• Under the second alternative, veterans who began receiving the IU supplement after December 2023 would no longer receive those payments once they reached age 67, and no new applicants age 67 or older would be eligible for IU benefits after that date. (cbo.gov)
  • Register now or submit an abstract and join the IFA in Bangkok, Thailand from the 27th - 30th June 2023 to learn, connect and continue to drive the age-friendly movement forward across the globe. (who.int)
  • Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). (neurology.org)
  • Recently we have demonstrated that aging information is encoded within biophysical properties of cells, and as such can be used as biomarkers of aging in health and disease. (aiche.org)
  • Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
  • Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • And at the Buck, Newman and Stubbs will be evaluating the use of biomarkers that are often available in clinical labs ― insulin, C-reactive protein, cystatin, and natriuretic peptide tests ― for use as outcome measures that are responsive to treatment interventions and that can be used to track outcomes in future research on aging. (medscape.com)
  • To investigate further, the WTCHP convened a scientific workshop that examined the natural history of cognitive aging and impairment, biomarkers in the pathway of neurodegenerative diseases, the neuropathological changes associated with hazardous exposures, and the evidence of cognitive decline and impairment in the 9/11-exposed population. (cdc.gov)
  • In contrast, a 2001 joint report by the U.S. National Institute on Aging and the World Health Organization [WHO] Regional Office for Africa set the beginning of old age in Sub-Saharan Africa at 50. (wikipedia.org)
  • White matter is critical for normal brain function, and little is known about how white matter develops in humans or how it is related to growth of cognitive skills in early childhood, including language development. (sciencedaily.com)
  • When the mice were examined at 22 to 26 months of age (equivalent to approximately 80 years old in humans), the liver cells of transgenic mice digested and recycled protein far more efficiently than in their normal counterparts of the same age - and, in fact, just as efficiently as in normal six-month old mice. (scienceblog.com)
  • The accumulation of CD28(-) T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. (nih.gov)
  • As humans age, cells within organs and tissues undergo profound biophysical and biomolecular changes, which significantly influence the rate of progressive functional decline. (aiche.org)
  • To keep the level of the receptor constant throughout life, Dr. Cuervo waited until mice were six months old (the age that the chaperone system's efficiency begins to decline) before turning on the added receptor gene. (scienceblog.com)
  • Since a key function of the liver is metabolizing chemicals, Dr. Cuervo answered this question by injecting a muscle relaxant into very old transgenic mice and very old normal mice. (scienceblog.com)
  • An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. (nih.gov)
  • For example, giving old mice factors found in young blood can enhance the birth of new neurons, which typically slows with age. (simonsfoundation.org)
  • Harvard stem cell researchers say protein can make those body parts function in old mice much as they did when younger. (neurosciencenews.com)
  • Researchers at the Harvard Stem Cell Institute (HSCI) have shown that a protein, which they previously demonstrated can make failing hearts in aging mice appear more like those of young and healthy mice, similarly improves brain and skeletal muscle function in aging mice. (neurosciencenews.com)
  • Second, they injected the older mice with GDF11, which in an earlier study by Wagers and Richard Lee of Brigham and Women's Hospital was shown to be sufficient to reverse characteristics of aging in the heart. (neurosciencenews.com)
  • Injections of the protein GDF11 improved exercise capability and function of the olfactory region in the brain of older mice. (neurosciencenews.com)
  • As Melton mentioned, GDF11 is naturally found in much higher concentrations in younger mice than in older ones, and raising its level in older mice has improved function of every organ system studied so far. (neurosciencenews.com)
  • Last year, she and Lee published a paper in which they reported that, when exposed to the blood of young mice, the enlarged, weakened hearts of older mice returned to a more youthful size, and their function improved. (neurosciencenews.com)
  • A study in mice finds that white matter - the tissue that transmits messages around the brain - shows the greatest changes as the animals age. (stanford.edu)
  • In a Stanford study, sedentary mice appear to benefit from another same-aged mouse's exercise - if they receive injections of its blood. (stanford.edu)
  • Klotho mutant mice designated as a preclinical model of aging. (mugen-noe.org)
  • the Void and bladder contraction test klotho mutant mice revealed that, similar to other aging models, has risen to cancel the frequency and decreased urinary volume per micturition event. (mugen-noe.org)
  • These data suggest that bladder klotho mutant mice have impaired bladder function. (mugen-noe.org)
