• Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. (wikipedia.org)
  • Also, the oil from Ocimum basilicum L., (BO) has been proven scientifically to significantly block clonic seizures induced by PTZ and picrotoxin in seizure models. (bvsalud.org)
  • RESULTS: Cocktail antibiotic pre-treatment significantly reversed the anticonvulsant effect of BO by increasing frequency and duration of seizures but did not affect latency to seizure. (bvsalud.org)
  • In mice pre-treated with single antibiotics, the anticonvulsant effect of BO was lost as latency to seizures, frequency and duration of seizures increased compared to mice that received only BO. (bvsalud.org)
  • Biphasic GABA A -mediated postsynaptic responses can be readily evoked in CA1 pyramidal neurons of rat hippocampal slices by high-frequency stimulus (HFS) trains in the presence of ionotropic glutamate receptor antagonists. (jneurosci.org)
  • This means that, even in the presence of low concentrations of picrotoxin, the response of neurons to GABA is reduced. (wikipedia.org)
  • By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the γ-aminobutyric acid type A (GABA A ) ionophore. (nih.gov)
  • Rather, they found that picrotoxin "binds preferentially to an agonist bound form of the receptor. (wikipedia.org)
  • GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with sub convulsive doses of picrotoxin. (ac.ir)
  • A study by Newland and Cull-Candy found that, in high enough concentrations, picrotoxin reduced the amplitude of GABA currents. (wikipedia.org)
  • TETS also dramatically affected Ca²⁺ dynamics causing an immediate but transient elevation of neuronal intracellular Ca²⁺ followed by decreased frequency of Ca²⁺ oscillations but greater peak amplitude. (nih.gov)
  • Under kinetically controlled conditions, this process generally results in exo cyclization and forms bridged ring systems like those found in picrotoxin. (wikipedia.org)