• With the support of the Marie Skłodowska-Curie Actions programme, the EPPIMAL project will take a closer look at key enzymes (protein catalysts) in important metabolic pathways of existing land plants. (europa.eu)
  • Compared to non-living systems, living organisms have more complex biochemical processes, which can be comprehended by studying the most important metabolic pathways and their control mechanisms. (lu.se)
  • The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
  • Most of the existing research has focused on genes for prognosis prediction, whereas pathways based on mRNAs or miRNAs have never been used to predict survival. (aging-us.com)
  • Ingenuity Pathway Analysis revealed downregulation of genes associated with oxidative phosphorylation, protein ubiquitination, and ubiquinone biosynthesis with ketosis. (oregonstate.edu)
  • Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
  • The type of biological networks that studies gene coexpression, known as Gene Coexpression Networks, consist of an undirected graph depicting genes and their coexpression relationships. (mdpi.com)
  • For triterpene saponin biosynthesis, we found the genes in MVA and non-MVA pathways were differentially expressed among three examined tissues, indicating the parallel but compartmentally separated biosynthesis pathways of IPP and DMAPP in A. mongolicus . (biomedcentral.com)
  • The pathways that are probably regulated by the identified plant phytoconstituents were analyzed using Kyoto encyclopedia of genes and genomes. (ijpsonline.com)
  • Kyoto encyclopedia of genes and genomes pathway identified eight pathways that are directly related to cognitive impairment. (ijpsonline.com)
  • Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
  • Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
  • Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
  • The differentially expressed genes (DEGs) between SQC and metformin groups were screened, and the co-expression modules of the DEGs were constructed based on the weighted correlation network analysis (WGCNA) method. (benthamscience.com)
  • Analysis of can be extremely conserved throughout advancement as are many genes working upstream and downstream in the sterol synthesis pathway (11). (bioinf.org)
  • Three human being catalytic enzymes SC4MOL NSDHL and HSD17B7 and a gene with unknown function are orthologous to a organic of candida C4-sterol demethylation genes define the "ergosome" (fibroblasts (Fig. S3C). (bioinf.org)
  • The majority of ERG genes downstream of zymosterol (ERG6 ERG2 ERG3 ERG5 and ERG4) showed little or no sequence homology with human genes (KEGG pathways (17)) HMN-214 but instead proteins with unrelated sequence performed comparable enzymatic activities. (bioinf.org)
  • The network generated for ERG25 ERG26 ERG27 ERG28 proteins (Fig. 3A S4) revealed as expected many interactions reflecting their participation in the linear ergosterol biosynthesis pathway (green circles in Fig. 3A) as well as additional interactions with genes annotated for functions in lipid synthesis and metabolism. (bioinf.org)
  • On Mouse monoclonal to eNOS the other hand and which didn't affect response to EGFR-targeting agencies interacted with just 8 and 7 non-sterol pathway genes respectively and fewer genes general (Fig. S4B). (bioinf.org)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • Over the last 15 years I have developed a research pathway in auxin biosynthesis going back to my degree and PhD work at the Technical University of Munich where I studied the nitrilase pathway in maize auxin biosynthesis and maize tryptophan synthase complex. (brookes.ac.uk)
  • Based on this work I won a fellowship from the Korean Federation of Science and Technology Societies to investigate the subcellular localisation of maize auxin biosynthesis at Dankook University in Seoul which lead to a publication that showed for the first time that both steps of the TAA/YUC pathway of auxin biosynthesis can be ER-localised. (brookes.ac.uk)
  • Among all sterol metabolizing enzymes and their corresponding substrates ERG1 ERG7 ERG11 ERG24 ERG25 ERG26 ERG27 were conserved between Saccharomyces cerevisiae and humans such that proteins with high levels of sequence homology performed comparable functions in sterol biosynthesis HMN-214 (Fig. 1 S4A S4B and Table S1). (bioinf.org)
  • Sunitinib treatment results in an increased reliance on glycolysis, increased myocardial lipid deposition and perturbed mitochondrial function, indicative of a fundamental energy crisis resulting in compromised myocardial energy metabolism and function. (nih.gov)