  • METHODS: Item response theory (IRT) analyses of DIF were conducted comparing data from the 5-7 age group with data from the established scales for ages 8-17 across 5 generic health domains (physical functioning, pain, fatigue, emotional health, and social health) and asthma. (rand.org)
  • We aimed to obtain the mean values for physical function tests in healthy community-dwelling people aged 50-79 years and to compare these values between age decades. (galileo-training.com)
  • Grip strength (GS), isometric knee extension torque (IKET), and the times for performing the sit-to-stand test (STS) and timed up-and-go test (TUG) were used as indicators of physical function. (galileo-training.com)
  • The target values for physical function tests in people aged 50-79 years were established, and they were found to change with age. (galileo-training.com)
  • Associations between physical activity (PA), physical performance and psycho-cognitive functioning have been understudied in aged care residents. (monash.edu)
  • This study investigated associations between PA, and both physical performance and psycho-cognitive functioning in older adults living in RACFs. (monash.edu)
  • This suggests that physical activity programs targeting balance and dual-task ability could help prevent falls in aged care residents. (monash.edu)
  • Many physical age-related changes, such as prostate enlargement or testicular atrophy, are not preventable. (medlineplus.gov)
  • An interaction among muscle function, physical demand, and cardiovascular stress has been observed, meaning that physical fitness is important but does not explain away the effect of working conditions. (cdc.gov)
  • Age-related decreases in physical capacity, particularly in peak performance, vary greatly. (cdc.gov)
  • In another study, participants who reported higher levels of PIL exhibited better cognitive function, and further, PIL protected those with already existing pathological conditions, thus slowing their decline. (sciencedaily.com)
  • Now, for the first time, scientists at the Albert Einstein College of Medicine of Yeshiva University have prevented this age-related decline in an entire organ - the liver - and shown that, as a result, the livers of older animals functioned as well as they did when the animals were much younger. (scienceblog.com)
  • She also detected the primary cause for this age-related decline: a fall-off in the number of lysosomal receptors capable of binding chaperones and their damaged proteins. (scienceblog.com)
  • The animal model established here should enable progress toward defining the neurobiological mechanisms that mediate the beneficial effects of estrogen on age-related cognitive decline in primates. (jneurosci.org)
  • Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function. (nih.gov)
  • We have discovered that blood contains proteins that can restore some age-related cognitive decline. (simonsfoundation.org)
  • They are used to diagnose airways obstruction, assess its severity and prognosis, delineate risk factors ( e.g . pre-operative assessment), detect early lung disease, and monitor for normal lung growth and lung function decline. (ersjournals.com)
  • The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
  • Scientists at Stanford and the Buck Institute have found a way to predict an individual's immunological decline as well as the likelihood of incurring age-associated diseases and becoming frail. (stanford.edu)
  • A smaller decline in FEV 1 after ages 22 to 32 yr occurs in asthmatics who quit smoking and who continue to use inhaled corticosteroids. (atsjournals.org)
  • Many published epidemiologic studies on age-related growth and decline of lung function have as their primary aim the natural history of FEV 1 and FVC throughout childhood and adulthood in healthy subjects ( 1-9 ). (atsjournals.org)
  • These studies generally show that a growth in FEV 1 during childhood is followed by a stable phase from adolescence through early adulthood and a decline in FEV 1 after the age of 32 yr ( 4 , 5 ). (atsjournals.org)
  • Both the obtained maximal level of FEV 1 and the rate of decline of FEV 1 determine the severity of lung function impairment at older age in symptomatic persons. (atsjournals.org)
  • Studies of risk factors for accelerated decline in FEV 1 have generally focused on the effect of smoking on lung function, and have involved subjects with chronic obstructive pulmonary disease (COPD) or subjects from the general population. (atsjournals.org)
  • Two longitudinal studies, one of middle-aged and older men with no history of asthma, the other of subjects aged 65 yr or older, found that bronchial hyperresponsiveness (BHR) and atopy were both independent predictors of decline of lung function ( 15 , 16 ). (atsjournals.org)
  • The study authors used these brain scans to investigate the microstructure of 12 white matter fiber tracts important for cognitive function, their relationship to developing cognitive function and their heritability. (sciencedaily.com)
  • The aim for this study was to investigate the association between kidney function and specific cognitive domains. (lu.se)
  • Purpose To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD). (bmj.com)
  • The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. (bmj.com)
  • To investigate the cognitive functioning of healthy elderly practitioners and non-practitioners of Yoga. (bvsalud.org)
