Full transporter atp binding cassette transporters. Medical search. Frequent questions

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. (wikipedia.org)
ABC transporters are considered to be an ABC superfamily based on the similarities of the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins appear to have evolved independently several times, and thus comprise different protein families. (wikipedia.org)
it is a member of the ABC transporter superfamily. (medscape.com)
However, the ABC (ATP-binding cassette) (Cdr1p, Cdr2p) and major facilitator superfamily (MFS) (Mdr1p) transporters are considered the major contributors to drug resistance in C. albicans [ 13 , 14 ]. (springeropen.com)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). (embl.de)
The major facilitator superfamily (MFS) of membrane proteins represents the largest family of secondary transporters with members from Archaea to Homo sapiens. (embl.de)

This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. (nih.gov)
Here, we examined the effect of two lipid transporters, FAX1 ( fatty acid export1 ) and ABCA9 ( ATP-binding cassette transporter subfamily A9 ) on oil production and lipid metabolism in the oilseed plant Camelina sativa . (biomedcentral.com)
ATP-binding cassette domain 2 of NFT1, subfamily C. Domain 2 of NFT1 (New full-length MRP-type transporter 1). (umbc.edu)

ATP-binding cassette (ABC) efflux transporters, including multidrug resistance protein 1 (Mdr1), breast cancer resistance protein (Bcrp), and multidrug resistance-associated proteins (Mrps) extrude chemicals from the brain. (nih.gov)
Both transcriptional expression and activity of efflux transporters were not strongly modified by the presence of DIPG. (biomedcentral.com)

The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate. (wikipedia.org)

ABC transporters utilize the energy of ATP binding and hydrolysis to transport various substrates across cellular membranes. (wikipedia.org)
The structure shows that two EIIA(Glc) molecules bind to the cytoplasmic ATPase subunits, stabilizing the transporter in an inward-facing conformation and preventing the structural rearrangements necessary for ATP hydrolysis. (nih.gov)
Solubilization and partial purification on sucrose gradient allowed to detect significant Yor1p ATP hydrolysis activity (approximately 100 nmol of Pi.min-1.mg-1). (ox.ac.uk)
Both ABC transporters exhibit ATP hydrolysis in vitro, but Pdr5p ATPase activity is about 15 times higher than that of Yor1p, which may indicate mechanistic or regulatory differences between the two enzymes. (ox.ac.uk)

ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. (wikipedia.org)
The third subgroup of ABC proteins do not function as transporters, but are rather involved in translation and DNA repair processes. (wikipedia.org)
Pathogens use siderophores, such as Enterobactin, to scavenge iron that is in complex with high-affinity iron-binding proteins or erythrocytes. (wikipedia.org)
8] "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (tcdb.org)
Although ABC transporters are critical for blood-brain barrier integrity, less attention has been placed on the regulation of these proteins in brain parenchymal cells such as microglia. (nih.gov)
After acyl-CoA transported to cytosol, it bound to acyl-CoA-binding proteins (ACBPs), which might contribute to drive plastid FA-export [ 7 ]. (biomedcentral.com)

NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. (umbc.edu)

A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. (researchgate.net)

Furthermore, we found that AtSTAR1 may interact with ALS3, a transmembrane-binding domain in Arabidopsis to form a complex because introduction of OsSTAR1, a functional substitute of AtSTAR1, into als3 mutant resulted in the loss of OsSTAR1 protein. (elsevierpure.com)

Most of the uptake systems also have an extracytoplasmic receptor, a solute binding protein. (wikipedia.org)
Transporters are extremely vital in cell survival such that they function as protein systems that counteract any undesirable change occurring in the cell. (wikipedia.org)
2] "Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: a member of ATP-binding cassette transporters. (tcdb.org)
7] "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. (tcdb.org)
This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. (nih.gov)
Breast cancer resistance protein (BCRP), a biliary efflux transporter, exhibits increased liver mRNA expression in NASH patients and preclinical NASH models, but the impact on function is unknown. (aspetjournals.org)

The membrane-spanning region of the ABC transporter protects hydrophilic substrates from the lipids of the membrane bilayer thus providing a pathway across the cell membrane. (wikipedia.org)
However, membrane transporters often carry substrates against a concentration gradient. (fu-berlin.de)

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. (nih.gov)

We search literatures in scientific databases with key words of "each main SHXXT constituent," in combination with "each main inflammatory pathway target molecule" or each main intestinal transporter, respectively. (frontiersin.org)
We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. (frontiersin.org)
Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. (nih.gov)