  • Transcriptomic analysis of liver biopsies in patients with NASH revealed that NASH progression is associated with rewiring of metabolic pathways, including upregulation of de novo lipid/cholesterol synthesis and fatty acid remodelling. (nih.gov)
  • Lim SA, Su W, Chapman NM, Chi H . Lipid metabolism in T cell signaling and function. (stjude.org)
  • Metabolic Dysfunction-Associated Liver Disease (MASLD) Steatotic liver disease is due to excessive accumulation of lipid in hepatocytes. (msdmanuals.com)
  • NEW YORK (GenomeWeb News) - A European Commission-led synthetic biology program plans to use €15.5 million ($20 million) to fund international, multi-partner projects that will use synthetic biology in a range of research areas, including genomics, biological nanoscience, metabolic engineering, and other areas. (genomeweb.com)
  • Your Favorite Gene is a dynamic web-based research tool provided by Sigma-Aldrich Corp and powered by Ingenuity Systems' Knowledge Base, a repository of biological and chemical networks that is the largest database of its kind. (wikipedia.org)
  • Biological pathways, metabolic pathways, and gene interaction networks are available. (wikipedia.org)
  • A new field of research, known as systems biology if applied to model systems or network medicine if applied to human beings, has emerged over the past decade or so, to address biological complexity in a holistic, integrated way. (ersjournals.com)
  • Gene ontology functional enrichment analysis revealed twenty eight biological processes and 10 molecular functions associated with cognitive impairment. (ijpsonline.com)
  • Enzymatic glycosylation of proteins involves a complex metabolic network and different types of glycosylation pathways that orchestrate enormous amplification of the proteome in producing diversity of proteoforms and its biological functions. (ku.dk)
  • The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. (nih.gov)
  • This FOA encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. (nih.gov)
  • It is expected that these awards will lead to new collaborations between researchers emphasizing biological function and researchers emphasizing biological structure. (nih.gov)
  • While the term metabolome was coined in 1998 and the metabolomics field was considered emerging until recently, metabolic profiles have been studied in biological fluids for centuries. (cdc.gov)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
  • These result in imbalances in the connectivity of neuronal circuitry, and also negatively impact the intracellular connectivity of neuronal proteins and protein pathways, contributing to cognitive decline associated with AD 6 . (nature.com)
  • However, little is known about the proteins in these pathways and their interactions in complex protein networks. (europa.eu)
  • Characterising protein-protein interaction networks will shed light on the evolution of plant metabolic pathways and potentially reveal overlooked proteins. (europa.eu)
  • While these three plant metabolic pathways are almost fully elucidated, little is known about (i) the organization of involved proteins in interacting networks and (ii) the evolutionary relevance of protein-protein interaction (PPI) networks for the emergence and function of metabolic pathways. (europa.eu)
  • Via interaction network mapping, significant proteins could be annotated to specific pathways of mitochondrial function (oxidative phosphorylation and TCA cycle), metabolic pathways, AD pathway and synaptic functions (long term potentiation). (aau.dk)
  • The tremendous structural diversity of glycans attached to proteins poses analytical challenges that limit exploration of specific functions of glycosylation. (ku.dk)
  • For this we used the yeast sterol pathway proteins as seeds to mine data from large-scale yeast genetic arrays (18) affinity purification and mass spectroscopy resolution of protein complexes (19-21) and protein complementation screens (22) to gain further insight into their function (Physique S4 Table S1 and supplemental Cytoscape file). (bioinf.org)
  • Unexpectedly multiple genetic and protein-protein interactions were HMN-214 also detected between and proteins with Gene Ontology (GO) annotations indicating direct involvement HMN-214 in vesicular transport secretory pathway and cellular localization: of 178 ERG25-interacting proteins 53 had such GO annotations representing a highly significant enrichment (e.g. vesicle-mediated transport p=1.4*10?8) (Fig. 3B). (bioinf.org)