  • The purpose of this review was to investigate the impact of aging on the ability for serial sarcomerogenesis and elucidate the molecular pathways that may limit serial sarcomerogenesis in old age. (mcmaster.ca)
  • Hormone treatment substantially reversed the marked age-related impairment vehicle-injected monkeys exhibited on a delayed response test of spatial working memory. (jneurosci.org)
  • Conclusions: Impaired kidney function as well as the severity of impaired kidney function is associated with impairment in learning and memory, language, complex attention, executive function and global cognitive function, but not meta-memory. (lu.se)
  • A workshop on cognitive aging and impairment in the 9/11-exposed population. (cdc.gov)
  • During natural aging, skeletal muscle experiences impairments in mechanical performance due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross-sectional area (CSA). (mcmaster.ca)
  • To gain insight into mechanisms associated with longevity and negligible senescence, age-related transcriptional profiles were examined in tissues of the red sea urchin. (nature.com)
  • Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)
  • Some disciplines and domains focus on the aging and the aged, such as the organic processes of aging (senescence), medical studies of the aging process (gerontology), diseases that afflict older adults (geriatrics), technology to support the aging society (gerontechnology), and leisure and sport activities adapted to older people (such as senior sport). (wikipedia.org)
  • To find out, Dr. Cuervo created a transgenic mouse model equipped with an extra gene - one that codes for the receptor that normally declines in number with increasing age. (scienceblog.com)
  • Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
  • This unique age-related gene expression profile in the red sea urchin nervous system may play a role in mitigating the detrimental effects of aging in this long-lived animal. (nature.com)
  • Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)
  • Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
  • Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)
  • Gene expression stability during aging was also observed in tissues of the long-lived giant mole-rat ( Fukomys mechowii ) with a maximum lifespan of more than 20 years 14 . (nature.com)
  • Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients. (ox.ac.uk)
  • Considering this, we hypothesized that klotho gene involved in the regulation of bladder function. (mugen-noe.org)
  • This blunted effect may be partly due to age-related impairments in the pathways regulating mechanotransduction, muscle gene expression, and protein synthesis, as some have been implicated in SSN adaptation. (mcmaster.ca)
  • Two similar experiments were carried out, the first comparing 24 young, episodic migraine patients and 28 healthy age- and gender-matched controls and the second 36 middle-aged, episodic migraine patients and 30 healthy age- and gender-matched controls. (biomedcentral.com)
  • However, the group of practitioners had an average of percentile considerably higher than the other group in immediate recall verbal episodic memory and intellectual functioning. (bvsalud.org)
  • Objectives: Insight into modifiable factors related to falls risk in older adults living in residential aged care facilities (RACFs) is necessary to tailor preventive strategies for this high-risk population. (monash.edu)
  • To our knowledge, this study is the first to measure and describe the development of white matter microstructure in children and its relationship to cognitive development from the time they are born until the age of 2 years," said John H. Gilmore, MD, senior author of the study and director of the Early Brain Development Program in the UNC Department of Psychiatry. (sciencedaily.com)
  • The most interesting finding from the study was that the common relationship between white matter tracts at birth predicted overall cognitive development at age 1 and language development at age 2, indicating that it may be possible to use brain imaging at birth to better understand how a child's cognitive development will proceed in the first years after birth. (sciencedaily.com)
  • The kidney function of 600 participants 70 years and older were measured in several blood samples with the help of small amounts of contrast agents. (charite.de)
  • Elke S. Schaeffner et al: Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older. (charite.de)
  • Mean age was 87 ± 10 years and 62% of subjects were female. (neurology.org)
  • and that from the age of 15 to 16 years, boys develop a small IQ advantage of approximately 1 IQ point, which increases in later adolescence and reaches approximately 4 IQ points in adulthood [ 3 , 4 ]. (biomedcentral.com)
  • The analysis results suggested that depressive symptoms at T2 significantly mediated the longitudinal association between the two types of discrimination and the two types of couple relationships spanning 8 years while controlling for race, age, gender, education, number of reasons for everyday discrimination and T1 assessments of couple support and couple strain. (umd.edu)
  • Here, we employ a gradient-based approach to characterize the functional heterogeneity in the organization of the LC over aging using 3T resting-state fMRI in a population-based cohort aged from 18 to 88 years of age (Cambridge Centre for Ageing and Neuroscience cohort, n=618). (elifesciences.org)
