• 2001
  • Although this might introduce bias, the cohort have been found at age 53 to be representative in most respects of the national population born at a similar time and the distribution of occupational class and unemployment at ages 60-64 was similar to the 2001 England Census reference population. (bmj.com)
  • specifically, "…as persons with disability reach age 50, many show the kind of functional ages that would not be expected until age 70-75 in people without disabilities" (2001, retrieved on March 28, 2012 from http://www.jik.com/awdrtcawd.html ). (naric.com)
  • Possible hypotheses include: (1) an accelerated biological aging process, (2) wear and tear on the body over time, (3) the era of onset (i.e. rehabilitation and/or technology available at onset), (4) latent illness (i.e. metabolic changes that culminate in a variety of illnesses), and (5) environmental factors (2001, retrieved on March 28, 2012 from http://www.jik.com/awdrtcawd.html ). (naric.com)
  • diseases
  • Results The number of physical functioning difficulties increased every 10 years by 0.17 (95% CI 0.04 to 0.29) when in full-time work and by 0.46 (95% CI 0.41 to 0.50) in retirement after adjusting for age, sex, race, education, total wealth, Body Mass Index, smoking, physical activity and number of diseases. (bmj.com)
  • Wyss-Coray is the co-founder of Alkahest, a company developing plasma-based therapies to counter age-related diseases such as Alzheimer's. (b2dg.org)
  • Certain medications, including some over-the-counter antihistamines, as well as life events such as pregnancy, lactation, menopause, aging or diseases such as diabetes, will inhibit lubrication. (wikipedia.org)
  • Underactive factor H may result in increased complement activity on healthy host cells - resulting in autoimmune diseases. (wikipedia.org)
  • In fact, changes in liver function associated with aging or diseases such as cirrhosis, may lead to impaired clearance of nordazepam. (wikipedia.org)
  • Abstract
  • Executive dysfunction is not the same as dysexecutive syndrome, a term coined by Alan Baddeley to describe a common pattern of dysfunction in executive functions, such as deficiencies in planning, abstract thinking, flexibility and behavioural control. (wikipedia.org)
  • systolic
  • Our results show a continued increase in peak systolic BP with age in both men and women to the sixth decade, followed by a plateau between the sixth and seventh decades. (feedage.com)
  • lifespan
  • 10 Authors concluded that enhanced lifespan with good health and functioning during older age (after age 90) was specifically associated with not smoking, blood pressure control, weight management, and regular vigorous exercise. (chiroaccess.com)
  • disease
  • There is growing evidence that interaction of AGEs and their specific receptor, the receptor for AGEs (RAGE), stimulates oxidative stress generation and plays an important role in cardiovascular disease and diabetes complications ( 4 - 6 ). (diabetesjournals.org)
  • However, in the case of domoic acid, we use the term "disease" because it is caused by a known external factor with a defined sequence of events and course of prognosis. (mdpi.com)
  • A total of 2917 maximal (peak respiratory exchange ratio ≥1.00) treadmill cardiopulmonary exercise testing responses from apparently healthy men and women (aged 20-79 years) without cardiovascular disease were submitted to FRIEND (Fitness Registry and the Importance of Exercise: A National Database). (feedage.com)
  • Shingles in children is often painless, but people are more likely to get shingles as they age, and the disease tends to be more severe. (wikipedia.org)
  • This includes providing therapeutic treatment in circumstances where movement and function are threatened by aging, injury, disease or environmental factors. (wikipedia.org)
  • This SNP, located in CCP module 7 of factor H, has been shown to affect the interaction between factor H and heparin indicating a causal relationship between the SNP and disease. (wikipedia.org)
  • This can be attributed to extremely variable hepatic and renal metabolic functions among individuals depending upon a number of factors (including age, ethnicity, disease, and current or previous use/abuse of other drugs/medicines). (wikipedia.org)
  • Brain Function
  • Executive processes are integral to higher brain function, particularly in the areas of goal formation, planning, goal-directed action, self-monitoring, attention, response inhibition, and coordination of complex cognition and motor control for effective performance. (wikipedia.org)