  • The vector stencils library " Biochemistry of metabolism" contains 46 metabolite symbols for drawing metabolic pathways maps, biochemical diagrams and metabolism process flow charts using the ConceptDraw PRO diagramming and vector drawing software. (conceptdraw.com)
  • The vector stencils library "Citric acid cycle (TCA cycle)" contains 26 symbols of metabolites for drawing metabolic pathway maps and biochemical shematic diagrams of the citric acid cycle (TCA cycle, tricarboxylic acid cycle, Krebs cycle) and diagrams of metabolism processes. (conceptdraw.com)
  • Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically. (conceptdraw.com)
  • Proteomic analyses indicated that oxidative metabolism, fatty acid β-oxidation and mitochondrial dysfunction were among the top myocardial signalling pathways perturbed. (nih.gov)
  • Four metabolic pathways and one oxidative stress pathway were identified in the miPPSPC, whereas linoleic acid metabolism and the pentose phosphate pathway were identified in the mPPSPC. (aging-us.com)
  • Key factors of the pentose phosphate pathway and linoleic acid metabolism, G6PD and CYP2C8/9/18/19, respectively, are related to the survival of PC patients according to our tissue microarray. (aging-us.com)
  • In response to the switch of carbon sources during the growth, the central metabolism (TCA cycle, glyoxylate shunt and futile pathways) of MR-1 also changes. (umsystem.edu)
  • To describe this dynamic metabolism, we combine the enzyme kinetic modeling with the isotopomer analysis to quantitatively understand the regulation of metabolic network and profile the flux distribution as the function of the time. (umsystem.edu)
  • Our results highlight the importance of intact muscle function and metabolism for whole-body homeostasis and indicate that modulation of PGC-1alpha levels in skeletal muscle presents an avenue for the prevention and treatment of a group of age-related disorders. (fightaging.org)
  • The epithelium function and the mucosal associated immune system are influenced by direct host-microbiota interactions and through modulation of the microbial metabolism [7]. (deepdyve.com)
  • Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)
  • In biochemistry, metabolic pathways are series of chemical reactions occurring within a cell. (conceptdraw.com)
  • Major advances have been made in understanding the biochemistry of essential fatty acids (FA) and their interactions with metabolic pathways leading to the production of longer and more complex fatty acids and lipids. (biu.ac.il)
  • She received her PhD in Biochemistry and Biophysics in 2013 from Caltech with Dr. Richard M. Murray (co-advised by Dr. Hana El-Samad at UCSF), where she studied single-cell growth and gene expression dynamics and the role of feedback loops in a metabolic gene regulatory network. (utexas.edu)
  • Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). (conceptdraw.com)
  • These efforts demonstrate the power of standardized and reproducible computational workflows for integrating and analysing varied omics data and gaining deeper insights into microbe community structure and function as well as host-microbe interactions. (deepdyve.com)
  • Gut microorganisms are the source of many bioactive products that play key functions in human host pathways and microbe-microbe interactions [2]. (deepdyve.com)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • In sum, microbial interactions can be engineered to design microbial communities with desired target functions and building microbiomes from the bottom-up is a powerful approach to exploring the structure-function landscapes of microbiomes. (utexas.edu)
  • The metabolic and oxidative stress pathways may participate in PC progression. (aging-us.com)
  • Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer's disease (AD). (nature.com)
  • We carried out a series of bioinformatics studies with the phytoconstituents of Amaranthus tricolor to elicit their possible molecular functions in cognitive disorders including Alzheimer's disease. (ijpsonline.com)
  • Cognitive impairment is a complex disorder of old age people characterized by changes in cognitive functions like trouble in remembering, concentrating, learning and decision making. (ijpsonline.com)
  • From a clinical point of view, AD has a strong impact on the lifestyle of patients which is characterized by a prodromal phase with a subsequent progressive loss of memory and decline of cognitive functions, leading to the need for continuous medical care [ 2 ]. (ijpsonline.com)