  • The red sea urchin, Mesocentrotus franciscanus , is one the earth's longest-lived animals, reported to live more than 100 years with indeterminate growth, life-long reproduction and no increase in mortality rate with age. (nature.com)
  • The naked mole rat ( Heterocephalus glaber ) is a long-lived rodent that can live more than 30 years with sustained reproduction, resistance to common age-related diseases such as cancer, and no age-related increase in mortality rate 13 . (nature.com)
  • To address this question we procured a panel of primary dermal fibroblasts from donors aged 2-92 years old, and tracked the movement of cells seeded on collagen-coated substrates for ten hours, taking images every 3 minutes. (aiche.org)
  • Plus, GenF20 has been a leader in the anti-aging supplement space for more than 20 years, so you know it's a reputable brand that you can trust. (dallasnews.com)
  • The United Nations, for example, considers old age to be 60 years or older. (wikipedia.org)
  • Dating back to the middle ages and prior, what certain scholars thought of as old age varied depending on the context, but the state of being elderly was often thought as being 60 years of age or older in many respects. (wikipedia.org)
  • Effects of lumacaftor-ivacaftor therapy on cystic fibrosis transmembrane conductance regulator function in F508del homozygous patients with cystic fibrosis aged 2-11 years. (bvsalud.org)
  • Rationale Lumacaftor/ivacaftor was approved for the treatment of patients with cystic fibrosis who are homozygous for F508del aged 2 years and older following positive results from phase three trials. (bvsalud.org)
  • However, the improvement in CFTR function associated with lumacaftor/ivacaftor has only been studied in patients over 12 years of age, while the rescue potential in younger children is unknown. (bvsalud.org)
  • A total of 13 children with CF homozygous for F508del aged 2-11 years were enrolled and 12 patients were analyzed. (bvsalud.org)
  • Lumacaftor/ivacaftor treatment reduced sweat chloride concentration by 26.8 mmol/L (p = 0.0006) and showed a mean improvement in CFTR activity, as assessed by intestinal current measurement in the rectal epithelium , of 30.5% compared to normal (p = 0.0015), exceeding previous findings of 17.7% of normal in CF patients homozygous for F508del aged 12 years and older. (bvsalud.org)
  • Lumacaftor/ivacaftor partially restores F508del CFTR function in children with CF who are homozygous for F508del, aged 2-11 years, to a level of CFTR activity seen in patients with CFTR variants with residual function. (bvsalud.org)
  • U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Centers for Disease Control National Center for Health Statistics Hyattsville, Maryland May 1990 Description This data tape contains demographic data and Behavior Questionnaire data for all examined persons 25 through 74 years of age. (cdc.gov)
  • The tape documented here contains demographic data and behavior questionnaire data from the survey for persons 25 through 74 years of age. (cdc.gov)
  • POPULATION DESCRIPTION Target Population: NHANES II was conducted on a nationwide probability sample of approximately 28,000 persons 6 months through 74 years of age from the civilian, noninstitutionalized population of the United States. (cdc.gov)
  • A Swedish construction worker 55-59 years old was more than twice as likely to have shoulder problems as a similarly aged office worker, but 25% less likely to be symptomatic when both were 25-29 years old. (cdc.gov)
  • In the Finnish studies, a clearly identifiable middle-aged subgroup declined rapidly in subsequent years, whereas a group maintaining high function through the sixth decade was also recognizable. (cdc.gov)
  • Research on the cognitive effects of hormone-replacement therapy (HRT), for example, is complicated by the difficulty of matching treatment and control groups according to chronological age, education, overall health status, and other subject characteristics that can influence neuropsychological function independent of ovarian hormone status. (jneurosci.org)
  • A recent study analyzed brain imaging data and chronological age (CA) information from twins and suggested that the brain aging process was heritable 14 . (nature.com)
  • Old age is not a definite biological stage: the chronological age denoted as "old age" varies culturally and historically. (wikipedia.org)
  • Unlike in the developed world, where chronological age determines retirement, societies in developing countries determine old age according to a person's ability to make active contributions to society. (wikipedia.org)
  • Chronological age may differ considerably from a person's functional age. (wikipedia.org)
  • In addition to chronological age, people can be considered old because of the other dimensions of old age. (wikipedia.org)
  • We think that's because their protein-clearance systems can handle abnormal proteins when the person is younger but get overwhelmed as their efficiency falls with age. (scienceblog.com)
  • Blood proteins from younger animals can also restore declining blood vessel function in older animals, improving blood flow and the delivery of key nutrients to brain cells. (simonsfoundation.org)
  • RESULTS: IRT DIF analyses revealed that the majority of the items functioned similarly with responses from parents of younger and older children. (rand.org)
