolases that degrade foreign materials and have specialized autolytic functions. (wikipedia.org)
Processes1
This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
Plasma6
They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
In animal cell, the plasma membrane functions as the outermost covering that separates the cell from the outside environment. (thesciencenotes.com)
The fluid-mosaic model is the recent concept accepted describing the plasma membrane structure . (jotscroll.com)
A plasma membrane appears as two dark lines by electronic microscopy. (jotscroll.com)
An animal cell is a eukaryotic cell that lacks a cell wall, and it is enclosed by the plasma membrane. (microbenotes.com)
In conclusion, idiopathic PD fibroblasts have decreased GCase activity primarily driven by altered LIMP2-mediated transport of GBA to lysosome and the reduced GCase activity exhibited by the genetic GBA N370S derived PD fibroblasts occurs through a different mechanism. (biomedcentral.com)
Structure4
The structure is similar to other reported structures of NPC1-C, with differences observed in the protruding loops when compared with NPC1-C in complex with Ebola virus glycoprotein or NPC2. (bvsalud.org)
Recognized as the cornerstone of life, cells play a pivotal role in the biological framework, providing both structure and function to every living being. (microbiologynote.com)
This theory posits three fundamental tenets: all living organisms are composed of cells, the cell is the primary unit of structure and function in these organisms, and all cells originate from pre-existing cells. (microbiologynote.com)
The exploration of cells has not only expanded our understanding of their structure and function but has also catalyzed advancements in related biological domains such as DNA discovery, cancer systems biology, aging, and developmental biology. (microbiologynote.com)
Pathophysiology1
Therefore, it is essential that nurses have knowledge of how cells function to understand normal physiology and pathophysiology, and how specific conditions are inherited. (researchgate.net)
Cells3
Most cells are covered by a protective membrane known as the cell wall which gives the cells their shape and rigidity. (microbenotes.com)
Generally, the combined effort by all animal cells is what enables the normal functioning of the body. (microbenotes.com)
Cells are incredibly diverse in their morphology and function. (microbiologynote.com)