  • Extracts containing these terpene indole alkaloids (TIAs) can inhibit the formation and destabilize preformed fibrils of amyloid β protein (a pathological marker of Alzheimer's disease), and have been shown to improve the cognitive function of mice with Alzheimer-like symptoms. (biomedcentral.com)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • Within the underlying theme of our research, we explore T cell responses from two complementary angles: the molecular pathways intrinsic to T cells, and the pathways that act in dendritic cells to cross-regulate T cell responses. (stjude.org)
  • This reaction is the first step in the gluconeogenic pathway, in which citric acid cycle intermediates are converted to hexose. (asm.org)
  • In Rhizobium species, a PEPCK-deficient mutant fails to grow on minimal medium with succinate or other citric acid cycle intermediates but can grow on glucose and glycerol as a sole carbon source, suggesting that PEPCK functions here as a key gluconeogenic enzyme ( 30 ). (asm.org)
  • Conversely, PEPCK also functions in the anaplerotic pathway of some organisms, such as Anaerobiospirillum succiniciproducens ( 37 ), Alcaligenes eutrophus ( 39 ), Ruminococcus flavefaciens ( 40 ), Dipetalonema viteae ( 4 ), and Trypanosoma cruzi ( 6 ), where it forms OAA from PEP, which in turn enters the citric acid cycle. (asm.org)
  • Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. (nih.gov)
  • Noncommunicable diseases, including cardiovascular, metabolic and respiratory diseases, among others, are the major medical challenge of the 21st century. (ersjournals.com)
  • This interdisciplinary expertise means the student will receive training in psychosocial assessments, psychophysiological testing, stress testing, neuroendocrine sampling and assays, physiological function tests, analysis of multi-disciplinary data, and public participant involvement among many other techniques, resulting in creating a PhD graduate with a broad range of interdisciplinary skills applicable for many settings. (findaphd.com)
  • Significant insight into the physiological roles of signaling and metabolic pathways could impact our understanding of fundamental mechanisms of immune regulation and manifest legitimate therapeutic opportunities. (stjude.org)
  • A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. (conceptdraw.com)
  • This pathway converts a C3 metabolite to two acetyl-CoA by fixation of one additional CO2 equivalent, or assimilates glyoxylate, a photorespiration intermediate, to produce acetyl-CoA without net carbon loss. (osti.gov)
  • article{osti_1500021, title = {Augmenting the Calvin-Benson-Bassham cycle by a synthetic malyl-CoA-glycerate carbon fixation pathway}, author = {Yu, Hong and Li, Xiaoqian and Duchoud, Fabienne and Chuang, Derrick S. and Liao, James C.}, abstractNote = {The Calvin-Benson-Bassham (CBB) cycle is presumably evolved for optimal synthesis of C3 sugars, but not for the production of C2 metabolite acetyl-CoA. (osti.gov)
  • Nevertheless supplementation of press with cholesterol or an upstream metabolite in the pathway such as for example lanosterol didn't have any influence on viability or level of sensitivity to EGFR inhibitors (Fig. S3D-G) recommending specific results at the amount of the C4 demethylation complicated. (bioinf.org)
  • On the other hand addition of T-MAS or especially its instant precursor FF-MAS towards the tradition medium reduced cancers cell viability (Fig. 2E) and improved cancer cells level of sensitivity to erlotinib (Fig. 2F G). Used amount these data support the interpretation that sensitization to erlotinib can be connected with perturbation of swimming pools of the sterol intermediate metabolite proximally upstream of SC4MOL in the metabolic pathway. (bioinf.org)
  • Metabolic pathway resources at MaizeGDB [abstract]. (usda.gov)
  • Mazza A1, Gat-Viks I, Sharan R. Elucidating Influenza Inhibition Pathways via Network Reconstruction. (tau.ac.il)
  • MaizeCyc and CornCyc are both based on B73 RefGen_v2 filtered gene set models, and offer visualization and analysis capabilities of Pathway Tools developed by SRI. (usda.gov)
  • Our lab aims to combine high-throughput measurements of microbial communities and computational modeling to predict, design and control microbiome functions. (utexas.edu)
  • Thus, we infer that a complex network of metabolic handoffs extensively cross-links subsurface biogeochemical cycles. (nih.gov)