  • Newman, an assistant professor at the Buck Institute and associate professor in the Division of Geriatrics at the University of California, San Francisco, said ketone bodies might have helpful applications in a variety of conditions of aging. (medscape.com)
  • The Social Function Lab at the UCSF Memory and Aging Center has a postdoctoral fellowship position open for a researcher specializing in brain imaging analyses. (ucsf.edu)
  • Multilevel analyses were used to assess sex differences in intellectual functioning in 7-10-year-old children in rural China. (biomedcentral.com)
  • In conclusion, bronchial hyperresponsiveness and a low level of lung function in childhood are independent risk factors for a low level of FEV 1 in early adulthood. (atsjournals.org)
  • Within the framework of a Berlin cohort study, scientists from Charité - Universitätsmedizin Berlin have succeeded in developing new mathematical formulas that dependently assess kidney function with age. (charite.de)
  • Methods: In this cross-sectional design, data from the general population based cohort study "Good aging in Skåne" (GÅS) was used. (lu.se)
  • Key activities during the fellowship will include analyzing fMRI (task-based and task-free), structural MRI, DTI and other data to examine the functional correlates of various social-cognitive and emotional mechanisms, as well as designing/conducting/analyzing data from task-based fMRI experiments with aging adults and patients. (ucsf.edu)
  • Moreover, effective and culturally-responsive interventions and programs are needed to decrease all types of discrimination and depression in order to improve couple relationship functioning among middled-aged and older-aged adults in the U.S. (umd.edu)
  • Researchers from the Ohio State University and the University of Connecticut will also participate in the TAKEOFF (Targeting Aging With Ketone Ester in Older Adults for Function in Frailty) trial, which seeks to recruit a total of 180 people across the three sites. (medscape.com)
  • Could replenishing lost receptors in older animals maintain the efficiency of this protein-removal system throughout an animal's lifespan and, perhaps, maintain the function of the animal's cells and organs as well? (scienceblog.com)
  • Does maintaining efficient protein clearance in liver cells of an older animal translate into better functioning for the liver as a whole? (scienceblog.com)
  • Our study showed that functions can be maintained in older animals so long as damaged proteins continue to be efficiently removed - strongly supporting the idea that protein buildup in cells plays an important role in aging itself," says Dr. Cuervo. (scienceblog.com)
  • Even more important, these results show that it's possible to correct this protein 'logjam' that occurs in our cells as we get older, thereby perhaps helping us to enjoy healthier lives well into old age. (scienceblog.com)
  • The results will make important contributions to rehabilitation knowledge, including approaches for improving swallowing function, oral health, and food intake and for improving the quality of oral care for older people. (diva-portal.org)
  • Under the first, VA would stop making IU payments to veterans age 67 or older (the full retirement age for Social Security benefits for those born after 1959). (cbo.gov)
  • veterans age 67 or older who are already receiving IU payments would no longer receive them after the effective date of the option. (cbo.gov)
  • Veterans who are currently receiving IU payments and who would reach age 67 or older after the effective date of the option would continue to collect the IU supplement. (cbo.gov)
  • There were also 234 798 older clients who received permanent care and 60 278 who received respite care in a residential aged care facility during that period. (pc.gov.au)
  • The aged care system aims to promote the wellbeing and independence of older people (and their carers), by enabling them to stay in their own homes or by assisting them in residential care. (pc.gov.au)
  • Older men are more likely to have good sex if they continue to be sexually active during middle age. (medlineplus.gov)
  • Yellow fever vaccine is recommended for people who are aged 9 months or older who are traveling to or living in areas at risk for yellow fever virus transmission in South America and Africa . (cdc.gov)
  • These invaluable opportunities are presented within the five overarching themes of digital technologies, older women, maintaining and improving function, immunisation, and age-friendly environments, which will be seen the lens of both the actions areas and enablers. (who.int)
  • Curriculum Associates, LLC, has developed a new iPad® application that provides users of the criterion-referenced BRIGANCE® Inventory of Early Development (IED II) and Online Management System (OMS) with a way to assess and report on the educational needs of students functioning below the developmental age of seven. (techlearning.com)
  • Future work should develop innovative methods for assessing and measuring allostatic load to test its possible mediation role between perceived discrimination and couple relationship functioning. (umd.edu)
  • Methods: Forty-four residents aged 85. (monash.edu)
  • Recently, researchers have successfully used machine-learning methods to derive a biomarker that is commonly referred to as predicted brain age (PBA) or brain age based on brain imaging data. (nature.com)