  • physical
  • Job demand and control in mid-life and physical and mental functioning in early old age: do childhood factors explain these associations in a British birth cohort? (bmj.com)
  • Objectives Adverse work-related exposures have been linked with decreased physical and mental functioning in later life, however, whether childhood factors explain the associations between work exposures and functioning is unknown. (bmj.com)
  • Our aim was to investigate if job demand and control in mid-life were related to self-reported physical and mental functioning in early old age and whether childhood factors explained these associations. (bmj.com)
  • 1485 occupationally active study members had data available on job demand and control in mid-life and on physical and mental functioning assessed using the Short Form-36 questionnaire at 60-64 years. (bmj.com)
  • Results Those with higher job control in mid-life had better physical functioning than those who reported lower job control (β 0.51, 95% CI 0.02 to 1.01, p=0.04 adjusted for adult confounders). (bmj.com)
  • Using data from a nationally representative British birth cohort followed up across life to early old age, we were able to use prospectively collected data on job demand and control in mid-life and self-reported mental and physical functioning in early old age. (bmj.com)
  • Background Loss of physical functioning is an early marker of declining health in older people. (bmj.com)
  • The objective of this study was to examine the age-related trajectories of physical functioning among those in full-time work and retirement. (bmj.com)
  • Details of physical functioning were asked about at all study phases and 10 items related to mobility and activities of daily living were summed to obtain a physical functioning score (0-10). (bmj.com)
  • Parents of an aging child with developmental disabilities or severe physical disabilities have additional emotional and financial stress in ensuring that their child is cared for when they are no longer able to do so themselves. (naric.com)
  • Physical therapy (PT), also known as physiotherapy, is one of the Allied health professions that, by using mechanical force and movements [Bio-mechanics or Kinesiology], Manual therapy, exercise therapy, and electrotherapy, remediates impairments and promotes mobility and function. (wikipedia.org)
  • Methods
  • Methods Based on the Health and Retirement Study, participants who were working full-time or were in full-time retirement and 65-85 years of age during the follow-up period from 1992 to 2010 were included (n=17 844, n of observations from repeated measures in full-time work 5891 and in retirement 57 117). (bmj.com)
  • During the early eighties, Palmiter and Brinster developed and led the field of transgenesis, refining methods of germline modification and using these techniques to elucidate the activity and function of genes in a way never possible before their unique approach. (wikipedia.org)
  • 14.5
  • Of those 50.6 million individuals, 15.3 percent were ages 18 through 44, 20.8 percent were ages 45 through 64, and 14.5 percent were 65 or older (2011, retrieved on April 19, 2012 from http://www.cdc.gov/ncbddd/disabilityandhealth/data.html ). (naric.com)
  • glycation
  • OBJECTIVE Advanced glycation end products (AGEs) and their specific receptor, the receptor for AGEs (RAGE), play an important role in atherosclerosis. (diabetesjournals.org)
  • It is well established, in vivo, that early glycation products react repeatedly with the amino groups of proteins and form irreversible cross-link moieties termed advanced glycation end products (AGEs) ( 3 ). (diabetesjournals.org)
  • The principal site of glycation of human complement factor B". The Biochemical Journal. (wikipedia.org)
  • gene
  • Recently it was discovered that about 35% of individuals carry an at-risk Single Nucleotide Polymorphism in one or both copies of their factor H gene. (wikipedia.org)
  • Entrez Gene: CFB complement factor B". Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990). (wikipedia.org)
  • Molecular cloning and characterization of the gene coding for human complement protein factor B". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
  • A haematologist and oncologist by training, his research focuses on cancer therapy and gene functions related to blood cells. (wikipedia.org)
  • cofactor