  • However, the microbial metabolic pathway of the fungicide and the genetic systems driving its degradation by strain P3 remain unknown. (nature.com)
  • In silico models predicting cellular glycosylation capacities and glycosylation outcomes are emerging, and refined maps of the glycosylation pathways facilitate genetic approaches to address functions of the vast glycoproteome. (ku.dk)
  • Her postdoctoral research aimed to manipulate intracellular resource allocation in bacteria to program the behaviors of synthetic genetic circuits and metabolic pathways and combine experiments and computational modeling to predict the assembly of synthetic human gut communities. (utexas.edu)
  • KEGG pathway enrichment correlation revealed that protein digestion and absorption (Ko04974), proximal tubule bicarbonate (Ko04964), and bile secretion (Ko04976) played important roles in Na + /H + and Na + /K + exchange. (hindawi.com)
  • Among most sensitive to PCBD are pathways with key roles in synaptic plasticity. (nature.com)
  • Mild, acute stress often enhances hippocampal function by augmenting synaptic plasticity, reflecting the adaptive importance of remembering threatening or dangerous circumstances 2 . (nature.com)
  • This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
  • Results: A total of 962 DEGs between SQC and Met groups were screened, and these DEGs were significantly enriched in various functions, such as sensory perception of the chemical stimulus, NADH dehydrogenase (ubiquinone) activity, and positive regulation of the fatty acid metabolic process. (benthamscience.com)
  • This has been for instance the case for the pathways generating phenylpropanoids, specialized molecules serving as anti-UV and precursors to structural polymers, and the hormones abscisic acid (ABA) and strigolactones (SL) that help plant coordinate stress responses and interaction with microorganisms. (europa.eu)
  • A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
  • In addition, numerous distinct pathways co-exist within a cell. (conceptdraw.com)
  • During organismal development, peroxisomes may alter their functions by compartmentalizing distinct sets of enzymes. (biorxiv.org)
  • Pathways are important to the maintenance of homeostasis within an organism. (conceptdraw.com)
  • Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
  • Metabolic homeostasis is vital for brain function, and a detailed metabolome atlas of the brain is essential for understanding the networks connecting different brain regions. (bvsalud.org)
  • The autonomic nervous system (ANS) is a very complex, multifaceted neural network that maintains internal physiologic homeostasis. (medscape.com)
  • Global transcriptome analysis profiles metabolic pathways in traditional herb Astragalus membranaceus Bge. (biomedcentral.com)
  • A transcriptome study was performed for A. mongolicus tissues to construct and profile their metabolic pathways, especially for the important bioactive molecules. (biomedcentral.com)
  • The transcriptome data from this study provides an important resource for understanding the formation of major bioactive constituents in the capsule extract from Uncaria , and provides information that may aid in metabolic engineering to increase yields of these important alkaloids. (biomedcentral.com)
  • The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions. (conceptdraw.com)
  • Their pipelines for enzymatic function assignment indicate some differences: MaizeCyc is mainly based on the exonerate scores generated via the Ensembl XRef pipeline, whereas CornCyc employs a scoring matrix based on performances obtained using BLAST, CatFam, and Priam. (usda.gov)
  • Importantly, MCK-PGC-1alpha animals also showed improved metabolic responses as evident by increased insulin sensitivity and insulin signaling in aged mice. (fightaging.org)
  • Failure of the PN is associated with broad range of diseases including cancer, neurodegeneration, and immunological and metabolic disorders [ 1 ]. (hindawi.com)
  • This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. (nih.gov)
  • Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. (bvsalud.org)
  • Analysis of the genome dataset revealed that multiple organisms, including some from ~34 newly detected phyla, are often required to complete redox pathways. (nih.gov)
  • For dendritic cell-mediated extrinsic control of T cell differentiation, we focus on metabolic and inflammatory pathways (see Du Nature 2018). (stjude.org)