  • The main hypothesis of the TAKEOFF study is "that if you target these fundamental mechanisms of aging, you would be able to impact many different diseases of aging across different organ systems. (medscape.com)
  • Age and Health-Chronic diseases affecting the cardiovascular and musculoskeletal systems inevitably rise as the workforce ages. (cdc.gov)
  • Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. (neurology.org)
  • As people age, their cells become less efficient at getting rid of damaged protein - resulting in a buildup of toxic material that is especially pronounced in Alzheimer's, Parkinson's disease, and other neurodegenerative disorders. (scienceblog.com)
  • The purpose of this paper was to assess sex differences in the intellectual function of early school-aged children in rural China. (biomedcentral.com)
  • Therefore, in this paper, we aim to assess sex differences in the intellectual functioning of early school-aged children in rural China, where sons are preferred. (biomedcentral.com)
  • While this question identifies difficulty with cognitive functioning, it does not provide information as to the underlying cause of the disability (i.e., intellectual disability, mental illness, etc. (cdc.gov)
  • It has also been found to increase blood flow to areas of the brain involved in cognition and emotional regulation and increases grey matter volume and decreases ventricular size in long-term practitioners, which may slow brain aging. (sciencedaily.com)
  • The ability of kidneys to free the blood from toxins slowly decreases with increasing age. (charite.de)
  • Although it is now recognized that there are ensemble decreases in the motile capacity of cells with increasing age, it is unclear how this motile regulation becomes impaired. (aiche.org)
  • Prompted by the extent of cell-to-cell variations, we hypothesized that these age-dependent decreases in cell motility was not due to global decreases in the movement of all cells, but a re-distribution of the proportions of highly-motile and non-motile cells with increasing age. (aiche.org)
  • Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
  • Restoration of Erectile Function by Suppression of Corporal Apoptosis and Oxidative Stress with Losartan in Aged Rats with Erectile Dysfunction. (physiciansweekly.com)
  • Levels of AGEs in serum, 5,6 skin 7 or cornea 8 were found to be correlated with the onset or clinical grade of diabetic retinopathy. (rsc.org)
  • Age-related changes in mechanistic target of rapamycin (mTOR), insulin-like growth factor 1 (IGF-1), myostatin, and serum response factor signaling, muscle ring finger protein (MuRFs), and satellite cells may hinder serial sarcomerogenesis. (mcmaster.ca)
  • Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
  • Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
  • Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
  • Although the main rostro-caudal direction of this gradient was consistent across age groups, its spatial features varied with increasing age, emotional memory, and emotion regulation. (elifesciences.org)
  • Scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system's front-line soldiers. (stanford.edu)
  • The performance indicator framework provides information on equity, efficiency and effectiveness, and distinguishes the outputs and outcomes of government aged care services. (pc.gov.au)
  • Researchers will also assess a variety of secondary outcomes that cover geriatric and cognitive function - measures such as gait speed and walking endurance, cognitive tests, and quality of life. (medscape.com)
  • Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging, and whether it is associated with cognition and mood. (elifesciences.org)
  • Looking further into these findings, we plotted the trajectories of individual cells across all ages, and found that there was a high decree os cellular heterogeneity among cells, with some cells from elderly donors exhibiting highly-motile features, and vice versa. (aiche.org)
  • Touted for its potential anti-aging benefits and ability to improve cellular energy, NMN has become the focus of numerous scientific studies and the centerpiece of many anti-aging supplements. (dallasnews.com)
  • Aging changes in the male reproductive system may include changes in testicular tissue, sperm production, and erectile function. (medlineplus.gov)
  • Neurotheological studies can help understanding of how a practice such as KK can lead to more permanent effects in brain function that support spiritual fitness, according to Dr. Khalsa and Dr. Newberg. (sciencedaily.com)
  • The International Federation on Ageing's (IFA) 16th Global Conference on Ageing is an Age-Friendly Practice that is set against the backdrop of important international agendas that align and intersect with the UN Decade of Healthy Ageing. (who.int)
  • Do you plan to evaluate your age-friendly practice? (who.int)
  • There is no evidence to suggest sex differences in the general intelligence of early school-aged children in rural China. (biomedcentral.com)
  • We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs elamipretide (SS-31) and nicotinamide mononucleotide (NMN) to reverse aging-associated changes in mouse hearts. (springer.com)
  • When it comes to overall wellness and anti-aging, one compound that has garnered significant attention is Nicotinamide Mononucleotide, or NMN for short. (dallasnews.com)