  • Information available to date indicates that CCP modules 1-4 is responsible for the cofactor and decay acceleration activities of factor H, whereas self/non-self discrimination occurs predominantly through GAG binding to CCP modules 7 and/or GAG or sialic acid binding to 19-20. (wikipedia.org)
  • the heavy chain plays an inhibitory role in maintaining the enzyme inactive until it meets the complex formed by the substrate (either C3b or C4b) and a cofactor protein (Factor H, CR1, MCP or C4BP). (wikipedia.org)
  • tissue
  • Aging in eukaryotes is accompanied by widespread deterioration of the somatic tissue. (genetics.org)
  • While brain cell and tissue intrinsic factors are likely key determinants of the aging process recent studies from our lab and others document a remarkable susceptibility of the brain to circulatory factors. (b2dg.org)
  • Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. (wikipedia.org)
  • receptor
  • These beneficial effects of exogenous administration of sRAGE on the vasculature are assumed to be due to capture of circulating AGEs by acting as a decoy receptor. (diabetesjournals.org)
  • BDNF binds at least two receptors on the surface of cells that are capable of responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). (wikipedia.org)
  • years
  • The number of new cases per year ranges from 1.2-3.4 per 1,000 person-years among healthy individuals to 3.9-11.8 per 1,000 person-years among those older than 65 years of age. (wikipedia.org)
  • infections
  • Overactive factor H may result in reduced complement activity on pathogenic cells - increasing susceptibility to microbial infections. (wikipedia.org)
  • secondary
  • Many individuals develop strategies for overcoming these barriers that may become less successful as they experience more secondary conditions concomitant with the aging process. (biomedsearch.com)
  • mutations
  • It is not surprising therefore that mutations or single nucleotide polymorphisms (SNPs) in factor H often result in pathologies. (wikipedia.org)
  • older
  • The increase in lysosomal pH in older worms is not a passive consequence of aging, but instead is timed with the cessation of reproduction and correlates with the reduction in proteostasis in early adult life. (genetics.org)
  • higher quality of life - therefore older people are a major social, political and economic factor in society. (slideserve.com)
  • protease
  • Conventional protease inhibitors do not completely inactivate Factor I but they can do so if the enzyme is pre-incubated with its substrate: this supports the proposed rearrangement of the molecule upon binding to the substrate. (wikipedia.org)
  • Evaluation
  • When BEACH (Bettering the Evaluation of care and health) conducted a study which gathered information of people over the age of 18, it defined binge drinkers as those who consumed six or more standard drinks on one occasion whether that be weekly or monthly. (wikipedia.org)
  • serum
  • Multivariate analysis revealed that the ratio of AGEs to sRAGE remained an independent predictor of FMD, while serum level of AGEs alone or sRAGE alone was not associated with FMD. (diabetesjournals.org)
  • dysfunction
  • Deficits of the executive functions are observed in all populations to varying degrees, but severe executive dysfunction can have devastating effects on cognition and behaviour in both individual and social contexts. (wikipedia.org)
  • acute
  • Aim To correlate light increment sensitivity (LIS) and visual acuity (VA) with birth weight (BW), gestational age (GA) and stage of acute retinopathy of prematurity (ROP) (STG) in premature children at school age. (bmj.com)
  • lung
  • A minimally invasive radical cystectomy more commonly known as a robot-assisted radical cystectomy (RARC) may be an option for individuals depending on several factors including but not limited to: their overall health (with special attention to their lung health), body mass index (BMI), number and types of previous surgeries, along with the location and size of the bladder cancer. (wikipedia.org)
  • During this method of surgery the positioning and abdominal insufflation places extra strain on the chest wall impairing lung function and the ability to oxygenate the blood. (wikipedia.org)
  • kidney
  • However, blood urea nitrogen (BUN) and creatinine will not be raised above the normal range until 60% of total kidney function is lost. (wikipedia.org)
  • risk
  • Research that has been done on this age group had previously explored more negative aspects, such as problem and risk behaviours (i.e. drug and alcohol use). (wikipedia.org)