This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome . (springer.com)
The term "chemical defensome" refers to a wide range of transcription factors, enzymes, transporters, and antioxidant enzymes that together function to detoxify and eliminate harmful compounds, including xenobiotic and endobiotic chemicals. (springer.com)
Disease progression to nonalcoholic steatohepatitis (NASH) has profound effects on the expression and function of drug-metabolizing enzymes and transporters, which provide a mechanistic basis for variable drug response. (aspetjournals.org)

Despite their different topologies, both Yor1p and Pdr5p mediated the ATP-dependent translocation of similar drugs and phospholipids across the yeast cell membrane. (ox.ac.uk)

The Saccharomyces cerevisiae genome encodes 15 full-size ATP binding cassette transporters (ABC), of which PDR5, SNQ2, and YOR1 are known to be regulated by the transcription factors Pdr1p and Pdr3p (pleiotropic drug resistance). (ox.ac.uk)

6] "Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters. (tcdb.org)

We have identified two new ABC transporter-encoding genes, PDR10 and PDR15, which were up-regulated by the PDR1-3 mutation. (ox.ac.uk)
These genes, as well as four other ABC transporter-encoding genes, were deleted in order to study the properties of Yor1p. (ox.ac.uk)

19. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. (nih.gov)

9] "Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters. (tcdb.org)

Kugele A, Ketter S, Silkenath B, Wittmann V, Joseph, B* Drescher M * ( 2021 ) In situ EPR Spectroscopy of a Bacterial Membrane Transporter using an Expanded Genetic Code. (fu-berlin.de)

Overexpressed Yor1p was photolabeled by [gamma-32P]2', 3'-O-(2,4,6-trinitrophenyl)-8-azido-ATP (K0.5 = 45 microM) and inhibited by ATP (KD = 0.3 mM) in plasma membranes. (ox.ac.uk)
Joseph B, Sikora A, Bordignon E, Jeschke G, Cafiso DS, Prisner TF ( 2015) Distance Measurement on an Endogenous Membrane Transporter in E. coli Cells and Native Membranes Using EPR Spectroscopy. (fu-berlin.de)

Here, we sought to determine the effects of inflammation on the expression and function of transporters in microglia. (nih.gov)

ABC transporters are also involved in multiple drug resistance, and this is how some of them were first identified. (wikipedia.org)

However, understanding the underlying molecular mechanism has been hindered by the complete absence of structures for any EIIA(Glc)-transporter complexes. (nih.gov)
We study molecular principles underlying energy transduction and conformational dynamics in Type IV and Type VI ATP Binding Cassette (ABC) transporters. (fu-berlin.de)

Depending on the nature of the transporter, the energy may be provided by ATP, electrochemical gradient, or light etc. (fu-berlin.de)

The sequences identity ranges around 12-18% but regions of functional similarity (e.g., substrate- or H-binding sites) align for only very closely related MFS transporters. (embl.de)

Bacterial ABC transporters are essential in cell viability, virulence, and pathogenicity. (wikipedia.org)
Lipid transporters play an essential role in lipid delivery and distribution, but their influence on seed oil production in oilseed crops is not well studied. (biomedcentral.com)

Here we report a gene, AtSTAR1, only encoding an ATP-binding domain of a bacterial-type ABC transporter in Arabidopsis (Arabidopsis thaliana). (elsevierpure.com)

Here we present the 3.9 Å crystal structure of Escherichia coli EIIA(Glc) in complex with the maltose transporter, an ATP-binding cassette (ABC) transporter. (nih.gov)

ATP-binding cassette (ABC) transporters represent a large family in plants, but the functions of most of these transporters are unknown. (elsevierpure.com)

The cat has three binding sites (mouth, front paws and. (researchgate.net)

Although these represent a wide array of mechanisms, it is likely that the full range of anti-fungal resistance pathways is even greater, for several reasons. (biomedcentral.com)

Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. (nih.gov)

Rudolph M, Tampé R, Joseph B ( 2023 ) Time-resolved Mn2+-NO and NO-NO distance measurements reveal that catalytic asymmetry regulates alternating access in an ABC transporter. (fu-berlin.de)

List of abbreviations or acronyms of the full target name. (nih.gov)

2) The interaction between the main constituents and efflux pumps or intestinal transporters. (frontiersin.org)

Anatomy9

Organisms8

Diseases3

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes35

Information Science3

Superfamily7

SUBFAMILY3

Efflux transporters2

Adenosine triphosphate1

Hydrolysis4

Proteins6

Multidrug1

Abstract1

Transmembrane1

Protein6

Substrates2

Anion1

Inflammatory3

Enzymes3

Translocation1

Genome1

Homo1

Genes2

Yeast1

Characterization1

20211

Membranes2

Function1

Multiple1

Molecular2

Energy1

Functional1

Essential2

Domain1

Complex1

Large1

Sites1

Range1

Drugs1

Access1

Target1

Main1