  • Your mind and body have been carefully calibrated at that age to make you think you're invincible, with muscles and bones that seem to snap right back into place after the roughest of trampoline falls or snowboarding accidents. (cracked.com)
  • One of the common things that happen during aging is that tissues - such as of the heart, brain, and muscle - lose the ability to metabolize glucose effectively. (medscape.com)
  • More specifically, a loss of rostral-like connectivity, more clustered functional topography, and greater asymmetry between right and left LC gradients was associated with higher age and worse behavioral performance. (elifesciences.org)
  • The age at which workers become eligible for full retirement benefits from Social Security-known as the full retirement age (FRA)-depends on their year of birth. (cbo.gov)
  • Parliamentarians voted in favour of raising women's retirement age progressively so that it will be 65 from the beginning of 2009. (swissinfo.ch)
  • The statutory retirement age for men in Switzerland is currently 65, while women get their pension at 63. (swissinfo.ch)
  • This in turn usually implies that the person is over the retirement age, which varies according to country. (wikipedia.org)
  • These results identify a subset of protein abundance and acetylation changes in muscle, mitochondrial, and structural proteins that appear to be essential in regulating diastolic function in old hearts. (springer.com)
  • There seems to be little question that, at least in animals, GDF11 has an amazing capacity to restore aging muscle and brain function," he said. (neurosciencenews.com)
  • Interventions that promote the growth of new serial sarcomeres, such as chronic stretching and eccentric-biased resistance training, have been suggested as potential ways to mitigate age-related impairments in muscle function. (mcmaster.ca)
  • Although current research suggests it is possible to stimulate serial sarcomerogenesis in muscle in old age, the magnitude of sarcomerogenesis may be less than in young muscle. (mcmaster.ca)
  • Future research should explore the effects of age-related changes in the identified pathways on the ability to stimulate serial sarcomerogenesis, and better estimate SSN adaptations to gain a deeper understanding of the adaptability of muscle in old age. (mcmaster.ca)
  • Efficacy Tests - in vitro tests:The efficacy of the SYN(R)-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time. (platinumskincare.com)
  • Here, the goal was to determine whether factors such as age and/or disease severity may exert a modulatory influence on sensory sensitivity, cortical excitability, and habituation. (biomedcentral.com)
  • A new study led by UNC School of Medicine researchers concluded that patterns of white matter microstructure present at birth and that develop after birth predict the cognitive function of children at ages 1 and 2. (sciencedaily.com)
  • Besides creatinine, the formula applied in the current study also includes blood values from the protein cystatin C which appears to be more appropriate than creatinine for assessing kidney function, especially with age," states Dr. Elke Schaeffner, primary author of the study and physician at the Department of Nephrology and Internal Intensive Care Medicine at Charité. (charite.de)
  • CONCLUSIONS: The study confirms that most of the items in the PROMIS parent proxy-report item banks can be used with parents of children ages 5-7. (rand.org)
  • In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell -based models were investigated. (rsc.org)
  • In this study, we used MRI to visualize how the brain develops motor functions during the so-called 'golden age' of elementary school. (nii.ac.jp)
  • This study focused on follow-up assessments of early school-aged children's mental and psychomotor development. (biomedcentral.com)
  • Overall, the current study did not find evidence supporting the pathway from perceived discrimination to couple relationship functioning through allostatic load. (umd.edu)
  • But aging researchers continue debating whether this protein buildup actually contributes to the functional losses of aging or instead is merely associated with those losses. (scienceblog.com)
  • This gradual reduction in kidney function is fundamentally normal, must however, be taken seriously. (charite.de)
  • Here we conducted a controlled, prospective analysis in a nonhuman primate model to test whether surgical menopause and estrogen replacement influence the cognitive outcome of normal aging. (jneurosci.org)
  • Together, these results demonstrate that ovarian hormone status can broadly influence normal cognitive aging in monkeys, affecting capacities mediated by multiple brain regions, including the prefrontal cortex and the medial temporal lobe memory system. (jneurosci.org)
  • The significance of this demographic shift is underscored by evidence that the regulatory effects of ovarian hormones extend well beyond the neuroendocrine reproductive axis, affecting the structure and function of a variety of extrahypothalamic brain regions that are critical for normal cognition ( McEwen, 2002 ). (jneurosci.org)
  • Here we adopted a controlled, prospective design in a nonhuman primate model to test the effects of ovariectomy and estrogen replacement on normal cognitive aging. (jneurosci.org)
  • Spirometric prediction equations for the 3-95-age range are now available that include appropriate age-dependent lower limits of normal. (ersjournals.com)