  • Therefore, elucidation of the microbial metabolic pathway of OPP is a prerequisite for the downstream exploitation of strain P3 in any environmental application. (nature.com)
  • Gene set variation analysis (GSVA), a functional enrichment analysis method similar to gene set enrichment analysis (GSEA), allows the assessment of underlying pathway activity variation in each sample by pre-inputting a selected gene set [ 11 ]. (aging-us.com)
  • Here we present some statistics from both metabolic networks, provide snapshots of various views and analysis tools available in Pathway Tools, and show examples of how these tools and resources can be used to derive biologically-meaningful hypotheses. (usda.gov)
  • Gene set variation analysis (GSVA) was used to establish and validate a miRNA set-based pathway prognostic signature for PC (miPPSPC) and a mRNA set-based pathway prognostic signature for PC (mPPSPC) in independent datasets. (aging-us.com)
  • Recently, we apply systems biology approaches, such as proteomics, metabolomics, single cell RNA-sequencing (scRNA-seq), CRISPR screening and integrative network analysis, to reconstruct metabolic signaling circuits and identify new therapeutic targets. (stjude.org)
  • In this State of the Art review we present the basic concepts of systems biology, use some examples to illustrate the potential of network medicine to address complex medical problems, and review some recent publications that show how a systems-based research strategy can contribute to improve our understanding of multimorbidity and age-related respiratory diseases. (ersjournals.com)
  • The study of metabolic impairments in neuropsychiatric diseases including depression, schizophrenia and Alzheimer's disease. (duke.edu)
  • Altogether, EPPIMAL will bring original information on the evolution of protein networks shaping three iconic land plant metabolic pathways that supported plant adaptation to land. (europa.eu)
  • Chapman NM, Chi H . Metabolic adaptation of lymphocytes in immunity and disease. (stjude.org)
  • Our study provides actionable knowledge about the pathways and mechanisms involved in NAFLD pathogenesis, which may prove useful for developing new therapeutic strategies. (nih.gov)
  • Using multivariate and univariate statistical techniques, we generated a metabolome atlas of mouse brain on the global metabolic signature dynamics across multiple brain regions following short-term fasting (STF). (bvsalud.org)
  • The results revealed a comprehensive profile for metabolic activities among tissues, pointing to the equal importance of leaf, stem, and root in A. mongolicus for the production of bioactive compounds. (biomedcentral.com)
  • These structures provide the backbone upon which proteome-wide connectivity, and in turn, protein networks become disturbed and ultimately dysfunctional. (nature.com)
  • Mazza A, Gat-Viks I, Farhan H, Sharan R. A minimum-labeling approach for reconstructing protein networks across multiple conditions. (tau.ac.il)
  • Targeted metabolomics studies apply single to multianalyte quantitative approaches to analyze a predefined selection (1 to 100s) of compounds originating from a specific metabolic pathway. (cdc.gov)
  • A complete understanding of adaptive compensatory metabolic programmes that modulate non-alcoholic steatohepatitis (NASH) progression is lacking. (nih.gov)
  • Consecutive sleepless nights will shorten the time these pathways function, and therefore there will be an accumulation of toxic waste that could be one of the triggers for brain degeneration that causes dementia. (ksusentinel.com)
  • The correlation between modules and metabolic pathways was also calculated. (benthamscience.com)
  • Two maize metabolic networks are available at MaizeGDB: MaizeCyc (http://maizecyc.maizegdb.org, also at Gramene) and CornCyc (http://corncyc.maizegdb.org, also at the Plant Metabolic Network). (usda.gov)
  • Even the crudest transcriptional network is shown to substantially increase the fitness of the organism, and this effect persists even when the range of nutrient levels is kept very narrow. (lu.se)
  • Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
  • We first functionally demonstrate the design of the MCG pathway in vitro and in Escherichia coli. (osti.gov)
  • Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
  • Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. (hindawi.com)
  • When combined with appropriate experimental design, these methods deliver insightful knowledge about cellular function under diverse conditions. (mdpi.com)