  • Does work add to or interact with the physiologic changes of 'normal aging? (cdc.gov)
  • Directed by Dr. Kate Rankin , the Social Function Lab is an NIH-funded research program that studies the neural correlates of behavior, socioemotional processing and social interactions, both in patients with neurodegenerative disease and healthy aging individuals. (ucsf.edu)
  • They first became interested in disulfiram after reading about the benefits this class of drug has shown in treating type 2 diabetes in rats, coupled with the growing interest in repurposing drugs that may also improve healthy aging. (nih.gov)
  • Are Ketogenic Supplements the Key to Healthy Aging? (medscape.com)
  • Based on the analysis of average of percentiles and standard deviations of the two groups' results concerning evaluated cognitive functions, it appears that there was no significant difference between the performances of the groups. (bvsalud.org)
  • Cardiac aging: from molecular mechanisms to significance in human health and disease. (springer.com)
  • Published in the online edition of Nature Medicine, these findings suggest that therapies for boosting protein clearance might help stave off some of the declines in function that accompany old age. (scienceblog.com)
  • Furthermore, reliable information about kidney function is decisive for determining when a patient must begin dialysis (blood washing), or in deciding to be a living donor for kidney transplantation. (charite.de)
  • As a result of the population's increasing age, more and more people are affected by a reduction of kidney function. (charite.de)
  • In daily clinic life, kidney function is estimated with the help of mathematical formulas. (charite.de)
  • Impaired kidney function is associated with lower cognitive function in the elder general population. (lu.se)
  • Background: A possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. (lu.se)
  • No association was found between kidney function and meta-memory. (lu.se)
  • There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
  • While associations between individual human brain regions and environmental or genetic factors have been investigated, how brain age is associated with those factors remains unclear. (nature.com)
  • The results from the multi-group analysis suggested that several structural paths differed significantly across gender, age groups, and number of reasons for everyday discrimination, but none of the paths differed significantly based on race. (umd.edu)
  • Our results suggest that both environmental and genetic factors are associated with structural brain aging. (nature.com)
  • An overview of the Aged care services performance indicator results are presented. (pc.gov.au)
  • Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain anatomical characteristics. (nature.com)
  • The authors discuss the research on how these factors affect brain function and cognition. (sciencedaily.com)
  • This complexity presents a formidable challenge to neuroscientists studying the aging brain. (simonsfoundation.org)
  • Second, we will use RNA sequencing and high-resolution imaging to determine how factors that don't enter the brain restore blood vessel function. (simonsfoundation.org)
  • A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. (neurology.org)
  • Executive function is a set of mental skills that act as a command center in the brain. (understood.org)
  • We first trained a statistical model for obtaining relative brain age (RBA), a metric describing a subject's brain age relative to peers, based on whole-brain anatomical measurements, from training set subjects (n = 5,193). (nature.com)
  • Therefore, to understand the factors associated with brain aging becomes increasingly important. (nature.com)
  • To date, it is still unclear how smoking and alcohol consumption is associated with brain structural aging, especially when the morphology of all the brain regions is considered. (nature.com)
  • Besides lifestyle habits, genetic factors are also thought to be involved in brain aging. (nature.com)
  • Therefore, we also investigated if genetic factors are associated with brain aging in addition to smoking and alcohol consumption. (nature.com)
  • Therefore, it is important to explore if there is genetic and environmental factor interaction in association with brain aging. (nature.com)
  • Finally, we will use molecular and behavioral assays to determine how selected factors exert their effects on neural function and improve cognitive performance. (simonsfoundation.org)
  • Aging may cause cognitive and behavioral alterations. (bvsalud.org)
  • This report summarizes findings from cognitive testing of two questions on cognitive functioning intended for inclusion on the National Health Interview Survey (NHIS): an initial question on cognitive difficulties and a follow-up question on the main cause of cognitive difficulties. (cdc.gov)
  • Sixteen aged rhesus monkeys were ovariectomized, and throughout the course of subsequent neuropsychological assessment, half received a regimen of low-dose, cyclic estradiol replacement. (jneurosci.org)
  • The subjects underwent a test battery of neuropsychological tests assessing global cognitive function, learning and memory, language, complex attention, executive function, perceptual motor and meta-memory. (lu.se)