  • Our understanding of the complexity of signalling pathways to and from the mitochondria is increasing, describing a network through which mitochondria may communicate functional status to the nucleus to impact cellular function. (fightaging.org)
  • Significant metabolic differences across brain regions along with STF-triggered region-dependent metabolic remodeling were identified. (bvsalud.org)
  • However, clinically significant liver injury (eg, with jaundice, abdominal pain, or pruritus) or impaired liver function-ie, resulting in deficient protein synthesis (eg, with prolonged prothrombin time [PT] or with hypoalbuminemia)-is rare. (msdmanuals.com)
  • What is even less well understood is how stress across the lifespan might interact with stress reactivity to predict CV and cardio-metabolic disease risk. (findaphd.com)
  • Developing the capability to predict and design the community-level functions of gut microbiota hold tremendous therapeutic potential. (utexas.edu)
  • Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
  • In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
  • MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)
  • Is such compartmentalization necessary for optimal cell function? (biorxiv.org)
  • Metabolic block upstream of SC4MOL with ketoconazole or CYP51A1 siRNA rescued cancer cell EGFR and viability degradation. (bioinf.org)
  • Our laboratory has made important discoveries in understanding the principle of metabolic reprogramming for immune cell fate, state and tolerance. (stjude.org)
  • Chi H . Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology. (stjude.org)
  • The actin cytoskeleton has several critical functions, including determining cell shape and allowing cells to move. (medlineplus.gov)
  • Relevant to the studies presented in this manuscript, mitochondrial dysfunction is a key contributor to the perpetuation of metabolic inflammation caused by nutrient excess. (frontiersin.org)
  • Besides OXPHOS, mitochondrial dysfunction is also present in the examination of mitochondrial morphology, the balance of mitochondrial network formation, and fission and fusion. (frontiersin.org)
  • Metabolic dysfunction-associated liver disease (MASLD) includes simple fatty infiltration (a benign condition. (msdmanuals.com)
  • This system is an intracerebral drainage network that removes metabolic debris from the brain and replenishes nutrients. (ksusentinel.com)
  • Peritoneal stomata constitute the principal pathways for the drainage of intraperitoneal contents from the PERITONEAL CAVITY to the LYMPHATIC SYSTEM. (bvsalud.org)
  • Subsurface processes impact the composition and functioning of the biosphere and atmosphere over both short and geological timescales. (nih.gov)
  • 6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
  • In Escherichia coli , besides the PEPCK reaction, there is another pathway to form PEP from C 4 -dicarboxylic acid which involves the NAD- and NADP-dependent malic enzymes (MAEA and MAEB) and phosphoenolpyruvate synthase (PPS). (asm.org)
  • The network involves the cerebral cortex (the insular and medial prefrontal regions), amygdala, stria terminalis, hypothalamus, and brainstem centers (periaqueductal gray, parabrachial pons, nucleus of the tractus solitarius, and intermediate reticular zone of the medulla). (medscape.com)
  • The biochemical diagram example "Metabolic pathway map" was created using the ConceptDraw PRO diagramming and vector drawing software extended with the Biology solution from the Science and Education area of ConceptDraw Solution Park. (conceptdraw.com)
  • Systems biology-inspired computational methods for translating metabolomics data into fluxomics provide a direct functional, dynamic readout of metabolic networks. (mdpi.com)
  • Awardee principal investigators will become part of the PSI:Biology Network Steering Committee and will work jointly with other investigators and NIH staff to manage the overall PSI:Biology initiative. (nih.gov)
  • The project should involve both studies of protein function by the applicant researchers and structural studies by the PSI:Biology network. (nih.gov)
  • Compartmentalization of enzymes and their reactants optimizes reaction flux within multiple metabolic networks and manages toxic effects of reaction by-products ( Chen and Silver, 2012 ). (biorxiv.org)
  • We show at cellular and target organ levels that network connectivity and functional imbalances revert to normal levels upon epichaperome inhibition. (nature.com)